Evidence for immunomodulation and apoptotic processes induced by cationic polystyrene nanoparticles in the hemocytes of the marine bivalve Mytilus

Andrady, 2011, Microplastics in the marine environment, Mar. Pollut. Bull., 62, 1596, 10.1016/j.marpolbul.2011.05.030 ASTM, 2004, E 724 Bexiga, 2011, Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line, Nanotoxicology, 5, 557, 10.3109/17435390.2010.539713 Browne, 2008, Ingested microscopic plastic translocates to the circulatory system of the mussel, Mytilus edulis (L.), Environ. Sci. Technol., 42, 5026, 10.1021/es800249a Canesi, 2013, The invertebrate immune system as a model for investigating the environmental impact of nanoparticles, 91 Canesi, 2002, Bacteria – hemocyte interactions and phagocytosis in marine bivalves, Microsc. Res. Tech., 57, 469, 10.1002/jemt.10100 Canesi, 2008, Immunotoxicity of carbon black nanoparticles to blue mussel hemocytes, Environ. Int., 34, 1114, 10.1016/j.envint.2008.04.002 Canesi, 2010, In vitro effects of suspensions of selected nanoparticles (C60 fullerene, TiO2, SiO2) on Mytilus hemocytes, Aquat. Toxicol., 96, 151, 10.1016/j.aquatox.2009.10.017 Canesi, 2012, Bivalve molluscs as a unique target group for nanoparticle toxicity, Mar. Environ. Res., 76, 16, 10.1016/j.marenvres.2011.06.005 Canesi, 2015, Interactive effects of nanoparticles with other contaminants in aquatic organisms: friend or foe?, Mar. Environ. Res., 10.1016/j.marenvres.2015.03.010 Casado, 2013, Ecotoxicological assessment of silica and polystyrene nanoparticles assessed by a multitrophic test battery, Environ. Int., 51, 97, 10.1016/j.envint.2012.11.001 Ciacci, 2012, Immunomodulation by different types of n-oxides in the hemocytes of the marine bivalve Mytilus galloprovincialis, PLoS One, 7, e36937, 10.1371/journal.pone.0036937 Cole, 2011, Microplastics as contaminants in the marine environment: a review, Mar. Pollut. Bull., 62, 2588, 10.1016/j.marpolbul.2011.09.025 Corsi, 2014, Common strategies and technologies for the ecosafety assessment and design of nanomaterials entering the marine environment, ACS Nano, 8, 9694, 10.1021/nn504684k Crane, 2008, Ecotoxicity test methods and environmental hazard assessment for engineered nanoparticles, Ecotoxicology, 17, 421, 10.1007/s10646-008-0215-z Della Torre, 2014, Accumulation and embryotoxicity of polystyrene nanoparticles at early stage of development of sea urchin embryos Paracentrotus lividus, Environ. Sci. Technol., 48, 12302, 10.1021/es502569w Fleischer, 2014, Nanoparticle-cell interactions: molecular structure of the protein corona and cellular outcomes, Acc. Chem. Res., 47, 2651, 10.1021/ar500190q Hidalgo-Ruz, 2012, Microplastics in the marine environment: a review of the methods used for identification and quantification, Environ. Sci. Technol., 46, 3060, 10.1021/es2031505 Jovanovic, 2012, Immunotoxicology of non-functionalized engineered nanoparticles in aquatic organisms with special emphasis on fish-review of current knowledge, gap identification, and call for further research, Aquat. Toxicol., 15, 118 Liu, 2011, Intracellular dynamics of cationic and anionic polystyrene nanoparticles without direct interaction with mitotic spindle and chromosomes, Biomaterials, 32, 8291, 10.1016/j.biomaterials.2011.07.037 Lundqvist, 2008, Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts, Proc.Natl. Acad. Sci. U. S. A., 105, 14265, 10.1073/pnas.0805135105 Lunov, 2011, Amino-functionalized polystyrene nanoparticles activate the NLRP3 inflammasome in human macrophages, ACS Nano, 5, 9648, 10.1021/nn203596e Matranga, 2012, Toxic effects of engineered nanoparticles in the marine environment: model organisms and molecular approaches, Mar. Environ. Res., 76, 32, 10.1016/j.marenvres.2012.01.006 Moore, 2006, Do nanoparticles present ecotoxicological risks for the health of the aquatic environment?, Environ. Int., 32, 967, 10.1016/j.envint.2006.06.014 Nel, 2009, Understanding biophysicochemical interactions at the nano-bio interface, Nat. Mater., 8, 543, 10.1038/nmat2442 Oliveri, 2014, Biochemical and proteomic characterisation of haemolymph serum reveals the origin of the alkali-labile phosphate (ALP) in mussel (Mytilus galloprovincialis), Comp. Biochem. Physiol. Part D. Genomics Proteomics, 11, 29, 10.1016/j.cbd.2014.07.003 PlasticsEurope, 2013 Stern, 2012, Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity, Part. Fibre Toxicol., 9, 20, 10.1186/1743-8977-9-20 Sun, 2014, Comprehensive probabilistic modelling of environmental emissions of engineered nanomaterials, Environ. Pollut., 185, 69, 10.1016/j.envpol.2013.10.004 Van Cauwenberghe, 2014, Microplastics in bivalves cultured for human consumption, Environ. Pollut., 193, 65, 10.1016/j.envpol.2014.06.010 Wang, 2013, Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles, Nanoscale, 5, 10868, 10.1039/c3nr03249c Ward, 2009, Marine aggregates facilitate ingestion of nanoparticles by suspension-feeding bivalves, Mar. Environ. Res., 68, 137, 10.1016/j.marenvres.2009.05.002 Wegner, 2012, Effects of nanopolystyrene on the feeding behavior of the blue mussel (Mytilus edulis L.), Environ. Toxicol. Chem., 31, 2490, 10.1002/etc.1984 Wright, 2013, The physical impacts of microplastics on marine organisms: a review, Environ. Pollut., 178, 483, 10.1016/j.envpol.2013.02.031