Experimental modulation of MRP (multidrug resistanceassociated protein)-mediated resistance

Danks, 1987, Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26), Cancer Res, 47, 1297 Danks, 1988, Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26, Biochemistry, 27, 8861, 10.1021/bi00424a026 Mirski, 1987, Multidrug resistance in a human small cell line selected in adriamycin, Cancer Res, 47, 1780 Twentyman, 1986, Derivation and preliminary characterization of adriamycin resistant lines of human lung cancer cells, Br J Cancer, 53, 529, 10.1038/bjc.1986.83 Zijlstra, 1987, Multifactorial drug resistance in an Adriamycin-resistant human small cell lung carcinoma cell line, Cancer Res, 47, 1780 Kuiper, 1990, Drug transport variants without P-glycoprotein overexpression from a human squamous lung cancer cell line after selection with doxorubicin, J Cell Pharmacol, 1, 35 McGrath, 1987, Adriamycin resistance in HL60 cells in the absence of detectable P-glycoprotein, Biochem Biophys Res Commun, 145, 1171, 10.1016/0006-291X(87)91560-9 Hindenberg, 1989, Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and resistant HL-60 cells, Cancer Res, 49, 4607 Slovak, 1988, Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines, Cancer Res, 48, 2793 Marquardt, 1990, Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein, Cancer Res, 50, 1426 Versantvoort, 1992, Overexpression of 110 and 190 kD proteins in cancer cells may be involved in drug resistant phenotype, 33, 456 Cole, 1992, Overexpression of a novel transporter gene in a multidrug resistant human lung cancer cell line, Science, 258, 1650, 10.1126/science.1360704 Krishnamachary, 1993, The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein, Cancer Res, 53, 3658 Zaman, 1993, Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines, Cancer Res, 53, 1747 Barrand, 1994, A 190k protein overexpressed in non-P-glycoprotein-containing MDR cells and its relation to the MRP gene, J Natl Cancer Inst, 86, 110, 10.1093/jnci/86.2.110 Grant, 1994, Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs, Cancer Res, 54, 357 Zaman, 1994, The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump, 91, 8822 Jedlitschky, 1994, ATP-dependent transport of glutathione S-conjugates by the multidrug resistanceassociated protein, Cancer Res, 54, 4833 Müller, 1994, Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport, 91, 13027 Tsuruo, 1981, Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil, Cancer Res, 41, 1967 Slater, 1986, Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro, J Clin Invest, 77, 1405, 10.1172/JCI112450 Twentyman, 1987, Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multidrug resistant human lung cancer cell line, Br J Cancer, 56, 55, 10.1038/bjc.1987.153 Twentyman, 1988, Modification of cytotoxic drug resistance by non-immunosuppressive cyclosporins, Br J Cancer, 57, 254, 10.1038/bjc.1988.55 Gaveriaux, 1991, SDZ-PSC-833, a non-immunosuppressive cyclosporin analog, is a very potent multidrug-resistance modifier, J Cell Pharmacol, 2, 225 Ford, 1995, Modulators of multidrug resistance—Preclinical studies, Hematol Oncol Clin North Am, 9, 337, 10.1016/S0889-8588(18)30098-4 Safa, 1988, Photoaffinity labeling of the multidrug-resistancerelated P-glycoprotein with photoactive analogs of verapamil, 85, 7187 Foxwell, 1989, Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein, Mol Pharmacol, 36, 543 Cole, 1989, Effect of calcium antagonists on the chemosensitivity of two multidrug resistant human tumour cell lines which do not overexpress P-glycoprotein, Br J Cancer, 59, 42, 10.1038/bjc.1989.9 Barrand, 1993, Chemosensitisation and drug accumulation effects of cyclosporin A, PSC833 and verapamil in human MDR large cell lung cancer cells expressing a 190 k membrane protein distinct from P-glycoprotein, Eur J Cancer, 29A, 408, 10.1016/0959-8049(93)90397-X Leier, 1994, The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates, J Biol Chem, 269, 27807, 10.1016/S0021-9258(18)46856-1 Zaman, 1994, The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump, 91, 8822 Feller, 1995, Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry, Br J Cancer, 72, 543, 10.1038/bjc.1995.371 Cole, 1994, Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells, Cancer Res, 54, 5902 Coley, 1993, Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines, Br J Cancer, 67, 1316, 10.1038/bjc.1993.244 Marquardt, 1992, Drug transport mechanism in HL-60 cells isolated for resistance to Adriamycin: evidence for nuclear drug accumulation in resistant cells, Cancer Res, 52, 3157 Marquardt, 1991, Involvement of vacuolar H+-adenosine triphosphatase activity in multidrug resistance in HL60 cells, J Natl Cancer Inst, 83, 1098, 10.1093/jnci/83.15.1098 Rhodes, 1994, Modification by brefeldin A, bafilomycin A, and 7-chloro-4-nitrobenz-2-oxa-l,3-diazole (NBD) of cellular accumulation and intracellular distribution of anthracyclines in the non-P-glycoprotein-mediated multidrugresistant cell line COR-L23/R, Br J Cancer, 70, 60, 10.1038/bjc.1994.250 Chin, 1993, Function and regulation of the human multidrug resistance gene, Adv in Cancer Res, 60, 157, 10.1016/S0065-230X(08)60825-8 Takeda, 1992, Reversal of multidrug resistance by genistein in non-P-glycoprotein mediated multidrug-resistant cell line (K562/TPA), 33, 476 Versantvoort, 1993, Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells, Br J Cancer, 68, 939, 10.1038/bjc.1993.458 Twentyman, 1994, A comparison of rhodamine 123 accumulation and efflux in cells with P-glycoproteinmediated and MRP-associated multidrug resistance phenotypes, Eur J Cancer, 30A, 1360, 10.1016/0959-8049(94)90187-2 Versantvoort, 1996, Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds, Br J Cancer, 10.1038/bjc.1996.658 Gottesman, 1993, Biochemistry of multidrug resistance mediated by the multidrug transporter, Ann Rev Biochem, 62, 385, 10.1146/annurev.bi.62.070193.002125 Tew, 1994, Glutathione-associated enzymes in anticancer drug resistance, Cancer Res, 54, 4313 Kramer, 1988, Role of the glutathione redox cycle in acquired and de novo multidrug resistance, Science, 241, 694, 10.1126/science.3399900 Dusre, 1989, Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrugresistant human breast tumor cells, Cancer Res, 49, 511 Lutzky, 1989, Role of glutathione and dependent enzymes in anthracycline-resistant HL60/AR cells, Cancer Res, 49, 4120 Meijer, 1991, Combined in vitro modulation of adriamycin resistance, Int J Cancer, 49, 582, 10.1002/ijc.2910490419 Larsson, 1991, Combination of cyclosporin A and buthionine sulfoximine (BSO) as a pharmacological strategy for circumvention of multidrug resistance in small cell lung cancer cell lines selected for resistance to doxorubicin, Anticancer Res, 11, 455 Cole, 1990, Alterations in glutathione and glutathione-related enzymes in a multidrugresistant small cell lung cancer cell line, Mol Pharmacol, 37, 192 Versantvoort, 1995, Regulation by gluthione of drug transport in multidrug resistant human lung tumour cell lines overexpressing MRP, Br J Cancer, 72, 82, 10.1038/bjc.1995.281 Leier, 1994, Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells, Eur J Biochem, 220, 599, 10.1111/j.1432-1033.1994.tb18661.x Leier, 1994, The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates, J Biol Chem, 269, 27807, 10.1016/S0021-9258(18)46856-1 Gekeler, 1995, The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance, Biochem Biophys Res Commun, 208, 345, 10.1006/bbrc.1995.1344 Gekeler, 1995, The specific bisindolylmaleimide PKC-inhibitor GF 109203X efficiently modulates MRP-associated multiple drug resistance, Biochem Biophys Res Commun, 206, 119, 10.1006/bbrc.1995.1017 Homolya, 1993, Fluorescent cellular indicators are extruded by the multidrug resistance protein, J Biol Chem, 268, 21493, 10.1016/S0021-9258(20)80566-3 Hollo, 1994, Calcein accumulation as a fluorometric functional assay of the multidrug transporter, Biochim Biophys Acta, 1191, 385, 10.1016/0005-2736(94)90190-2 Versantvoort, 1995, On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein (MRP), Int J Cancer, 63, 855, 10.1002/ijc.2910630617 Feller, 1995, ATPdependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion, FEBS Lett, 368, 385, 10.1016/0014-5793(95)00677-2 Versantvoort, 1994, Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells, Biochem Pharmacol, 48, 1129, 10.1016/0006-2952(94)90149-X Ishikawa, 1992, The ATP-dependent glutathione 5-conjugate export pump, Trends Biochem Soc, 17, 463, 10.1016/0968-0004(92)90489-V