Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma

Springer Science and Business Media LLC - Tập 145 - Trang 501-503 - 2023
A. Basit Khan1, Collin W. English1, William C. Chen2,3,4, Prazwal Athukuri1, James C. Bayley1, Vicky L. Brandt5, Arya Shetty1, Caroline C. Hadley1, Abrar Choudhury2,3,4, Hsiang-Chih Lu5,6, Arif O. Harmanci7, Akdes S. Harmanci1, Stephen T. Magill8, David R. Raleigh2,3,4, Tiemo J. Klisch5,9, Akash J. Patel1,5,10
1Department of Neurosurgery, Baylor College of Medicine, Houston, USA
2Department of Radiation Oncology, University of California San Francisco, San Francisco, USA
3Department of Neurological Surgery, University of California, San Francisco, San Francisco, USA
4Department of Pathology, University of California, San Francisco, San Francisco, USA
5Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, USA
6Department of Pathology and Immunology, Baylor College of Medicine, Houston, USA
7Center for Secure Artificial Intelligence For hEalthcare (SAFE), Center for Precision Health, School of Biomedical Informatics, University of Texas Health Science Center Houston, Houston, USA
8Department of Neurological Surgery, Northwestern University, Chicago, USA
9Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA
10Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, USA

Tài liệu tham khảo

Bayley JC, Hadley CC, Harmanci AO, Harmanci AS, Klisch TJ, Patel AJ (2022) Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies. Sci Adv 8:eabm6247. https://doi.org/10.1126/sciadv.abm6247 Bi WL, Abedalthagafi M, Horowitz P, Agarwalla PK, Mei Y, Aizer AA et al (2016) Genomic landscape of intracranial meningiomas. J Neurosurg 125:525–535. https://doi.org/10.3171/2015.6.JNS15591 Bi WL, Greenwald NF, Abedalthagafi M, Wala J, Gibson WJ, Agarwalla PK et al (2017) Genomic landscape of high-grade meningiomas. NPJ Genomic Med 2:15. https://doi.org/10.1038/s41525-017-0014-7 Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA et al (2022) Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet 54:649–659. https://doi.org/10.1038/s41588-022-01061-8 Guyot A, Duchesne M, Robert S, Lia A-S, Derouault P, Scaon E et al (2019) Analysis of CDKN2A gene alterations in recurrent and non-recurrent meningioma. J Neuro-Oncol 145:449–459. https://doi.org/10.1007/s11060-019-03333-6 Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D et al (2021) The 2021 who classification of tumors of the central nervous system: a summary. Neuro Oncol. https://doi.org/10.1093/neuonc/noab106 Nassiri F, Liu J, Patil V, Mamatjan Y, Wang JZ, Hugh-White R et al (2021) A clinically applicable integrative molecular classification of meningiomas. Nature 597:119–125. https://doi.org/10.1038/s41586-021-03850-3 Patel AJ, Wan Y-W, Al-Ouran R, Revelli J-P, Cardenas MF, Oneissi M et al (2019) Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors. Proc Natl Acad Sci USA 116:21715–21726. https://doi.org/10.1073/pnas.1912858116 Sievers P, Hielscher T, Schrimpf D, Stichel D, Reuss DE, Berghoff AS et al (2020) CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas. Acta Neuropathol 140:409–413. https://doi.org/10.1007/s00401-020-02188-w Zhou W, Triche TJ, Laird PW, Shen H (2018) SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions. Nucleic Acids Res 46:e123. https://doi.org/10.1093/nar/gky691
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Springer Science and Business Media LLC

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