Establishment of a cost-effective method to detect FLT-ITD and D835 mutations in acute myeloid leukemia patients in the Taiwanese population

Tzu Chi Medical Journal - Tập 27 Số 1 - Trang 18-24 - 2015
Hsingjin Eugene Liu1, Ching-Huai Ko2, Freda Lam3, Lawrence Shih-Hsin Wu4, Kuei-Fang Lee5
1Department of Radiation Oncology, Wan Fang Hospital, Taipei, Taiwan
2Medigen Biotechnology Corp., Taipei, Taiwan
3Research Development Division, Vita Genomics Inc., Taipei, Taiwan
4Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
5Laboratory for Cytogenetics, Center for Genetic Counseling, Buddhist Tzu Chi General Hospital, Hualien, Taiwan

Tóm tắt

Từ khóa


Tài liệu tham khảo

Pokharel, 2012, Leukemia: a review article, Int J Adv Res Pharm Bio Sci, 2, 397

Sacha, 2014, Imatinib in chronic myeloid leukemia: an overview, Mediterr J Hematol Infect Dis, 6, e2014007, 10.4084/mjhid.2014.007

Huang, 2012, Estimations of the increasing prevalence and plateau prevalence of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy, Cancer, 118, 3123, 10.1002/cncr.26679

Müller, 2009, Harmonization of molecular monitoring of CML therapy in Europe, Leukemia, 23, 1957, 10.1038/leu.2009.168

Jabbour, 2014, Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management, Am J Hematol, 89, 547, 10.1002/ajh.23691

List, 2001, Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study, Blood, 98, 3212, 10.1182/blood.V98.12.3212

Fukushima, 2012, Low-dose cytarabine plus aclarubicin for patients with previously untreated acute myeloid leukemia or high-risk myelodysplastic syndrome ineligible for standard-dose cytarabine plus anthracycline, Anticancer Res, 32, 1347

Liu Yin, 2001, Comparison of ‘sequential’ versus ‘standard’ chemotherapy as re-induction treatment, with or without cyclosporine, in refractory/relapsed acute myeloid leukaemia (AML): results of the UK Medical Research Council AML-R trial, Br J Haematol, 113, 713, 10.1046/j.1365-2141.2001.02785.x

Ling, 2013, Utility of a clinical risk score to identify high-risk patients with de novo acute myeloid leukaemia in first remission after high-dose cytarabine (HiDAC) based induction chemotherapy, Br J Haematol, 160, 861, 10.1111/bjh.12178

Roumier, 2009, Pharmacogenomics in acute myeloid leukemia, Pharmacogenomics, 10, 1839, 10.2217/pgs.09.130

Boissel, 2002, Prognostic significance of FLT3 internal tandem repeat in patients with de novo acute myeloid leukemia treated with reinforced courses of chemotherapy, Leukemia, 16, 1699, 10.1038/sj.leu.2402622

Boissel, 2005, Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype, Blood, 106, 3618, 10.1182/blood-2005-05-2174

Paschka, 2008, Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study, J Clin Oncol, 26, 4595, 10.1200/JCO.2007.15.2058

Whitman, 2008, DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication, Blood, 112, 2013, 10.1182/blood-2008-01-128595

Huang, 2007, Epidemiology of multiple myeloma in Taiwan: increasing incidence for the past 25 years and higher prevalence of extramedullary myeloma in patients younger than 55 years, Cancer, 110, 896, 10.1002/cncr.22850

Chen, 2010, An epidemiological investigation of leukemia incidence between 2003 and 2007 in Nanjing, China, J Hematol Oncol, 3, 21, 10.1186/1756-8722-3-21

Parkin, 2005, Global cancer statistics, 2002, CA Cancer J Clin, 55, 74, 10.3322/canjclin.55.2.74

Jemal, 2002, Cancer statistics, 2002, CA Cancer J Clin, 52, 23, 10.3322/canjclin.52.1.23

Jemal, 2007, Cancer statistics, 2007, CA Cancer J Clin, 57, 43, 10.3322/canjclin.57.1.43

Small, 1994, STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells, Proc Natl Acad Sci USA, 91, 459, 10.1073/pnas.91.2.459

Kiyoi, 1997, Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho), Leukemia, 11, 1447, 10.1038/sj.leu.2400756

Thiede, 2002, Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis, Blood, 99, 4326, 10.1182/blood.V99.12.4326

Kottaridis, 2001, Blood, 98, 1752, 10.1182/blood.V98.6.1752

Chang, 2003, Simplified capillary electrophoresis detection of the Flt-3 internal tandem duplications and D835 point mutations in acute myeloid leukemia, Haematologica, 88, ELT04

Kottaridis, 2002, Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors, Blood, 100, 2393, 10.1182/blood-2002-02-0420

Assem, 2012, FLT3 internal tandem duplication and JAK2 V617F mutations in de novo acute myelogenous leukemia: relation with induction chemotherapy and overall survival, Life Sci J, 9, 1053

Döhner, 2005, Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations, Blood, 106, 3740, 10.1182/blood-2005-05-2164

Thiede, 2006, Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML), Blood, 107, 4011, 10.1182/blood-2005-08-3167

Suzuki, 2005, Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia, Blood, 106, 2854, 10.1182/blood-2005-04-1733

Schlenk, 2008, Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia, N Engl J Med, 358, 1909, 10.1056/NEJMoa074306

Colovic, 2007, Importance of early detection and follow-up of FLT3 mutations in patients with acute myeloid leukemia, Ann Hematol, 86, 741, 10.1007/s00277-007-0325-3

Stirewalt, 2003, The role of FLT3 in haematopoietic malignancies, Nat Rev Cancer, 3, 650, 10.1038/nrc1169

Muñoz, 2003, Immunophenotypic findings in acute myeloid leukemia with FLT3 internal tandem duplication, Haematologica, 88, 637

Kiyoi, 1998, Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product, Leukemia, 12, 1333, 10.1038/sj.leu.2401130

Gregory, 2009, Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics, J Hematol Oncol, 2, 23, 10.1186/1756-8722-2-23

Liang, 2003, FLT3-TKD mutation in childhood acute myeloid leukemia, Leukemia, 17, 883, 10.1038/sj.leu.2402928

Lin, 2005, Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells, Clin Cancer Res, 11, 1372, 10.1158/1078-0432.CCR-04-1816

Chou, 2006, Nucleophosmin mutations in de novo acute myeloid leukemia: the age-dependent incidences and the stability during disease evolution, Cancer Res, 66, 3310, 10.1158/0008-5472.CAN-05-4316

Tang, 2009, AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations, Blood, 114, 5352, 10.1182/blood-2009-05-223784

Whitman, 2008, FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications, Blood, 111, 1552, 10.1182/blood-2007-08-107946

Sheikhha, 2003, Prognostic significance of FLT3 ITD and D835 mutations in AML patients, Hematol J, 4, 41, 10.1038/sj.thj.6200224

Whitman, 2007, FLT3 D835/I836 mutations predict worse disease-free survival (DFS) in younger adults with cytogenetically normal acute myeloid leukemia (CN AML) without FLT3 internal tandem duplications (ITD): A Cancer and Leukemia Group B (CALGB) study, J Clin Oncol, 25, 10532, 10.1200/jco.2007.25.18_suppl.10532