Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

Bartel DP . MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281–297.

He L, Hannon GJ . MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004; 5:522–531.

Calin GA, Croce CM . MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6:857–866.

Esquela-Kerscher A, Slack FJ . Oncomirs – microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259–269.

Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008; 18:997–1006.

Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 2008; 105:10513–10518.

Gilad S, Meiri E, Yogev Y, et al. Serum microRNAs are promising novel biomarkers. PLoS One 2008; 3:e3148.

Li LM, Hu ZB, Zhou ZX, et al. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res 2010; 70:9798–9807.

Ng EK, Chong WW, Jin H, et al. Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening. Gut 2009; 58:1375–1381.

Resnick KE, Alder H, Hagan JP, Richardson DL, Croce CM, Cohn DE . The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. Gynecol Oncol 2009; 112:55–59.

Wang K, Zhang S, Marzolf B, et al. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci USA 2009; 106:4402–4407.

Zhang C, Wang C, Chen X, et al. Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem 2010; 56:1871–1879.

Cocucci E, Racchetti G, Meldolesi J . Shedding microvesicles: artefacts no more. Trends Cell Biol 2009; 19:43–51.

Thery C, Zitvogel L, Amigorena S . Exosomes: composition, biogenesis and function. Nat Rev Immunol 2002; 2:569–579.

Zhang Y, Liu D, Chen X, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell 2010; 39:133–144.

Skog J, Wurdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008; 10:1470–1476.

Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9:654–659.

Collino F, Deregibus MC, Bruno S, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One 2010; 5:e 11803.

Meckes DG Jr, Shair KH, Marquitz AR, Kung CP, Edwards RH, Raab-Traub N . Human tumor virus utilizes exosomes for intercellular communication. Proc Natl Acad Sci USA 2010; 107:20370–20375.

Ogawa R, Tanaka C, Sato M, et al. Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation. Biochem Biophys Res Commun 2010; 398:723–729.

Pegtel DM, Cosmopoulos K, Thorley-Lawson DA, et al. Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci USA 2010; 107:6328–6333.

Yu B, Yang Z, Li J, et al. Methylation as a crucial step in plant microRNA biogenesis. Science 2005; 307:932–935.

Grimson A, Srivastava M, Fahey B, et al. Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals. Nature 2008; 455:1193–1197.

Hartig JV, Forstemann K . Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila. Nucleic Acids Res 2011; 39:3836–3851.

Gazzani S, Li M, Maistri S, et al. Evolution of MIR168 paralogs in Brassicaceae. BMC Evol Biol 2009; 9:62.

Jia X, Mendu V, Tang G . An array platform for identification of stress-responsive microRNAs in plants. Methods Mol Biol 2010; 639:253–269.

Chen X . MicroRNA biogenesis and function in plants. FEBS Lett 2005; 579:5923–5931.

Du T, Zamore PD . microPrimer: the biogenesis and function of microRNA. Development 2005; 132:4645–4652.

Garcia CK, Wilund K, Arca M, et al. Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. Science 2001; 292:1394–1398.

Huang S, Wu S, Ding J, et al. MicroRNA-181a modulates gene expression of zinc finger family members by directly targeting their coding regions. Nucleic Acids Res 2010; 38:7211–7218.

Qin W, Shi Y, Zhao B, et al. miR-24 regulates apoptosis by targeting the open reading frame (ORF) region of FAF1 in cancer cells. PLoS One 2010; 5:e9429.

Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I . MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 2008; 455:1124–1128.

Gibbings DJ, Ciaudo C, Erhardt M, Voinnet O . Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nat Cell Biol 2009; 11:1143–1149.

Goldstein JL, Brown MS . The low-density lipoprotein pathway and its relation to atherosclerosis. Annu Rev Biochem 1977; 46:897–930.

Wilund KR, Yi M, Campagna F, et al. Molecular mechanisms of autosomal recessive hypercholesterolemia. Hum Mol Genet 2002; 11:3019–3030.

Zuliani G, Arca M, Signore A, et al. Characterization of a new form of inherited hypercholesterolemia: familial recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol 1999; 19:802–809.

Mallory AC, Vaucheret H . ARGONAUTE 1 homeostasis invokes the coordinate action of the microRNA and siRNA pathways. EMBO Rep 2009; 10:521–526.

Vaucheret H, Mallory AC, Bartel DP . AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1. Mol Cell 2006; 22:129–136.

Vaucheret H, Vazquez F, Crete P, Bartel DP . The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. Genes Dev 2004; 18:1187–1197.

Lima WF, Wu H, Nichols JG, Sun H, Murray HM, Crooke ST . Binding and cleavage specificities of human Argonaute2. J Biol Chem 2009; 284:26017–26028.

Brown BD, Naldini L . Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nat Rev Genet 2009; 10:578–585.

Brown BD, Gentner B, Cantore A, et al. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state. Nat Biotechnol 2007; 25:1457–1467.

Chen C, Ridzon DA, Broomer AJ, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005; 33:e179.

Neilson JR, Zheng GX, Burge CB, Sharp PA . Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev 2007; 21:578–589.

Bissels U, Wild S, Tomiuk S, et al. Absolute quantification of microRNAs by using a universal reference. RNA 2009; 15:2375–2384.

Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T . MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007; 133:647–658.

Shimizu S, Takehara T, Hikita H, et al. The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. J Hepatol 2010; 52:698–704.

Tomimaru Y, Eguchi H, Nagano H, et al. MicroRNA-21 induces resistance to the anti-tumour effect of interferon-alpha/5-fluorouracil in hepatocellular carcinoma cells. Br J Cancer 2010; 103:1617–1626.

Zhang J, Yang Y, Yang T, et al. microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer 2010; 103:1215–1220.

Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P . Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 2005; 309:1577–1581.

Roney JK, Khatibi PA, Westwood JH . Cross-species translocation of mRNA from host plants into the parasitic plant dodder. Plant Physiol 2007; 143:1037–1043.

Chen X, Li Q, Wang J, et al. Identification and characterization of novel amphioxus microRNAs by Solexa sequencing. Genome Biol 2009; 10:R78.

Jiang J, Lee EJ, Gusev Y, Schmittgen TD . Real-time expression profiling of microRNA precursors in human cancer cell lines. Nucleic Acids Res 2005; 33:5394–5403.

Ohara T, Sakaguchi Y, Suzuki T, Ueda H, Miyauchi K . The 3′ termini of mouse Piwi-interacting RNAs are 2′-O-methylated. Nat Struct Mol Biol 2007; 14:349–350.

Smalheiser NR, Torvik VI . Complications in mammalian microRNA target prediction. Methods Mol Biol 2006; 342:115–127.