Exosome engineering: Current progress in cargo loading and targeted delivery

Agrawal, 2017, Milk-derived exosomes for oral delivery of paclitaxel, Nanomedicine, 13, 1627, 10.1016/j.nano.2017.03.001 Alavi, 2017, Application of various types of liposomes in drug delivery systems, Adv. Pharm. Bull., 7, 3, 10.15171/apb.2017.002 Allen, 2013, Liposomal drug delivery systems: from concept to clinical applications, Adv. Drug Deliv. Rev., 65, 36, 10.1016/j.addr.2012.09.037 Altanerova, 2017, Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia, Int. J. Nanomedicine, 12, 7923, 10.2147/IJN.S145096 Alvarez-Erviti, 2011, Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes, Nat. Biotechnol., 29, 341, 10.1038/nbt.1807 Andaloussi, 2013, Exosomes for targeted siRNA delivery across biological barriers, Adv. Drug Deliv. Rev., 65, 391, 10.1016/j.addr.2012.08.008 Aqil, 2016, Exosomal formulation enhances therapeutic response of celastrol against lung cancer, Exp. Mol. Pathol., 101, 12, 10.1016/j.yexmp.2016.05.013 Astruc, 2010, Dendrimers designed for functions: from physical, photophysical, and supramolecular properties to applications in sensing, catalysis, molecular electronics, photonics, and nanomedicine, Chem. Rev., 110, 1857, 10.1021/cr900327d Baek, 2019, Mesenchymal stem cell-derived extracellular vesicles as therapeutics and as a drug delivery platform, Stem Cells Transl. Med., 8, 880, 10.1002/sctm.18-0226 Balachandran, 2019, Extracellular vesicles-based drug delivery system for cancer treatment, Cogent Med., 6, 1635806, 10.1080/2331205X.2019.1635806 Baldari, 2019, Extracellular vesicles-encapsulated microRNA-125b produced in genetically modified mesenchymal stromal cells inhibits hepatocellular carcinoma cell proliferation, Cells, 8, 10.3390/cells8121560 Bangham, 1965, Diffusion of univalent ions across the lamellae of swollen phospholipids, J. Mol. Biol., 13, 238, 10.1016/S0022-2836(65)80093-6 Banizs, 2014, In vitro evaluation of endothelial exosomes as carriers for small interfering ribonucleic acid delivery, Int. J. Nanomedicine, 9, 4223 Bebelman, 2018, Biogenesis and function of extracellular vesicles in cancer, Pharmacol. Ther., 188, 1, 10.1016/j.pharmthera.2018.02.013 Bellavia, 2017, Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo chronic myelogenous Leukemia cell growth, Theranostics, 7, 1333, 10.7150/thno.17092 Betzer, 2017, In vivo neuroimaging of exosomes using gold nanoparticles, ACS Nano, 11, 10883, 10.1021/acsnano.7b04495 Bryniarski, 2013, Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity, J. Allergy Clin. Immunol., 132, 170, 10.1016/j.jaci.2013.04.048 Burges, 1985, Growth factors and cancer, Aust. N. Z. J. Surg., 55, 105, 10.1111/j.1445-2197.1985.tb00868.x Cao, 2019, Engineered exosome-mediated near-infrared-II region V2C quantum dot delivery for nucleus-target low-temperature photothermal therapy, ACS Nano, 13, 1499 Chang, 2019, Exosomes and their noncoding RNA cargo are emerging as new modulators for diabetes mellitus, Cells, 8, 853, 10.3390/cells8080853 Chen, 2014, Epigenetic regulation of connective tissue growth factor by microRNA-214 delivery in exosomes from mouse or human hepatic stellate cells, Hepatology, 59, 1118, 10.1002/hep.26768 Chen, 2020, Bone marrow mesenchymal stem cell-secreted exosomes carrying microRNA-125b protect against myocardial ischemia reperfusion injury via targeting SIRT7, Mol. Cell. Biochem., 465, 103, 10.1007/s11010-019-03671-z Cho, 2005, Exosomes: a new delivery system for tumor antigens in cancer immunotherapy, Int. J. Cancer, 114, 613, 10.1002/ijc.20757 Choi, 2019, Mannose-modified serum exosomes for the elevated uptake to murine dendritic cells and lymphatic accumulation, Macromol. Biosci., 19, 10.1002/mabi.201900042 Console, 2019, Exosomes in inflammation and role as biomarkers, Clin. Chim. Acta, 488, 165, 10.1016/j.cca.2018.11.009 Cui, 2019, RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease, Immun. Ageing, 16, 10, 10.1186/s12979-019-0150-2 Das, 2019, Exosome as a novel shuttle for delivery of therapeutics across biological barriers, Mol. Pharm., 16, 24, 10.1021/acs.molpharmaceut.8b00901 Dusoswa, 2019, Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells, J. Extracell. Vesicles, 8, 1648995, 10.1080/20013078.2019.1648995 Fattahi, 2011, Magnetoliposomes as multimodal contrast agents for molecular imaging and cancer nanotheragnostics, Nanomedicine (London), 6, 529, 10.2217/nnm.11.14 Felgner, 1987, Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure, Proc. Natl. Acad. Sci. U. S. A., 84, 7413, 10.1073/pnas.84.21.7413 Feng, 2018, The acidic tumor microenvironment: a target for smart cancer nano-theranostics, Natl. Sci. Rev., 5, 269, 10.1093/nsr/nwx062 Ferrante, 2015, Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease, Pediatr. Res., 77, 447, 10.1038/pr.2014.202 Ferreira Ddos, 2013, pH-sensitive liposomes for drug delivery in cancer treatment, Ther. Deliv., 4, 1099, 10.4155/tde.13.80 Fuhrmann, 2015, Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins, J. Control. Release, 205, 35, 10.1016/j.jconrel.2014.11.029 Gao, 2019, Glutaminase C regulates microglial activation and pro-inflammatory exosome release: relevance to the pathogenesis of Alzheimer’s disease, Front. Cell. Neurosci., 13, 264, 10.3389/fncel.2019.00264 Gao, 2020, Glutaminase 1 regulates neuroinflammation after cerebral ischemia through enhancing microglial activation and pro-inflammatory exosome release, Front. Immunol., 11, 10.3389/fimmu.2020.00161 Gilligan, 2017, Engineering exosomes for cancer therapy, Int. J. Mol. Sci., 18, 1122, 10.3390/ijms18061122 Gomari, 2018, Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle, Onco Targets Ther., 11, 5753, 10.2147/OTT.S173110 Gong, 2019, Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy, J. Nanobiotechnology, 17, 93, 10.1186/s12951-019-0526-7 Gutierrez-Vazquez, 2013, Transfer of extracellular vesicles during immune cell-cell interactions, Immunol. Rev., 251, 125, 10.1111/imr.12013 Hadla, 2016, Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models, Nanomedicine, 11, 2431, 10.2217/nnm-2016-0154 Haney, 2015, Exosomes as drug delivery vehicles for Parkinson’s disease therapy, J. Control. Release, 207, 18, 10.1016/j.jconrel.2015.03.033 Haney, 2019, Macrophage-derived extracellular vesicles as drug delivery systems for triple negative breast cancer (TNBC) therapy, J. NeuroImmune Pharmacol., 15, 487, 10.1007/s11481-019-09884-9 Harrell, 2019, Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases, Cells, 8, 10.3390/cells8121605 He, 2018, Exosome theranostics: biology and translational medicine, Theranostics, 8, 237, 10.7150/thno.21945 Hong, 2017, Exosome as a vehicle for delivery of membrane protein therapeutics, PH20, for enhanced tumor penetration and antitumor efficacy, Adv. Funct. Mater., 28, 1703074, 10.1002/adfm.201703074 Hood, 2016, Post isolation modification of exosomes for nanomedicine applications, Nanomedicine (London), 11, 1745, 10.2217/nnm-2016-0102 Hood, 2014, Maximizing exosome colloidal stability following electroporation, Anal. Biochem., 448, 41, 10.1016/j.ab.2013.12.001 Huang, 2018, Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons, FASEB J., 32, 512, 10.1096/fj.201700673r Huang, 2020, Exosomes derived from miR-126-modified MSCs promote angiogenesis and neurogenesis and attenuate apoptosis after spinal cord injury in rats, Neuroscience, 424, 133, 10.1016/j.neuroscience.2019.10.043 Hung, 2016, A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery, J. Extracell. Vesicles, 5, 31027, 10.3402/jev.v5.31027 Hwang, 2019, Chemical modulation of bioengineered exosomes for tissue-specific biodistribution, Adv. Ther., 2, 1900111, 10.1002/adtp.201900111 Illes, 2017, Exosome-coated metal–organic framework nanoparticles: an efficient drug delivery platform, Chem. Mater., 29, 8042, 10.1021/acs.chemmater.7b02358 Izco, 2019, Systemic exosomal delivery of shRNA minicircles prevents parkinsonian pathology, Mol. Ther., 27, 2111, 10.1016/j.ymthe.2019.08.010 James, 2003, Metal-organic frameworks, Chem. Soc. Rev., 32, 276, 10.1039/b200393g Jang, 2013, Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics tomalignant tumors, ACS Nano, 7, 7698, 10.1021/nn402232g Janos, 2009, Liposome triggering of innate immune responses: a perspective on benefits and adverse reactions, J. Liposome Res., 19, 85, 10.1080/08982100902792855 Jeong, 2020, Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model, Lab Chip, 20, 548, 10.1039/C9LC00958B Jeyaram, 2019, Enhanced loading of functional miRNA cargo via ph gradient modification of extracellular vesicles, Mol. Ther., 28, 975, 10.1016/j.ymthe.2019.12.007 Jhan, 2020, Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery, Int. J. Pharm., 573, 118802, 10.1016/j.ijpharm.2019.118802 Jia, 2017, Exosome: emerging biomarker in breast cancer, Oncotarget, 8, 41717, 10.18632/oncotarget.16684 Jia, 2018, NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo, Biomaterials, 178, 302, 10.1016/j.biomaterials.2018.06.029 Jiang, 2017, Exosomes mediate epithelium-mesenchyme crosstalk in organ development, ACS Nano, 11, 7736, 10.1021/acsnano.7b01087 Kanchanapally, 2019, Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis, Int. J. Nanomedicine, 14, 531, 10.2147/IJN.S191313 Karpman, 2017, Extracellular vesicles in renal disease, Nat. Rev. Nephrol., 13, 545, 10.1038/nrneph.2017.98 Katakowski, 2013, Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth, Cancer Lett., 335, 201, 10.1016/j.canlet.2013.02.019 Kibria, 2018, Exosomes as a drug delivery system in cancer therapy: potential and challenges, Mol. Pharm., 15, 3625, 10.1021/acs.molpharmaceut.8b00277 Kim, 2016, Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells, Nanomedicine, 12, 655, 10.1016/j.nano.2015.10.012 Kim, 2018, I-motif-coated exosomes as a pH-sensitive carrier for anticancer drugs, Appl. Biol. Chem., 61, 599, 10.1007/s13765-018-0394-0 Kim, 2019, Delivery of high mobility group box-1 siRNA using brain-targeting exosomes for ischemic stroke therapy, J. Biomed. Nanotechnol., 15, 2401, 10.1166/jbn.2019.2866 Kim, 2020, Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes, J. Control. Release, 317, 273, 10.1016/j.jconrel.2019.11.009 Koh, 2017, Exosome-SIRP alpha, a CD47 blockade increases cancer cell phagocytosis, Biomaterials, 121, 121, 10.1016/j.biomaterials.2017.01.004 Kojima, 2018, Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment, Nat. Commun., 9, 1305, 10.1038/s41467-018-03733-8 Kooijmans, 2016, Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting, J. Extracell. Vesicles, 5, 31053, 10.3402/jev.v5.31053 Kooijmans, 2018, Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach, Nanoscale, 10, 2413, 10.1039/C7NR06966A Kosaka, 2012, Competitive interactions of cancer cells and normal cells via secretory microRNAs, J. Biol. Chem., 287, 1397, 10.1074/jbc.M111.288662 Kowal, 2014, Biogenesis and secretion of exosomes, Curr. Opin. Cell Biol., 29, 116, 10.1016/j.ceb.2014.05.004 Lai, 2014, Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter, ACS Nano, 8, 483, 10.1021/nn404945r Lang, 2017, Mesenchymal stem cells as natural bio-factories for exosomes carrying miR-124a in the treatment of gliomas, Neuro-Oncology, 20, 380, 10.1093/neuonc/nox152 Lara, 2020, Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors, J. Nanobiotechnology, 18, 20, 10.1186/s12951-020-0573-0 Lee, 2017, Exosome-based delivery of miR-124 in a Huntington’s disease model, J. Mov. Disord., 10, 45, 10.14802/jmd.16054 Lee, 2018, pH-responsive hyaluronate-anchored extracellular vesicles to promote tumor-targeted drug delivery, Carbohydr. Polym., 202, 323, 10.1016/j.carbpol.2018.08.141 Li, 2018, A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer, Nanomedicine, 14, 1973, 10.1016/j.nano.2018.05.020 Li, 2019, In vitro and in vivo rNA inhibition by CD9-HuR functionalized exosomes encapsulated with miRNA or CRISPR/dCas9, Nano Lett., 19, 19, 10.1021/acs.nanolett.8b02689 Li, 2020, Gemcitabine loaded autologous exosomes for effective and safe chemotherapy of pancreatic cancer, Acta Biomater., 101, 519, 10.1016/j.actbio.2019.10.022 Liang, 2020, Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer, J. Nanobiotechnology, 18, 10, 10.1186/s12951-019-0563-2 Limoni, 2019, Engineered exosomes for targeted transfer of siRNA to HER2 positive breast cancer cells, Appl. Biochem. Biotechnol., 187, 352, 10.1007/s12010-018-2813-4 Lin, 2018, Exosome-liposome hybrid nanoparticles deliver CRISPR/Cas9 system in MSCs, Adv. Sci. (Weinh), 5, 1700611, 10.1002/advs.201700611 Liu, 2015, Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse, Sci. Rep., 5, 17543, 10.1038/srep17543 Liu, 2019, Functional extracellular vesicles engineered with lipid-grafted hyaluronic acid effectively reverse cancer drug resistance, Biomaterials, 223, 119475, 10.1016/j.biomaterials.2019.119475 Liu, 2019, Focused ultrasound-augmented targeting delivery of nanosonosensitizers from homogenous exosomes for enhanced sonodynamic cancer therapy, Theranostics, 9, 5261, 10.7150/thno.33183 Longatti, 2018, High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles, Nanoscale, 10, 14230, 10.1039/C8NR03970D Lou, 2015, Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma, J. Hematol. Oncol., 8, 122, 10.1186/s13045-015-0220-7 Lu, 2018, Functionalized extracellular vesicles as advanced therapeutic nanodelivery systems, Eur. J. Pharm. Sci., 121, 34, 10.1016/j.ejps.2018.05.001 Luan, 2017, Engineering exosomes as refined biological nanoplatforms for drug delivery, Acta Pharmacol. Sin., 38, 754, 10.1038/aps.2017.12 Luo, 2019, Biomimetic carriers based on giant membrane vesicles for targeted drug delivery and photodynamic/Photothermal synergistic therapy, ACS Appl. Mater. Interfaces, 11, 43811, 10.1021/acsami.9b11223 Luo, 2019, Aptamer-functionalized exosomes from bone marrow stromal cells target bone to promote bone regeneration, Nanoscale, 11, 20884, 10.1039/C9NR02791B Ma, 2019, Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a, Cell Commun. Signal, 17, 96, 10.1186/s12964-019-0418-3 Ma, 2019, Induced neural progenitor cells abundantly secrete extracellular vesicles and promote the proliferation of neural progenitors via extracellular signal-regulated kinase pathways, Neurobiol. Dis., 124, 322, 10.1016/j.nbd.2018.12.003 Machida, 2016, miR-1246 and miR-4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer, Oncol. Rep., 36, 2375, 10.3892/or.2016.5021 Maia, 2018, Exosome-based cell-cell communication in the tumor microenvironment, Front. Cell. Dev. Biol., 6, 18, 10.3389/fcell.2018.00018 Malm, 2016, Exosomes in Alzheimer’s disease, Neurochem. Int., 97, 193, 10.1016/j.neuint.2016.04.011 Masud, 2019, Superparamagnetic nanoarchitectures for disease-specific biomarker detection, Chem. Soc. Rev., 48, 5717, 10.1039/C9CS00174C Matsumoto, 2017, The transport mechanism of extracellular vesicles at the blood-brain barrier, Curr. Pharm. Des., 23, 6206, 10.2174/1381612823666170913164738 McKenzie, 2016, KRAS-MEK signaling controls Ago2 sorting into exosomes, Cell Rep., 15, 978, 10.1016/j.celrep.2016.03.085 Mendt, 2019, Mesenchymal stem cell-derived exosomes for clinical use, Bone Marrow Transplant., 54, 789, 10.1038/s41409-019-0616-z Meyer, 2017, Pseudotyping exosomes for enhanced protein delivery in mammalian cells, Int. J. Nanomedicine, 12, 3153, 10.2147/IJN.S133430 Min, 2015, Clinical translation of nanomedicine, Chem. Rev., 115, 11147, 10.1021/acs.chemrev.5b00116 Morishita, 2016, Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA, Biomaterials, 111, 55, 10.1016/j.biomaterials.2016.09.031 Morton, 2018, Neonatal subventricular zone neural stem cells release extracellular vesicles that act as a microglial morphogen, Cell, 23, 78 Munagala, 2016, Bovine milk-derived exosomes for drug delivery, Cancer Lett., 371, 48, 10.1016/j.canlet.2015.10.020 Munoz, 2013, Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity, Mol. Ther. Nucleic Acids, 2, 10.1038/mtna.2013.60 Narayanan, 2020, Exosomes as drug delivery vehicles for cancer treatment, Curr. Nanosci., 16, 15, 10.2174/1573413715666190219112422 Naseri, 2020, Delivery of LNA-antimiR-142-3p by mesenchymal stem cells-derived exosomes to breast cancer stem cells reduces tumorigenicity, Stem Cell Rev. Rep., 16, 541, 10.1007/s12015-019-09944-w Nie, 2020, Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer, Nanoscale, 12, 877, 10.1039/C9NR09011H van Niel, 2018, Shedding light on the cell biology of extracellular vesicles, Nat. Rev. Mol. Cell Biol., 19, 213, 10.1038/nrm.2017.125 Ohno, 2013, Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells, Mol. Ther., 21, 185, 10.1038/mt.2012.180 Oku, 1983, Differential effects of alkali metal chlorides on formation of giant liposomes by freezing and thawing and dialysist, Biochemistry, 22, 855, 10.1021/bi00273a023 Oskouie, 2019, Therapeutic use of curcumin-encapsulated and curcumin-primed exosomes, J. Cell. Physiol., 234, 8182, 10.1002/jcp.27615 Pan, 2020, Passion fruit-like exosome-PMA/Au-BSA@Ce6 nanovehicles for real-time fluorescence imaging and enhanced targeted photodynamic therapy with deep penetration and superior retention behavior in tumor, Biomaterials, 230, 119606, 10.1016/j.biomaterials.2019.119606 Pang, 2020, Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis, Theranostics, 10, 2309, 10.7150/thno.39486 Pant, 2012, The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities, Biochem. Pharmacol., 83, 1484, 10.1016/j.bcp.2011.12.037 Park, 2018, Efficient delivery of tyrosinase related protein-2 (TRP2) peptides to lymph nodes using serum-derived exosomes, Macromol. Biosci., 18, 10.1002/mabi.201800301 Pascucci, 2014, Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery, J. Control. Release, 192, 262, 10.1016/j.jconrel.2014.07.042 Pegtel, 2019, Exosomes, Annu. Rev. Biochem., 88, 487, 10.1146/annurev-biochem-013118-111902 Pi, 2018, Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression, Nat. Nanotechnol., 13, 82, 10.1038/s41565-017-0012-z Pick, 1981, Liposomes with a large trapping capacity prepared by freezing and thawing of sonicated phospholipid mixtures, Arch. Biochem. Biophys., 212, 186, 10.1016/0003-9861(81)90358-1 Podolak, 2010, Saponins as cytotoxic agents: a review, Phytochem. Rev., 9, 425, 10.1007/s11101-010-9183-z Poovaiah, 2018, Treatment of neurodegenerative disorders through the blood-brain barrier using nanocarriers, Nanoscale, 10, 16962, 10.1039/C8NR04073G Pullan, 2019, Exosomes as drug carriers for cancer therapy, Mol. Pharm., 16, 1789, 10.1021/acs.molpharmaceut.9b00104 Qi, 2016, Blood exosomes endowed with magnetic and targeting properties for cancer therapy, ACS Nano, 10, 3323, 10.1021/acsnano.5b06939 Ran, 2020, Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice, Biomaterials, 236, 119826, 10.1016/j.biomaterials.2020.119826 Ren, 2019, Exosomal DNA aptamer targeting α-synuclein aggregates reduced neuropathological deficits in a mouse Parkinson’s disease model, Mol. Ther. Nucleic Acids, 17, 726, 10.1016/j.omtn.2019.07.008 Reshke, 2020, Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone, Nat. Biomed. Eng., 4, 52, 10.1038/s41551-019-0502-4 Saari, 2015, Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of paclitaxel in autologous prostate cancer cells, J. Control. Release, 220, 727, 10.1016/j.jconrel.2015.09.031 Sancho-Albero, 2019, Efficient encapsulation of theranostic nanoparticles in cell-derived exosomes: leveraging the exosomal biogenesis pathway to obtain hollow gold nanoparticle-hybrids, Nanoscale, 11, 18825, 10.1039/C9NR06183E Sancho-Albero, 2019, Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis, Nat. Catal., 2, 864, 10.1038/s41929-019-0333-4 Sato, 2016, Engineering hybrid exosomes by membrane fusion with liposomes, Sci. Rep., 6, 21933, 10.1038/srep21933 Schorey, 2008, Exosome function: from tumor immunology to pathogen biology, Traffic, 9, 871, 10.1111/j.1600-0854.2008.00734.x Shao, 2018, New technologies for analysis of extracellular vesicles, Chem. Rev., 118, 1917, 10.1021/acs.chemrev.7b00534 Shew, 1985, A novel method for encapsulation of macromolecules in liposomes, Biochim. Biophys. Acta, 816, 1, 10.1016/0005-2736(85)90386-4 Shtam, 2013, Exosomes are natural carriers of exogenous siRNA to human cells in vitro, Cell Commun. Signal., 11, 88, 10.1186/1478-811X-11-88 Silva, 2015, Combining magnetic nanoparticles with cell derived microvesicles for drug loading and targeting, Nanomedicine, 11, 645, 10.1016/j.nano.2014.11.009 Smyth, 2014, Surface functionalization of exosomes using click chemistry, Bioconjug. Chem., 25, 1777, 10.1021/bc500291r Soltani, 2015, Synthetic and biological vesicular nano-carriers designed for gene delivery, Curr. Pharm. Des., 21, 6214, 10.2174/1381612821666151027153410 Stamatikos, 2020, Exosome-mediated transfer of anti-miR-33a-5p from transduced endothelial cells enhances macrophage and vascular smooth muscle cell cholesterol efflux, Hum. Gene Ther., 31, 219, 10.1089/hum.2019.245 Subhan, 2020, siRNA based drug design, quality, delivery and clinical translation, Nanomedicine, 29, 102239, 10.1016/j.nano.2020.102239 Sukhanova, 2018, Dependence of nanoparticle toxicity on their physical and chemical properties, Nanoscale Res. Lett., 13, 44, 10.1186/s11671-018-2457-x Sun, 2010, A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes, Mol. Ther., 18, 1606, 10.1038/mt.2010.105 Szoka, 1978, Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation, Proc. Natl. Acad. Sci. U. S. A., 75, 4194, 10.1073/pnas.75.9.4194 Tang, 2012, Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery, Adv. Mater., 24, 1504, 10.1002/adma.201104763 Tang, 2012, Delivery of chemotherapeutic drugs in tumour cell-derived microparticles, Nat. Commun., 3, 1282, 10.1038/ncomms2282 Temchura, 2008, Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus, Vaccine, 26, 3662, 10.1016/j.vaccine.2008.04.069 Testa, 2002, Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis, Blood, 100, 2980, 10.1182/blood-2002-03-0852 Tian, 2014, A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy, Biomaterials, 35, 2383, 10.1016/j.biomaterials.2013.11.083 Tian, 2018, Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy, Biomaterials, 150, 137, 10.1016/j.biomaterials.2017.10.012 Tran, 2019, Aspirin-loaded nanoexosomes as cancer therapeutics, Int. J. Pharm., 572, 118786, 10.1016/j.ijpharm.2019.118786 Unsoy, 2018, Smart drug delivery systems in cancer therapy, Curr. Drug Targets, 19, 202, 10.2174/1389450117666160401124624 Vader, 2016, Extracellular vesicles for drug delivery, Adv. Drug Deliv. Rev., 106, 148, 10.1016/j.addr.2016.02.006 Vandergriff, 2018, Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide, Theranostics, 8, 1869, 10.7150/thno.20524 Villarroya-Beltri, 2013, Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs, Nat. Commun., 4, 2980, 10.1038/ncomms3980 Vlassov, 2012, Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials, Biochim. Biophys. Acta, 1820, 940, 10.1016/j.bbagen.2012.03.017 Vrijsen, 2016, Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis via EMMPRIN, Adv. Healthc. Mater., 5, 2555, 10.1002/adhm.201600308 Wahlgren, 2012, Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes, Nucleic Acids Res., 40, 10.1093/nar/gks463 Wan, 2017, Molecular recognition-based DNA Nanoassemblies on the surfaces of nanosized exosomes, J. Am. Chem. Soc., 139, 5289, 10.1021/jacs.7b00319 Wang, 2017, Chemically edited exosomes with dual ligand purified by microfluidic device for active targeted drug delivery to tumor cells, ACS Appl. Mater. Interfaces, 9, 27441, 10.1021/acsami.7b06464 Wang, 2017, Exosome is a mechanism of intercellular drug transfer: application of quantitative pharmacology, J. Control. Release, 268, 147, 10.1016/j.jconrel.2017.10.020 Wang, 2018, Designer exosomes for active targeted chemo-photothermal synergistic tumor therapy, Adv. Funct. Mater., 28 Wang, 2019, Engineered cell-derived microparticles Bi2Se3/DOX@MPs for imaging guided synergistic photothermal/low-dose chemotherapy of cancer, Adv. Sci. (Weinh), 7 Wang, 2019, Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the tau protein through the AKT/GSK-3beta pathway, Nanoscale, 11, 7481, 10.1039/C9NR01255A Wei, 2019, A nanodrug consisting of doxorubicin and exosome derived from mesenchymal stem cells for osteosarcoma treatment in vitro, Int. J. Nanomedicine, 14, 8603, 10.2147/IJN.S218988 Wei, 2019, miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury, Life Sci., 232, 116632, 10.1016/j.lfs.2019.116632 Whiteside, 2013, Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes), Biochem. Soc. Trans., 41, 245, 10.1042/BST20120265 Wiklander, 2015, Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting, J. Extracell. Vesicles, 4, 26316, 10.3402/jev.v4.26316 Wong, 2010, Nanotechnology applications for improved delivery of antiretroviral drugs to the brain, Adv. Drug Deliv. Rev., 62, 503, 10.1016/j.addr.2009.11.020 Wortzel, 2019, Exosome-mediated metastasis: communication from a distance, Dev. Cell, 49, 347, 10.1016/j.devcel.2019.04.011 Wu, 2016, Exosomes derived from gastric cancer cells activate NF-kappaB pathway in macrophages to promote cancer progression, Tumour Biol., 37, 12169, 10.1007/s13277-016-5071-5 Xia, 2019, Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents, Prog. Neurobiol., 183, 101694, 10.1016/j.pneurobio.2019.101694 Yang, 2015, Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in Danio rerio, Pharm. Res., 32, 2003, 10.1007/s11095-014-1593-y Yang, 2017, Amorphous TiO2 shells: A vital elastic buffering layer on silicon nanoparticles for high-performance and safe lithium storage, Adv. Mater., 29, 1700523, 10.1002/adma.201700523 Yang, 2017, Exosome mediated delivery of miR-124 promotes neurogenesis after ischemia, Mol. Ther. Nucleic Acids, 7, 278, 10.1016/j.omtn.2017.04.010 Yang, 2017, Virus-mimetic fusogenic exosomes for direct delivery of integral membrane proteins to target cell membranes, Adv. Mater., 29, 1605604, 10.1002/adma.201605604 Yang, 2019, Exosome biochemistry and advanced nanotechnology for next-generation theranostic platforms, Adv. Mater., 31 Yang, 2019, Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation, Nat. Biomed. Eng., 4, 69, 10.1038/s41551-019-0485-1 Yong, 2019, Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy, Nat. Commun., 10, 3838, 10.1038/s41467-019-11718-4 Yousefi, 2020, Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance, Oncogene, 39, 953, 10.1038/s41388-019-1040-y Yu, 2014, A pH and thermosensitive choline phosphate-based delivery platform targeted to the acidic tumor microenvironment, Biomaterials, 35, 278, 10.1016/j.biomaterials.2013.09.052 Yu, 2019, Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells, Cancer Sci., 110, 3173, 10.1111/cas.14181 Yuan, 2017, Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain, Biomaterials, 142, 1, 10.1016/j.biomaterials.2017.07.011 Zhang, 2006, Quantitative PET imaging of tumor integrin αv F-FRGD2 β3 with 18F-FRGD2, J. Nucl. Med., 47, 113 Zhang, 2017, Magnetic and folate functionalization enables rapid isolation and enhanced tumor-targeting of cell-derived microvesicles, ACS Nano, 11, 277, 10.1021/acsnano.6b05630 Zhang, 2019, Exosome-delivered syndecan-1 rescues acute lung injury via a FAK/p190RhoGAP/RhoA/ROCK/NF-kappaB signaling axis and glycocalyx enhancement, Exp. Cell Res., 384, 111596, 10.1016/j.yexcr.2019.111596 Zhang, 2019, Extracellular vesicles based self-grown gold nanopopcorn for combinatorial chemo-photothermal therapy, Biomaterials, 197, 220, 10.1016/j.biomaterials.2019.01.024 Zhang, 2019, Exosomes - beyond stem cells for restorative therapy in stroke and neurological injury, Nat. Rev. Neurol., 15, 193, 10.1038/s41582-018-0126-4 Zhu, 2013, Stimulus-responsive nanopreparations for tumor targeting, Integr. Biol. (Camb.), 5, 96, 10.1039/c2ib20135f Zhu, 2012, Nanoparticle-induced exosomes target antigen-presenting cells to initiate Th1-type immune activation, Small, 8, 2841, 10.1002/smll.201200381 Zhu, 2017, Folate-engineered microvesicles for enhanced target and synergistic therapy toward breast cancer, ACS Appl. Mater. Interfaces, 9, 5100, 10.1021/acsami.6b14633 Zhu, 2019, Controlled release of therapeutic agents with near-infrared laser for synergistic photochemotherapy toward cervical cancer, Anal. Chem., 91, 6555, 10.1021/acs.analchem.8b05982 Zhu, 2020, Tumor-exocytosed exosome/aggregation-induced emission luminogen hybrid nanovesicles facilitate efficient tumor penetration and photodynamic therapy, Angew. Chem. Int. Ed. Eng., 59, 13836, 10.1002/anie.202003672 Zhu, 2020, Stellate plasmonic exosomes for penetrative targeting tumor NIR-II thermo-radiotherapy, ACS Appl. Mater. Interfaces, 12, 36928, 10.1021/acsami.0c09969 Zhuang, 2011, Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain, Mol. Ther., 19, 1769, 10.1038/mt.2011.164 Zhuang, 2019, SPION-decorated exosome delivered BAY55-9837 targeting the pancreas through magnetism to improve the blood GLC response, Small, 15, 10.1002/smll.201903135 Zhuang, 2020, SPION decorated exosome delivery of TNF-alpha to cancer cell membranes through magnetism, Nanoscale, 12, 173, 10.1039/C9NR05865F