Erythropoietin in acute renal failure (and acute myocardial infarction)

Clinical Research in Cardiology Supplements - Tập 2 - Trang S75-S80 - 2007
A. Covic1, P. Gusbeth-Tatomir1
1Dialysis and Renal Transplantation Center, Parhon University Hospital, Iasi, Romania

Tóm tắt

Erythropoietin (EPO) has been used largely in the last fifteen years for the treatment of renal anemia. Recent experimental data have demonstrated several pleiotropic actions of EPO administered acutely (in large doses): limitation of apoptosis, promotion of neovascularization, antiinflammatory effects. Thus, acute administration of EPO in clinical settings characterized by ischemia-reperfusion injury is of large interest. The limited clinical data in humans with acute renal failure or acute myocardial infarction are promising but not definitive, so that large randomized trials are urgently needed. The concern of significant side effects with acutely administered high-dose EPO may be overcome by the use on EPO analogues, without erythropoietic effects.

Tài liệu tham khảo

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