Estrogen Receptor-α is Involved in Tamoxifen Neuroprotective Effects in a Traumatic Brain Injury Male Rat Model

Lucas, 2006, The role of inflammation in CNS injury and disease, Br J Pharmacol, 147, 232, 10.1038/sj.bjp.0706400 Hanisch, 2002, Microglia as a source and target of cytokine, Glia, 40, 140, 10.1002/glia.10161 Tang, 2016, Early electroacupuncture treatment ameliorates neuroinflammation in rats with traumatic brain injury, BMC Complement Altern Med, 16, 470, 10.1186/s12906-016-1457-6 Wajant, 2003, Tumor necrosis factor signaling, Cell Death Differ, 10, 45, 10.1038/sj.cdd.4401189 Soustiel, 2005, Neuroprotective anti-apoptosis effect of estrogen in traumatic brain injury, J Neurotrauma, 22, 345, 10.1089/neu.2005.22.345 Chen, 2009, Premarin stimulates estrogen receptor-alpha to protect against traumatic brain injury in male rats, Crit Care Med, 37, 3097, 10.1097/CCM.0b013e3181bc7986 Shughrue, 1997, Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system, J Comp Neurol, 388, 507, 10.1002/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO;2-6 Mitra, 2003, Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha, Endocrinology, 144, 2055, 10.1210/en.2002-221069 Smith, 2004, Coregulator function: a key to understanding tissue specificity of selective receptor modulators, Endocr Rev, 25, 45, 10.1210/er.2003-0023 Lien, 1991, Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients, Br J Cancer, 63, 641, 10.1038/bjc.1991.147 Grill, 1991, Pharmacokinetics of droloxifene and its metabolites in breast cancer patients, Am J Clin Oncol, 14, S21, 10.1097/00000421-199112002-00006 Tian, 2009, Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats, J Neurochem, 109, 1658, 10.1111/j.1471-4159.2009.06077.x Dhandapani, 2002, Protective effects of estrogen and selective estrogen receptor modulators in the brain, Biol Reprod, 67, 1379, 10.1095/biolreprod.102.003848 Tsai, 2014, Extracellular signal-regulated kinase 1/2 is involved in a tamoxifen neuroprotective effect in a lateral fluid percussion injury rat model, J Surg Res, 189, 106, 10.1016/j.jss.2014.02.009 McIntosh, 1989, Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model, Neuroscience, 28, 233, 10.1016/0306-4522(89)90247-9 Pierce, 1998, Enduring cognitive, neurobehavioral and histopathological changes persist for up to one year following severe experimental brain injury in rats, Neuroscience, 87, 359, 10.1016/S0306-4522(98)00142-0 Sudoh, 2003, Tricyclic antidepressants as long-acting local anesthetics, Pain, 103, 49, 10.1016/S0304-3959(02)00375-5 Mehta, 2003, Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat, Neuroendocrinology, 77, 44, 10.1159/000068332 Thalhammer, 1995, Neurologic evaluation of the rat during sciatic nerve block with lidocaine, Anesthesiology, 82, 1013, 10.1097/00000542-199504000-00026 Kuo, 2007, Resuscitation from experimental traumatic brain injury by agmatine therapy, Resuscitation, 75, 506, 10.1016/j.resuscitation.2007.05.011 Mullen, 1992, Neu-N, a neuronal specific nuclear protein in vertebrates, Development, 116, 201, 10.1242/dev.116.1.201 Koshinaga, 2000, Rapid and widespread microglial activation induced by traumatic brain injury in rat brain slices, J Neurotrauma, 17, 185, 10.1089/neu.2000.17.185 Roberta Diaz Brinton, 2009, Estrogen-induced plasticity from cells to circuits: predictions for cognitive function, Trends Pharmacol Sci, 30, 212, 10.1016/j.tips.2008.12.006 Dubal, 1999, Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors, J Neurosci, 19, 6385, 10.1523/JNEUROSCI.19-15-06385.1999 Dubal, 2006, Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death, Endocrinology, 147, 3076, 10.1210/en.2005-1177 Lee, 2008, TNF alpha-induced down-regulation of estrogen receptor alpha in MCF-7 breast cancer cells, Mol Cells, 26, 285 Gatson, 2012, Estrone is neuroprotective in rats after traumatic brain injury, J Neurotrauma, 29, 2209, 10.1089/neu.2011.2274 Bermpohl, 2007, TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice, J Cereb Blood Flow Metab, 27, 1806, 10.1038/sj.jcbfm.9600487 Williams, 2007, Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat, J Neuroinflammation, 4, 17, 10.1186/1742-2094-4-17 Dhandapani, 2003, Neuroprotective effects of estrogen and tamoxifen in vitro: a facilitative role for glia?, Endocrine, 21, 59, 10.1385/ENDO:21:1:59 Garcia-Ovejero, 2005, Glia-neuron cross talk in the neuroprotective mechanisms of sex steroid hormones, Brain Res Rev, 48, 273, 10.1016/j.brainresrev.2004.12.018 García-Ovejero, 2002, Glial expression of estrogen and androgen receptors after rat brain injury, J Comp Neurol, 450, 256, 10.1002/cne.10325 Tapia-Gonzalez, 2008, Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: potential role of microglial ERs, J Endocrinol, 198, 219, 10.1677/JOE-07-0294 Dhandapani, 2005, Astrocyte-derived transforming growth factor-β mediates the neuroprotective effects of 17 β-estradiol: involvement of nonclassical genomic signaling pathways, Endocrinology, 146, 2749, 10.1210/en.2005-0014 Mendez, 2003, Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinasein the adult rat brain, Mol Brain Res, 112, 170, 10.1016/S0169-328X(03)00088-3 Ross, 1994, The presence of tumour necrosis factor in CSF and plasma after severe head injury, Br J Neurosurg, 8, 419, 10.3109/02688699408995109 Holmin, 1999, Long-term intracerebral inflammatory response after experimental focal brain injury in rat, Neuroreport, 10, 1889, 10.1097/00001756-199906230-00017 Chio, 2013, Etanercept attenuates traumatic brain injury in rats by reducing early microglial expression of tumor necrosis factor-α, BMC Neurosci, 14, 33, 10.1186/1471-2202-14-33 Lim, 2013, Microglial activation induced by traumatic brain injury is suppressed by postinjury treatment with hyperbaric oxygen therapy, J Surg Res, 184, 1076, 10.1016/j.jss.2013.04.070 Kimelberg, 2003, Neuroprotective activity of tamoxifen in permanent focal ischemia, J Neurosurg, 99, 138, 10.3171/jns.2003.99.1.0138 Asl, 2013, Contribution of estrogen receptors alpha and beta in the brain response to traumatic brain injury, J Neurosurg, 119, 353, 10.3171/2013.4.JNS121636 Baker, 2004, Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor, Endocrinology, 145, 5021, 10.1210/en.2004-0619 Liu, 2005, Estrogen provides neuroprotection against activated microglia-induced dopaminergic neuronal injury through both estrogen receptor-alpha and estrogen receptor-beta in microglia, J Neurosci Res, 81, 653, 10.1002/jnr.20583 Behl, 2002, Oestrogen as a neuroprotective hormone, Nat Rev Neurosci, 3, 433, 10.1038/nrn846 Cui, 2013, Estrogen synthesis and signaling pathways during aging: from periphery to brain, Trends Mol Med, 19, 197, 10.1016/j.molmed.2012.12.007 Zhang, 2007, Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity, Exp Neurol, 204, 819, 10.1016/j.expneurol.2007.01.015