Experiences with the human tumor colony-forming assay in gynecologic malignancies

Journal of Cancer Research and Clinical Oncology - Tập 110 - Trang 234-237 - 1985
Günter E. Umbach1, Judith Poethen1, Heino v. Matthiessen1, Hans Georg Bender1, Ursula Koldovsky1
1Department of Obstetrics and Gynecology, Düsseldorf University, Düsseldorf, Federal Republic of Germany

Tóm tắt

Tumor samples from 74 patients with gynecologic malignancies including breast cancer were processed in a soft agar colony-forming assay. None of the samples resulted in a pure single cell suspension. Of the 10 samples meeting our criteria of evaluability for chemosensitivity testing, only 5 samples showed in vitro sensitivity to any drug. Of the 3 evaluable correlations between in vitro and in vivo results, 2 were correct. Due to the low rate of evaluable samples the assay has only limited value in the assignment of chemotherapeutic drugs for patients treated at our institution.

Tài liệu tham khảo

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