Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values

International Journal of Pharmaceutics - Tập 194 - Trang 169-180 - 2000
L. Ferreira1, M.M. Vidal1, M.H. Gil1
1Departamento de Engenharia Quı́mica, Universidade de Coimbra, Pinhal de Marrocos, 3030 Coimbra, Portugal

Tài liệu tham khảo

Abounassif, 1994, Salicylic acid, 23, 421 Allen, 1992, Water in methacrylates-I. Sorption and desorption properties of poly(2-hydroxyethyl methacrylate-co-glycol dimethacrylate) networks, Eur. Polym. J., 28, 347, 10.1016/0014-3057(92)90252-W Bettini, 1995, Solubility effects on drug transport through pH-sensitive, swelling-controlled release systems: transport of theophyline and metoclopramide monohydrochloride, J. Controlled Rel., 37, 105, 10.1016/0168-3659(95)00069-K Blanco, 1994, Drug release with simultaneous dimensional changes from a new copolymeric hydrogel, Polymer, 35, 3487, 10.1016/0032-3861(94)90913-X Brannon-Peppas, 1991, Equilibrium swelling behaviour of dilute ionic hydrogels in electrolytic solutions, J. Controlled Rel., 16, 319, 10.1016/0168-3659(91)90009-3 Corkhill, 1987, Synthetic hydrogels: 1. Hydroxyalkyl acrylate and methacrylate copolymers-water binding studies, Polymer, 28, 1758, 10.1016/0032-3861(87)90021-8 Crank, 1975 Denizli, 1988, Subcutaneous polymeric matrix system poly(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouacil), Biomaterials, 9, 363, 10.1016/0142-9612(88)90034-8 Faria, 1991, Conformational stability for methyl acrylate: a vibrational spectroscopic and ab initio MO study, Vibrat. Spectrosc., 2, 43, 10.1016/0924-2031(91)85043-M Ferreira, L., Vidal, M.M., Geraldes, C.F.G.C., Gil, M.H., 1999. Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate. Carbohydrate Polymers (in press). Garcia, 1994, Influence of degree of crosslinking on 5-fluorouacil release from poly(2-hydroxyethyl methacrylate) hydrogels, Biomaterials, 15, 689, 10.1016/0142-9612(94)90167-8 Garner, 1973, A rapid method for the simultaneous estimation of acetyl salicylic and salicylic acids in body fluids, Anal. Lett., 6, 275, 10.1080/00032717308062888 Huglin, 1983, Release of ergotamine from poly(2-hydroxyethyl methacrylate), Br. Polym. J., 15, 165, 10.1002/pi.4980150405 Khare, 1993, Investigation of hydrogel water in polyelectrolyte gels using differential scanning calorimetry, Polymer, 34, 4736, 10.1016/0032-3861(93)90710-R Khare, 1995, Swelling/deswelling of anionic copolymer gels, Biomaterials, 16, 559, 10.1016/0142-9612(95)91130-Q Khaw, 1976, The thermodynamics of water sorption in irradiation-grafted hydrogels, 31, 295 Kulbida, 1995, Rotational isomerism in acrylic acid, J. Chem. Soc. Faraday Trans., 91, 1571, 10.1039/ft9959101571 Montheard, 1992, 2-Hydroxyethyl methacrylate (HEMA): chemical properties and applications in biomedical fields, J.M.S. — Rev. Macromol. Chem. Phys., C32, 1, 10.1080/15321799208018377 Morrison, 1983 Peluso, 1997, The differential effects of poly(2-hydroxyethyl methacrylate) and poly(2-hydroxyethyl methacrylate)/poly(caprolactone) polymers on cell proliferation and collagen synthesis by human lung fibroblasts, J. Biomed. Mater. Res., 34, 327, 10.1002/(SICI)1097-4636(19970305)34:3<327::AID-JBM7>3.0.CO;2-M Ratner, 1976, Synthetic hydrogels for biomedical applications, 31, 1 Refojo, 1967, Hydrophobic interaction in poly(2-hydroxyethyl methacrylate) homogeneous hydrogel, J. Polym. Sci., 5, 3103, 10.1002/pol.1967.150051211 Refojo, 1965, Hydrogels from 2-hydroxyethyl methacrylate and propylene glycol monoacrylate, J. Appl. Polym. Sci., 9, 2425, 10.1002/app.1965.070090707 Robert, 1985, Effect of degree of crosslinking on water transport in polymer microparticles, J. Appl. Polym. Sci., 30, 301, 10.1002/app.1985.070300125 Shane, 1967, Use of isosbestic point as a base line in differential spectrophotometer, Anal. Chem., 39, 414, 10.1021/ac60247a038 Svecik, 1995, Surface alkaline hydrolysis of 2-hydroxyethyl methacrylate gels, J. Mater. Sci. Mater. Med., 4, 505, 10.1007/BF00151030 Teijon, 1997, Cytarabine trapping in poly(2-hydroxyethyl methacrylate) hydrogels: drug delivery studies, Biomaterials, 18, 383, 10.1016/S0142-9612(96)00139-1 Trigo, 1994, Anticancer drug, ara-C, release from pHEMA hydrogels, Biomaterials, 15, 1181, 10.1016/0142-9612(94)90240-2 Warren, 1972, Polymer-diluent interaction in cross-linked gels of poly(2-hydroxyethyl methacrylate), Macromolecules, 5, 506, 10.1021/ma60028a029 Wisniewski, 1976, Diffusion through hydrogel membranes. 1. Permeation of water through poly(2-hydroxyethyl methacrylate) and related polymers, 31, 80 Wood, 1982, The influence of gel formulation on the diffusion of salicylic acid in poly HEMA hydrogels, J. Pharm. Pharmacol., 34, 1, 10.1111/j.2042-7158.1982.tb04666.x Zalipsky, 1983, Attachment of drugs to polyethylene glycols, Eur. Polym. J., 19, 1177, 10.1016/0014-3057(83)90016-2