Exercise Your Kynurenines to Fight Depression

Trends in Neurosciences - Tập 41 - Trang 491-493 - 2018
Francesca M. Notarangelo1, Ana Pocivavsek1, Robert Schwarcz1
1Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228 USA

Tài liệu tham khảo

Otte, 2016, Major depressive disorder, Nat. Rev. Dis. Primers, 2, 16065, 10.1038/nrdp.2016.65 Kim, 2017, The influence of stress on neuroinflammation and alterations in brain structure and function in major depressive disorder, Behav. Brain Res., 329, 6, 10.1016/j.bbr.2017.04.020 Heyes, 1996, Human microglia convert l-tryptophan into the neurotoxin quinolinic acid, Biochem. J., 320, 595, 10.1042/bj3200595 Pocivavsek, 2016, Astrocytes as pharmacological targets in the treatment of schizophrenia: focus on kynurenic acid, 423 Dantzer, 2017, Role of the kynurenine metabolism pathway in inflammation-induced depression: preclinical approaches, Curr. Top. Behav. Neurosci., 31, 117, 10.1007/7854_2016_6 Fukui, 1991, Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism, J. Neurochem., 56, 2007, 10.1111/j.1471-4159.1991.tb03460.x Agudelo, 2014, Skeletal muscle PGC-1alpha1 modulates kynurenine metabolism and mediates resilience to stress-induced depression, Cell, 159, 33, 10.1016/j.cell.2014.07.051 Eyre, 2012, Neuroimmunological effects of physical exercise in depression, Brain Behav. Immun., 26, 251, 10.1016/j.bbi.2011.09.015 Lee, 2017, Role of exercise on molecular mechanisms in the regulation of antidepressant effects, J. Exerc. Rehabil., 13, 617, 10.12965/jer.1735188.594 Baar, 2002, Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1, FASEB J., 16, 1879, 10.1096/fj.02-0367com Bansi, 2018, Persons with secondary progressive and relapsing remitting multiple sclerosis reveal different responses of tryptophan metabolism to acute endurance exercise and training, J. Neuroimmunol., 314, 101, 10.1016/j.jneuroim.2017.12.001 Mudry, 2016, Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes, Diabetes Metab. Res. Rev., 32, 754, 10.1002/dmrr.2798 Clark, 2016, Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals, J. Psychiatry Neurosci., 41, 386, 10.1503/jpn.150226 Millischer, 2017, Twelve-week physical exercise does not have a long-lasting effect on kynurenines in plasma of depressed patients, Neuropsychiatr. Dis. Treat., 13, 967, 10.2147/NDT.S131746 Ciobanu, 2016, Differential gene expression in brain and peripheral tissues in depression across the life span: a review of replicated findings, Neurosci. Biobehav. Rev., 71, 281, 10.1016/j.neubiorev.2016.08.018