Establishment and Characterization of Advanced Penile Cancer Patient-derived Tumor Xenografts: Paving the Way for Personalized Treatments

European Urology Focus - Tập 8 - Trang 1787-1794 - 2022
Laura Elst1,2, Anne-Sophie Van Rompuy3, Eduard Roussel1,2, Lien Spans4, Isabelle Vanden Bempt4, Andrea Necchi5,6, Jeffrey Ross7,8, Joseph M. Jacob8, Maria-Francesca Baietti9,10, Eleonora Leucci9,10, Maarten Albersen1,2
1Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium
2Department of Urology, University Hospitals Leuven, Leuven, Belgium
3Department of pathology, University Hospitals Leuven, Leuven, Belgium
4Department of Human Genetics, University Hospitals Leuven, Leuven, Belgium
5San Raffaele Hospital and Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
6Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
7Foundation Medicine, Cambridge, MA, USA
8Upstate Medical University Syracuse, NY, USA
9Trace, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium
10Laboratory of RNA Cancer Biology, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium

Tài liệu tham khảo

Thomas, 2021, Penile cancer, Nat Rev Dis Primers, 7, 11, 10.1038/s41572-021-00246-5 Favorito, 2008, Epidemiologic study on penile cancer in Brazil, Clin Urol, 34, 587 Robinson, 2018, Risks and benefits of adjuvant radiotherapy after inguinal lymphadenectomy in node-positive penile cancer: a systematic review by the European Association of Urology Penile Cancer Guidelines Panel, Eur Urol, 74, 76, 10.1016/j.eururo.2018.04.003 Necchi, 2016, Panitumumab treatment for advanced penile squamous cell carcinoma when surgery and chemotherapy have failed, Clin Genitourin Cancer, 14, 231, 10.1016/j.clgc.2015.08.001 Vanthoor, 2021, Penile cancer: potential target for immunotherapy?, World J Urol, 39, 1405, 10.1007/s00345-020-03510-7 Huang, 2020, Effective combinatorial immunotherapy for penile squamous cell carcinoma, Nat Commun, 11, 2124, 10.1038/s41467-020-15980-9 Medeiros-Fonseca, 2020, HPV16 induces penile intraepithelial neoplasia and squamous cell carcinoma in transgenic mice: first mouse model for HPV-related penile cancer, J Pathol, 251, 411, 10.1002/path.5475 Woo, 2021, Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts, Nat Genet, 53, 86, 10.1038/s41588-020-00750-6 Thomas, 2020, Establishment, characterization, and imaging of a first platinum-resistant penile cancer patient-derived xenograft in nude mice: a eUROGEN project, Eur Urol, 78, 294, 10.1016/j.eururo.2020.05.033 Roussel, 2021, Predictors of local recurrence and its impact on survival after glansectomy for penile cancer: time to challenge the dogma?, BJU Int, 127, 606, 10.1111/bju.15297 Cubilla, 2011, Value of p16INK4a in the pathology of invasive penile squamous cell carcinomas: a report of 202 cases, Am J Surg Pathol, 35, 253, 10.1097/PAS.0b013e318203cdba Vanden Bempt, 2021, Comprehensive targeted next-generation sequencing approach in the molecular diagnosis of gastrointestinal stromal tumor, Genes Chromosomes Cancer, 60, 239, 10.1002/gcc.22923 Jacob, 2019, Comparative genomic profiling of refractory and metastatic penile and nonpenile cutaneous squamous cell carcinoma: implications for selection of systemic therapy, J Urol, 201, 541, 10.1016/j.juro.2018.09.056 John, 2012, Characterization of lymphomas developing in immunodeficient mice implanted with primary human non-small cell lung cancer, J Thorac Oncol, 7, 1101, 10.1097/JTO.0b013e3182519d4d Leiting, 2019, Rituximab decreases lymphoproliferative tumor formation in hepatopancreaticobiliary and gastrointestinal cancer patient-derived xenografts, Sci Rep, 9, 5901, 10.1038/s41598-019-42470-w Karamboulas, 2018, Patient-derived xenografts for prognostication and personalized treatment for head and neck squamous cell carcinoma, Cell Rep, 25, 1318, 10.1016/j.celrep.2018.10.004 Jung, 2020, PDX models of human lung squamous cell carcinoma: consideration of factors in preclinical and co-clinical applications, J Transl Med, 18, 307, 10.1186/s12967-020-02473-y Bandini, 2021, Association between human papillomavirus infection and outcome of perioperative nodal radiotherapy for penile carcinoma, Eur Urol Oncol, 4, 802, 10.1016/j.euo.2020.10.011 Schiffman, 2016, Carcinogenic human papillomavirus infection, Nat Rev Dis Primers, 2, 16086, 10.1038/nrdp.2016.86 McDaniel, 2015, Genomic profiling of penile squamous cell carcinoma reveals new opportunities for targeted therapy, Cancer Res, 75, 5219, 10.1158/0008-5472.CAN-15-1004 Chahoud, 2021, Whole-exome sequencing in penile squamous cell carcinoma uncovers novel prognostic categorization and drug targets similar to head and neck squamous cell carcinoma, Clin Cancer Res, 27, 2560, 10.1158/1078-0432.CCR-20-4004 de Vries, 2020, Establishment and characterisation of testicular cancer patient-derived xenograft models for preclinical evaluation of novel therapeutic strategies, Sci Rep, 10, 18938, 10.1038/s41598-020-75518-3 Eirew, 2015, Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution, Nature, 518, 422, 10.1038/nature13952 Freshour, 2021, Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts, Nucleic Acids Res, 49, D1144, 10.1093/nar/gkaa1084 Sambandam, 2019, PDK1 mediates NOTCH1-mutated head and neck squamous carcinoma vulnerability to therapeutic PI3K/mTOR inhibition, Clin Cancer Res, 25, 3329, 10.1158/1078-0432.CCR-18-3276 Ho, 2021, Tipifarnib in head and neck squamous cell carcinoma with HRAS mutations, J Clin Oncol, 39, 1856, 10.1200/JCO.20.02903 Hakenberg, 2018 Cubilla, 2001, Histologic classification of penile carcinoma and its relation to outcome in 61 patients with primary resection, Int J Surg Pathol, 9, 111, 10.1177/106689690100900204 Van De Merbel, 2021, Patient-derived tumour models for personalized therapeutics in urological cancers, Nat Rev Urol, 18, 33, 10.1038/s41585-020-00389-2