Estimating F-Statistics

Annual Review of Genetics - Tập 36 Số 1 - Trang 721-750 - 2002
B. S. Weir1, William G. Hill2
1Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695-7566, USA.
2*Institute for Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom

Tóm tắt

▪ Abstract  A moment estimator of θ, the coancestry coefficient for alleles within a population, was described by Weir & Cockerham in 1984 ( 100 ) and is still widely cited. The estimate is used by population geneticists to characterize population structure, by ecologists to estimate migration rates, by animal breeders to describe genetic variation, and by forensic scientists to quantify the strength of matching DNA profiles. This review extends the work of Weir & Cockerham by allowing different levels of coancestry for different populations, and by allowing non-zero coancestries between pairs of populations. All estimates are relative to the average value of θ between pairs of populations. Moment estimates for within- and between-population θ values are likely to have large sampling variances, although these may be reduced by combining information over loci. Variances also decrease with the numbers of alleles at a locus, and with the numbers of populations sampled. This review also extends the work of Weir & Cockerham by employing maximum likelihood methods under the assumption that allele frequencies follow the normal distribution over populations. For the case of equal θ values within populations and zero θ values between populations, the maximum likelihood estimate is the same as that given by Robertson & Hill in 1984 ( 70 ). The review concludes by relating functions of θ values to times of population divergence under a pure drift model.

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Annual Review of Genetics

Tập 36 Số 1

721-750

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