Evaluation of the Success of High-Throughput Physiologically Based Pharmacokinetic (HT-PBPK) Modeling Predictions to Inform Early Drug Discovery
Tóm tắt
Từ khóa
Tài liệu tham khảo
Prescott L. F., 1975, Concepts in Biochemical Pharmacology: Part 3, 234, 10.1007/978-3-642-46314-3_9
Chung T. D. Y., 2004, Assay Guidance Manual
Parrott, N. In Physiologically Based Pharmacokinetic (PBPK) Modeling Predictions for Entry Into Human (EIH) Studies: An Analysis of Small Molecule Development Candidates at Hoffmann-La Roche, 2003–2016, ASCPT Annual Meeting American Society for Clinical Pharmacology and Therapeutics, Washington, DC, March 15–18, 2017.
Higuchi T., 1965, Phase Solubility Techniques, 117
Tanimoto T. T., 1958, An Elementary Mathematical Theory of Classification and Prediction
Lukacova, V.; P, N.; Lavé, T.; Fraczkiewicz, G.; Bolger, M.; Woltosz, W. In General Approach to Calculation of Tissue:plasma Partition Coefficients for Physiologically Based Pharmacokinetic (PBPK) Modeling, AAPS National Annual Meeting and Exposition, Atlanta, GA, Nov 16–20, 2008.
R Core Team, 2021, R: A Language and Environment for Statistical Computing