Establishing a quantitative index of meropenem hydrolysis for the detection of KPC- and NDM-producing bacteria by MALDI-TOF MS

Anantharajah, 2019, Performance evaluation of the MBT STAR®-CArBA IVD assay for the detection of carbapenemases with MALDI-TOF MS, Front. Microbiol., 10, 1, 10.3389/fmicb.2019.01413 Bonomo, 2018, Carbapenemase-producing organisms: a global scourge, Clin. Infect. Dis., 66, 1290, 10.1093/cid/cix893 Brazil. Ministério da Saúde Burckhardt, 2011, Using matrix-assisted laser desorption ionization-time of flight mass spectrometry to detect carbapenem resistance within 1 to 2.5 hours, J. Clin. Microbiol., 49, 3321, 10.1128/JCM.00287-11 Choquet, 2018, Comparison of MALDI-ToF MS with the Rapidec Carba NP test for the detection of carbapenemase-producing Enterobacteriaceae, Eur. J. Clin. Microbiol. Infect. Dis., 37, 149, 10.1007/s10096-017-3115-4 Cui, 2019, Carbapenemases in Enterobacteriaceae: detection and antimicrobial therapy, Front. Microbiol., 10, 1, 10.3389/fmicb.2019.01823 Dortet, 2018, MALDI-TOF for the rapid detection of carbapenemase-producing Enterobacteriaceae: comparison of the commercialized MBT STAR® -carba IVD kit with two in-house MALDI-TOF techniques and the RAPIDEC® CARBA NP, J. Antimicrob. Chemother., 73, 2352, 10.1093/jac/dky209 European Committee on Antimicrobial Susceptibility Testing, 2020, 0 Gaibani, 2016, Evaluation of matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of KPC-producing Klebsiella pneumoniae, J. Clin. Microbiol., 54, 2609, 10.1128/JCM.01242-16 Giske, 2011, A sensitive and specific phenotypic assay for detection of metallo-β-lactamases and KPC in Klebsiella pneumoniae, Clin. Microbiol. Infect., 17, 552, 10.1111/j.1469-0691.2010.03294.x Hrabák, 2015, Detection of carbapenemases using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) meropenem hydrolysis assay, 91 Hrabák, 2012, Detection of NDM-1, VIM-1, KPC, OXA-48, and OXA-162 carbapenemases by matrix-assisted laser desorption ionization-time of flight mass spectrometry, J. Clin. Microbiol., 50, 2441, 10.1128/JCM.01002-12 Hrabák, 2013, Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry for detection of antibiotic resistance mechanisms: from research to routine diagnosis, Clin. Microbiol. Rev., 26, 103, 10.1128/CMR.00058-12 Iredell, 2016, Antibiotic resistance in Enterobacteriaceae: mechanisms and clinical implications, BMJ, 351, 1 Johansson, 2014, The detection and verification of carbapenemases using ertapenem and matrix assisted laser desorption ionization-time of flight, BMC Microbiol., 14, 1, 10.1186/1471-2180-14-89 Kawamoto, 2018, Performance evaluation of the MALDI Biotyper selective testing of antibiotic resistance–β-lactamase (MBT STAR-BL) assay for the detection of IMP metallo-β-lactamase activity in Enterobacteriaceae, Diagn. Microbiol. Infect. Dis., 92, 275, 10.1016/j.diagmicrobio.2018.06.018 Kim, 2019, Rapid discrimination of methicillin-resistant Staphylococcus aureus by MALDI-TOF MS, Pathogens, 8, 1, 10.3390/pathogens8040214 Kost, 2017, Comparison of clinical methods for detecting carbapenem-resistant Enterobacteriaceae, Pract. Lab. Med., 8, 18, 10.1016/j.plabm.2017.03.002 Lange, 2014, Quantitative matrix-assisted laser desorption ionization-time of flight mass spectrometry for rapid resistance detection, J. Clin. Microbiol., 52, 4155, 10.1128/JCM.01872-14 Lasserre, 2015, Efficient detection of carbapenemase activity in Enterobacteriaceae by matrix-assisted laser desorption ionization - time of flight mass spectrometry in less than 30 minutes, J. Clin. Microbiol., 53, 2163, 10.1128/JCM.03467-14 Lee, 2018, Comprehensive evaluation of the MBT STAR-BL module for simultaneous bacterial identification and β-lactamase-mediated resistance detection in gram-negative rods from cultured isolates and positive blood cultures, Front. Microbiol., 9 Logan, 2017, The epidemiology of Carbapenem-resistant Enterobacteriaceae: the impact and evolution of a global menace, J. Infect. Dis., 215, S28, 10.1093/infdis/jiw282 Miltgen, 2018, Detection of carbapenemase activity in Pseudomonas aeruginosa by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), J. Microbiol. Methods, 145, 66, 10.1016/j.mimet.2017.12.011 Mirande, 2015, Rapid detection of carbapenemase activity: benefits and weaknesses of MALDI-TOF MS, Eur. J. Clin. Microbiol. Infect. Dis., 34, 2225, 10.1007/s10096-015-2473-z Monteferrante, 2016, Evaluation of different pretreatment protocols to detect accurately clinical carbapenemase-producing Enterobacteriaceae by MALDI-TOF, J. Antimicrob. Chemother., 71, 2856, 10.1093/jac/dkw208 Monteiro, 2012, Rapid detection of carbapenemase genes by multiplex real-time PCR, J. Antimicrob. Chemother., 67, 906, 10.1093/jac/dkr563 Nordmann, 2012, Rapid detection of carbapenemase-producing Enterobacteriaceae, Emerg. Infect. Dis., 18, 1503, 10.3201/eid1809.120355 Österblad, 2014, Evaluation of the Carba NP test for carbapenemase detection, Antimicrob. Agents Chemother., 58, 7553, 10.1128/AAC.02761-13 Oviaño, 2016, Universal protocol for the rapid automated detection of carbapenem-resistant gram-negative bacilli directly from blood cultures by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF/MS), Int. J. Antimicrob. Agents, 48, 655, 10.1016/j.ijantimicag.2016.08.024 Palmeiro, 2019, 10, 1 Papadimitriou-Olivgeris, 2017, Carbapenemase-producing Klebsiella pneumoniae bloodstream infection in critically ill patients: risk factors and predictors of mortality, Eur. J. Clin. Microbiol. Infect. Dis., 36, 1125, 10.1007/s10096-017-2899-6 Papagiannitsis, 2015, Matrix-assisted laser desorption ionization-time of flight mass spectrometry meropenem hydrolysis assay with NH4HCO3, a reliable tool for direct detection of carbapenemase activity, J. Clin. Microbiol., 53, 1731, 10.1128/JCM.03094-14 Pires, 2013, Blue-Carba, an easy biochemical test for detection of diverse Carbapenemase producers directly from bacterial cultures, J. Clin. Microbiol., 51, 4281, 10.1128/JCM.01634-13 Potter, 2017, The rapid spread of carbapenem-resistant Enterobacteriaceae, Physiol. Behav., 176, 139 Ramos-Castañeda, 2018, Mortality due to KPC carbapenemase-producing Klebsiella pneumoniae infections: systematic review and meta-analysis: mortality due to KPC Klebsiella pneumoniae infections, J. Inf. Secur., 76, 438 Rozales, 2014, Emergence of NDM-1-producing Enterobacteriaceae in Porto Alegre, Brazil, Int. J. Infect. Dis., 25, 79, 10.1016/j.ijid.2014.01.005 Salomão, 2017, Carbapenem-resistant Enterobacteriaceae in patients admitted to the emergency department: new risk factors and occurrence in patients coming directly from the community, J. Hosp. Infect., 10.1016/j.jhin.2017.08.012 Sauget, 2014, Rapid, sensitive and specific detection of OXA-48-like-producing Enterobacteriaceae by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, J. Microbiol. Methods, 105, 88, 10.1016/j.mimet.2014.07.004 Seo, 2020, Comparison of clinical outcomes of patients infected with KPC- and NDM-producing Enterobacterales: a retrospective cohort study, Clin. Microbiol. Infect. Tamma, 2017, Comparing the outcomes of patients with carbapenemase-producing and non-carbapenemase- producing carbapenem-resistant enterobacteriaceae bacteremia, Clin. Infect. Dis., 64, 257, 10.1093/cid/ciw741 Tamma, 2017, Comparison of 11 phenotypic assays for accurate detection of carbapenemase- producing Enterobacteriaceae, J. Clin. Microbiol., 55, 1046, 10.1128/JCM.02338-16 Tsakris, 2009, Evaluation of boronic acid disk tests for differentiating KPC-possessing Klebsiella pneumoniae isolates in the clinical laboratory, J. Clin. Microbiol., 47, 362, 10.1128/JCM.01922-08 Van Der Zwaluw, 2015, The Carbapenem inactivation method (CIM), a simple and low-cost alternative for the carba NP test to assess phenotypic carbapenemase activity in gram-negative rods, PLoS One, 10, 1, 10.1371/journal.pone.0123690 Vrioni, 2018, MALDI-TOF mass spectrometry technology for detecting biomarkers of antimicrobial resistance: current achievements and future perspectives, Ann. Transl. Med., 6, 10.21037/atm.2018.06.28 WHO, 2017, 7 Yoon, 2020, Direct detection of intact Klebsiella pneumoniae carbapenemases produced by Enterobacterales using MALDI-TOF MS, J. Antimicrob. Chemother., 1–8 Yu, 2018, Rapid detection of carbapenemase activity of Enterobacteriaceae isolated from positive blood cultures by MALDI-TOF MS, Ann. Clin. Microbiol. Antimicrob., 17, 1, 10.1186/s12941-018-0274-9