Evaluation of fundamental hypotheses underlying constrained mixture models of arterial growth and remodelling

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences - Tập 367 Số 1902 - Trang 3585-3606 - 2009
Andreas Valentin1, Jay D. Humphrey1
1Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, Texas A&M University, College Station, TX 77843-3120, USA

Tóm tắt

Evolving constituent composition and organization are important determinants of the biomechanical behaviour of soft tissues. In arteries, vascular smooth muscle cells and fibroblasts continually produce and degrade matrix constituents in preferred modes and at altered rates in response to changing mechanical stimuli. Smooth muscle cells similarly exhibit vasoactive changes that contribute to the control of overall structure, function and mechanical behaviour. Constrained mixture models provide a useful framework in which to quantify arterial growth and remodelling for they can account for cell-mediated changes in individual structurally significant constituents. Our simulations show that the combined effects of changing mass density turnover and vasoactivity, as well as the prestretch at which constituents are incorporated within extant matrix, are essential to capture salient features of bounded arterial growth and remodelling. These findings emphasize the importance of formulating biologically motivated constitutive relations in any theory of growth and remodelling and distinct advantages of the constrained mixture approach, in particular.

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Thông tin xuất bản

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

Tập 367 Số 1902

3585-3606

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