Evaluation of Biologically Based Dose–Response Modeling for Developmental Toxicity: A Workshop Report

Regulatory Toxicology and Pharmacology - Tập 31 - Trang 190-199 - 2000
Christopher Lau1, Melvin E. Andersen2, Douglas J. Crawford-Brown3, Robert J. Kavlock1, Carole A. Kimmel4, Thomas B. Knudsen5, Ken Muneoka6, John M. Rogers1, R.Woodrow Setzer7, Gary Smith8, Rochelle Tyl9
1Reproductive Toxicology Division, NHEERL, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711
2ICF Kaiser, Fairfax, Virginia
3Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill, North Carolina
4NCEA, U.S. Environmental Protection Agency, Washington, DC
5Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania
6Department of Biology, Tulane University, New Orleans, Louisiana
7Office of Associate Director for Health, NHEERL, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711
8Department of Biochemistry, Glaxo Wellcome, Research Triangle Park, North Carolina
9Research Triangle Institute, Research Triangle Park, North Carolina

Tài liệu tham khảo

Barton, 1998, Harmonization: Developing consistent guidelines for applying mode of action and dosimetry information to cancer and noncancer risk assessment, Hum. Ecol. Risk Assess., 4, 75, 10.1080/10807039891284226 Dagg, 1960, Sensitive stages for the production of developmental abnormalities in mice with 5-fluorouracil, Am. J. Anat., 106, 89, 10.1002/aja.1001060202 Elstein, 1993, Utility of the murine erythroleukemic cells (MELC) in assessing mechanisms of action of DNA-active developmental toxicants: Application to 5-fluorouracil, Teratology, 48, 75, 10.1002/tera.1420480112 Elstein, 1997, Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells, Toxicol. Appl. Pharmacol., 146, 29, 10.1006/taap.1997.8208 Fell, 1997 Heinmets, 1989, Supercomputer analysis of purine and pyrimidine metabolism leading to DNA synthesis, Cell Biophys., 14, 283, 10.1007/BF02797274 Heinmets, 1992, A study of deoxyribonucleotide metabolism and its relation to DNA synthesis, Cell Biophys., 17, 263 Jackson, 1984, A kinetic model of regulation of the deoxyribonucleoside triphosphate pool composition, Pharmacol. Ther., 24, 279, 10.1016/0163-7258(84)90038-X Karnofsky, 1958, Comparative toxicologic and teratologic effects of 5-fluoro-substituted pyrimidines in the chick embryos and pregnant rat, Proc. Am. Assoc. Cancer Res., 2, 312 Lau, C, Mole, M. L, Copeland, M. F, Rogers, J. M, Kavlock, R. J, Shuey, D. L, Cameron, A. M, Ellis, D. H, Merriman, J, and, Setzer, R. W. 1999, Toward building a biologically based dose–response model for developmental toxicity of 5-fluorouracil in the rat: Acquisition of experimental data. Submitted for publication. Mole, 1998, Sample preparation and high-performance liquid chromatographic analysis of deoxyribonucleoside triphosphates in individual rat embryos, Anal. Biochem., 259, 245, 10.1006/abio.1998.2647 Muneoka, 1997, Vertebrate limb development, 41 O'Flaherty, 1997, Pharmacokinetics, pharmacodynamics, and prediction of developmental abnormalities, Reprod. Toxicol., 11, 413, 10.1016/S0890-6238(96)00155-4 Ovadi, 1991, Physiological significance of metabolic channelling, J. Theor. Biol., 152, 1, 10.1016/S0022-5193(05)80500-4 Parker, 1991, Metabolism and mechanism of action of 5-fluorouracil, Pharmacol. Ther., 48, 381, 10.1016/0163-7258(90)90056-8 Pinendo, 1988, Fluorouracil: Biochemistry and pharmacology, J. Clin. Oncol., 6, 1653, 10.1200/JCO.1988.6.10.1653 Setzer, 1993, Development of biologically-based dose–response models: Modeling the effects of 5-FU on cell cycle kinetics, Teratology, 47, 435 Setzer, R. W, Lau, C, Copeland, F. M, Mole, M. L, Rogers, J. M, and, Kavlock, R. J. 1999, Toward building a biologically based dose–response model for developmental toxicity of 5-fluorouracil in the rat: Modeling nucleotide pool perturbation. Submitted for publication. Shah, 1978, Teratological evaluation of 5-fluorouracil and 5-bromo-2-deoxyuridine on hamster fetuses, J. Embryol. Exp. Morphol., 57, 119 Shuey, 1994, Biologically based dose–response modeling in developmental toxicology: Biochemical and cellular sequelae of 5-fluorouracil exposure in the developing rat, Toxicol. Appl. Pharmacol., 126, 129, 10.1006/taap.1994.1099 Shuey, 1994, Fetal anemia following maternal exposure to 5-fluorouracil in the rat, Teratology, 49, 311, 10.1002/tera.1420490411 Shuey, 1994, Early events following maternal exposure to 5-fluorouracil lead to dysmorphology in cultured embryonic tissues, Teratology, 50, 379, 10.1002/tera.1420500603 Stephens, 1980, Multiple congenital anomalies in a fetus exposed to 5-fluorouracil during the first trimester, Am. J. Obstet. Gynecol., 137, 747, 10.1016/S0002-9378(15)33259-2 Werkheiser, 1973, Mathematical simulation of the interaction of drugs that inhibit deoxyribonucleic acid biosynthesis, Mol. Pharmacol., 9, 320 Wilson, 1971, Use of rhesus monkeys in teratological studies, Fed. Proc., 30, 104 Wilson, 1973 Zimmerman, 1997, Palate, 183 Zucker, 1995, Flow cytometric detection of abnormal fetal erythropoiesis: Application to 5-fluorouracil-induced anemia, Teratology, 51, 37, 10.1002/tera.1420510106