Evolutionary neuropathology and Down syndrome: An analysis of the etiological and phenotypical characteristics of Down syndrome suggests that it may represent an adaptive response to severe maternal deprivation

Antonarakis, 1991, Parental origin of the extra chromosome in trisomy 21 as indicated by analysis of DNA polymorphisms, N Engl J Med, 324, 872, 10.1056/NEJM199103283241302 Sherman, 1991, Trisomy 21: association between reduced recombination and nondisjunction, Am J Hum Genet, 49, 608 Brenner, 1974, The genetics of Caenorhabditis elegans, Genetics, 77, 71, 10.1093/genetics/77.1.71 Hodgkin, 1987, Sex determination and dosage compensation in Caenorhabditis elegans, Annu Rev of Genet, 21, 133, 10.1146/annurev.ge.21.120187.001025 Meyer, 2000, Sex in the worm – counting and compensating X-chromosome dose, Trends Genet, 16, 247, 10.1016/S0168-9525(00)02004-7 Down, 1866, Observations on an ethnic classification of idiots, London Hospi Clin Lect Rep, 3, 259 Lejune, 1959, Les chromosomes humains en culture de tissus, C R Acad Sci Paris, 248, 602 Penrose, 1933, The relative effects of paternal and maternal age in mongolism, J Genet, 27, 219, 10.1007/BF02984413 Nicolaidis, 1998, Origin and mechanisms of non-disjunction in human autosomal trisomies, Hum Reprod, 13, 313, 10.1093/humrep/13.2.313 Hook, 1981, Down Syndrome: frequency in human populations and factors pertinent to variation in rates, 3 Hook, 1983, Chromosomal abnormality rates at amniocentesis and in live-born infants, J Am Med Assoc, 249, 2034, 10.1001/jama.1983.03330390038028 Kaplan, 2000, The evolution of intelligence and the human life history, Evol Anthrop, 9, 156, 10.1002/1520-6505(2000)9:4<156::AID-EVAN5>3.0.CO;2-7 Hook, 1981, Rates of chromosome abnormalities at different maternal ages, Obstet Gynecol, 58, 282 Mackay, 1983 Blurton Jones, 1992, Demography of the Hadza, an increasing and high density population of savanna foragers, Am J Phys Anthropol, 89, 159, 10.1002/ajpa.1330890204 Hill, 1996 de Gruyter, 1979 Huskey RJ. Chromosome non-disjunction rates. Available from: http://www.people.virginia.edu/~rjh9u/chromtri.html 1998 [accessed 25 Feb 2006]. Kloss, 1992, Trisomy: Chromosome competition or maternal strategy? Increase of trisomy incidence with increasing maternal age does not result from competition between chromosomes, Etho Sociobio, 13, 283, 10.1016/0162-3095(92)90027-2 Brender J. Down syndrome cluster in Pampa, Gray County 1985. Internal report of the Texas Department of Health (unpublished). Jongbloet, 1982, Seasonality of pre-ovulatory non-disjunction and the aetiology of Down syndrome. A European Collaborative Study, Hum Genet, 62, 134, 10.1007/BF00282301 Jongbloet, 1985, Down Syndrome: increased frequency of maternal meiosis I nondisjunction during the transitional stages of the ovulatory seasons, Hum Genet, 71, 241, 10.1007/BF00284583 Murdoch, 1984, Characteristics of parents of Down’s children and control children with respect to factors present before conception, J Ment Defic Res, 28, 177 Aagesen, 1984, Advanced grandmaternal age on the mother’s side – a risk of giving rise to trisomy 21, Ann Hum Gene, 48, 297, 10.1111/j.1469-1809.1984.tb00843.x Mikkelsen, 1995, Epidemiological study of Down syndrome in Denmark, including family studies of chromosomes and DNA markers, Dev Brain Dysfunct, 8, 4 Sear, 2000, Maternal grandmothers improve nutritional status and survival of children in rural Gambia, Proc Roy Soc Lond, 267, 1641, 10.1098/rspb.2000.1190 Voland, 2002, Opposite effects of maternal and paternal grandmothers on infant survival in historical Krummhorn, Behav Ecol Sociobiol, 52, 435, 10.1007/s00265-002-0539-2 Hawkes, 1989, Hardworking Hadza grandmothers, 341 Hawkes, 1997, Hadza women’s time allocation, offspring provisioning, and the evolution of long postmenopausal life spans, Curr Anthropol, 38, 551, 10.1086/204646 Luke, 1994, Energy expenditure in children with Down syndrome: correcting metabolic rate for movement, J Pediatr, 125, 829, 10.1016/S0022-3476(06)80193-9 Allison, 1995, Decreased resting metabolic rate among persons with Down syndrome, Int J Obes Relat Metab Disord, 12, 858 Karlsson, 1998, Thyroid dysfunction in Down syndrome: relation to age and thyroid autoimmunity, Arch Dis Child, 79, 242, 10.1136/adc.79.3.242 Cronk, 1985, Assessment of overweight children with trisomy 21, Am J Ment Defic, 89, 433 Aiello, 1995, The expensive tissue hypothesis: the brain and the digestive system in human and primate evolution, Curr Anthropol, 36, 199, 10.1086/204350 Aschoff, 1971 Crome, 1972 Sylvester, 1983, The hippocampus in Down syndrome, J Ment Defic Res, 27, 227 Crome, 1966, A statistical note on cerebellar and brain stem weight in mongolism, J Ment Defic Res, 10, 69 Jernigan, 1993, Cerebral morphologic distinctions between Williams and Down syndromes, Arch Neurol, 50, 186, 10.1001/archneur.1993.00540020062019 Kesslak, 1994, Magnetic resonance imaging analysis of age-related changes in the brains of individuals with Down syndrome, Neurology, 44, 1039, 10.1212/WNL.44.6.1039 Aylward, 1999, MRI volumes of the hippocampus and amygdala in adults with Down syndrome with and without dementia, Am J Psychiatry, 156, 564, 10.1176/ajp.156.4.564 Pulsifer, 1996, The neuropsychology of mental retardation, J Int Neuropsychol Soc, 2, 159, 10.1017/S1355617700001016 Dukas, 2004, Evolutionary biology of animal cognition, Annu Rev Ecol Evol Syst, 35, 347, 10.1146/annurev.ecolsys.35.112202.130152 Jacobs, 1996, The economy of winter: phenotypic plasticity in behavior and brain structure, Biol Bull, 191, 92, 10.2307/1543068 Kempermann, 2002, Why new neurons? Possible functions for adult hippocampal neurogenesis, J Neurosci, 22, 635, 10.1523/JNEUROSCI.22-03-00635.2002 Devlin, 2004, Accuracy of the clinical diagnosis of Down syndrome, The Ulster Med J, 73, 4 Desai, 1997, Down syndrome: a review of the literature, Oral Surg, Oral Med, Oral Pathol, 84, 279, 10.1016/S1079-2104(97)90343-7 Jinxiu, 2003, Divergence of the genes on human chromosome 21 between human and other hominoids and variation of substitution rates among transcription units, Proc Natl Acad Sci USA, 100, 8331, 10.1073/pnas.1332748100 Anwar, 1998, Type 1 diabetes mellitus and Down syndrome: prevalence, management and diabetic complications, Diabetic Med, 15, 160, 10.1002/(SICI)1096-9136(199802)15:2<160::AID-DIA537>3.0.CO;2-J Marino, 1993, Congenital heart disease in patients with Down syndrome: anatomic and genetic aspects, Biomed Pharmacother, 47, 197, 10.1016/0753-3322(93)90056-Q Spicer, 1984, Cardiovascular disease in Down syndrome, Pediatr Clin North Am, 31, 1331, 10.1016/S0031-3955(16)34725-3 Tubman, 1991, Congenital heart disease in Down’s syndrome: two year prospective early screening study, BMJ, 302, 1425, 10.1136/bmj.302.6790.1425 Bell, 1992, Prevalence of overweight and obesity in Down syndrome and other mentally handicapped adults living in the community, J Intellect Disabil Res, 36, 359, 10.1111/j.1365-2788.1992.tb00534.x Luke, 1996, Nutrient intake and obesity in prepubescent children with down syndrome, J Am Diet Assoc, 96, 1262, 10.1016/S0002-8223(96)00330-6 Prasher, 1995, Overweight and obesity amongst Down’s syndrome adults, J Intellect Disabil Res, 39, 437, 10.1111/j.1365-2788.1995.tb00548.x Baty, 2005, Natural history of trisomy 18 and trisomy 13: Growth, physical assessment, medical histories, survival, and recurrence risk, Am J Med Genet, 49, 175, 10.1002/ajmg.1320490204 Hales, 1992, Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis, Diabetologia, 35, 595, 10.1007/BF00400248 Hales, 2001, The thrifty phenotype hypothesis, Br Med Bull, 60, 5, 10.1093/bmb/60.1.5 Bateson, 2004, Developmental plasticity and human health, Nature, 430, 419, 10.1038/nature02725 Neel, 1982, The thrifty genotype revisited, 137 Neel, 1999, The “Thrifty genotype” in 1998, Nutr Rev, 57, S2 1992 Barker D, Gluckman P, Godfrey K, Harding J, Owens J, Robinson J. Fetal nutrition and cardiovascular disease in adult life. Lancet 1993 10;341(8850):938–41. Barker, 1994 van Allen, 1999, Health care concerns and guidelines for adults with Down syndrome, Am J Med Genet, 89, 100, 10.1002/(SICI)1096-8628(19990625)89:2<100::AID-AJMG8>3.0.CO;2-N Zuhlke, 1994, Down syndrome and male fertility: PCR-derived fingerprinting, serological and andrological investigations, Clin Genet, 46, 324, 10.1111/j.1399-0004.1994.tb04171.x Van Dyke DC, McBrien DM, Mattheis PJ. In: Psychosexual behavior, sexuality, and management issues in individuals with Down syndrome. Presentation, European Down syndrome symposium 1995; Mallorca, Spain. Schwab, 1992, Sexuality and community living, 157 Furey, 1994, Sexual abuse of adults with mental retardation: who and where, Ment Retard, 32, 173 Gross, 1991, Salmon breeding behavior and life history evolution in changing environments, Ecology, 72, 1180, 10.2307/1941091 Wisniewski, 1996, Growth hormone neuropathology in Down syndrome (trisomy 21), Dev Brain Dysfunc, 2, 100 Schwartz, 1995, Hypothalamic response to starvation: implications for the study of wasting disorders, Am J Physiol, 269, R949 Flier, 1998, Clinical review.94: What’s in a name? In search of leptin’s physiologic role, J Clin Endocrinol Metab, 83, 1407, 10.1210/jc.83.5.1407 Jarow, 1993, Effect of obesity and fertility status on sex steroid levels in men, Urology, 42, 171, 10.1016/0090-4295(93)90641-M Jung, 2000, Male infertility. Current lifestyle could be responsible for infertility, MMW Fortschr Med, 142, 31 Griffin, 2005, The genetic and cytogenetic basis of male infertility, Human Fertility, 8, 19, 10.1080/14647270400016407