Experimental infection of cats with Tritrichomonas foetus

American Journal of Veterinary Research - Tập 62 Số 11 - Trang 1690-1697 - 2001
Jody L. Gookin1, Michael G. Levy2, J. Mac Law2, Mark G. Papich2, Matthew F. Poore2, Edward B. Breitschwerdt2
1Department of Anatomy, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
2American College of Veterinary Internal Medicine Forum, May 2000, Seattle, Wash.

Tóm tắt

AbstractObjective—To determine whether infection withTritrichomonas foetuscauses diarrhea in specific pathogen-free orCryptosporidiumcoinfected cats.Animals—4 cats with subclinical cryptosporidiosis (group 1) and 4 specific-pathogen-free cats (group 2).Procedure—Cats were infected orogastrically with an axenic culture ofT foetusisolated from a kitten with diarrhea. Direct microscopy and protozoal culture of feces, fecal character, serial colonic mucosal biopsy specimens, and response to treatment with nitazoxanide (NTZ; group 1) or prednisolone (groups 1 and 2) were assessed.Results—Infection withT foetuspersisted in all cats for the entire 203-day study and resulted in diarrhea that resolved after 7 weeks. Group-1 cats had an earlier onset, more severe diarrhea, and increased number of trichomonads on direct fecal examination, compared with group-2 cats. Use of NTZ eliminated shedding ofT foetusandCryptosporidiumoocysts, but diarrhea consisting of trichomonad-containing feces recurred when treatment was discontinued. Prednisolone did not have an effect on infection withT foetusbut resulted in reappearance ofCryptosporidiumoocysts in the feces of 2 of 4 cats. During necropsy,T foetuswas isolated from contents of the ileum, cecum, and colon.Tritrichomonas foetusorganisms and antigen were detected on surface epithelia and within superficial detritus of the cecal and colonic mucosa.Conclusions and Clinical Relevance—After experimental inoculation in cats,T foetusorganisms colonize the ileum, cecum, and colon, reside in close contact with the epithelium, and are associated with transient diarrhea that is exacerbated by coexisting cryptosporidiosis but not treatment with prednisolone. (Am J Vet Res2001;62:1690–1697)

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Thông tin xuất bản

American Journal of Veterinary Research

Tập 62 Số 11

1690-1697

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