Experimental model of anal fistula in rats

Journal of Coloproctology - Tập 33 - Trang 135-138 - 2013
Mariana Sousa Arakaki1, Carlos Henrique Marques dos Santos1,2,3, Gustavo Ribeiro Falcão2, Pedro Carvalho Cassino2, Ricardo Kenithi Nakamura2, Nathália Favero Gomes2, Ricardo Gasparin Coutinho dos Santos2
1Hospital Regional de Mato Grosso do Sul, Campo Grande, MS, Brazil
2Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
3Sociedade Brasileira de Coloproctologia, Rio de Janeiro, RJ, Brazil

Tóm tắt

Abstract Introduction the management of anal fistula remains debatable. The lack of a standard treatment free of complications stimulates the development of new options. Objective to develop an experimental model of anal fistula in rats. Methods to surgically create an anal fistula in 10 rats with Seton introduced through the anal sphincter musculature.The animals were euthanized for histological fistula tract assessment. Results all ten specimens histologically assessed had a lumen and surrounding granulation tissue. There was complete epithelialization of the tract in two samples, halfway epithelialization in one sample and epithelialization of only the outer portion in six samples. Epithelialization was not evident in one tract. Conclusion anal fistulas in rats were histologically proved.

Tài liệu tham khảo

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Thông tin
Thông tin xuất bản

Journal of Coloproctology

Tập 33

135-138

Thông tin tác giả