Exendin-4 inhibits endothelial protein C receptor shedding in vitro and in vivo

Fulcher, 1984, Proteolytic inactivation of human factor viii procoagulant protein by activated human protein c and its analogy with factor v, Blood, 63, 486, 10.1182/blood.V63.2.486.486 Mosnier, 2007, The cytoprotective protein c pathway, Blood, 109, 3161, 10.1182/blood-2006-09-003004 Xu, 2000, Metalloproteolytic release of endothelial cell protein c receptor, J Biol Chem, 275, 6038, 10.1074/jbc.275.8.6038 Kurosawa, 1997, Identification of functional endothelial protein c receptor in human plasma, J Clin Invest, 100, 411, 10.1172/JCI119548 Liaw, 2000, Mechanisms by which soluble endothelial cell protein c receptor modulates protein c and activated protein c function, J Biol Chem, 275, 5447, 10.1074/jbc.275.8.5447 Kurosawa, 1998, Plasma levels of endothelial cell protein c receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes, Blood, 91, 725, 10.1182/blood.V91.2.725 Menschikowski, 2009, Regulation of endothelial protein c receptor shedding by cytokines is mediated through differential activation of map kinase signaling pathways, Exp Cell Res, 315, 2673, 10.1016/j.yexcr.2009.05.015 Han, 2010, Cadpe inhibits pma-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by fak/mek/erk-mediated ap-1 activation, Mol Cancer Res, 8, 1477, 10.1158/1541-7786.MCR-10-0114 Leng, 2004, Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice, Diabetes, 53, 1436, 10.2337/diabetes.53.6.1436 Huovila, 2005, Shedding light on adam metalloproteinases, Trends Biochem Sci, 30, 413, 10.1016/j.tibs.2005.05.006 Murphy, 2008, The adams: signalling scissors in the tumour microenvironment, Nat Rev Cancer, 8, 929, 10.1038/nrc2459 Drucker, 2006, The biology of incretin hormones, Cell Metab, 3, 153, 10.1016/j.cmet.2006.01.004 Timmers, 2009, Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury, J Am Coll Cardiol, 53, 501, 10.1016/j.jacc.2008.10.033 Sonne, 2008, Protective effects of glp-1 analogues exendin-4 and glp-1(9-36) amide against ischemia-reperfusion injury in rat heart, Regul Pept, 146, 243, 10.1016/j.regpep.2007.10.001 Lorber, 2013, Glp-1 receptor agonists: effects on cardiovascular risk reduction, Cardiovasc Ther, 31, 238, 10.1111/1755-5922.12000 Okerson, 2012, The cardiovascular effects of glp-1 receptor agonists, Cardiovasc Ther, 30, e146, 10.1111/j.1755-5922.2010.00256.x Eng, 1992, Isolation and characterization of exendin-4, an exendin-3 analogue, from heloderma suspectum venom, further evidence for an exendin receptor on dispersed acini from guinea pig pancreas, J Biol Chem, 267, 7402, 10.1016/S0021-9258(18)42531-8 Baggio, 2007, Biology of incretins: Glp-1 and gip, Gastroenterology, 132, 2131, 10.1053/j.gastro.2007.03.054 Edwards, 1999, Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: Studies with the antagonist exendin 9-39, Diabetes, 48, 86, 10.2337/diabetes.48.1.86 Thorens, 1993, Cloning and functional expression of the human islet glp-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor, Diabetes, 42, 1678, 10.2337/diab.42.11.1678 Kieffer, 1999, The glucagon-like peptides, Endocr Rev, 20, 876, 10.1210/edrv.20.6.0385 Oeseburg, 2010, Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase a, Arterioscler Thromb Vasc Biol, 30, 1407, 10.1161/ATVBAHA.110.206425 Shimoda, 2011, The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes, Diabetologia, 54, 1098, 10.1007/s00125-011-2069-9 Iwai, 2006, Glucagon-like peptide-1 inhibits lps-induced il-1beta production in cultured rat astrocytes, Neurosci Res, 55, 352, 10.1016/j.neures.2006.04.008 Hattori, 2010, A glucagon-like peptide-1 (glp-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells, Diabetologia, 53, 2256, 10.1007/s00125-010-1831-8 Kim, 2009, Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of parkinson's disease, J Endocrinol, 202, 431, 10.1677/JOE-09-0132 Matsubara, 2012, A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein e-deficient mice, J Am Coll Cardiol, 59, 265, 10.1016/j.jacc.2011.07.053 Borgel, 2007, A comparative study of the protein c pathway in septic and nonseptic patients with organ failure, Am J Respir Crit Care Med, 176, 878, 10.1164/rccm.200611-1692OC Bae, 2011, Activated protein c inhibits high mobility group box 1 signaling in endothelial cells, Blood, 118, 3952, 10.1182/blood-2011-06-360701 Bae, 2007, Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein c eliminates its anticoagulant but not its protective signaling properties, J Biol Chem, 282, 9251, 10.1074/jbc.M610547200 Kim, 2011, Vascular anti-inflammatory effects of curcumin on hmgb1-mediated responses in vitro, Inflamm Res, 60, 1161, 10.1007/s00011-011-0381-y Miller, 2013, Adam-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling, Proc Natl Acad Sci U S A, 110, E2074, 10.1073/pnas.1222387110 Wang, 2004, Cholinergic agonists inhibit hmgb1 release and improve survival in experimental sepsis, Nat Med, 10, 1216, 10.1038/nm1124 Schaefer, 1992, Growth characteristics of a permanent human endothelial cell line, In Vitro Cell Dev Biol, 28A, 465, 10.1007/BF02634126 Edgell, 1983, Permanent cell line expressing human factor viii-related antigen established by hybridization, Proc Natl Acad Sci U S A, 80, 3734, 10.1073/pnas.80.12.3734 Qu, 2006, The ser219 → gly dimorphism of the endothelial protein c receptor contributes to the higher soluble protein levels observed in individuals with the a3 haplotype, J Thromb Haemost, 4, 229, 10.1111/j.1538-7836.2005.01676.x Qu, 2007, Regulated endothelial protein c receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/adam17, J Thromb Haemost, 5, 395, 10.1111/j.1538-7836.2007.02347.x Michie, 1988, Detection of circulating tumor necrosis factor after endotoxin administration, N Engl J Med, 318, 1481, 10.1056/NEJM198806093182301 Kremer, 1996, Interleukin-1, -6 and tumor necrosis factor-alpha release is down-regulated in whole blood from septic patients, Acta Haematol, 95, 268, 10.1159/000203895 Buras, 2005, Animal models of sepsis: setting the stage, Nat Rev Drug Discov, 4, 854, 10.1038/nrd1854 Yang, 2004, Reversing established sepsis with antagonists of endogenous high-mobility group box 1, Proc Natl Acad Sci U S A, 101, 296, 10.1073/pnas.2434651100 Brubaker, 2004, Mini review glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system, Endocrinology, 145, 2653, 10.1210/en.2004-0015 Thalhamer, 2008, Mapks and their relevance to arthritis and inflammation, Rheumatology (Oxford), 47, 409, 10.1093/rheumatology/kem297 Hu, 2013, Exendin-4 attenuates myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein expression, Cardiol J, 20, 600, 10.5603/CJ.2013.0159 Killeen, 2006, The phase 2 enzyme inducers ethacrynic acid, dl-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by raw 264.7 cells, J Pharmacol Exp Ther, 316, 1070, 10.1124/jpet.105.092841 Du, 2014, Anti-inflammatory effect of exendin-4 postconditioning during myocardial ischemia and reperfusion, Mol Biol Rep, 10.1007/s11033-014-3252-0