Evaluation of the efficacy of Thymus kotschyanus extract as an additive treatment in patients with ulcerative colitis: a randomized double-blind placebo-controlled trial

Akiho H, Yokoyama A, Abe S, Nakazono Y, Murakami M, Otsuka Y et al (2015) Promising biological therapies for ulcerative colitis: a review of the literature. World J Gastrointest Pathophysiol 6(4):219–227

Algieri F, Rodriguez-Nogales A, Garrido-Mesa N, Zorrilla P, Burkard N, Pischel I et al (2014) Intestinal anti-inflammatory activity of the Serpylli herba extract in experimental models of rodent colitis. J Crohns Colitis 8(8):775–788

Almanea A, Abd El-Aziz GS, Ahmed MMMJB (2019) The potential gastrointestinal health benefits of Thymus vulgaris essential oil: a review. Biomed Pharmacol 12(04):1793–1799

Bakhtiarian A, Aarabi Moghaddam F, Zamani MM, Ghamami SG, Farahanikia B, Khanavi M (2011) Anti-inflammatory effect of Thymus kotschyanus Boiss. & Hohen. Extract on rat’s hind paw edema induced by Carrageenan. JMPIR 10(37):25–32

Basch E, Ulbricht C, Hammerness P, Bevins A, Sollars D (2004) Thyme (Thymus vulgaris L.) Thymol. J Herbal Pharmacother 4:49–67

Bukovská A, Cikoš Š, Juhás Š, Il’ková G, Rehák P, Koppel J (2007) Effects of a combination of thyme and oregano essential oils on TNBS-induced colitis in mice. Mediat Inflam 2007:023296

Chamanara M, Abdollahi A, Rezayat SM, Ghazi-Khansari M, Dehpour A, Nassireslami E et al (2019) Thymol reduces acetic acid-induced inflammatory response through inhibition of NF-kB signaling pathway in rat colon tissue. Inflammopharmacology 27(6):1275–1283

Costa MF, Durço AO, Rabelo TK, Barreto RSS, Guimarães AG (2019) Effects of carvacrol, thymol and essential oils containing such monoterpenes on wound healing: a systematic review. J Pharm Pharmacol 71(2):141–155

Ghasemi G, Alirezalu A, Ghosta Y, Jarrahi A, Safavi SA, Abbas-Mohammadi M et al (2020) Composition, antifungal, phytotoxic, and insecticidal activities of Thymus kotschyanus essential oil. Molecules 25(5):1152

Gholijani N, Amirghofran Z (2016) Effects of thymol and carvacrol on T-helper cell subset cytokines and their main transcription factors in ovalbumin-immunized mice. J Immunotoxicol 13(5):729–737

Guslandi M (1998) Nitric oxide and inflammatory bowel diseases. Eur J Clin Invest 28(11):904–907

Hassanzadeh M, Emami S, Asili J, Tayarani-Najaran Z (2011) Review of the essential oil composition of Iranian Lamiaceae. J Essent Oil Res 23:35–74

Jahani R, Mojab F, Mahboubi A, Nasiri A, Tahamtani A, Faizi M (2019) An in-vivo study on anticonvulsant, anxiolytic, and sedative-hypnotic effects of the polyphenol-rich thymus kotschyanus extract; evidence for the involvement of GABA(A) receptors. Iran J Pharm Res 18(3):1456–1465

Khanavi M, Farahanikia B, Rafiee F, Dalili D, Safaripour E, Ajani Y et al (2011) Reversal of resistance in MRSA strains by Thymus kotschyanus essential oil. J Essent Oil Bear Plants 14(6):684–692

Li M-C, He S-H (2004) IL-10 and its related cytokines for treatment of inflammatory bowel disease. World J Gastroenterol 10(5):620–625

Liu T, Zhang L, Joo D, Sun SC (2017) NF-κB signaling in inflammation. Sig Transduct Target Ther 2:17023

Liu D-M, Zhou C-Y, Meng X-L, Wang P, Li W (2018) Thymol exerts anti-inflammatory effect in dextran sulfate sodium-induced experimental murine colitis. Trop J Pharm Res 17:1803

Maaser C, Sturm A, Vavricka SR, Kucharzik T, Fiorino G, Annese V et al (2018) ECCO-ESGAR guideline for diagnostic assessment in IBD part 1: initial diagnosis, monitoring of known IBD, detection of complications. J Crohns Colitis 13(2):144–164

Madsen K (2002) Combining T cells and IL-10: a new therapy for Crohn’s disease? Gastroenterology 123(6):2140–2144

Morteza-Semnani K, Rostami B, Akbarzadeh M (2006) Essential oil composition of Thymus kotschyanus and Thymus pubescens from Iran. J Essent Oil Res 18(3):272–274

Navaei MS, Taleb A, Isfahani M, Amin G, Faghihi A, Lakeh MM (2012) Study on the phytochemical constituents of Thymus kotschyanus Boiss. Et Hohen and its efficacy on the symptoms’ improvement of irritant bowel syndrome. Res Pharm Sci 7(5):741

Pathirana WGW, Chubb SP, Gillett MJ, Vasikaran SD (2018) Faecal calprotectin. The clinical biochemist. Reviews 39(3):77–90

Sanchez-Munoz F, Dominguez-Lopez A, Yamamoto-Furusho J-K (2008) Role of cytokines in inflammatory bowel disease. World J Gastroenterol 14(27):4280–4288

Tagore A, Gonsalkorale WM, Pravica V, Hajeer AH, McMahon R, Whorwell PJ et al (1999) Interleukin-10 (IL-10) genotypes in inflammatory bowel disease. Tissue Antigens 54(4):386–390

Tahmasebi P, Abtahi Froushani SM, Afzale AN (2019) Thymol has beneficial effects on the experimental model of ulcerative colitis. Avicenna J Phytomed 9(6):538–550

Tohidi B, Rahimmalek M, Arzani A (2018) Variations in chemical composition and bioactive compounds of Thymus kotschyanus Boiss & Hohen populations originated from different collection sites. J Essent Oil Bear Plants 21(5):1272–1283

Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF (2017) Ulcerative colitis. Lancet (london, England) 389(10080):1756–1770