Etiology of lung cancer: Evidence from epidemiologic studies

Sung, 2021, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J Clin, 71, 209, 10.3322/caac.21660 Zhang, 2021, Global patterns and trends in lung cancer incidence: a population-based study, J Thorac Oncol, 16, 933, 10.1016/j.jtho.2021.01.1626 Chen, 2016, Cancer statistics in China, 2015, CA Cancer J Clin, 66, 115, 10.3322/caac.21338 Lu, 2019, Trends in the incidence, treatment, and survival of patients with lung cancer in the last four decades, Cancer Manag Res, 11, 943, 10.2147/CMAR.S187317 Zou, 2014, Histological subtypes of lung cancer in Chinese males from 2000 to 2012, Biomed Environ Sci, 27, 3 Gao, 2022, Association of computed tomographic screening promotion with lung cancer overdiagnosis among Asian women, JAMA Intern Med, 182, 283, 10.1001/jamainternmed.2021.7769 Hsu, 2018, Modified lung-RADS improves performance of screening LDCT in a population with high prevalence of non-smoking-related lung cancer, Acad Radiol, 25, 1240, 10.1016/j.acra.2018.01.012 2004, Tobacco smoke and involuntary smoking, IARC Monogr Eval Carcinog Risks Hum, 83, 1 2012, Personal habits and indoor combustions. Volume 100 E. A review of human carcinogens, IARC Monogr Eval Carcinog Risks Hum, 100, 1 Risch, 1993, Are female smokers at higher risk for lung cancer than male smokers? A case-control analysis by histologic type, Am J Epidemiol, 138, 281, 10.1093/oxfordjournals.aje.a116857 Zang, 1996, Differences in lung cancer risk between men and women: examination of the evidence, J Natl Cancer Inst, 88, 183, 10.1093/jnci/88.3-4.183 Flanders, 2003, Lung cancer mortality in relation to age, duration of smoking, and daily cigarette consumption: results from Cancer Prevention Study II, Cancer Res, 63, 6556 Freedman, 2008, Cigarette smoking and subsequent risk of lung cancer in men and women: analysis of a prospective cohort study, Lancet Oncol, 9, 649, 10.1016/S1470-2045(08)70154-2 Gandini, 2008, Tobacco smoking and cancer: a meta-analysis, Int J Cancer, 122, 155, 10.1002/ijc.23033 Haiman, 2006, Ethnic and racial differences in the smoking-related risk of lung cancer, N Engl J Med, 354, 333, 10.1056/NEJMoa033250 Khuder, 2001, Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis, Lung Cancer, 31, 139, 10.1016/S0169-5002(00)00181-1 Wakai, 2006, Tobacco smoking and lung cancer risk: an evaluation based on a systematic review of epidemiological evidence among the Japanese population, Jpn J Clin Oncol, 36, 309, 10.1093/jjco/hyl025 Schivo, 2014, Non-cigarette tobacco and the lung, Clin Rev Allergy Immunol, 46, 34, 10.1007/s12016-013-8372-0 Wynder, 1972, Lung cancer among cigar and pipe smokers, Prev Med, 1, 529, 10.1016/0091-7435(72)90035-7 Akl, 2010, The effects of waterpipe tobacco smoking on health outcomes: a systematic review, Int J Epidemiol, 39, 834, 10.1093/ije/dyq002 Boffetta, 1999, Cigar and pipe smoking and lung cancer risk: a multicenter study from Europe, J Natl Cancer Inst, 91, 697, 10.1093/jnci/91.8.697 Iribarren, 1999, Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary disease, and cancer in men, N Engl J Med, 340, 1773, 10.1056/NEJM199906103402301 Boffetta, 2005, Smokeless tobacco use and risk of cancer of the pancreas and other organs, Int J Cancer, 114, 992, 10.1002/ijc.20811 Luo, 2007, Oral use of Swedish moist snuff (snus) and risk for cancer of the mouth, lung, and pancreas in male construction workers: a retrospective cohort study, Lancet, 369, 2015, 10.1016/S0140-6736(07)60678-3 Andreotti, 2017, Tobacco use and cancer risk in the agricultural health study, Cancer Epidemiol Biomarkers Prev, 26, 769, 10.1158/1055-9965.EPI-16-0748 Accortt, 2005, Cancer incidence among a cohort of smokeless tobacco users (United States), Cancer Causes Control, 16, 1107, 10.1007/s10552-005-0247-0 Boffetta, 2008, Smokeless tobacco and cancer, Lancet Oncol, 9, 667, 10.1016/S1470-2045(08)70173-6 Bracken-Clarke, 2021, Vaping and lung cancer - a review of current data and recommendations, Lung Cancer, 153, 11, 10.1016/j.lungcan.2020.12.030 Orr, 2014, Electronic cigarettes in the USA: a summary of available toxicology data and suggestions for the future, Tob Control, 23, 22 Kosmider, 2014, Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage, Nicotine Tob Res, 16, 1319, 10.1093/ntr/ntu078 Dinardo, 2019, Vaping: the new wave of nicotine addiction, Cleve Clin J Med, 86, 789, 10.3949/ccjm.86a.19118 Tang, 2019, Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice, Proc Natl Acad Sci U S A, 116, 21727, 10.1073/pnas.1911321116 Bagnardi, 2015, Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis, Br J Cancer, 112, 580, 10.1038/bjc.2014.579 Chao, 2007, Associations between beer, wine, and liquor consumption and lung cancer risk: a meta-analysis, Cancer Epidemiol Biomarkers Prev, 16, 2436, 10.1158/1055-9965.EPI-07-0386 Brenner, 2019, Alcohol consumption and lung cancer risk: a pooled analysis from the international lung cancer consortium and the SYNERGY study, Cancer Epidemiol, 58, 25, 10.1016/j.canep.2018.10.006 Freudenheim, 2005, Alcohol consumption and risk of lung cancer: a pooled analysis of cohort studies, Am J Clin Nutr, 82, 657, 10.1093/ajcn/82.3.657 Im, 2021, Alcohol drinking and risks of total and site-specific cancers in China: a 10-year prospective study of 0.5 million adults, Int J Cancer, 149, 522, 10.1002/ijc.33538 Shen, 2013, Alcohol intake and death from cancer in a prospective Chinese elderly cohort study in Hong Kong, J Epidemiol Community Health, 67, 813, 10.1136/jech-2013-202684 Yang, 2012, Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220,000 men with 15 years of follow-up, Int J Epidemiol, 41, 1101, 10.1093/ije/dys075 Bagnardi, 2011, Alcohol consumption and lung cancer risk in never smokers: a meta-analysis, Ann Oncol, 22, 2631, 10.1093/annonc/mdr027 Bandera, 1992, Alcohol consumption and lung cancer in white males, Cancer Causes Control, 3, 361, 10.1007/BF00146890 Benedetti, 2006, Consumption of alcoholic beverages and risk of lung cancer: results from two case-control studies in Montreal, Canada, Cancer Causes Control, 17, 469, 10.1007/s10552-005-0496-y Chow, 1992, A cohort study of tobacco use, diet, occupation, and lung cancer mortality, Cancer Causes Control, 3, 247, 10.1007/BF00124258 De Stefani, 2002, Alcohol intake and risk of adenocarcinoma of the lung. A case-control study in Uruguay, Lung Cancer, 38, 9, 10.1016/S0169-5002(02)00153-8 De Stefani, 1993, The effect of alcohol on the risk of lung cancer in Uruguay, Cancer Epidemiol Biomarkers Prev, 2, 21 Hu, 2002, Canadian cancer registries epidemiology research G. Risk factors for lung cancer among Canadian women who have never smoked, Cancer Detect Prev, 26, 129, 10.1016/S0361-090X(02)00038-7 Kubik, 2004, Dietary habits and lung cancer risk among non-smoking women, Eur J Cancer Prev, 13, 471, 10.1097/00008469-200412000-00002 Mettlin, 1989, Milk drinking, other beverage habits, and lung cancer risk, Int J Cancer, 43, 608, 10.1002/ijc.2910430412 Pollack, 1984, Prospective study of alcohol consumption and cancer, N Engl J Med, 310, 617, 10.1056/NEJM198403083101003 Prescott, 1999, Alcohol intake and the risk of lung cancer: influence of type of alcoholic beverage, Am J Epidemiol, 149, 463, 10.1093/oxfordjournals.aje.a009834 Ruano-Ravina, 2004, Type of wine and risk of lung cancer: a case-control study in Spain, Thorax, 59, 981, 10.1136/thx.2003.018861 Rohrmann, 2006, Ethanol intake and risk of lung cancer in the European prospective investigation into cancer and nutrition (EPIC), Am J Epidemiol, 164, 1103, 10.1093/aje/kwj326 Shimazu, 2008, Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study, Cancer Causes Control, 19, 1095, 10.1007/s10552-008-9173-2 Li, 2011, Association between alcohol consumption and cancers in the Chinese population–a systematic review and meta-analysis, PLoS ONE, 6, e18776, 10.1371/journal.pone.0018776 Bandera, 1997, Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States), Cancer Causes Control, 8, 828, 10.1023/A:1018456127018 Dosemeci, 1997, Tobacco, alcohol use, and risks of laryngeal and lung cancer by subsite and histologic type in Turkey, Cancer Causes Control, 8, 729, 10.1023/A:1018479304728 Koo, 1988, Dietary habits and lung cancer risk among Chinese females in Hong Kong who never smoked, Nutr Cancer, 11, 155, 10.1080/01635588809513983 Troche, 2016, The association between alcohol consumption and lung carcinoma by histological subtype, Am J Epidemiol, 183, 110 Woodson, 1999, Association between alcohol and lung cancer in the alpha-tocopherol, beta-carotene cancer prevention study in Finland, Cancer Causes Control, 10, 219, 10.1023/A:1008911624785 Malhotra, 2020, Epidemiology of occupational lung cancer, 287 Veglia, 2007, Occupational exposures, environmental tobacco smoke, and lung cancer, Epidemiology, 18, 769, 10.1097/EDE.0b013e318142c8a1 Wang, 2011, Attributable causes of lung cancer incidence and mortality in China, Thorac Cancer, 2, 156, 10.1111/j.1759-7714.2011.00067.x Ge, 2020, Diesel engine exhaust exposure, smoking, and lung cancer subtype risks. a pooled exposure-response analysis of 14 case-control studies, Am J Respir Crit Care Med, 202, 402, 10.1164/rccm.201911-2101OC Ge, 2020, Respirable crystalline silica exposure, smoking, and lung cancer subtype risks. A pooled analysis of case-control studies, Am J Respir Crit Care Med, 202, 412, 10.1164/rccm.201910-1926OC 2019, The world is failing on silicosis, Lancet Respir Med, 7, 283, 10.1016/S2213-2600(19)30078-5 Christiani, 2020, Occupational exposures and lung cancer, Am J Respir Crit Care Med, 202, 317, 10.1164/rccm.202004-1404ED 2019, Carcinogenicity of night shift work, Lancet Oncol, 20, 1058, 10.1016/S1470-2045(19)30455-3 Arafa, 2021, Night work, rotating shift work, and the risk of cancer in japanese men and women: the JACC study, J Epidemiol, 31, 585, 10.2188/jea.JE20200208 Kwon, 2015, Night shift work and lung cancer risk among female textile workers in Shanghai, China, J Occup Environ Hyg, 12, 334, 10.1080/15459624.2014.993472 McNeil, 2020, The effects of shift work and sleep duration on cancer incidence in Alberta`s Tomorrow Project cohort, Cancer Epidemiol, 67, 10.1016/j.canep.2020.101729 Parent, 2012, Night work and the risk of cancer among men, Am J Epidemiol, 176, 751, 10.1093/aje/kws318 Schernhammer, 2013, Rotating night-shift work and lung cancer risk among female nurses in the United States, Am J Epidemiol, 178, 1434, 10.1093/aje/kwt155 Schwartzbaum, 2007, Cohort study of cancer risk among male and female shift workers, Scand J Work Environ Health, 33, 336, 10.5271/sjweh.1150 Yong, 2014, A retrospective cohort study of shift work and risk of incident cancer among German male chemical workers, Scand J Work Environ Health, 40, 502, 10.5271/sjweh.3438 Pukkala, 2012, Cancer incidence among Nordic airline cabin crew, Int J Cancer, 131, 2886, 10.1002/ijc.27551 Pukkala, 2014, Cancer incidence among firefighters: 45 years of follow-up in five Nordic countries, Occup Environ Med, 71, 398, 10.1136/oemed-2013-101803 Gu, 2016, Sleep duration and cancer in the NIH-AARP diet and health study cohort, PLoS ONE, 11, 10.1371/journal.pone.0161561 Hurley, 2015, Sleep duration and cancer risk in women, Cancer Causes Control, 26, 1037, 10.1007/s10552-015-0579-3 Khawaja, 2014, Sleep duration and risk of lung cancer in the physicians' health study, Zhongguo Fei Ai Za Zhi, 17, 649 Luojus, 2014, Sleep duration and incidence of lung cancer in ageing men, BMC Public Health, 14, 295, 10.1186/1471-2458-14-295 Wang, 2021, Association between sleep traits and lung cancer: a mendelian randomization study, J Immunol Res, 2021, 10.1155/2021/1893882 Xie, 2021, Relationships between sleep traits and lung cancer risk: a prospective cohort study in UK Biobank, Sleep, 44, zsab089, 10.1093/sleep/zsab089 Kendzia, 2013, Welding and lung cancer in a pooled analysis of case-control studies, Am J Epidemiol, 178, 1513, 10.1093/aje/kwt201 Consonni, 2015, Lung cancer risk among bricklayers in a pooled analysis of case-control studies, Int J Cancer, 136, 360, 10.1002/ijc.28986 Guha, 2021, Lung cancer risk in painters: results from the SYNERGY pooled case-control study consortium, Occup Environ Med, 78, 269, 10.1136/oemed-2020-106770 1988, Man-made mineral fibres, IARC Monographs Eval Carcinogenic Risks Humans, 43, 39 Darby, 2005, Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies, BMJ, 330, 223, 10.1136/bmj.38308.477650.63 Krewski, 2005, Residential radon and risk of lung cancer: a combined analysis of 7 North American case-control studies, Epidemiology, 16, 137, 10.1097/01.ede.0000152522.80261.e3 Lubin, 2004, Risk of lung cancer and residential radon in China: pooled results of two studies, Int J Cancer, 109, 132, 10.1002/ijc.11683 Malinovsky, 2019, Meta-analysis of case-control studies on the relationship between lung cancer and indoor radon exposure, Radiat Environ Biophys, 58, 39, 10.1007/s00411-018-0770-5 Tchorz-Trzeciakiewicz, 2017, Factors affecting atmospheric radon concentration, human health, Sci Total Environ, 584-585, 911, 10.1016/j.scitotenv.2017.01.137 Li, 2020, Residential radon and histological types of lung cancer: a meta-analysis of case‒control studies, Int J Environ Res Public Health, 17, 1457, 10.3390/ijerph17041457 2016, Outdoor air pollution, IARC Monogr Eval Carcinog Risks Hum, 109, 9 Krewski, 2009, Extended follow-up and spatial analysis of the American Cancer Society study linking particulate air pollution and mortality, Res Rep Health Eff Inst, 5 Raaschou-Nielsen, 2013, Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE), Lancet Oncol, 14, 813, 10.1016/S1470-2045(13)70279-1 Turner, 2011, Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers, Am J Respir Crit Care Med, 184, 1374, 10.1164/rccm.201106-1011OC Hamra, 2014, Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis, Environ Health Perspect, 122, 906, 10.1289/ehp/1408092 Pope, 2020, Fine particulate air pollution and human mortality: 25+ years of cohort studies, Environ Res, 183, 10.1016/j.envres.2019.108924 Cao, 2011, Association between long-term exposure to outdoor air pollution and mortality in China: a cohort study, J Hazard Mater, 186, 1594, 10.1016/j.jhazmat.2010.12.036 Katanoda, 2011, An association between long-term exposure to ambient air pollution and mortality from lung cancer and respiratory diseases in Japan, J Epidemiol, 21, 132, 10.2188/jea.JE20100098 Peng, 2017, Long-term exposure to ambient air pollution and mortality in a Chinese tuberculosis cohort, Sci Total Environ, 580, 1483, 10.1016/j.scitotenv.2016.12.128 Wong, 2016, Cancer mortality risks from long-term exposure to ambient fine particle, Cancer Epidemiol Biomarkers Prev, 25, 839, 10.1158/1055-9965.EPI-15-0626 Yin, 2017, Long-term fine particulate matter exposure and nonaccidental and cause-specific mortality in a large national cohort of chinese men, Environ Health Perspect, 125, 10.1289/EHP1673 Bai, 2020, Exposure to ambient air pollution and the incidence of lung cancer and breast cancer in the ontario population health and environment cohort, Int J Cancer, 146, 2450, 10.1002/ijc.32575 Coleman, 2020, Cancer mortality risk, fine particulate air pollution, and smoking in a large, representative cohort of US adults, Cancer Causes Control, 31, 767, 10.1007/s10552-020-01317-w Hvidtfeldt, 2019, Long-term residential exposure to PM2.5 constituents and mortality in a Danish cohort, Environ Int, 133 Pun, 2017, Long-term PM2.5 exposure and respiratory, cancer, and cardiovascular mortality in older US adults, Am J Epidemiol, 186, 961, 10.1093/aje/kwx166 Wang, 2020, The impact of long-term PM2.5 exposure on specific causes of death: exposure-response curves and effect modification among 53 million U.S. Medicare beneficiaries, Environ Health, 19, 20, 10.1186/s12940-020-00575-0 Klompmaker, 2020, Surrounding green, air pollution, traffic noise exposure and non-accidental and cause-specific mortality, Environ Int, 134, 10.1016/j.envint.2019.105341 Atkinson, 2018, Long-term concentrations of nitrogen dioxide and mortality: a meta-analysis of cohort studies, Epidemiology, 29, 460, 10.1097/EDE.0000000000000847 Hamra, 2015, Lung cancer and exposure to nitrogen dioxide and traffic: a systematic review and meta-analysis, Environ Health Perspect, 123, 1107, 10.1289/ehp.1408882 Eum, 2019, Long-term NO2 exposures and cause-specific mortality in American older adults, Environ Int, 124, 10, 10.1016/j.envint.2018.12.060 Gowda, 2019, Ambient air pollution and lung cancer risk among never-smokers in the Women's health initiative, Environ Epidemiol, 3, e076, 10.1097/EE9.0000000000000076 Kazemiparkouhi, 2020, Long-term ozone exposures and cause-specific mortality in a US Medicare cohort, J Expo Sci Environ Epidemiol, 30, 650, 10.1038/s41370-019-0135-4 2010, Household use of solid fuels and high-temperature frying, IARC Monogr Eval Carcinog Risks Hum, 95, 1 2016 Gao, 1996, Risk factors for lung cancer among nonsmokers with emphasis on lifestyle factors, Lung Cancer, 14, S39, 10.1016/S0169-5002(96)90209-3 Zhao, 2006, Air pollution and lung cancer risks in China–a meta-analysis, Sci Total Environ, 366, 500, 10.1016/j.scitotenv.2005.10.010 Bruce, 2015, Does household use of biomass fuel cause lung cancer? A systematic review and evaluation of the evidence for the GBD 2010 study, Thorax, 70, 433, 10.1136/thoraxjnl-2014-206625 Gharibvand, 2017, The association between ambient fine particulate matter and incident adenocarcinoma subtype of lung cancer, Environ Health, 16, 71, 10.1186/s12940-017-0268-7 Tomczak, 2016, Long-term exposure to fine particulate matter air pollution and the risk of lung cancer among participants of the Canadian National Breast Screening Study, Int J Cancer, 139, 1958, 10.1002/ijc.30255 Moon, 2020, Air pollution and incidence of lung cancer by histological type in Korean adults: a Korean national health insurance service health examinee cohort study, Int J Environ Res Public Health, 17, 915, 10.3390/ijerph17030915 Consonni, 2018, Outdoor particulate matter (PM10) exposure and lung cancer risk in the EAGLE study, PLoS ONE, 13, 10.1371/journal.pone.0203539 2017 Weichenthal, 2016, Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian census health and environment cohort (CanCHEC), Environ Res, 146, 92, 10.1016/j.envres.2015.12.013 Cakmak, 2018, Associations between long-term PM2.5 and ozone exposure and mortality in the Canadian census health and environment cohort (CANCHEC), by spatial synoptic classification zone, Environ Int, 111, 200, 10.1016/j.envint.2017.11.030 Raaschou-Nielsen, 2016, Particulate matter air pollution components and risk for lung cancer, Environ Int, 87, 66, 10.1016/j.envint.2015.11.007 Turner, 2016, Long-term ozone exposure and mortality in a large prospective study, Am J Respir Crit Care Med, 193, 1134, 10.1164/rccm.201508-1633OC 2014, Diesel and Gasoline Engine Exhausts and Some Nitroarenes. IARC monographs on the evaluation of carcinogenic riskd to humans, IARC Monogr Evaluat Carcinogenic Risks Humans, 105, 9 Cogliano, 2011, Preventable exposures associated with human cancers, J Natl Cancer Inst, 103, 1827, 10.1093/jnci/djr483 Turner, 2014, Interactions between cigarette smoking and fine particulate matter in the risk of lung cancer mortality in cancer prevention study II, Am J Epidemiol, 180, 1145, 10.1093/aje/kwu275 Wang, 2019, The associations of fruit and vegetable intake with lung cancer risk in participants with different smoking status: a meta-analysis of prospective cohort studies, Nutrients, 11, 1791, 10.3390/nu11081791 Wang, 2015, Fruit and vegetable consumption and risk of lung cancer: a dose-response meta-analysis of prospective cohort studies, Lung cancer, 88, 124, 10.1016/j.lungcan.2015.02.015 Yang, 2011, Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies, Am J Clin Nutr, 94, 1575, 10.3945/ajcn.111.020966 Song, 2014, Fish consumption and lung cancer risk: systematic review and meta-analysis, Nutr Cancer, 66, 539, 10.1080/01635581.2014.894102 Farvid, 2021, Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies, Eur J Epidemiol, 36, 937, 10.1007/s10654-021-00741-9 Xue, 2014, Red and processed meat consumption and the risk of lung cancer: a dose-response meta-analysis of 33 published studies, Int J Clin Exp Med, 7, 1542 Cho, 2006, Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: a pooled analysis of 8 prospective studies, Int J Cancer, 118, 970, 10.1002/ijc.21441 Gallicchio, 2008, Carotenoids and the risk of developing lung cancer: a systematic review, Am J Clin Nutr, 88, 372, 10.1093/ajcn/88.2.372 1994, The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers, N Engl J Med, 330, 1029, 10.1056/NEJM199404143301501 Omenn, 1996, Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial, J Natl Cancer Inst, 88, 1550, 10.1093/jnci/88.21.1550 Middha, 2019, β-carotene supplementation and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: the role of tar and nicotine, Nicotine Tob Res, 21, 1045, 10.1093/ntr/nty115 Anic, 2016, Index-based dietary patterns and risk of lung cancer in the NIH-AARP diet and health study, Eur J Clin Nutr, 70, 123, 10.1038/ejcn.2015.122 Gnagnarella, 2013, Nutrient intake and nutrient patterns and risk of lung cancer among heavy smokers: results from the COSMOS screening study with annual low-dose CT, Eur J Epidemiol, 28, 503, 10.1007/s10654-013-9803-1 Gorlova, 2011, Dietary patterns affect lung cancer risk in never smokers, Nutr Cancer, 63, 842, 10.1080/01635581.2011.589958 Mai, 2005, Diet quality and subsequent cancer incidence and mortality in a prospective cohort of women, Int J Epidemiol, 34, 54, 10.1093/ije/dyh388 Balder, 2005, Dietary patterns associated with male lung cancer risk in the Netherlands Cohort Study, Cancer Epidemiol Biomarkers Prev, 14, 483, 10.1158/1055-9965.EPI-04-0353 De Stefani, 2009, Dietary patterns and risk of cancer: a factor analysis in Uruguay, Int J Cancer, 124, 1391, 10.1002/ijc.24035 Tsai, 2003, Genetic susceptibility and dietary patterns in lung cancer, Lung Cancer, 41, 269, 10.1016/S0169-5002(03)00238-1 Gnagnarella, 2013, Red meat, Mediterranean diet and lung cancer risk among heavy smokers in the COSMOS screening study, Ann Oncol, 24, 2606, 10.1093/annonc/mdt302 De Stefani, 2008, Nutrient patterns and risk of lung cancer: a factor analysis in Uruguayan men, Lung Cancer, 61, 283, 10.1016/j.lungcan.2008.01.004 Friedenreich, 2021, Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms, Mol Oncol, 15, 790, 10.1002/1878-0261.12772 Liu, 2019, Association between physical activity and lower risk of lung cancer: a meta-analysis of cohort studies, Front Oncol, 9, 5, 10.3389/fonc.2019.00005 Brenner, 2016, Leisure-time physical activity and lung cancer risk: a systematic review and meta-analysis, Lung cancer, 95, 17, 10.1016/j.lungcan.2016.01.021 Rezende, 2018, Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases, Br J Sports Med, 52, 826, 10.1136/bjsports-2017-098391 Schmid, 2016, Does smoking influence the physical activity and lung cancer relation? A systematic review and meta-analysis, Eur J Epidemiol, 31, 1173, 10.1007/s10654-016-0186-y Bak, 2005, Physical activity and risk for lung cancer in a Danish cohort, Int J Cancer, 116, 439, 10.1002/ijc.21085 Steindorf, 2006, Physical activity and lung cancer risk in the European prospective investigation into cancer and nutrition cohort, Int J Cancer, 119, 2389, 10.1002/ijc.22125 Colbert, 2002, Physical activity and lung cancer risk in male smokers, Int J Cancer, 98, 770, 10.1002/ijc.10156 Dosemeci, 1993, Occupational physical activity, socioeconomic status, and risks of 15 cancer sites in Turkey, Cancer Causes Control, 4, 313, 10.1007/BF00051333 Lee, 1999, Physical activity and risk of lung cancer, Int J Epidemiol, 28, 620, 10.1093/ije/28.4.620 Parent, 2011, Occupational and recreational physical activity during adult life and the risk of cancer among men, Cancer Epidemiol, 35, 151, 10.1016/j.canep.2010.09.004 Severson, 1989, A prospective analysis of physical activity and cancer, Am J Epidemiol, 130, 522, 10.1093/oxfordjournals.aje.a115366 Thune, 1997, The influence of physical activity on lung-cancer risk: a prospective study of 81,516 men and women, Int J Cancer, 70, 57, 10.1002/(SICI)1097-0215(19970106)70:1<57::AID-IJC9>3.0.CO;2-5 Brownson, 1991, Physical activity on the job and cancer in Missouri, Am J Public Health, 81, 639, 10.2105/AJPH.81.5.639 He, 2017, A case-control study of the association between self-reported occupational and recreational physical activity and lung cancer, Medicine (Baltimore), 96, e7923, 10.1097/MD.0000000000007923 Ho, 2017, Physical activity and lung cancer risk in men and women, Cancer Causes Control, 28, 309, 10.1007/s10552-017-0872-4 Kaneko, 2019, Risk of cancer and longest-held occupations in Japanese workers: a multicenter hospital-based case-control study, Cancer Med, 8, 6139, 10.1002/cam4.2499 Rana, 2020, Occupational physical activity and lung cancer risk: a systematic review and meta-analysis, Sports Med, 50, 1637, 10.1007/s40279-020-01312-w Heikkila, 2013, Work stress and risk of cancer: meta-analysis of 5700 incident cancer events in 116,000 European men and women, BMJ, 346, f165, 10.1136/bmj.f165 Kennedy, 2014, Loss of a parent and the risk of cancer in early life: a nationwide cohort study, Cancer Causes Control, 25, 499, 10.1007/s10552-014-0352-z Chida, 2008, Do stress-related psychosocial factors contribute to cancer incidence and survival?, Nat Clin Pract Oncol, 5, 466, 10.1038/ncponc1134 Wang, 2020, Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies, Mol Psychiatry, 25, 1487, 10.1038/s41380-019-0595-x Howren, 2009, Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis, Psychosom Med, 71, 171, 10.1097/PSY.0b013e3181907c1b Spiegel, 2003, Depression and cancer: mechanisms and disease progression, Biol Psychiatry, 54, 269, 10.1016/S0006-3223(03)00566-3 Strine, 2008, The association of depression and anxiety with obesity and unhealthy behaviors among community-dwelling US adults, Gen Hosp Psychiatry, 30, 127, 10.1016/j.genhosppsych.2007.12.008 Ang, 2020, Association between family history of lung cancer and lung cancer risk: a systematic review and meta-analysis, Lung Cancer, 148, 129, 10.1016/j.lungcan.2020.08.012 Cote, 2012, Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium, Eur J Cancer, 48, 1957, 10.1016/j.ejca.2012.01.038 Gu, 2010, Systematic review of the relationship between family history of lung cancer and lung cancer risk, Zhongguo Fei Ai Za Zhi, 13, 224 Matakidou, 2005, Systematic review of the relationship between family history and lung cancer risk, Br J Cancer, 93, 825, 10.1038/sj.bjc.6602769 Lissowska, 2010, Family history and lung cancer risk: international multicentre case-control study in Eastern and Central Europe and meta-analyses, Cancer Causes Control, 21, 1091, 10.1007/s10552-010-9537-2 Bosse, 2018, A decade of GWAS results in lung cancer, Cancer Epidemiol Biomarkers Prev, 27, 363, 10.1158/1055-9965.EPI-16-0794 Musolf, 2016, Parametric linkage analysis identifies five novel genome-wide significant loci for familial lung cancer, Hum Hered, 82, 64, 10.1159/000479028 Amos, 2008, Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1, Nat Genet, 40, 616, 10.1038/ng.109 Broderick, 2009, Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study, Cancer Res, 69, 6633, 10.1158/0008-5472.CAN-09-0680 Hung, 2008, A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25, Nature, 452, 633, 10.1038/nature06885 Liu, 2008, Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer, J Natl Cancer Inst, 100, 1326, 10.1093/jnci/djn268 McKay, 2008, Lung cancer susceptibility locus at 5p15.33, Nat Genet, 40, 1404, 10.1038/ng.254 Thorgeirsson, 2008, A variant associated with nicotine dependence, lung cancer and peripheral arterial disease, Nature, 452, 638, 10.1038/nature06846 Wang, 2008, Common 5p15.33 and 6p21.33 variants influence lung cancer risk, Nat Genet, 40, 1407, 10.1038/ng.273 McKay, 2017, Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes, Nat Genet, 49, 1126, 10.1038/ng.3892 Wang, 2014, Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer, Nat Genet, 46, 736, 10.1038/ng.3002 Wang, 2016, Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium, Carcinogenesis, 37, 888, 10.1093/carcin/bgw070 Li, 2012, Genetic association analysis of complex diseases incorporating intermediate phenotype information, PLoS ONE, 7, e46612, 10.1371/journal.pone.0046612 Poirier, 2015, Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer, Genet Epidemiol, 39, 197, 10.1002/gepi.21882 Landi, 2009, A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma, Am J Hum Genet, 85, 679, 10.1016/j.ajhg.2009.09.012 Timofeeva, 2012, Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls, Hum Mol Genet, 21, 4980, 10.1093/hmg/dds334 Brenner, 2015, Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia, Carcinogenesis, 36, 1314, 10.1093/carcin/bgv128 Brennan, 2007, Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study, Hum Mol Genet, 16, 1794, 10.1093/hmg/ddm127 Dong, 2012, Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population, Nat Genet, 44, 895, 10.1038/ng.2351 Hu, 2011, A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese, Nat Genet, 43, 792, 10.1038/ng.875 Jin, 2015, Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations, Am J Hum Genet, 96, 832, 10.1016/j.ajhg.2015.03.009 Miki, 2010, Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations, Nat Genet, 42, 893, 10.1038/ng.667 Shiraishi, 2012, A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population, Nat Genet, 44, 900, 10.1038/ng.2353 Yoon, 2010, A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population, Hum Mol Genet, 19, 4948, 10.1093/hmg/ddq421 Dong, 2013, Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in Han Chinese, PLoS Genet, 9, 10.1371/journal.pgen.1003190 Lan, 2012, Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia, Nat Genet, 44, 1330, 10.1038/ng.2456 Li, 2010, Genetic variants and risk of lung cancer in never smokers: a genome-wide association study, Lancet Oncol, 11, 321, 10.1016/S1470-2045(10)70042-5 Wang, 2016, Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women, Hum Mol Genet, 25, 620, 10.1093/hmg/ddv494 Kim, 2013, Genome-wide association study of lung cancer in Korean non-smoking women, J Korean Med Sci, 28, 840, 10.3346/jkms.2013.28.6.840 Ahn, 2012, The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations, Hum Genet, 131, 365, 10.1007/s00439-011-1080-z Dai, 2019, Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations, Lancet Respir Med, 7, 881, 10.1016/S2213-2600(19)30144-4 Zhang, 2014, A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility, Carcinogenesis, 35, 1528, 10.1093/carcin/bgu076 Hosgood, 2015, Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA), Hum Genet, 134, 333, 10.1007/s00439-014-1528-z Liu, 2015, Genome-wide gene-asbestos exposure interaction association study identifies a common susceptibility variant on 22q13.31 associated with lung cancer risk, Cancer Epidemiol Biomarkers Prev, 24, 1564, 10.1158/1055-9965.EPI-15-0021 Wei, 2012, Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility, Carcinogenesis, 33, 1531, 10.1093/carcin/bgs188 Malhotra, 2015, Effect of occupational exposures on lung cancer susceptibility: a study of gene-environment interaction analysis, Cancer Epidemiol Biomarkers Prev, 24, 570, 10.1158/1055-9965.EPI-14-1143-T Hoeijmakers, 2009, DNA damage, aging, and cancer, N Engl J Med, 361, 1475, 10.1056/NEJMra0804615 Negrini, 2010, Genomic instability-an evolving hallmark of cancer, Nat Rev Mol Cell Biol, 11, 220, 10.1038/nrm2858 Hidayat, 2016, Abdominal obesity and lung cancer risk: systematic review and meta-analysis of prospective studies, Nutrients, 8, 810, 10.3390/nu8120810 Gao, 2019, The comparison of different obesity indexes and the risk of lung cancer: a meta-analysis of prospective cohort studies, Nutr Cancer, 71, 908, 10.1080/01635581.2019.1595037 Boscoe, 2014, The relationship between area poverty rate and site-specific cancer incidence in the United States, Cancer, 120, 2191, 10.1002/cncr.28632 Casetta, 2017, Association between cigarette smoking prevalence and income level: a systematic review and meta-analysis, Nicotine Tob Res, 19, 1401 Lehrer, 2014, Poverty and lung cancer incidence, Cancer, 120, 4007, 10.1002/cncr.28960 Fuentes, 2021, Role of sex hormones in lung cancer, Exp Biol Med (Maywood), 246, 2098, 10.1177/15353702211019697 Zeng, 2021, Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones, BMC Cancer, 21, 690, 10.1186/s12885-021-08437-9 Hyde, 2012, Associations between testosterone levels and incident prostate, lung, and colorectal cancer. A population-based study, Cancer Epidemiol Biomarkers Prev, 21, 1319, 10.1158/1055-9965.EPI-12-0129 Budisan, 2021, Links between infections, lung cancer, and the immune system, Int J Mol Sci, 22, 9394, 10.3390/ijms22179394 Ang, 2021, Association between previous lung diseases and lung cancer risk: a systematic review and meta-analysis, Carcinogenesis, 42, 1461, 10.1093/carcin/bgab082 Sun, 2007, Lung cancer in never smokers–a different disease, Nat Rev Cancer, 7, 778, 10.1038/nrc2190 Couraud, 2012, Lung cancer in never smokers–A review, Eur J Cancer, 48, 1299, 10.1016/j.ejca.2012.03.007 Taylor, 2007, Meta-analysis of studies of passive smoking and lung cancer: effects of study type and continent, Int J Epidemiol, 36, 1048, 10.1093/ije/dym158 Li, 2018, The relationship of indoor coal use and environmental tobacco smoke exposure with lung cancer in China: a meta-analysis, J Cancer Res Ther, 14, S7, 10.4103/0973-1482.168965 Cheng, 2021, Systematic review and meta-analysis of residential radon and lung cancer in never-smokers, Eur Respir Rev, 30, 10.1183/16000617.0230-2020 Ko, 2000, Chinese food cooking and lung cancer in women nonsmokers, Am J Epidemiol, 151, 140, 10.1093/oxfordjournals.aje.a010181 Brownson, 1993, Occupational risk factors for lung cancer among nonsmoking women: a case-control study in Missouri (United States), Cancer Causes Control, 4, 449, 10.1007/BF00050864 Zeka, 2006, Lung cancer and occupation in nonsmokers: a multicenter case-control study in Europe, Epidemiology, 17, 615, 10.1097/01.ede.0000239582.92495.b5 Huang, 2022, Current situation and prospect of primary prevention of malignant tumor in China, Zhonghua Zhong Liu Za Zhi, 44, 942