Evaluation of the safety profile and antioxidant activity of fatty hydroxamic acid from underutilized seed oil of Cyperus esculentus

Kim, 2002, Intraocular distribution of 70-kDa dextran after subconjunctival injection in mice, Invest Ophthalmol Vis Sci, 43, 1809 Steward, 2000, Genome size distributions indicate variability and similarities among marine viral assemblages from diverse environments, Limnol Oceanogr, 45, 1697, 10.4319/lo.2000.45.8.1697 Tilvawala, 2013, Covalent inhibition of serine β-lactamases by novel hydroxamic acid derivatives, Biochemistry, 52, 3712, 10.1021/bi4003887 Sani, 2004, Synthesis and evaluation of stereopure α-trifluoromethyl-malic hydroxamates as inhibitors of matrix metalloproteinases, Tetrahedron Lett, 45, 1611, 10.1016/j.tetlet.2003.12.131 Chen, 2012, Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage, Br J Pharmacol, 165, 494, 10.1111/j.1476-5381.2011.01575.x Cini, 2007, J Inorg Biochem, 101, 1140, 10.1016/j.jinorgbio.2007.04.015 Nebbioso, 2012, Trials with ‘epigenetic’ drugs: an update, Mol Oncol, 6, 657, 10.1016/j.molonc.2012.09.004 Munster, 2009, Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker, Br J Cancer, 101, 1044, 10.1038/sj.bjc.6605293 Garcia-Manero, 2008, Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes, Blood, 111, 1060, 10.1182/blood-2007-06-098061 Arora, 2012, Benzohydroxamic acid and its applications: a review, Int Rev Biophys Chem, 3, 212 Singh, 2014, Evaluation of antioxidant activity and DNA cleavage protection effect of naphthyl hydroxamic acid derivatives through conventional and fluorescence microscopic methods, Chem Pap, 68, 1298, 10.2478/s11696-014-0576-0 Brandhuber, 2013, Tabun scavengers based on hydroxamic acid containing cyclodextrins, Chem Commun (Camb), 49, 3425, 10.1039/c3cc41290c Sur, 1997, Chloroaceto hydroxamic acid as antitumor agent against Ehrlich ascites carcinoma in mice, Neoplasma, 44, 197 Usachova, 2010, Synthesis of hydroxamic acids by activation of carboxylic acids with N,N′-carbonyldiimidazole: exploring the efficiency of the method, Synth Commun, 40, 927, 10.1080/00397910903026723 Pal, 2012, Hydroxamic acid – a novel molecule for anticancer therapy, J Adv Pharm Technol Res, 3, 92, 10.4103/2231-4040.97281 Sánchez-Zapata, 2012, Tiger nut (Cyperus esculentus) commercialization: health aspects, composition, properties, and food applications, Compr Rev Food Sci Food Saf, 11, 366, 10.1111/j.1541-4337.2012.00190.x Bahorun, 2006, Free radicals and antioxidants in cardiovascular health and disease, Int J Med Update, 1, 1 Belewu, 2008, Preparation of kunnu from unexploited rich food source: tiger nut (Cyperus esculentus), Pak J Nutr, 10.3923/pjn.2008.109.111 Etshola, 1996, Fatty acid compositions of tigernut tubers (Cyperus esculentus L.), baobab seeds (Adansonia digitata L.), and their mixture, J Am Oil Chem Soc, 73, 255, 10.1007/BF02523905 Martinez, 2003, Scientific analysis of effects of tiger nut on heart diseases and related aspects, Valencia Med, 1 Ozcan, 2010, Chemical and fatty acid composition of Cyperus esculentus, Chem Nat Compd, 46, 276, 10.1007/s10600-010-9586-5 Muhammad, 2011, Physicochemical properties and fatty acid composition of Cyperus esculentus (tiger nut) tuber oil, Biores Bull, 5, 51 Adewuyi, 2012, Analysis of the lipids and molecular speciation of the triacylglycerol of the oils of Luffa cylindrical and Adenopus breviflorus, CyTA J Food, 10, 313, 10.1080/19476337.2012.658870 Adewuyi, 2013, Properties of sodium phosphate-hydroxy ethanolamide gemini surfactant synthesized from the seed oil of Luffa cylindrical, Cent Eur J Chem, 11, 1368 Atolani, 2012, Antioxidant and cytotoxicity effect of seed oils from edible fruits, J Acute Dis, 1, 130 Amarowicz, 2004, Free-radical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies, Food Chem, 84, 551, 10.1016/S0308-8146(03)00278-4 Arnao, 2000, Some methodological problems in the determination of antioxidant using chromogen radicals: a practical case, Trends Food Sci Technol, 11, 419, 10.1016/S0924-2244(01)00027-9 Otuechere, 2012, Protective effects of vitamin C against propanil-induced hepatotoxicity in Wistar rats, Asian Pac J Trop Dis, 2, S212, 10.1016/S2222-1808(12)60154-6 Izydore, 1990, Hypolipidemic activity of benzohydroxamic acids and dibenzohydroxamic acids in rodents, Res Commun Chem Pathol Pharmacol, 70, 307 Adeneye, 2006, Preliminary toxicity and phytochemical studies of the stem bark aqueous extract of Musanga cecropioides in rats, J Ethnopharmacol, 105, 374, 10.1016/j.jep.2005.11.027 Hassan, 2011, Preparation of poly (hydroxamic acid) for separation of Zr/Y, Sr system, Chromatogr Res Int, 10.4061/2011/638090 Shankar, 2014, Antimicrobial activity of newly synthesized hydroxamic acid of pyrimidine-5-carboxylic acid and its complexes with Cu(II), Ni(II), Co(II) and Zn(II) metal ions, J Chem Pharm Res, 6, 925 Ahn, 2012, Solvent-free acid-catalyzed ring-opening of epoxidized oleochemicals using stearates/stearic acid, and its applications, J Agric Food Chem, 60, 2179, 10.1021/jf204275q Cellai, 2012, The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukaemia cells, J Cell Mol Med, 16, 1758, 10.1111/j.1582-4934.2011.01464.x Paul, 2014, Synthesis and structural characterization of dioxomolybdenum and dioxotungsten hydroxamato complexes and their function in the protection of radiation induced DNA damage, Dalton Trans, 43, 2835, 10.1039/C3DT52434E Garcia, 2012, Antioxidant activity by DPPH assay of potential solutions to be applied on bleached teeth, Braz Dent J, 23, 22, 10.1590/S0103-64402012000100004 Sharma, 2009, DPPH antioxidant assay revisited, Food Chem, 113, 1202, 10.1016/j.foodchem.2008.08.008 Lambert, 2010, The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention, Arch Biochem Biophys, 501, 65, 10.1016/j.abb.2010.06.013 Procházková, 2011, Antioxidant and prooxidant properties of flavonoids, Fitoterapia, 82, 513, 10.1016/j.fitote.2011.01.018 Duarte, 2005, Review: when is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C, Free Radic Res, 39, 671, 10.1080/10715760500104025 Zhang, 2014, Melatonin: a well-documented antioxidant with conditional pro-oxidant actions, J Pineal Res, 57, 131, 10.1111/jpi.12162 Wise, 2008, Assessment of female and male fertility in Sprague-Dawley rats administered vorinostat, a histone deacetylase inhibitor, Birth Defects Res B Dev Reprod Toxicol, 83, 19, 10.1002/bdrb.20139 Olaleye, 2010, Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats, Food Chem Toxicol, 48, 2200, 10.1016/j.fct.2010.05.047 Suchy, 2014, 1 Yeboah, 2012, Compositional and structural studies of the oils from two edible seeds: tiger nut, Cyperus esculentum, and asiato, Pachira insignis, from Ghana, Food Res Int, 47, 259, 10.1016/j.foodres.2011.06.036 Otuechere, 2014, Virgin coconut oil protects against liver damage in albino rats challenged with the anti-folate combination, trimethoprim-sulfamethoxazole, J Basic Clin Physiol Pharmacol, 25, 249