Exosomes contain ubiquitinated proteins

Stoorvogel, 1991, Late endosomes derive from early endosomes by maturation, Cell, 65, 417, 10.1016/0092-8674(91)90459-C

Katzmann, 2002, Receptor downregulation and multivesicular-body sorting, Nat. Rev., Mol. Cell Biol., 3, 893, 10.1038/nrm973

Murk, 2003, Endosomal compartmentalization in three dimensions: implications for membrane fusion, Proc. Natl. Acad. Sci. U. S. A., 100, 13332, 10.1073/pnas.2232379100

Futter, 1996, Multivesicular endosomes containing internalized EGF–EGF receptor complexes mature and then fuse directly with lysosomes, J. Cell Biol., 132, 1011, 10.1083/jcb.132.6.1011

Mullock, 1998, Fusion of lysosomes with late endosomes produces a hybrid organelle of intermediate density and is NSF dependent, J. Cell Biol., 140, 591, 10.1083/jcb.140.3.591

Felder, 1990, Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body, Cell, 61, 623, 10.1016/0092-8674(90)90474-S

Bishop, 2002, Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates, J. Cell Biol., 157, 91, 10.1083/jcb.200112080

Kleijmeer, 2001, Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells, J. Cell Biol., 155, 53, 10.1083/jcb.200103071

Stoorvogel, 2002, The biogenesis and functions of exosomes, Traffic, 3, 321, 10.1034/j.1600-0854.2002.30502.x

Thery, 2002, Exosomes: composition, biogenesis and function, Nat. Rev., Immunol., 2, 569, 10.1038/nri855

Pan, 1983, Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor, Cell, 33, 967, 10.1016/0092-8674(83)90040-5

Harding, 1983, Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes, J. Cell Biol., 97, 329, 10.1083/jcb.97.2.329

Segura, 2005, ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming, Blood, 106, 216, 10.1182/blood-2005-01-0220

Thery, 2002, Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes, Nat. Immunol., 3, 1156, 10.1038/ni854

Zitvogel, 1998, Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes, Nat. Med., 4, 594, 10.1038/nm0598-594

Raposo, 1996, B lymphocytes secrete antigen-presenting vesicles, J. Exp. Med., 183, 1161, 10.1084/jem.183.3.1161

Babst, 2005, A protein's final ESCRT, Traffic, 6, 2, 10.1111/j.1600-0854.2004.00246.x

Sachse, 2004, ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles, J. Cell Sci., 117, 1699, 10.1242/jcs.00998

Raiborg, 2002, Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes, Nat. Cell Biol., 4, 394, 10.1038/ncb791

Babst, 2002, Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body, Dev. Cell, 3, 283, 10.1016/S1534-5807(02)00219-8

Katzmann, 2001, Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I, Cell, 106, 145, 10.1016/S0092-8674(01)00434-2

Amerik, 2000, The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways, Mol. Biol. Cell, 11, 3365, 10.1091/mbc.11.10.3365

Barois, 1997, Selective modulation of the major histocompatibility complex class II antigen presentation pathway following B cell receptor ligation and protein kinase C activation, J. Biol. Chem., 272, 3641, 10.1074/jbc.272.6.3641

Wubbolts, 2003, Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation, J. Biol. Chem., 278, 10963, 10.1074/jbc.M207550200

Fujiki, 1982, Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum, J. Cell Biol., 93, 97, 10.1083/jcb.93.1.97

Winzler, 1997, Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures, J. Exp. Med., 185, 317, 10.1084/jem.185.2.317

Lankar, 2002, Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation, J. Exp. Med., 195, 461, 10.1084/jem.20011543

Thery, 2001, Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles, J. Immunol., 166, 7309, 10.4049/jimmunol.166.12.7309

Haglund, 2003, Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation, Nat. Cell Biol., 5, 461, 10.1038/ncb983

Reggiori, 2001, Sorting of proteins into multivesicular bodies: ubiquitin-dependent and-independent targeting, EMBO J., 20, 5176, 10.1093/emboj/20.18.5176

Bache, 2003, STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes, J. Biol. Chem., 278, 12513, 10.1074/jbc.M210843200

van Kerkhof, 2001, Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins, Mol. Biol. Cell, 12, 2556, 10.1091/mbc.12.8.2556

Longva, 2002, Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies, J. Cell Biol., 156, 843, 10.1083/jcb.200106056

Carter, 2004, The met receptor degradation pathway: requirement for Lys48-linked polyubiquitin independent of proteasome activity, J. Biol. Chem., 279, 52835, 10.1074/jbc.M407769200

Laszlo, 1991, Immunogold localisation of ubiquitin–protein conjugates in primary (azurophilic) granules of polymorphonuclear neutrophils, FEBS Lett., 279, 175, 10.1016/0014-5793(91)80142-P