Evaluation of bioink printability for bioprinting applications

Applied Physics Reviews - Tập 5 Số 4 - 2018
Zhengyi Zhang1, Yifei Jin2, Jun Yin3, Changxue Xu4, Ruitong Xiong2, Kyle Christensen2, Bradley R. Ringeisen5, Douglas B. Chrisey6, Yong Huang7,8,2
1School of Naval Architecture and Ocean Engineering, Huazhong University of Science and Technology 1 , Wuhan 430074, People's Republic of China
2Department of Mechanical and Aerospace Engineering, University of Florida 2 , Gainesville, Florida 32611, USA
3College of Mechanical Engineering, Zhejiang University 3 , Hangzhou 310028, China
4Department of Industrial, Manufacturing, and Systems Engineering, Texas Tech University 4 , Lubbock, Texas 79409, USA
5Defense Advanced Research Projects Agency 5 , Arlington, Virginia 22203, USA
6Department of Physics and Engineering Physics, Tulane University 6 , New Orleans, Louisiana 70118, USA
7Department of Biomedical Engineering, University of Florida 8 , Gainesville, Florida 32611, USA
8Department of Materials Science and Engineering, University of Florida 7 , Gainesville, Florida 32611, USA

Tóm tắt

Three-dimensional (3D) bioprinting, as a freeform biomedical manufacturing approach, has been increasingly adopted for the fabrication of constructs analogous to living tissues. Generally, materials printed during 3D bioprinting are referred as bioinks, which may include living cells, extracellular matrix materials, cell media, and/or other additives. For 3D bioprinting to be an enabling tissue engineering approach, the bioink printability is a critical requirement as tissue constructs must be able to be printed and reproduce the complex micro-architecture of native tissues in vitro in sufficient resolution. The bioink printability is generally characterized in terms of the controllable formation of well-defined droplets/jets/filaments and/or the morphology and shape fidelity of deposited building blocks. This review presents a comprehensive overview of the studies of bioink printability during representative 3D bioprinting processes, including inkjet printing, laser printing, and micro-extrusion, with a focus on the understanding of the underlying physics during the formation of bioink-based features. A detailed discussion is conducted based on the typical time scales and dimensionless quantities for printability evaluation during bioprinting. For inkjet printing, the Z (the inverse of the Ohnesorge number), Weber, and capillary numbers have been employed for the construction of phase diagrams during the printing of Newtonian fluids, while the Weissenberg and Deborah numbers have been utilized during the printing of non-Newtonian bioinks. During laser printing of Newtonian solutions, the jettability can be characterized using the inverse of the Ohnesorge number, while Ohnesorge, elasto-capillary, and Weber numbers have been utilized to construct phase diagrams for typical non-Newtonian bioinks. For micro-extrusion, seven filament types have been identified including three types of well-defined filaments and four types of irregular filaments. During micro-extrusion, the Oldroyd number has been used to characterize the dimensions of the yielded areas of Herschel-Bulkley fluids. Non-ideal jetting behaviors are common during the droplet-based inkjet and laser printing processes due to the local nonuniformity and nonhomogeneity of cell-laden bioinks.

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