Mô hình động vật thí nghiệm và can thiệp RNA: một mối liên hệ đầy hứa hẹn cho nghiên cứu ung thư bàng quang

Springer Science and Business Media LLC - Tập 27 - Trang 353-361 - 2009
Leonardo Oliveira Reis1, Tiago Campos Pereira2, Wagner José Favaro3, Valéria Helena Alves Cagnon3, Iscia Lopes-Cendes2, Ubirajara Ferreira1
1Department of Urology, Faculty of Medical Sciences, University of Campinas, UNICAMP, Campinas, Brazil
2Department of Medical Genetics, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil
3Department of Anatomy, Institute of Biology, University of Campinas, UNICAMP, Campinas, Brazil

Tóm tắt

Mô hình động vật là trung tâm của nghiên cứu ung thư bàng quang (BC) trong phòng thí nghiệm và đồng thời, là cầu nối đến lâm sàng. Một phương pháp điều trị mới rất hứa hẹn là làm câm các gen được điều chỉnh tăng một cách bất thường trong ung thư, thông qua các phân tử RNA can thiệp nhỏ (siRNA). Việc sử dụng siRNA trong điều trị và thành công của chúng sẽ phụ thuộc phần lớn vào sự truyền đạt an toàn và hiệu quả trong môi trường sống, cũng như việc tránh các hiệu ứng không mong muốn ngoài mục tiêu. SiRNA qua đường lòng bàng quang là một chiến lược có thể là lựa chọn giao hàng tốt nhất cho ung thư bàng quang bề mặt, giống như liệu pháp miễn dịch qua đường lòng bàng quang. Hành động trực tiếp của nó có thể cho phép tiếp xúc tế bào liên tục với các nồng độ siRNA hiệu quả. Trong khi quy trình quản lý siRNA qua niệu đạo đầy hứa hẹn cho nghiên cứu ung thư bàng quang cho phép phát hiện các mục tiêu mới trong điều trị ung thư bàng quang, các chất mang qua đường lòng bàng quang tối ưu và các mục tiêu tốt nhất cho siRNA vẫn cần được xác định.

Từ khóa

#ung thư bàng quang #RNA can thiệp nhỏ #mô hình động vật #liệu pháp miễn dịch #truyền đạt in vivo

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