Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

Artym, 2006, Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function, Cancer Res., 66, 3034, 10.1158/0008-5472.CAN-05-2177

Bobrie, 2012, Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression, Cancer Res., 72, 4920, 10.1158/0008-5472.CAN-12-0925

Branch, 2012, Adhesion rings surround invadopodia and promote maturation, Biol. Open, 1, 711, 10.1242/bio.20121867

Clark, 2008, A new role for cortactin in invadopodia: regulation of protease secretion, Eur. J. Cell Biol., 87, 581, 10.1016/j.ejcb.2008.01.008

Gálvez-Santisteban, 2012, Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells, Nat. Cell Biol., 14, 838, 10.1038/ncb2541

Gligorijevic, 2012, N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors, J. Cell Sci., 125, 724, 10.1242/jcs.092726

Hakulinen, 2008, Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes, J. Cell. Biochem., 105, 1211, 10.1002/jcb.21923

Hanson, 2012, Multivesicular body morphogenesis, Annu. Rev. Cell Dev. Biol., 28, 337, 10.1146/annurev-cellbio-092910-154152

Hoshino, 2012, Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis, Sci. Signal., 5, ra66, 10.1126/scisignal.2002964

Hoshino, 2012, Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies, PLoS Comput. Biol., 8, e1002479, 10.1371/journal.pcbi.1002479

Hsu, 2010, Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C, J. Cell Biol., 189, 223, 10.1083/jcb.200911018

Mathivanan, 2010, Exosomes: extracellular organelles important in intercellular communication, J. Proteomics, 73, 1907, 10.1016/j.jprot.2010.06.006

Mittelbrunn, 2011, Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells, Nature communications, 2, 282, 10.1038/ncomms1285

Muralidharan-Chari, 2009, ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles, Curr. Biol., 19, 1875, 10.1016/j.cub.2009.09.059

Murphy, 2011, The ‘ins’ and ‘outs’ of podosomes and invadopodia: characteristics, formation and function, Nat. Rev. Mol. Cell Biol., 12, 413, 10.1038/nrm3141

Ostrowski, 2010, Rab27a and Rab27b control different steps of the exosome secretion pathway, Nat. Cell Biol., 12, 19, 10.1038/ncb2000

Peinado, 2012, Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET, Nat. Med., 18, 883, 10.1038/nm.2753

Steffen, 2008, MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7, Curr. Biol., 18, 926, 10.1016/j.cub.2008.05.044

Tamai, 2010, Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein, Biochem. Biophys. Res. Commun., 399, 384, 10.1016/j.bbrc.2010.07.083

Théry, 2011, Exosomes: secreted vesicles and intercellular communications, F1000 Biol. Rep., 3, 15, 10.3410/B3-15

Trajkovic, 2008, Ceramide triggers budding of exosome vesicles into multivesicular endosomes, Science, 319, 1244, 10.1126/science.1153124

Yamaguchi, 2011, Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation, J. Cell Biol., 193, 1275, 10.1083/jcb.201009126

Yang, 2011, The roles of tumor-derived exosomes in cancer pathogenesis, Clin. Dev. Immunol., 2011, 842849, 10.1155/2011/842849

Yu, 2012, N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods, J. Cell Biol., 199, 527, 10.1083/jcb.201203025