Evaluation of the Antiseptic Efficacy and Local Tolerability of a Polihexanide-Based Antiseptic on Resident Skin Flora

Advances in Skin and Wound Care - Tập 25 Số 9 - Trang 404-408 - 2012
Dianne Egli-Gany1,2, F.H.H. Brill1,2, Matthias Hintzpeter3,1,2, Simone Andrée1,2, Viktoria Pavel1,2,4
1Submitted June 7, 2011
2accepted in revised form January 13, 2012.
3Matthias Hintzpeter, PhD, is Manager, Regulatory Affairs, B. Braun Melsungen AG, Melsungen, Germany.
4e, MSc, is Medical Writer, and Viktoria Pavel, PhD, is Project Manager, Proinnovera GmbH, Munster, Germany.

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Tài liệu tham khảo

Shorr, 2007, Epidemiology of staphylococcal resistance., Clin Infect Dis, 45, S171, 10.1086/519473

Kaehn, 2010, Polihexanide: a safe and highly effective biocide., Skin Pharmacol Physiol, 23, 7, 10.1159/000318237

Koburger, 2010, Standardized comparison of antiseptic efficacy of tricolsan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate., J Antimicrob Chemother, 65, 1712, 10.1093/jac/dkq212

Roth, 2010, Response analysis of stimulating efficacy of polihexanide in an in vitro wound model with respiratory ciliary epithelial cell., Skin Pharmacol Physiol, 23, 35, 10.1159/000319602

Kramer, 2004, Influence of the antiseptic agents polyhexanide and octenidine on FL cells and on healing of experimental superficial aseptic wound in piglets. A double blind, randomized, stratified, controlled, parallel-group study., Skin Pharmacol Physiol, 17, 141, 10.1159/000077241

Hubner, 2010, Review on the efficacy, safety and clinical applications of polihexanide, a modern wound antiseptic., Skin Pharmacol Physiol, 23, 17, 10.1159/000318264

Sibbald, 2011, Reduction of bacterial burden and pain in chronic wounds using a new polyhexamethylene biguanide antimicrobial foam dressingclinical trial results., Adv Skin Wound Care, 24, 78, 10.1097/01.ASW.0000394027.82702.16

Atiyeh, 2009, Wound cleansing, topical antiseptics and wound healing., Int Wound J, 6, 420, 10.1111/j.1742-481X.2009.00639.x

Kampf, 2004, Epidemiologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs., Clin Microbiol Rev, 17, 863, 10.1128/CMR.17.4.863-893.2004

Mailhol, 2009, Prevalence and risk factors for allergic contact dermatitis to topical treatment in atopic dermatitis: a study in 641 children., Allergy, 64, 801, 10.1111/j.1398-9995.2008.01890.x

Batra, 2010, Efficacy and limitation of a chlorhexidine-based decolonization strategy in preventing transmission of methicillin-resistant Staphylococcus aureus in an intensive care unit., Clin Effect Dis, 50, 210, 10.1086/648717

Muller, 2008, Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity., J Antimicrob Chemother, 61, 1281, 10.1093/jac/dkn125

Drosou, 2003, Antiseptics on wounds: an area of controversy., Wounds, 15, 149

Darouiche, 2010, . Chlorhexidine-alcohol versus povidone iodine for surgical-site antisepsis., N Eng J Med, 362, 18, 10.1056/NEJMoa0810988

Mimoz, 2007, . Chlorhexidine-based antiseptic solution versus alcohol-based povidone iodine for central venous catheter care., Arch Intern Med, 167, 2066, 10.1001/archinte.167.19.2066

Fabry, 2006, . Bacterial decontamination of surgical wounds treated with Lavasept., Int J Hyg Environ Health, 209, 567, 10.1016/j.ijheh.2006.03.008

Romanelli, 2010, Evaluation of the efficacy and tolerability of a solution containing propyl betaine and polihexanide for wound irrigation., Skin Pharmacol Physiol, 23, 41, 10.1159/000318266