Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

Protein & Cell - Tập 13 Số 3 - Trang 220-226 - 2022
Jinghui Lei1, Xiaoyu Jiang2, Wei Li1, Jie Ren3, Datao Wang4, Zhejun Ji5, Zeming Wu2, Fang Cheng6, Yusheng Cai2, Zhengrong Yu7, Juan Carlos Izpisúa Belmonte8, Chunyi Li4, Guang‐Hui Liu2, Weiqi Zhang3, Jing Qu5, Si Wang9
1Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China
2State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
3CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
4Institute of Antler Science and Product Technology, Changchun Sci-Tech University, Changchun, 130000, China
5State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
6University of Chinese Academy of Sciences, Beijing, 100049, China
7Department of Orthopaedics, Peking University First Hospital, Beijing, 100034, China
8Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA
9Aging Translational Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

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Tài liệu tham khảo

Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W, Song M et al (2020) SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell 11:483–504

Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L et al (2019) Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell 10:417–435

Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N et al (2017) Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med 23:775–781

Kalluri R, LeBleu VS (2020) The biology, function, and biomedical applications of exosomes. Science 367:eaau6977

Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI et al (2021a) FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction. Protein Cell 12:145–151

Lei Q, Gao F, Liu T, Ren W, Chen L, Cao Y, Chen W, Guo S, Zhang Q, Chen W et al (2021b) Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration. Sci Transl Med 13:eaaz8697

Rong X, Chu W, Zhang H, Wang Y, Qi X, Zhang G, Wang Y, Li C (2019) Antler stem cell-conditioned medium stimulates regenerative wound healing in rats. Stem Cell Res Ther 10:326

Rong X, Yang Y, Zhang G, Zhang H, Li C, Wang Y (2020) Antler stem cells as a novel stem cell source for reducing liver fibrosis. Cell Tissue Res 379:195–206

Sui Z, Sun H, Weng Y, Zhang X, Sun M, Sun R, Zhao B, Liang Z, Zhang Y, Li C et al (2020) Quantitative proteomics analysis of deer antlerogenic periosteal cells reveals potential bioactive factors in velvet antlers. J Chromatogr A 1609:

Tran C, Damaser MS (2015) Stem cells as drug delivery methods: application of stem cell secretome for regeneration. Adv Drug Deliv Rev 82–83:1–11

Wang D, Berg D, Ba H, Sun H, Wang Z, Li C (2019) Deer antler stem cells are a novel type of cells that sustain full regeneration of a mammalian organ-deer antler. Cell Death Dis 10:443

Xu M, Bradley EW, Weivoda MM, Hwang SM, Pirtskhalava T, Decklever T, Curran GL, Ogrodnik M, Jurk D, Johnson KO et al (2017) Transplanted senescent cells induce an osteoarthritis-like condition in mice. J Gerontol A 72:780–785

Yao B, Zhang M, Leng X, Liu M, Liu Y, Hu Y, Zhao D, Zhao Y (2018) Antler extracts stimulate chondrocyte proliferation and possess potent anti-oxidative, anti-inflammatory, and immune-modulatory properties. In Vitro Cell Dev Biol Anim 54:439–448

Yin K, Wang S, Zhao RC (2019) Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm. Biomark Res 7:8

Zhang J, Liu GH, Qu J, Song M (2020) Treating osteoarthritis via gene therapy with rejuvenation factors. Gene Ther 27:309–311