Evaluation of the risk of diarrhea induced by epidermal growth factor receptor tyrosine kinase inhibitors with cultured intestinal stem cells originated from crypts in humans and monkeys

Toxicology in Vitro - Tập 93 - Trang 105691 - 2023
Yoshiki Hashimoto1, Kazuya Maeda1,2, Osamu Shimomura3, Yoshihiro Miyazaki3, Shinji Hashimoto3, Akiko Moriyama4, Tatsuya Oda3, Hiroyuki Kusuhara1
1Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
2Laboratory of Pharmaceutics, School of Pharmacy, Kitasato University, Tokyo, Japan
3Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
4Pathology Department, Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima, Japan

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