Euglycemic diabetic ketoacidosis: The clinical concern of SGLT2 inhibitors

Jamila A. Benmoussa1, Matthew Clarke1, Amulya Penmetsa1, Le Yu Khine1, Lina Leykina1, Keith Diaz1, Philip Otterbeck1
1Internal Medicine, Richmond University Medical Center, Staten Island, NY 10310, USA

Tài liệu tham khảo

FDA Drug Safety Communication Peters, 2015, Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition, Diabetes Care, 38, 1687, 10.2337/dc15-0843 Ogawa, 2016, Euglycemic diabetic ketoacidosis induced by SGLT2 inhibitors: possible mechanism and contributing factors, J Diabetes Investig, 7, 135, 10.1111/jdi.12401 Thawabi, 2015, Euglycemic diabetic ketoacidosis, a misleading presentation of diabetic ketoacidosis, N Am J Med Sci, 7, 291, 10.4103/1947-2714.157490 Graham, 2008, Euglycaemic diabetic ketoacidosis, Pract Diab Int, 25, 106, 10.1002/pdi.1220 Prater, 2015, Euglycemic diabetic ketoacidosis with acute pancreatitis in a patient not known to have diabetes, AACE Clin Case Rep, 1, 1 Erondu, 2015, Diabetic ketoacidosis and related events in the canagliflozin type 2 diabetes clinical program, Diabetes Care, 38, 1680, 10.2337/dc15-1251 Lamos, 2014, Empagliflozin, a sodium glucose co-transporter 2 inhibitor, in the treatment of type 1 diabetes, Expert Opin Investig Drugs, 23, 875, 10.1517/13543784.2014.909407 Perkins, 2014, Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial: Figure 1, Diabetes Care, 37, 1480, 10.2337/dc13-2338 Taylor, 2015, SGLT2 inhibitors may predispose to ketoacidosis, J Clin Endocrinol Metab, 100, 2849, 10.1210/jc.2015-1884 Sha, 2011, Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects, Diabetes Obes Metab, 13, 669, 10.1111/j.1463-1326.2011.01406.x Ferrannini, 2013, Renal glucose handling: impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes, Diabetes Care, 36, 1260, 10.2337/dc12-1503 Ferrannini, 2014, Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients, J Clin Invest, 124, 499, 10.1172/JCI72227 Bonner, 2015, Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion, Nat Med, 21, 512, 10.1038/nm.3828 Rosenstock, 2015, Euglycemic diabetic ketoacidosis: a predictable, detectable, and preventable safety concern with SGLT2 inhibitors, Diabetes Care, 38, 1638, 10.2337/dc15-1380