Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction

Department of Health, 1999

National Institute for Clinical Excellence, 2001

Khong, 1986, Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants, Br J Obstet Gynaecol, 93, 1049, 10.1111/j.1471-0528.1986.tb07830.x

Redman, 1999, Preeclampsia: an excessive maternal inflammatory response to pregnancy, Am J Obstet Gynecol, 180, 499, 10.1016/S0002-9378(99)70239-5

Sacks, 1998, Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis, Am J Obstet Gynecol, 179, 80, 10.1016/S0002-9378(98)70254-6

von Dadelszen, 2000, The maternal syndrome of preeclampsia: a forme fruste of the systemic inflammatory response syndrome, Sepsis, 4, 43, 10.1023/A:1009801001596

Smarason, 1993, The effect of placental syncytiotrophoblast microvillous membranes from normal and pre-eclamptic women on the growth of endothelial cells in vitro, Br J Obstet Gynaecol, 100, 943, 10.1111/j.1471-0528.1993.tb15114.x

Cockell, 1997, Human placental syncytiotrophoblast microvillous membranes impair maternal vascular endothelial function, Br J Obstet Gynaecol, 104, 235, 10.1111/j.1471-0528.1997.tb11052.x

Smarason, 1996, Endothelial cell proliferation is suppressed by plasma but not serum from women with preeclampsia, Am J Obstet Gynecol, 174, 787, 10.1016/S0002-9378(96)70466-0

Knight, 1998, Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies, Br J Obstet Gynaecol, 105, 632, 10.1111/j.1471-0528.1998.tb10178.x

Johansen, 1999, Trophoblast deportation in human pregnancy – its relevance for pre-eclampsia, Placenta, 20, 531, 10.1053/plac.1999.0422

Huppertz, 2003, Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation, Placenta, 24, 181, 10.1053/plac.2002.0903

Huppertz, 2002, Trophoblast turnover in health and disease, Fetal Matern Med Rev, 13, 103, 10.1017/S0965539502000220

Allaire, 2000, Placental apoptosis in preeclampsia, Obstet Gynecol, 96, 271, 10.1016/S0029-7844(00)00895-4

Ishihara, 2002, Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation, Am J Obstet Gynecol, 186, 158, 10.1067/mob.2002.119176

Salafia, 1995, Intrauterine growth restriction in infants of less than thirty-two weeks' gestation: associated placental pathologic findings, Am J Obstet Gynecol, 173, 1049, 10.1016/0002-9378(95)91325-4

Redman, 2000, Placental debris, oxidative stress and pre-eclampsia, Placenta, 21, 597, 10.1053/plac.2000.0560

Roberts, 1989, Preeclampsia: an endothelial cell disorder, Am J Obstet Gynecol, 161, 1200, 10.1016/0002-9378(89)90665-0

Kertesz, 2000, Adhesion molecules of syncytiotrophoblast microvillous membranes inhibit proliferation of human umbilical vein endothelial cells, Placenta, 21, 150, 10.1053/plac.1999.0476

de Jager, 2003, Matrix metalloprotease-9, placental syncytiotrophoblast and the endothelial dysfunction of pre-eclampsia, Placenta, 24, 84, 10.1053/plac.2002.0871

von Dadelszen, 1999, Supernatants from co-cultured endothelial cells and syncytiotrophoblast microvillous membranes activate peripheral blood leukocytes in vitro, Hum Reprod, 14, 919, 10.1093/humrep/14.4.919

Cocker, 2004, An image analysis technique for the investigation of human placental morphology in pregnancies complicated by pre-eclampsia and intrauterine growth restriction, J Soc Gynecol Invest, 11, 347A

Sargent, 2003, Trophoblast deportation and the maternal inflammatory response in pre-eclampsia, J Reprod Immunol, 59, 153, 10.1016/S0165-0378(03)00044-5

Huppertz, 2004, Apoptosis in the trophoblast – role of apoptosis in placental morphogenesis, J Soc Gynecol Invest, 11, 353, 10.1016/j.jsgi.2004.06.002

Sacks, 2003, Monocytes are primed to produce the Th1 type cytokine IL-12 in normal pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells, Clin Exp Immunol, 131, 490, 10.1046/j.1365-2249.2003.02082.x

von Dadelszen, 1999, Maternal neutrophil apoptosis in normal pregnancy, preeclampsia, and normotensive intrauterine growth restriction, Am J Obstet Gynecol, 181, 408, 10.1016/S0002-9378(99)70570-3

Hung, 2002, Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia, Circ Res, 90, 1274, 10.1161/01.RES.0000024411.22110.AA

von Dadelszen, 2003, Levels of antibodies against cytomegalovirus and Chlamydophila pneumoniae are increased in early onset pre-eclampsia, BJOG, 110, 725, 10.1111/j.1471-0528.2003.02481.x

Chappell, 2002, A longitudinal study of biochemical variables in women at risk of preeclampsia, Am J Obstet Gynecol, 187, 127, 10.1067/mob.2002.122969