Euchronin A–F isolated from the Arnebia euchroma (Royle) Johnst. and their anti-proliferative activities in vitro

Journal of Natural Medicines - Tập 78 - Trang 33-41 - 2023
Zhen-Peng Zhang1, Yan Liu1, Hai-Dan Zou1, Juan Pan1, Zhi-Chao Hao1, Wei Guan1, Adnan Mohammed Algradi1, Hai-Xue Kuang1, Bing-You Yang1
1Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, People’s Republic of China

Tóm tắt

Six new naphthoquinones, euchronin A–F (1–6) and nine known naphthoquinones (7–15), were isolated from the roots of Arnebia euchroma (Royle) Johnst. The structures of the new compounds were confirmed by extensive spectroscopic analyses, including UV, IR, HR-ESI–MS, 1D and 2D NMR. In the present study, we estimated the anti-proliferative activities of these compounds with HaCaT cells. The results indicated that compounds 2 and 4 showed strong anti-proliferative activities at 25 μM, with relative viability at 38.83% and 68.44%, respectively.

Tài liệu tham khảo

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