Evidence for prescribing exercise as therapy in chronic disease

Scandinavian Journal of Medicine and Science in Sports - Tập 16 Số S1 - Trang 3-63 - 2006
Bente Klarlund Pedersen1,2, Bengt Saltin2
1The Centre of Inflammation and Metabolism, Department of Infectious Diseases,
2The Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

Tóm tắt

Considerable knowledge has accumulated in recent decades concerning the significance of physical activity in the treatment of a number of diseases, including diseases that do not primarily manifest as disorders of the locomotive apparatus. In this review we present the evidence for prescribing exercise therapy in the treatment of metabolic syndrome‐related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases (chronic obstructive pulmonary disease, coronary heart disease, chronic heart failure, intermittent claudication), muscle, bone and joint diseases (osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, chronic fatigue syndrome) and cancer, depression, asthma and type 1 diabetes. For each disease, we review the effect of exercise therapy on disease pathogenesis, on symptoms specific to the diagnosis, on physical fitness or strength and on quality of life. The possible mechanisms of action are briefly examined and the principles for prescribing exercise therapy are discussed, focusing on the type and amount of exercise and possible contraindications.

Từ khóa


Tài liệu tham khảo

1981, A comparison on Beck's cognitive therapy and jogging as treatments for depression [dissertation]

10.1053/euhj.1997.0736

10.1136/thorax.56.11.827

10.1053/euhj.2000.2440

10.1161/hy0202.104270

10.1016/0735-1097(93)90231-O

10.1016/S0735-1097(01)01795-8

10.1053/euhj.2000.2285

Agren B, 1989, Improvements of the lipoprotein profile after coronary bypass surgery, additional effects of an exercise training program, 10, 451

10.2337/diacare.20.10.1503

10.1378/chest.103.4.1135

Akinpelu AO., 1990, Responses of the African hypertensive to exercise training, preliminary observations, 4, 74

10.1210/jc.2003-031036

10.1097/00005768-200007000-00024

10.1016/0022-3999(92)90111-E

10.1111/j.0954-6820.1988.tb15886.x

10.1249/00005768-199310000-00024

American Diabetes Association, 2002, Clinical practice recommendations, Diabetes Care, S1

American Thoracic Society, 1995, Standards for the diagnosis and care of patients with COPD, Am J Respir Crit Care Med, 152, S77

10.1164/ajrccm.159.5.ats2-99

Andersen GS, 1981, Value of regular supervised physical training after acute myocardial infarction], Ugeskr Laeger, 143, 2952

Andersen RE, 1999, Effects of lifestyle activity vs structured aerobic exercise in obese women, a randomized trial, 281, 335

Anderson JW, 2001, Long‐term weight‐loss maintenance, a meta-analysis of US studies, 74, 579

Anderssen S, 1995, Diet and exercise intervention have favourable effects on blood pressure in mild hypertensives, the Oslo Diet and Exercise Study (ODES), 4, 343

10.1161/01.CIR.96.2.526

10.1080/08964289.1996.9933757

Armstrong N, 1994, Physical activity and blood lipids in adolescents, Pediatr Exerc, 6, 631

Arroll B, 1995, Salt restriction and physical activity in treated hypertensives, N Z Med J, 108, 266

Asikainen TM, 2003, Walking trials in postmenopausal women, effect of low doses of exercise and exercise fractionization on coronary risk factors, 13, 284

Babyak M, 2000, Exercise treatment for major depression, maintenance of therapeutic benefit at 10 months, 62, 633

10.1136/qhc.11.3.284

Baker KR, 2001, The efficacy of home based progressive strength training in older adults with knee osteoarthritis, a randomized controlled trial, 28, 1655

10.1161/01.CIR.65.5.913

10.1038/sj.ijo.0800647

Baslund B, 1993, Effect of 8 wk of bicycle training on the immune system of patients with rheumatoid arthritis, J Appl Physiol, 75, 1691, 10.1152/jappl.1993.75.4.1691

Bauldoff GS, 2002, Exercise maintenance following pulmonary rehabilitation, effect of distractive stimuli, 122, 948

10.1136/ard.59.11.887

Beals CA, 1985, Measurement of exercise tolerance in patients with rheumatoid arthritis and osteoarthritis, J Rheumatol, 12, 458

10.1093/rheumatology/41.2.157

Beck‐NielsenH HenriksenJE HermansenK MadsenLD OlivariusNF Mandrup‐PoulsenTR PedersenOB RichelsenB SchmitzOE.Type 2 diabetes and the metabolic syndrome – diagnosis and treatment.2000:6:1–36. Copenhagen Lægeforeningens forlag.

10.1053/rmed.2000.0949

Belardinelli R, 1999, Randomized, controlled trial of long‐term moderate exercise training in chronic heart failure, effects on functional capacity, quality of life, and clinical outcome, 99, 1173

10.1161/01.CIR.97.6.553

10.1016/0735-1097(95)00267-1

Belardinelli R, 2001, Exercise training intervention after coronary angioplasty, the ETICA trial, 37, 1891

Bell JA., 1998, Comparison of a multi‐disciplinary home based cardiac rehabilitation programme with comprehensive conventional rehabilitation in post‐myocardial infarction patients

10.3109/03009748609092661

Bennell KL, 2005, Efficacy of physiotherapy management of knee joint osteoarthritis, a randomised, double blind, placebo controlled trial, 64, 906

10.1002/anr.1780320415

Bertie J, 1992, Benefits and weaknesses of a cardiac rehabilitation programme, J R Coll Physicians London, 26, 147

10.1136/hrt.64.6.370

Bild DE, 1996, Correlates and predictors of weight loss in young adults, the CARDIA study, 20, 47

10.1111/j.1532-5415.1996.tb00907.x

Blood Pressure Lowering Treatment Trialists' Collaboration, 2000, Effects of ACE inhibitors, calcium antagonists, and other blood‐pressure‐lowering drugs, results of prospectively designed overviews of randomised trials, 355, 1955

10.1001/archinte.159.19.2349

Blumenthal JA, 2000, Exercise and weight loss reduce blood pressure in men and women with mild hypertension, effects on cardiovascular, metabolic, and hemodynamic functioning, 160, 1947

Blumenthal JA, 1991, Failure of exercise to reduce blood pressure in patients with mild hypertension. Results of a randomized controlled trial, JAMA, 266, 2098, 10.1001/jama.1991.03470150070033

Bogardus C, 1984, Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non‐insulin‐dependent diabetes mellitus, Diabetes, 33, 311, 10.2337/diab.33.4.311

10.1002/14651858.CD000333

Booker HA., 1984, Exercise training and breathing control in patients with chronic airflow limitation, Physiotherapy, 70, 258

Borjesson M, 1996, Physiotherapy in knee osteoarthrosis, effect on pain and walking, 1, 89

Bosscher RJ., 1993, Running and mixed physical exercises with depressed psychiatric patients, Int J Sport Psychol, 24, 170

Boule NG, 2001, Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus, a meta-analysis of controlled clinical trials, 286, 1218

10.1007/s00125-003-1160-2

Bradham WS, 2002, TNF‐alpha and myocardial matrix metalloproteinases in heart failure, relationship to LV remodeling, 282, H1288

10.1016/0002-9149(94)90294-1

10.1093/gerona/58.8.M740

Brandsma JW, 1998, The effect of exercises on walking distance of patients with intermittent claudication, a study of randomized clinical trials, 78, 278

10.1111/j.1532-5415.1996.tb03730.x

10.1007/BF02883427

10.1093/rheumatology/31.5.293

Brooks GA, 1995, Exercise physiology: human bioenergetics and its applicatons

Brosse AL, 2002, Exercise and the treatment of clinical depression in adults, recent findings and future directions, 32, 741

Brown DR, 2001, Physical activity and public health, training courses for researchers and practitioners, 116, 197

Buckelew SP, 1998, Biofeedback/relaxation training and exercise interventions for fibromyalgia, a prospective trial, 11, 196

10.1002/anr.1790020412

10.1161/01.HYP.25.3.305

10.1002/14651858.CD003786

10.1093/ptj/68.4.469

10.1172/JCI116149

Cambach W, 1997, The effects of a community‐based pulmonary rehabilitation programme on exercise tolerance and quality of life, a randomized controlled trial, 10, 104

10.1046/j.1467-789x.2001.00035.x

10.1002/14651858.CD001871

10.1016/j.prrv.2003.09.010

10.1016/S1526-0550(02)00009-4

10.1080/140174398427956

10.1136/hrt.77.3.256

Carson P, 1982, Exercise after myocardial infarction, a controlled trial, 16, 147

Carter ND, 2002, Community‐based exercise program reduces risk factors for falls in 65‐ to 75‐year‐old women with osteoporosis, randomized controlled trial, 167, 997

Carter ND, 2001, Results of a 10 week community based strength and balance training programme to reduce fall risk factors, a randomised controlled trial in 65–75 year old women with osteoporosis, 35, 348

10.1016/j.apmr.2005.01.007

10.3109/09638288209166889

Chavannes N, 2002, Effects of physical activity in mild to moderate COPD, a systematic review, 52, 574

10.1053/ejvs.2000.1112

10.1136/bmj.295.6611.1441

Cider A, 1997, Peripheral muscle training in patients with clinical signs of heart failure, Scand J Rehabil Med, 29, 121

Ciuffetti G, 1994, Treating peripheral arterial occlusive disease, pentoxifylline vs exercise, 13, 33

10.1136/thx.43.10.745

10.1183/09031936.96.09122590

10.1183/09031936.00.15109200

10.1002/art.1790070410

10.1300/J094v01n03_19

10.1016/0735-1097(96)82380-1

Cleroux J, 1999, Recommendations on physical exercise training, Can Med Assoc J, 160

Coakley EH, 1998, Predictors of weight change in men, results from the Health Professionals Follow-up Study, 22, 89

10.1016/0140-6736(90)90536-E

10.1161/01.CIR.85.6.2119

10.1136/thx.45.5.345

10.1136/thx.37.6.413

10.1136/thx.36.3.200

10.1152/ajpendo.1993.264.2.E215

10.1016/0735-1097(90)90460-7

Colberg S., 2001, The diabetic athlete. Prescription for exercise and sports

10.1093/oxfordjournals.bmb.a072892

Collins R, 1990, Blood pressure, stroke, and coronary heart disease. Part 2, Short‐term reductions in blood pressure, overview of randomised drug trials in their epidemiological context, 335, 827

10.1016/0002-9149(82)90504-5

Cononie CC, 1991, Effect of exercise training on blood pressure in 70‐ to 79‐yr‐old men and women, Med Sci Sports Exerc, 23, 505

10.1053/euhj.2002.3239

10.1001/archinte.1995.00430070053006

Cooper AR, 2000, What is the magnitude of blood pressure response to a programme of moderate intensity exercise? Randomised controlled trial among sedentary adults with unmedicated hypertension, Br J Gen Pract, 50, 958

10.1161/01.HYP.0000184225.05629.51

Corra U, 2005, Executive summary of the position paper of the working group on cardiac rehabilitation and exercise physiology of the European Society of Cardiology (ESC), core components of cardiac rehabilitation in chronic heart failure, 12, 321

10.1016/j.ahj.2003.09.007

Courneya KS, 1997, Relationship between exercise during cancer treatment and current quality of life in survivors of breast cancer, J Psychosocial Oncol, 5, 120

10.1089/acm.1997.3.215

Courneya KS, 1999, Physical exercise and quality of life following cancer diagnosis, a literature review, 21, 171

10.1046/j.1365-2354.2003.00437.x

Courneya KS, 2000, Coping with cancer experience, can physical exercise help?, 28, 49

10.2337/diacare.22.2.233

Cox KL, 1996, Exercise and weight control in sedentary overweight men, effects on clinic and ambulatory blood pressure, 14, 779

10.1038/sj.ijo.0800845

10.1016/S0950-821X(05)80427-X

10.1152/jappl.1997.82.1.270

10.1056/NEJM199503233321202

10.1111/j.1365-2362.1974.tb00365.x

Dansk Lungemedicinsk Selskab and Dansk Selskab for Almen Medicin(1998). Kronisk obstruktiv lungesygdom. Ugeskr. Laeger.

Dansk Selskab for Adipositasforskning and Dansk Kirurgisk Selskab(2001). Er der indikation for kirurgisk behandling af ekstrem overvægt i Danmark? Ugeskr. Laeger.

Davey P, 1992, Ventilation in chronic heart failure, effects of physical training, 68, 473

10.1136/bmj.325.7356.128

Geus EJ, 1992, Effects of exercise training on plasminogen activator inhibitor activity, Med Sci Sports Exerc, 24, 1210

Jong Z, 2004, Slowing of bone loss in patients with rheumatoid arthritis by long‐term high‐intensity exercise, results of a randomized, controlled trial, 50, 1066

10.1002/art.11216

Plaen JF, 1980, Hemodynamic effects of physical training in established arterial hypertension, Acta Cardiol, 35, 179

Vries SO, 2002, Intermittent claudication, cost-effectiveness of revascularization versus exercise therapy, 222, 25

10.1113/jphysiol.1993.sp019833

10.2337/diab.44.9.1010

10.2337/diab.43.7.862

10.1152/ajpendo.00056.2004

10.1097/00005768-199908000-00004

Demopoulos L, 1997, Exercise training in patients with severe congestive heart failure, enhancing peak aerobic capacity while minimizing the increase in ventricular wall stress, 29, 597

DePue JD, 1995, Maintenance of weight loss, a needs assessment, 3, 241

Derby CA, 2000, Modifiable risk factors and erectile dysfunction, can lifestyle changes modify risk?, 56, 302

10.1097/00005768-199905001-01866

10.7326/0003-4819-132-3-200002010-00002

Di GX, 1993, Exercise therapy of non‐insulin dependent diabetes mellitus a report of 10 year studies. The efficacy of exercise therapy, Chin Med J (Engl), 106, 757

Dietz JH., 1981, Rehabilitaion oncology

10.1097/00005768-199804000-00001

10.1002/1097-0142(20010915)92:6 <1689::AID-CNCR1498>3.0.CO;2-H

10.1002/(SICI)1097-0142(19990515)85:10<2273::AID-CNCR24>3.0.CO;2-B

10.1002/(SICI)1097-0142(19970501)79:9<1717::AID-CNCR12>3.0.CO;2-0

10.1136/qshc.8.1.65

Donner CF, 1992, Pulmonary rehabilitation in chronic obstructive pulmonary disease (COPD) with recommendations for its use. Report of the European Respiratory Society Rehabilitation and Chronic Care Scientific Group (S.E.P.C.R. Rehabilitation Working Group), Eur Respir J, 5, 266, 10.1183/09031936.93.05020266

10.1037/0022-006X.55.5.748

10.1016/S0735-1097(97)82540-5

Duey WJ, 1998, Effects of exercise training on aerobic fitness in African‐American females, Ethn Dis, 8, 306

10.1136/hrt.81.4.359

10.1590/S1516-31802001000300008

10.1001/jama.1985.03360180113036

10.1001/jama.1991.03470230053030

10.1097/00005768-200106001-00027

Dunn AL, 2002, The DOSE study, a clinical trial to examine efficacy and dose response of exercise as treatment for depression, 23, 584

Dunn AL, 2005, Exercise treatment for depression, efficacy and dose response, 28, 1

10.2337/diacare.20.6.913

10.1016/S0168-8227(98)00027-8

Durstine JL, 1994, Effects of exercise training on plasma lipids and lipoproteins, Exerc Sport Sci Rev, 22, 477

10.1172/JCI116747

Ebrahim S, 1998, Lowering blood pressure, a systematic review of sustained effects of non-pharmacological interventions, 20, 441

10.1093/ageing/26.4.253

10.1164/ajrccm.164.8.2008109

10.3109/03009747409097136

Ekdahl C, 1992, Muscle strength, endurance, and aerobic capacity in rheumatoid arthritis, a comparative study with healthy subjects, 51, 35

Elliott TG, 1993, Inhibition of nitric oxide synthesis in forearm vasculature of insulin‐dependent diabetic patients, blunted vasoconstriction in patients with microalbuminuria, 85, 687

10.1016/S0003-9993(98)90070-3

10.1378/chest.109.2.323

10.1007/BF00635616

Engblom E, 1992, Exercise habits and physical performance during comprehensive rehabilitation after coronary artery bypass surgery, Eur Heart J, 13, 1053, 10.1093/oxfordjournals.eurheartj.a060313

10.1016/S0002-9149(96)00629-7

10.1097/00008483-199701000-00004

Engblom E, 1992, Coronary heart disease risk factors before and after bypass surgery, results of a controlled trial on multifactorial rehabilitation, 13, 232

Epstein D., 1986, Aerobic activity versus group cognitive therapy: an evaluative study of contrasting interventions for the alleviation of clinical depression [dissertation]

Epstein LH, 1999, Physical activity in the treatment of childhood overweight and obesity, current evidence and research issues, 31, S553

Erdman RA, 1986, Predictability of beneficial effects in cardiac rehabilitation, a randomized clinical trial of psychosocial variables, 6, 206

10.1055/s-2007-978828

10.1007/s001250051024

10.2165/00007256-199825060-00002

10.1161/01.CIR.76.5.1110

Esler M, 2001, The sympathetic neurobiology of essential hypertension, disparate influences of obesity, stress, and noradrenaline transporter dysfunction?, 14, 139S

Espallargues M, 2001, Identifying bone‐mass‐related risk factors for fracture to guide bone densitometry measurements, a systematic review of the literature, 12, 811

Esposito K, 2004, Effect of lifestyle changes on erectile dysfunction in obese men, a randomized controlled trial, 291, 2978

10.1001/jama.1997.03540250033028

10.1183/09031936.95.08081398

10.1002/j.1550-8528.1995.tb00146.x

10.1097/00005768-199911001-00022

10.1097/00005768-200106001-00018

Fairfield KM., 2002, Vitamins for chronic disease prevention in adults, scientific review, 287, 3116

10.1159/000057222

10.1111/j.1532-5415.1989.tb01562.x

Febbraio MA, 2002, Muscle‐derived interleukin‐6, mechanisms for activation and possible biological roles, 16, 1335

10.1164/ajrccm/140.3_Pt_2.S9

10.1002/art.1780300811

10.1161/01.HYP.38.2.222

Fitch KD, 1986, The effect of running training on exercise‐induced asthma, Ann Allergy, 57, 90

10.1016/0002-9149(94)90209-7

10.1001/archfami.2.10.1042

10.1046/j.1467-789x.2000.00016.x

Fogelholm M, 2000, Effects of walking training on weight maintenance after a very‐low‐energy diet in premenopausal obese women, a randomized controlled trial, 160, 2177

10.1016/0002-9149(88)91370-7

Foxx ML, 1998, Fox's physiological basis for exercise physiology

10.1007/BF01183268

10.1111/j.1471-6712.1991.tb00078.x

10.2337/diacare.25.10.1795

Fujii S, 1982, Effects of physical training on glucose tolerance and insulin response in diabetics, Osaka City Med J, 28, 1

10.1136/bmj.314.7095.1647

10.1136/jnnp.69.3.302

10.1056/NEJMoa021778

Gaffney FA, 1981, Adaptation to peripheral muscle training, Scand J Rehabil Med, 13, 11

10.1152/ajpheart.00238.2002

Gardner AW, 1995, Exercise rehabilitation programs for the treatment of claudication pain. A meta‐analysis, JAMA, 274, 975, 10.1001/jama.1995.03530120067043

Gardner AW, 2002, Effects of long‐term exercise rehabilitation on claudication distances in patients with peripheral arterial disease, a randomized controlled trial, 22, 192

10.1164/ajrccm/145.4_Pt_1.741

Geddes EL, 2005, Inspiratory muscle training in adults with chronic obstructive pulmonary disease, a systematic review

Gettman LR, 1976, Physiological responses of men to 1, 3, and 5 day per week training programs, Res Q, 47, 638

10.1097/01.hjr.0000086303.28200.50

10.1016/S0735-1097(03)00848-9

10.1002/14651858.CD000227

Girodo M, 1992, Deep diaphragmatic breathing, rehabilitation exercises for the asthmatic patient, 73, 717

10.1016/S0002-9149(02)02433-5

10.1159/000175862

10.1016/S0140-6736(94)90568-1

10.1002/clc.4960190709

Gordon NF, 1997, Comparison of single versus multiple lifestyle interventions, Are the antihypertensive effects of exercise training and diet-induced weight loss additive?, 79, 763

10.1002/1529-0131(199904)12:2<120::AID-ART7>3.0.CO;2-4

10.1136/thorax.56.2.143

10.1016/0010-440X(79)90058-0

Griffiths TL, 2000, Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation, a randomised controlled trial, 355, 362

10.1136/thorax.56.10.779

Grodstein F, 1996, Three‐year follow‐up of participants in a commercial weight loss program. Can you keep it off?, Arch Intern Med, 156, 1302, 10.1001/archinte.1996.00440110068009

10.1097/00008483-199907000-00002

Grove KA, 1992, Bone density in postmenopausal women, high impact vs low impact exercise, 24, 1190

10.7326/0003-4819-126-10-199705150-00002

Gunnarsson R, 1987, Serum lipid and lipoprotein levels in female type I diabetics, relationships to aerobic capacity and glycaemic control, 13, 417

Guo SS, 1999, Aging, body composition, and lifestyle, the Fels Longitudinal Study, 70, 405

10.1046/j.1365-2362.2001.00816.x

Guyatt GH, 1992, A methodologic framework for health status measures, clarity or oversimplification?, 45, 1353

10.1136/thx.39.11.818

10.1016/0021-9681(85)90035-9

10.1093/ije/26.4.739

10.1016/0002-9149(89)90533-X

Hakkinen A, 2001, Strength training induced adaptations in neuromuscular function of premenopausal women with fibromyalgia, comparison with healthy women, 60, 21

10.1093/rheumatology/34.4.355

10.1002/1529-0131(200103)44:3<515::AID-ANR98>3.0.CO;2-5

Hakkinen A, 1999, Dynamic strength training in patients with early rheumatoid arthritis increases muscle strength but not bone mineral density, J Rheumatol, 26, 1257

Hakkinen K, 2002, Effects of strength training on muscle strength, cross‐sectional area, maximal electromyographic activity, and serum hormones in premenopausal women with fibromyalgia, J Rheumatol, 29, 1287

10.1016/S0026-0495(99)90064-1

Hambrecht R, 2000, Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure, a randomized trial, 283, 3095

Hambrecht R, 1995, Physical training in patients with stable chronic heart failure, effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles, 25, 1239

10.1111/j.1445-5994.1999.tb01584.x

Hamdorf PA, 1992, Physical training effects on the fitness and habitual activity patterns of elderly women, Arch Phys Med Rehabil, 73, 603

10.3109/03009749309099253

10.1002/art.1780280106

10.1016/S0735-1097(97)00381-1

10.1111/j.1532-5415.2000.tb03863.x

10.1002/1098-108X(199307)14:1<87::AID-EAT2260140112>3.0.CO;2-2

10.1161/01.CIR.89.3.975

10.1007/s004210100435

10.1007/BF00571327

Haus G, 1994, Key modifiable factors in weight maintenance, fat intake, exercise, and weight cycling, 94, 409

10.1016/j.ahj.2004.09.006

10.1136/thorax.57.10.853

Heitmann BL, 1997, Are genetic determinants of weight gain modified by leisure‐time physical activity? A prospective study of Finnish twins, Am J Clin Nutr, 66, 672, 10.1093/ajcn/66.3.672

Heldal M, 2000, Randomised training after myocardial infarction, short and long-term effects of exercise training after myocardial infarction in patients on beta-blocker treatment. A randomized, controlled study, 34, 59

Helge EW., 2001, High prevalence of eating disorders among elite athletes. Increased risk of amenorrhea and premenopausal osteoporosis, Ugeskr Laeger, 163, 3473

10.1016/0021-9150(93)90042-S

10.1016/0002-9149(93)91058-P

10.1161/01.CIR.81.2.602

10.1161/01.CIR.90.4.1866

Higashi Y, 1999, Regular aerobic exercise augments endothelium‐dependent vascular relaxation in normotensive as well as hypertensive subjects, role of endothelium-derived nitric oxide, 100, 1194

10.1161/01.HYP.33.1.591

10.1016/S0738-3991(00)00164-6

Hinkleman LL, 1993, The effects of a walking program on body composition and serum lipids and lipoproteins in overweight women, J Sports Med Phys Fitness, 33, 49

10.1002/art.1780381103

10.1002/art.1780381104

Hoiberg A, 1984, Correlates of weight loss in treatment and at follow‐up, Int J Obes, 8, 457

Hoidrup S., 1997, Risk factors for hip fracture, 1

Holden JH, 1992, Long‐term follow‐up of patients attending a combination very‐low calorie diet and behaviour therapy weight loss programme, Int J Obes Relat Metab Disord, 16, 605

Holm J, 1973, Enzyme studies in muscles of patients with intermittent claudication. Effect of training, Scand J Clin Lab Invest Suppl, 128, 201

Holmback AM, 1994, Training after myocardial infarction, lack of long-term effects on physical capacity and psychological variables, 75, 551

Holmes GP, 1988, Chronic fatigue syndrome, a working case definition, 108, 387

10.1001/jama.293.20.2479

10.2337/diabetes.53.2.294

10.1007/s005920050082

Hopman‐Rock M, 2000, The effects of a health educational and exercise program for older adults with osteoarthritis for the hip or knee, J Rheumatol, 27, 1947

10.2337/diacare.13.2.87

Houde SC, 2002, Cardiovascular health and physical activity in older adults, an integrative review of research methodology and results, 38, 219

10.1152/japplphysiol.00707.2003

Hsieh LF, 1987, Isokinetic and isometric testing of knee musculature in patients with rheumatoid arthritis with mild knee involvement, Arch Phys Med Rehabil, 68, 294

Ivy JL, 1999, Prevention and treatment of non‐insulin‐dependent diabetes mellitus, Exerc Sport Sci Rev, 27, 1

10.1007/s007760100059

10.1016/0197-2456(89)90005-6

Jan MH, 1991, The effects of physiotherapy on osteoarthritic knees of females, J Formos Med Assoc, 90, 1008

Jennings G, 1986, The effects of changes in physical activity on major cardiovascular risk factors, hemodynamics, sympathetic function, and glucose utilization in man, a controlled study of four levels of activity, 73, 30

10.1023/A:1008287320868

10.1161/01.CIR.84.4.1561

10.1016/S0140-6736(69)92009-1

10.1053/euhj.1998.1024

10.1161/01.CIR.88.6.2510

Jolliffe JA, 2000, Exercise‐based rehabilitation for coronary heart disease. Cochrane, Database Syst Rev

Jonason T, 1987, Prediction of the effect of training on the walking tolerance in patients with intermittent claudication, Scand J Rehabil Med, 19, 47, 10.2340/1650197787194750

Jones DR., 1989, Cardiorespiratory responses to aerobic training by patients with postpoliomyelitis sequelae, JAMA, 261, 3255, 10.1001/jama.1989.03420220069029

Jones DT, 1985, Physical exercise and resistive breathing training in severe chronic airways obstruction – are they effective?, Eur J Respir Dis, 67, 159

Jones KD, 2002, A randomized controlled trial of muscle strengthening versus flexibility training in fibromyalgia, J Rheumatol, 29, 1041

Jones NL., 1988, In Clinical exercise testing, 123

Joslin EP, 1959, The treatment of diabetes mellitus

10.1249/01.MSS.0000135780.88930.A9

10.1016/S0140-6736(79)92502-9

10.1007/BF01621853

10.1001/jama.1979.03290450033020

10.1007/BF02596443

Kavanagh T, 1996, Quality of life and cardiorespiratory function in chronic heart failure, effects of 12 months' aerobic training, 76, 42

Kayman S, 1990, Maintenance and relapse after weight loss in women, behavioral aspects, 52, 800

10.1177/104345429901600402

Keefe FJ, 1999, Spouse‐assisted coping skills training in the management of knee pain in osteoarthritis, long-term followup results, 12, 101

Kelemen MH, 1990, Exercise training combined with antihypertensive drug therapy. Effects on lipids, blood pressure, and left ventricular mass, JAMA, 263, 2766, 10.1001/jama.1990.03440200070025

Kelley G., 1998, Aerobic exercise and lumbar spine bone mineral density in postmenopausal women, a meta-analysis, 46, 143

Kelley GA., 1998, Aerobic exercise and bone density at the hip in postmenopausal women, a meta-analysis, 27, 798

Kelley GA., 1998, Exercise and regional bone mineral density in postmenopausal women, a meta-analytic review of randomized trials, 77, 76

Kelley GA., 1999, Aerobic exercise and resting blood pressure among women, a meta-analysis, 28, 264

Kelley GA, 1999, Aerobic exercise and resting blood pressure in women, a meta-analytic review of controlled clinical trials, 8, 787

Kelley GA, 2000, Progressive resistance exercise and resting blood pressure, a meta-analysis of randomized controlled trials, 35, 838

Kelley GA, 2004, Efficacy of resistance exercise on lumbar spine and femoral neck bone mineral density in premenopausal women, a meta-analysis of individual patient data, 13, 293

Kelley GA, 2001, Aerobic exercise and resting blood pressure in older adults, a meta-analytic review of randomized controlled trials, 56, M298

Kelley GA, 2001, Aerobic exercise and resting blood pressure, a meta-analytic review of randomized, controlled trials, 4, 73

Kelley GA, 2001, Resistance training and bone mineral density in women, a meta-analysis of controlled trials, 80, 65

Kelley GA, 2001, Walking and resting blood pressure in adults, a meta-analysis, 33, 120

Kemper HC, 2000, A fifteen‐year longitudinal study in young adults on the relation of physical activity and fitness with the development of the bone mass, the Amsterdam Growth and Health Longitudinal Study, 27, 847

Kentala E., 1972, Physical fitness and feasibility of physical rehabilitation after myocardial infarction in men of working age, Ann Clin Res Suppl, 9, 1

10.1002/jbmr.5650110211

10.1249/01.MSS.0000106173.81966.90

10.7326/0003-4819-124-12-199606150-00004

Kiesewetter H, 1987, Training by walking and drug therapy of peripheral arterial occlusive disease, Vasa Suppl, 20, 384

10.1378/chest.110.4.985

10.1093/oxfordjournals.eurheartj.a060941

King AC, 1989, Diet vs exercise in weight maintenance. The effects of minimal intervention strategies on long‐term outcomes in men, Arch Intern Med, 149, 2741, 10.1001/archinte.1989.00390120085017

10.1001/jama.1991.03470110081037

King SJ, 2002, The effects of exercise and education, individually or combined, in women with fibromyalgia, J Rheumatol, 29, 2620

10.5694/j.1326-5377.1993.tb121740.x

10.2337/diacare.26.4.1186

10.1080/00207411.1984.11448982

10.1056/NEJM199908123410707

10.1056/NEJMoa012512

10.1378/chest.101.5_Supplement.231S

10.2337/diacare.15.2.184

10.1359/jbmr.1997.12.8.1253

Koivisto UM, 1991, Differential regulation of the GLUT‐1 and GLUT‐4 glucose transport systems by glucose and insulin in L6 muscle cells in culture, J Biol Chem, 266, 2615, 10.1016/S0021-9258(18)52289-4

10.1056/NEJM197801122980205

10.1056/NEJM199511303332204

Komatireddy GR, 1997, Efficacy of low load resistive muscle training in patients with rheumatoid arthritis functional class II and III, J Rheumatol, 24, 1531

10.1016/j.rmed.2004.03.003

10.1080/11026480310015549

10.7326/0003-4819-116-7-529

Krachler M, 1997, Trace elements in coronary heart disease, impact of intensified lifestyle modification, 60, 175

10.1097/00005768-200102000-00015

10.1152/jappl.1997.83.1.270

10.1097/00005768-199909000-00014

10.1056/NEJMoa020194

10.1016/0002-9149(87)91086-1

Krolner B, 1983, Vertebral bone loss, an unheeded side effect of therapeutic bed rest, 64, 537

10.1007/BF00703130

Krummel DA, 2001, Cardiovascular health interventions in women, what works?, 10, 117

Kukkonen K, 1982, Physical training of middle‐aged men with borderline hypertension, Ann Clin Res, 14, 139

Laaksonen DE, 2000, Aerobic exercise and the lipid profile in type 1 diabetic men, a randomized controlled trial, 32, 1541

Lacasse Y, 2002, Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane, Database Syst Rev

10.1016/S0140-6736(96)04201-8

10.1378/chest.97.5.1077

10.1067/mva.2002.123756

LangeP VestboJ.(2 A.D.). Obstruktive lungesygdomme. In Medicinsk kompendium.

Lansimies E, 1979, Exercise and sport biology, 199

10.1016/S0140-6736(66)92191-X

10.1007/BF01623922

10.1136/bmj.303.6800.453

Lawlor DA, 2001, The effectiveness of exercise as an intervention in the management of depression, systematic review and meta-regression analysis of randomised controlled trials, 322, 763

10.1161/01.CIR.60.7.1519

10.1152/japplphysiol.00053.2005

10.1016/S0306-4603(98)00090-2

10.1046/j.1365-2362.2001.00752.x

10.2337/diacare.20.10.1603

10.1007/BF00401764

10.1016/j.ahj.2003.07.001

10.1097/00005768-200203000-00016

10.1002/14651858.CD000990

10.1097/00008483-199101000-00008

Leon AS., 1999, Exercise and the heart in health and disease, 355

10.1097/00005768-200106001-00021

10.1097/00008483-199605000-00006

10.1161/01.CIR.56.3.375

10.1161/01.CIR.88.1.116

10.1016/0140-6736(92)90547-G

Lewington S, 2002, Age‐specific relevance of usual blood pressure to vascular mortality, a meta-analysis of individual data for one million adults in 61 prospective studies, 360, 1903

10.1097/00002281-200111000-00005

10.1111/j.0954-6820.1982.tb03179.x

Lindheim SR, 1994, The independent effects of exercise and estrogen on lipids and lipoproteins in postmenopausal women, Obstet Gynecol, 83, 167

Lindstrom J, 2003, Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the finnish diabetes prevention study, results from a randomized clinical trial, 14, S108

Lindstrom J, 2003, The Finnish Diabetes Prevention Study (DPS), lifestyle intervention and 3-year results on diet and physical activity, 26, 3230

Lisspers J, 1999, Behavioral effects of a comprehensive, multifactorial program for lifestyle change after percutaneous transluminal coronary angioplasty, a prospective, randomized controlled study, 46, 143

Lloyd‐Williams F, 2002, Exercise training and heart failure, a systematic review of current evidence, 52, 47

10.1200/JCO.1999.17.1.253

Lokey EA, 1989, Effects of exercise training on serum lipid and lipoprotein concentrations in women, a meta-analysis, 10, 424

10.1007/BF01623009

10.1097/00000658-198903000-00016

Lundgren F, 1989, Muscle enzyme adaptation in patients with peripheral arterial insufficiency, spontaneous adaptation, effect of different treatments and consequences on walking performance, 77, 485

10.1080/03009749950155788

10.1016/0003-9993(94)90003-5

MacVicar MG, 1986, Promoting the functional capacity of cancer patients, Cancer Bulletin, 38, 235

10.1016/S0008-6363(96)00249-0

10.1152/jappl.2000.88.5.1565

10.1161/01.CIR.95.3.618

10.1161/01.CIR.94.6.1276

10.1111/j.1600-0838.1998.tb00225.x

Manchanda SC, 2000, Retardation of coronary atherosclerosis with yoga lifestyle intervention, J Assoc Physicians India, 48, 687

10.1007/BF00943363

10.1016/0002-9343(69)90054-0

Mannarino E, 1991, Physical training and antiplatelet treatment in stage II peripheral arterial occlusive disease, alone or combined?, 42, 513

10.1080/030097402760375223

10.1161/01.CIR.88.6.2803

Marchionni N, 2003, Improved exercise tolerance and quality of life with cardiac rehabilitation of older patients after myocardial infarction, results of a randomized, controlled trial, 107, 2201

Marcus BH, 1994, The transtheoretical model, applications to exercise behavior, 26, 1400

10.1042/CS20010008

10.1002/jbmr.5650080805

10.1161/01.CIR.81.5.1560

Martin L, 1996, An exercise program in the treatment of fibromyalgia, J Rheumatol, 23, 1050

Martinsen EW., 1988, Comparing aerobic and non‐aerobic forms of exercise in the treatment of clinical depression: a randomised trial [abstract], 84

Martinsen EW, 1989, Comparing aerobic with nonaerobic forms of exercise in the treatment of clinical depression, a randomized trial, 30, 324

Martinsen EW, 1985, Effects of aerobic exercise on depression, a controlled study, 291, 109

10.1161/01.CIR.78.2.320

Mayoux‐Benhamou MA, 1997, Effect of psoas training on postmenopausal lumbar bone loss, a 3-year follow-up study, 60, 348

10.1249/00005768-199508000-00007

10.1002/art.1780310908

10.1037/0022-3514.46.5.1142

10.1016/0002-9343(72)90006-X

10.1007/BF00235178

McGavin CR, 1977, Physical rehabilitation for the chronic bronchitic, results of a controlled trial of exercises in the home, 32, 307

10.1002/j.1550-8528.1999.tb00416.x

McKay HA, 2000, Augmented trochanteric bone mineral density after modified physical education classes, a randomized school-based exercise intervention study in prepubescent and early pubescent children, 136, 156

10.1002/pri.1999.4.1.55

10.1042/cs0870031

10.1037/0882-7974.6.3.487

10.1007/BF00429099

Mengshoel AM, 1992, The effects of 20 weeks of physical fitness training in female patients with fibromyalgia, Clin Exp Rheumatol, 10, 345

10.1161/01.HYP.18.5.575

10.1097/00004872-199009000-00010

Messier SP, 2000, Exercise and weight loss in obese older adults with knee osteoarthritis, a preliminary study, 48, 1062

10.1123/jab.13.2.205

10.1016/S0002-9149(96)00527-9

Miedema H, 1994, Reuma‐Onderzoek Meerdere Echelons (ROME): Basisrapport

10.1161/01.CIR.70.4.645

10.1038/sj.ijo.0800499

10.1002/anr.1780321108

Minor MA, 1988, Exercise tolerance and disease related measures in patients with rheumatoid arthritis and osteoarthritis, J Rheumatol, 15, 905

10.1161/01.CIR.85.6.2323

10.1291/hypres.25.507

Mock V, 1994, A nursing rehabilitation program for women with breast cancer receiving adjuvant chemotherapy, Oncol Nurs Forum, 21, 899

10.1097/00005768-200111000-00005

Mosekilde L., 2001, Mechanisms in osteoporosis, Ugeskr Laeger, 163, 1243

10.2337/diacare.20.3.385

10.1093/oxfordjournals.aje.a116604

Muir JF, 1996, BMJ Books

10.1002/art.11382

10.1136/ard.2003.011189

10.1097/00005768-199801000-00021

Mutric N., 1988, Exercise as a treatment for moderate depression in the UK National Health Service [abstract], 96

10.1056/NEJMoa011858

10.1136/bmj.320.7226.26

Myrtek M, 1976, Psychological and physiological effects of a 5‐week ergometer training in healthy young men (author's transl), Med Klin, 71, 1623

National Heart, Lung and Blood Institute, 1998, Obesity education initiative expert panel: clinical guidelines on the identification, evaluation and treatment of overweight and obesity in adults: the evidence report. 98‐4083, 1

National Institute of Health N.H.L.a.B.I. (1995). Global initiative for asthma. NIH Publication No. 95‐3659.

National Institutes of Health Consensus Development Panel, 1993, Triglyceride, DLD, and CHD, JAMA, 269, 505

10.1016/S0140-6736(86)90354-5

10.1001/jama.1994.03520240037038

10.1016/S0026-0495(97)90194-3

10.3109/03009748309102902

10.1378/chest.121.4.1085

10.1053/euhj.2001.2942

Obrant KJ, 1989, Increasing age‐adjusted risk of fragility fractures, a sign of increasing osteoporosis in successive generations?, 44, 157

10.1016/S0002-9149(99)00748-1

10.1111/j.1532-5415.1996.tb01444.x

10.1097/01.hjr.0000099030.73419.67

10.1016/0002-9149(91)90870-Q

Oluseye KA., 1990, Cardiovascular responses to exercise in Nigerian women, J Hum Hypertens, 4, 77

Oluseye KA., 1990, Cardiovascular responses to exercise in Nigerian women, J Hum Hypertens, 4, 77

O'Reilly SC, 1999, Effectiveness of home exercise on pain and disability from osteoarthritis of the knee, a randomised controlled trial, 58, 15

Orenstein DM., 1995, Asthma and sports, 433

10.1016/0140-6736(90)91656-U

10.1016/S1388-9842(99)00067-7

10.1161/01.CIR.85.4.1265

10.1249/01.mss.0000175079.23850.95

Paganini‐Hill A, 1991, Exercise and other factors in the prevention of hip fracture, the Leisure World study, 2, 16

10.1016/S0300-2896(02)75224-1

10.2337/diacare.20.4.537

10.1016/0026-0495(91)90075-8

10.1038/sj.jhh.1001901

10.1042/cs1020001

Pasternak RC, 1990, Spectrum of risk factors for CHD, J Am Coll Cardiol, 27, 964

10.1093/ajcn/49.5.1115

Pedersen BK, 2000, Exercise and the immune system, regulation, integration and adaption, 80, 1055

Pedersen BK, 2001, Muscle‐derived interleukin‐6, possible biological effects, 536, 329

10.1001/archinte.161.19.2309

Perri MG, 1986, Enhancing the efficacy of behavior therapy for obesity, effects of aerobic exercise and a multicomponent maintenance program, 54, 670

10.1037/0022-006X.56.4.529

10.1249/01.MSS.0000115224.88514.3A

10.1093/fampra/19.6.665

10.1002/art.1790060104

10.1097/00042752-199807000-00011

Petrella RJ, 2000, Home based exercise therapy for older patients with knee osteoarthritis, a randomized clinical trial, 27, 2215

10.1136/bmj.328.7441.711-b

Pinkney JH, 1999, Endothelial dysfunction in Type 1 diabetes mellitus, relationship with LDL oxidation and the effects of vitamin E, 16, 993

10.1300/J077V16N02_03

Posner JD, 1992, Low to moderate intensity endurance training in healthy older adults, physiological responses after four months, 40, 1

10.1161/01.STR.26.1.101

10.1136/bmj.322.7283.387

10.1001/jama.286.3.327

10.1097/00002060-199503000-00006

10.1002/jbmr.5650100711

10.1056/NEJM199110243251701

10.1152/ajpendo.1999.277.3.E489

10.2165/00007256-199316060-00006

Province MA, 1995, The effects of exercise on falls in elderly patients. A preplanned meta‐analysis of the FICSIT Trials. Frailty and injuries, cooperative studies of intervention techniques, 273, 1341

10.1002/jbmr.5650101123

10.1152/jappl.2001.90.6.2341

Quittan M, 1999, Quality of life in patients with chronic heart failure, a randomized controlled trial of changes induced by a regular exercise program, 31, 223

10.2337/diacare.24.4.625

10.1097/00004872-199210000-00024

Ram FS, 2000, Effects of physical training in asthma, a systematic review, 34, 162

10.1002/14651858.CD001116

Raz I, 1994, Moderate exercise improves glucose metabolism in uncontrolled elderly patients with non‐insulin‐dependent diabetes mellitus, Isr J Med Sci, 30, 766

Ready AE, 1995, Walking program reduces elevated cholesterol in women postmenopause, Can J Cardiol, 11, 905

10.1097/00005768-199609000-00004

Redondo JR, 2004, Long‐term efficacy of therapy in patients with fibromyalgia, a physical exercise-based program and a cognitive-behavioral approach, 51, 184

10.1016/S0741-5214(05)80040-0

10.1097/00004872-199403000-00011

Reid WD, 1984, Ventilatory muscle strength and endurance training in elderly subjects and patients with chronic airflow limitation, a pilot study, 36, 305

Reilly JJ, 2002, Obesity, diagnosis, prevention, and treatment; evidence based answers to common questions, 86, 392

10.2337/diacare.7.5.434

Reuter M, 1984, Running as an adjunct to counseling in the treatment of depression [dissertation]

Revel M, 1993, One‐year psoas training can prevent lumbar bone loss in postmenopausal women, a randomized controlled trial, 53, 307

Richards SC, 2002, Prescribed exercise in people with fibromyalgia, parallel group randomised controlled trial, 325, 185

10.1053/rmed.1999.0704

Rissanen AM, 1991, Determinants of weight gain and overweight in adult Finns, Eur J Clin Nutr, 45, 419

Robeer GG, 1998, Exercise therapy for intermittent claudication, a review of the quality of randomised clinical trials and evaluation of predictive factors, 15, 36

10.1152/japplphysiol.00852.2004

Robertson MC, 2002, Preventing injuries in older people by preventing falls, a meta-analysis of individual-level data, 50, 905

Robillon JF, 1994, Abnormalities suggestive of cardiomyopathy in patients with type 2 diabetes of relatively short duration, Diabetes Metab, 20, 473

10.1097/00004872-199611000-00017

10.1016/S0003-9993(98)90238-6

10.1097/00008469-199510000-00010

10.1111/j.0954-6820.1986.tb02754.x

Ross R, 2001, Physical activity, total and regional obesity, dose-response considerations, 33, S521

10.7326/0003-4819-133-2-200007180-00008

Ross R, 2004, Exercise‐induced reduction in obesity and insulin resistance in women, a randomized controlled trial, 12, 789

10.1007/BF02908299

10.1007/BF00845347

Rowlands AV, 2000, The effect of type of physical activity measure on the relationship between body fatness and habitual physical activity in children, a meta-analysis, 27, 479

10.2337/diab.28.1.S89

10.1038/sj.jhh.1000608

Salman GF, 2003, Rehabilitation for patients with chronic obstructive pulmonary disease, meta-analysis of randomized controlled trials, 18, 213

Salmon P., 2001, Effects of physical exercise on anxiety, depression, and sensitivity to stress, a unifying theory, 21, 33

Saltin B, 2000, [Metabolic capacity of skeletal muscles and health], Ugeskr Laeger, 162, 2159

10.1111/j.1749-6632.1977.tb38182.x

Sant M, 1995, Comparisons of colon‐cancer survival among European countries, the Eurocare Study, 63, 43

10.1016/S0002-9149(03)00128-0

Santuz P, 1997, Exercise performance in children with asthma, is it different from that of healthy controls?, 10, 1254

Sarlio‐Lahteenkorva S, 1998, Weight loss maintenance, determinants of long-term success, 3, 131

Sarlio‐Lahteenkorva S, 2000, A descriptive study of weight loss maintenance, 6 and 15 year follow-up of initially overweight adults, 24, 116

10.1159/000175034

Schantz PG., 1986, Plasticity of human skeletal muscle with special reference to effects of physical training on enzyme levels of the NADH shuttles and phenotypic expression of slow and fast myofibrillar proteins, Acta Physiol Scand, 558, 1

Scherer TA, 2000, Respiratory muscle endurance training in chronic obstructive pulmonary disease, impact on exercise capacity, dyspnea, and quality of life, 162, 1709

10.1097/00006199-199603000-00002

10.1007/BF00266036

10.1161/01.CIR.86.1.1

10.1001/jama.1995.03520290060030

Schulz KH, 1998, [Implementation and evaluation of an ambulatory exercise therapy based rehabilitation program for breast cancer patients], Psychother Psychosom Med Psychol, 48, 398

Schulze PC, 2002, Chronic heart failure and skeletal muscle catabolism, effects of exercise training, 85, 141

Scott MG., 1960, The contributions of physical activity to psychological development, Res Q, 31, 307

Segal R, 2001, Structured exercise improves physical functioning in women with stages I and II breast cancer, results of a randomized controlled trial, 19, 657

Segar ML, 1998, The effect of aerobic exercise on self‐esteem and depressive and anxiety symptoms among breast cancer survivors, Oncol Nurs Forum, 25, 107

Seki E, 2003, Effects of phase III cardiac rehabilitation programs on health‐related quality of life in elderly patients with coronary artery disease, juntendo Cardiac Rehabilitation Program (J-CARP), 67, 73

10.1111/j.1600-0447.1989.tb01332.x

Sharpe MC, 1991, A report – chronic fatigue syndrome, guidelines for research, 84, 118

10.1016/0002-9149(81)90570-1

10.1097/00008483-199801000-00006

Sikand G, 1988, Two‐year follow‐up of patients treated with a very‐low‐calorie diet and exercise training, J Am Diet Assoc, 88, 487, 10.1016/S0002-8223(21)06865-6

10.1136/thx.47.2.70

Sinaki M, 1989, Efficacy of nonloading exercises in prevention of vertebral bone loss in postmenopausal women, a controlled trial, 64, 762

10.1093/gerona/52A.1.M27

10.1016/S0002-9343(96)00041-1

Sivarajan ES, 1982, Treadmill test responses to an early exercise program after myocardial infarction, a randomized study, 65, 1420

10.1034/j.1600-0838.2003.00300.x

10.1016/S0735-1097(99)00547-1

Slemenda C, 1998, Reduced quadriceps strength relative to body weight, a risk factor for knee osteoarthritis in women?, 41, 1951

Slentz CA, 2005, Inactivity, exercise, and visceral fat. STRRIDE, a randomized, controlled study of exercise intensity and amount, 99, 1613

Slentz CA, 2004, Effects of the amount of exercise on body weight, body composition, and measures of central obesity, stride – a randomized controlled study, 164, 31

Sly RM, 1972, The effect of physical conditioning upon asthmatic children, Ann Allergy, 30, 86

10.1097/00007632-199203000-00007

10.2337/diacare.19.6.575

10.1016/0026-0495(85)90005-8

10.1161/01.CIR.94.5.978

10.1097/00043798-200110000-00007

10.1080/003655000750045451

10.2337/diacare.16.2.434

Stefanick ML, 1994, Physical activity, fitness, health. International proceedings and consensus statement, 417

10.1056/NEJM199807023390103

10.1056/NEJM199807023390103

10.1001/archinte.143.9.1719

Stewart KJ., 2001, ACSM's resource manual for guidelines for exercise testing and prescription

Stewart KJ., 2002, Exercise training and the cardiovascular consequences of type 2 diabetes and hypertension, plausible mechanisms for improving cardiovascular health, 288, 1622

10.1161/01.CIR.81.2.518

10.1161/01.CIR.78.3.506

10.1161/01.CIR.79.2.324

10.1161/01.CIR.80.4.769

Suter E, 1990, Effects of self‐monitored jogging on physical fitness, blood pressure and serum lipids, a controlled study in sedentary middle-aged men, 11, 425

10.1016/0002-9343(93)90253-L

Svendsen OL, 1994, Six months' follow‐up on exercise added to a short‐term diet in overweight postmenopausal women – effects on body composition, resting metabolic rate, cardiovascular risk factors and bone, Int J Obes Relat Metab Disord, 18, 692

Svendsen OL, 2001, Fedme i Danmark. En rapport fra Dansk task force on obesity., Ugeskr Laeger, 163

Swann IL, 1983, The asthmatic child – in play and sport, 318

Sylvester KL., 1989, Pilot study, investigation of the effect of hydrotherapy in the treatment of osteoarthritic hips, 4, 228

10.1016/0002-9149(88)90149-X

10.1046/j.1365-2168.2000.01445.x

Tan RA, 2002, Exercise‐induced asthma, diagnosis and management, 89, 226

10.3109/10641968909035297

10.1097/00004872-199715060-00012

10.1159/000175987

TASC, 2000, Management of peripheral arterial disease, Eur J Vasc Endovasc Surg, 19, S1

10.1002/pri.171

10.1097/00001648-199411000-00007

10.1097/00008483-199705000-00002

Taylor RS, 2004, Exercise‐based rehabilitation for patients with coronary heart disease, systematic review and meta-analysis of randomized controlled trials, 116, 682

10.1016/S0167-4943(00)00076-5

The P.R.E.COR group, 1991, Comparison of a rehabilitation programme, a counselling programme and usual care after an acute myocardial infarction, results of a long-term randomized trial, 12, 612

Thomas KS, 2002, Home based exercise programme for knee pain and knee osteoarthritis, randomised controlled trial, 325, 752

10.1089/acm.1998.4.205

Thune I, 2001, Physical activity and cancer risk, dose-response and cancer, all sites and site-specific, 33, S530

Thune I, 2000, Is physical activity important in treatment and rehabilitation of cancer patients?, Tidsskr Nor Laegeforen, 120, 3302

Tipton CM., 1999, Exercise and the heart in health and disease, 463

10.1007/BF02895162

10.1053/apmr.2002.33988

10.1001/jama.1985.03360070057023

Tran ZV, 1983, The effects of exercise on blood lipids and lipoproteins, a meta-analysis of studies, 15, 393

10.2337/diacare.7.5.416

10.1081/CEH-120004234

10.1016/S0895-7061(02)02273-2

10.1046/j.1440-1681.2003.03846.x

Tudor‐Locke C, 2004, Controlled outcome evaluation of the first step program, a daily physical activity intervention for individuals with type II diabetes, 28, 113

Tudor‐Locke C, 2000, Formative evaluation of the first step program, a practical intervention to increase daily physical activity, 24, 34

Tudor‐Locke C, 2002, Preliminary outcome evaluation of the first step program, a daily physical activity intervention for individuals with type 2 diabetes, 47, 23

10.1177/014572170102700110

10.1056/NEJM200105033441801

10.1007/BF02369359

10.1016/S1388-9842(00)00087-8

10.1016/S1071-9164(96)80029-7

10.1016/S1071-9164(98)90503-6

10.1016/S0002-9149(97)00597-3

10.1016/S1071-9164(99)91334-9

US Department of Health and Human Services, 1996, Physical activity and health: a report of the surgeon general, 1

10.1016/S0140-6736(98)07037-8

10.1161/01.HYP.9.3.245

Baar ME, 1999, Effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee, a systematic review of randomized clinical trials, 42, 1361

Baar ME, 2001, Effectiveness of exercise in patients with osteoarthritis of hip or knee, nine months' follow up, 60, 1123

Baar ME, 1998, The effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee, a randomized clinical trial, 25, 2432

Dale D, 1990, Weight maintenance and resting metabolic rate 18‐40 months after a diet/exercise treatment, Int J Obes, 14, 347

Ende CH, 2000, Effect of intensive exercise on patients with active rheumatoid arthritis, a randomised clinical trial, 59, 615

10.1136/ard.55.11.798

Ende CH, 2000, Dynamic exercise therapy for rheumatoid arthritis. Cochrane, Database Syst Rev

Poest CE, 1999, Long‐term consequences of fracture of the lower leg, cross-sectional study and long-term longitudinal follow-up of bone mineral density in the hip after fracture of lower leg, 24, 131

Wiel HE, 1994, Loss of bone in the proximal part of the femur following unstable fractures of the leg, J Bone Joint Surg Am, 76, 230, 10.2106/00004623-199402000-00009

10.1016/0002-9149(89)90145-8

10.1016/0002-9149(89)90145-8

Santen M, 2002, High or low intensity aerobic fitness training in fibromyalgia, does it matter?, 29, 582

Vanninen E, 1992, Habitual physical activity, aerobic capacity and metabolic control in patients with newly‐diagnosed type 2 (non‐insulin‐dependent) diabetes mellitus, effect of 1-year diet and exercise intervention, 35, 340

10.1097/00004356-199512000-00002

10.1378/chest.99.3.579

Veale D, 1988, Aerobic exercise in the adjunctive treatment of depression: a randomised controlled trial [abstract], 106

Veale D, 1992, Aerobic exercise in the adjunctive treatment of depression, a randomized controlled trial, 85, 541

Vecchio C, 1981, [Early functional evaluation and physical rehabilitation in patients with wide myocardial infarction (author's transl)], G Ital Cardiol, 11, 419

Veje K, 2002, Osteoarthritis. Pathogenesis, clinical features and treatment, Ugeskr Laeger, 164, 3173

Vermeulen A, 1983, Effects of cardiac rehabilitation after myocardial infarction, changes in coronary risk factors and long-term prognosis, 105, 798

10.2337/diab.46.11.1846

Vroman NB, 1988, Cardiovascular response to lower body negative pressure (LBNP) following endurance training, Aviat Space Environ Med, 59, 330

Wadden TA, 1998, Exercise and the maintenance of weight loss, 1-year follow-up of a controlled clinical trial, 66, 429

10.1080/165019701750419581

10.2337/diacare.22.4.555

10.1007/s00223001089

Wallberg‐Henriksson H, 1984, Influence of physical training on formation of muscle capillaries in type I diabetes, Diabetes, 33, 851, 10.2337/diab.33.9.851

Wallberg‐Henriksson H, 1986, Long‐term physical training in female type 1 (insulin‐dependent) diabetic patients, absence of significant effect on glycaemic control and lipoprotein levels, 29, 53

Walsh MF, 1995, A 54‐month evaluation of a popular very low calorie diet program, J Fam Pract, 41, 231

10.1161/01.ATV.15.10.1668

10.1152/jappl.1997.83.6.2080

10.2337/diacare.17.8.924

10.1192/bjp.172.6.485

10.1016/0024-3205(92)90112-3

10.1378/chest.102.5.1351

Westby MD, 2000, A randomized controlled trial to evaluate the effectiveness of an exercise program in women with rheumatoid arthritis taking low dose prednisone, J Rheumatol, 27, 1674

Whelton SP, 2002, Effect of aerobic exercise on blood pressure, a meta-analysis of randomized, controlled trials, 136, 493

Wickham CA, 1989, Dietary calcium, physical activity, and risk of hip fracture, a prospective study, 299, 889

10.1053/euhj.1999.1485

Wiesinger GF, 2001, Health related quality of life in patients with long‐standing insulin dependent (type 1) diabetes mellitus, benefits of regular physical training, 113, 670

10.3109/03009749609069212

10.1136/thx.49.5.468

10.1055/s-2007-1021012

10.1016/0091-7435(75)90035-3

10.1053/euhj.1997.0853

Williamson DF, 1993, Recreational physical activity and ten‐year weight change in a US national cohort, Int J Obes Relat Metab Disord, 17, 279

10.1161/01.CIR.87.2.470

Wilson MG, 1990, Idiopathic symptomatic osteoarthritis of the hip and knee, a population-based incidence study, 65, 1214

10.1007/BF00265375

10.2337/diacare.21.3.350

Winningham ML, 1988, The effect of aerobic exercise on patient reports of nausea, Oncol Nurs Forum, 15, 447

10.1016/0168-8227(92)90143-F

Wolfe F., 1996, The fibromyalgia syndrome, a consensus report on fibromyalgia and disability, 23, 534

10.1002/art.1780370408

10.1002/art.1780330203

Wolff I, 1999, The effect of exercise training programs on bone mass, a meta-analysis of published controlled trials in pre- and postmenopausal women, 9, 1

10.1056/NEJM198811033191801

10.1097/00005768-200110000-00021

World Health Oganization, 1983, Rehabilitation and comprehensive secondary prevention after acute myocardial infarction, EURO Rep Stud, 84

10.1093/oxfordjournals.eurheartj.a014966

10.2337/diacare.18.6.775

Yasuda I, 1992, Systolic and diastolic left ventricular dysfunction in middle‐aged asymptomatic non‐insulin‐dependent diabetics, J Cardiol, 22, 427

10.2337/diacare.7.6.520

10.1016/S0002-9149(02)03159-4

Zavaroni I, 1999, Hyperinsulinemia in a normal population as a predictor of non‐insulin‐dependent diabetes mellitus, hypertension, and coronary heart disease, the Barilla factory revisited, 48, 989