Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease

Gastroenterology - Tập 160 Số 5 - Trang 1634-1646.e7 - 2021
Oveis Jamialahmadi1, Rosellina Margherita Mancina1, Ester Ciociola1, Federica Tavaglione2,1, Panu K. Luukkonen3,4,5, Guido Baselli6, Francesco Malvestiti7, Dorothée Thuillier8, Violeta Raverdy9,8, Ville Männistö10,11,12, Rosaria Maria Pipitone13, Grazia Pennisi13, Daniele Prati6, Rocco Spagnuolo14, Salvatore Petta13, Jussi Pihlajamäki10,12, François Pattou9,8, Hannele Yki–Järvinen4,5, Luca Valenti7,6, Stefano Romeo15,14,1
1Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden
2Clinical Medicine and Hepatology Unit, Department of Internal Medicine and Geriatrics, Campus Bio-Medico University, Rome, Italy
3Department of Internal Medicine, Yale University, New Haven, Connecticut
4Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
5Minerva Foundation Institute for Medical Research, Helsinki, Finland
6Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy
7Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy
8Univ Lille, Inserm, Lille Pasteur Institute, Centre Hospitalier Universitaire de Lille, European Genomic Institute for Diabetes, U1190 Translational Research in Diabetes, Lille University, Lille, France
9Centre Hospitalier Universitaire de Lille, Department of General and Endocrine Surgery, Integrated Center for Obesity, Lille, France
10Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Finland
11Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Finland
12Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland
13Section of Gastroenterology and Hepatology, Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro,” University of Palermo, Palermo, Italy
14Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
15Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden

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