Evidence for striatal dopamine release during a video game

Schultz, W., Apicella, P. & Ljungberg, T. Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task. J. Neurosci. 13, 900–913 (1993).

Robbins, T. W. & Everitt, B. J. Functions of dopamine in the dorsal and ventral striatum. Semin. Neurosci. 4, 119–127 (1992).

Hume, S. P. et al. Quantitation of carbon-11 labelled raclopride in rat straitum using positron emission tomography. Synapse 12, 47–54 (1992).

Laruelle, M. et al. Microdialysis and SPECT measurements of amphetamine-induced dopamine release in non human primates. Synapse 25, 1–14 (1997).

Farde, L. et al. Positron emission tomography analysis of central D1and D2dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Arch. Gen. Psychiatry 49, 538–544 (1992).

Volkow, N. D. et al. Imaging endogenous dopamine competition with [11C]raclopride in the human brain. Synapse 16, 255–262 (1994).

Dewey, S. L. et al. Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects. Proc. Natl Acad. Sci. USA 90, 11816–11820 (1993).

Breier, A. et al. Schizophrenia is associated with elevated amphetamine induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc. Natl Acad. Sci. USA 94, 2569–2574 (1997).

Ljunberg, T. J., Apicella, P. & Schultz, W. Responses of monkey dopamine neurons during learning of behavioural reactions. J. Neurophysiol. 67, 145–163 (1992).

Salamone, J. D., Cousins, M. S., McCullough, L. D., Carrier, O. D. L. & Berkovitz, R. J. Nucleus accumbens dopamine release increases during instrumental level pressing for food but not free food consumption. Pharmacol. Biochem. Behav. 49, 651–660 (1994).

Richardson, N. R. & Gratton, A. Behaviour-relevant changes in nucleus accumbens dopamine transmission elicited by food reinforcement: an electrochemical study in rat. J. Neurosci. 16, 8160–8169 (1996).

Fisher, R. E., Morris, E. D., Alpert, N. M. & Fischman, A. J. In-vivo imaging of neuromodulatory synaptic transmission using PET: a review of relevant neurophysiology. Hum. Brain Mapp. 3, 24–34 (1995).

Morris, E. D., Fisher, R. E., Alpert, N. M., Rauch, S. L. & Fischman, A. J. In vivo imaging of neuromodulation using positron emission tomography: optimal ligand characteristics and task length for detection of activation. Hum. Brain Mapp. 3, 35–55 (1995).

Graybiel, A. M., Aosaki, T., Flaherty, A. W. & Kimura, M. The basal ganglia and adaptive motor control. Science 265, 1826–1831 (1994).

Schultz, W. Dopamine neurons and their role in reward mechanisms. Curr. Opin. Neurobiol. 7, 191–197 (1997).

Brooks, D. J. The role of the basal ganglia in motor control: contributions from PET. J. Neurol. Sci. 128, 1–13 (1995).

Volkow, N. D. et al. Reproducibility of repeated measures of [11C]raclopride binding in the human brain. J. Nucl. Med. 34, 609–613 (1993).

Logan, J. et al. Effects of blood flow on [11C]raclopride binding in the brain: model simulations and kinetic analysis of PET data. J. Cereb. Blood Flow Metab. 14, 995–1010 (1994).

Endres, C. J. et al. Kinetic modelling of [11C]raclopride: combined PET-microdialysis studies. J. Cereb. Blood Flow Metab. 9, 932–942 (1997).

Yamamuro, Y., Hori, K., Iwano, H. & Nomura, M. The relationship between learning-performance and dopamine in the prefrontal cortex of the rat. Neurosci. Lett. 177, 83–86 (1993).

Friston, K. J. et al. Statistical parametric maps in functional imaging: a general linear approach. Hum. Brain Mapp. 2, 189–210 (1995).

Thierry, A. M., Tassin, J. P., Blanc, G. & Glowinski, J. Selective activation of the mesocortical dopaminergic system by stress. Nature 263, 242–244 (1976).

Wise, R. A. The dopamine synapse and the notion of “pleasure centres” in the brain. Trends Neurosci. 3, 91–94 (1980).

Gunn, R. N., Lammertsma, A. A., Hume, S. P. & Cunningham, V. J. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage 6, 279–287 (1997).

Lammertsma, A. A. & Hume, S. P. Simplified reference tissue model for PET receptor studies. Neuroimage 4, 153–158 (1996).

Ashburner, J., Haslam, J., Taylor, C., Cunningham, V. J. & Jones, T. in Quantification of Brain Function Using PET (eds Myers, R., Cunningham, V., Bailey, D. & Jones, T.) 301–306 (Academic, London, (1996)).