Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities

Psychopharmacology - Tập 167 Số 4 - Trang 353-362 - 2003
Connie Sánchez1, Peter B. F. Bergqvist2,1, Lise T. Brennum1, Sandeep Gupta3, Sandy Hogg1, Axel Larsen1, Ove Wiborg4
1Research Laboratories, H. Lundbeck A/S, Copenhagen, Denmark
2Astra Zeneca, Malmø, Sweden
3Forest Laboratories, New York, USA
4University of Aarhus, Aarhus, Denmark

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Aghajanian GK (1978) Feedback regulation of central monaminergic neurones: evidence from single-cell recording studies. In: Youdim MBH, Lovenberg W, Sharman DF, Lagando JR (eds) Essays in neurochemistry and neuropharmacology. Wiley, New York, pp 1–32

Blier P, de Montigny C (1997) Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15:220–226

Borsini F (1995) Role of the serotonergic system in the forced swimming test. Neurosci Biobehav Rev 19:377–395

Borsini F, Meli A (1988) Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology 94:147–160

Burke WJ, Gergel I, Bose A (2002) Fixed-dose trial of the single isomer SSRI escitalopram in depressed out patients. J Clin Psychiatry 63:331–336

Caldwell J (2002) Do single enantiomers have something special to offer? Hum Psychopharmacol Clin Exp 16:S67–S71

Costall B, Jones BJ, Kelly ME, Naylor RJ, Tomkins DM (1989) Exploration of mice in a black and white test box: validation as a model of anxiety. Pharmacol Biochem Behav 32:777–785

Crawley J, Goodwin FK (1980) Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav 13:167–170

De Vry J, Benz U, Schreiber R, Traber J (1993) Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anxiolytic drugs. Eur J Pharmacol 249:331–339

Gardner CR (1985) Distress vocalization in rat pups. A simple screening method for anxiolytic drugs. J Pharmacol Methods 14:181–187

Gorman JM, Korotzer A, Su G (2002) Efficacy comparison of escitalopram and citalopram in the treatment of major depressive disorder: pooled analysis of placebo controlled trials. CNS Spectrums 7:40–44

Hall H, Ögren SO (1984) Effects of antidepressant drugs on histamine-H1 receptors in the brain. Life Sci 34:597–605

Hyttel J (1982) Citalopram. Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Progr Neuropsychopharmacol Biol Psychiatry 6:177–295

Hyttel J, Bøgesø KP, Perregaard J, Sánchez C (1992) The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer. J Neur Transm 88:157–160

Kaltwasser MT (1990) Startle-inducing acoustic stimuli evoke ultrasonic vocalization in the rat. Physiol Behav 48:13–17

Meier E, Frederiksen K, Nielsen M, Lembøl HL, Pedersen H, Hyttel J (1997) Pharmacological in vitro characterization of Lu 25–109-T, a muscarinic compound with M1-agonistic and M2/M3-antagonistic properties. Drug Dev Res 40:1–16

Montgomery SA, Loft H, Sánchez C, Reines EH, Papp M (2001) Escitalopram (S-enantiomer of citalopram): clinical efficacy and onset of action predicted from a rat model. Pharmacol Toxicol 88:282–286

Olivier B, van Oorschot R, Mos J (1998) Rodent models of aggressive behaviour. In: Maes M, Coccaro E (eds) Neurobiology of aggression and impulsivity. Wiley, London, pp 167–182

Owens MJ, Rosenbaum JF (2002) Escitalopram: a second generation SSRI. CNS Spectr 7:34–39

Owens MJ, Knight DL, Nemeroff CB (2001) Second-generation SSRIs: Human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol Psychiatry 50:345–350

Porsolt RD, Bertin A, Jalfre M (1977) Behavioural despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327–336

Romero L, Bel N, Artigas F, de Montigny C, Blier P (1996) Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology 15:349–360

Sánchez C (1993) Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats. Behav Pharmacol 4:269–277

Sánchez C (1995) Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two-compartment black and white test box. Pharmacol Toxicol 77:71–78

Sánchez C (1998) 5-HT1A receptors in the treatment of aggression and impulse control disorders (ICDs). In: Maes M, Coccaro E (eds) Neurobiology of aggression and impulsivity. Wiley, London, pp 181–196

Sánchez C (2003) Stress-induced vocalisation in adult animals. A valid model of anxiety? Eur J Pharmacol (in press)

Sánchez C, Hyttel J (1994) Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors. Eur J Pharmacol 264:241–247

Sánchez C, Meier E (1997) Behavioral profile of SSRIs in animal models of depression, anxiety and aggression. Are they all alike? Psychopharmacology 129:197–205

Sánchez C, Arnt J, Hyttel J, Moltzen EK (1993) The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice. Psychopharmacology 110:53–59

Sánchez C, Arnt J, Costall B, Kelly ME, Meier E, Naylor RJ, Perregaard J (1997) The selective σ2 ligand Lu 28–179 has potent anxiolytic-like effects in rodents. J Pharmacol Exp Ther 283:1343–1353

Schreiber R, Melon C, De Vry J (1998) The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalisation test. Psychopharmacology 135:383–391

Tonoue T, Ashida Y, Makino H, Hata H (1986) Inhibition of shock-elicited ultrasonic vocalization by opioid peptides in the rat: a psychotropic effect. Psychoneuroendocrinology 11:177–184

Wade A, Lemming OM, Hedegaard KB (2002) Escitalopram 10 mg/day is effective and well tolerated in a placebo controlled study in depression in primary care. Int Clin Psychopharmacol 17:95–102