Rối Loạn Cương Dương và Trầm Cảm: Một Tổng Quan Hệ Thống và Phân Tích Meta

The Journal of Sexual Medicine - Tập 15 - Trang 1073-1082 - 2018
Qian Liu1,2, Youpeng Zhang1, Jin Wang1, Sen Li1, Yongbiao Cheng1, Jialun Guo1, Yong Tang1, Hanqing Zeng1, Zhaohui Zhu1
1Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2Department of Nosocomial Infection Management, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Tóm tắt

Tóm tắt Đặt vấn đề Các nghiên cứu đã báo cáo rằng việc tiếp xúc với trầm cảm làm tăng nguy cơ mắc rối loạn cương dương (ED), trong khi một số nghiên cứu khác lại không thấy có mối liên hệ. Hơn nữa, một số nghiên cứu bổ sung cho thấy việc tiếp xúc với ED cũng làm tăng nguy cơ mắc trầm cảm. Mục tiêu Xác định và tổng hợp định lượng tất cả các nghiên cứu đánh giá mối liên hệ giữa ED và trầm cảm cũng như khám phá các yếu tố có thể giải thích sự khác biệt trong mối liên hệ đã quan sát. Phương pháp Chúng tôi đã tiến hành một tổng quan hệ thống và phân tích meta. Chúng tôi đã tìm kiếm trên Medline, Ovid Embase và Thư viện Cochrane cho đến tháng 10 năm 2017 các nghiên cứu đã đánh giá mối liên hệ giữa ED và trầm cảm. Các nghiên cứu được đưa vào xem xét theo tiêu chí bao gồm Đối tượng hoặc Vấn đề, Can thiệp, So sánh, Kết quả và Thiết lập (PICOS). Kết quả Tỷ lệ odds ratio (OR) được coi là kích thước hiệu ứng, và sự khác biệt giữa các nghiên cứu được đánh giá bằng thống kê I2. Kết quả Chúng tôi đã xác định được 49 công trình xuất bản đủ điều kiện. Tỷ lệ OR chung cho các nghiên cứu đánh giá sự tiếp xúc với trầm cảm và nguy cơ ED là 1.39 (95% CI: 1.35–1.42; n = 46 công trình với 48 nghiên cứu). Mặc dù chúng tôi quan sát thấy sự khác biệt lớn (I2 = 93.6%), phân tích theo nhóm cho thấy có thể là do sự khác biệt trong thiết kế nghiên cứu, các bệnh đi kèm, đánh giá ED, đánh giá trầm cảm, nguồn gốc của kích thước hiệu ứng ban đầu, v.v. Không phát hiện thiên lệch xuất bản có ý nghĩa (P = .315), và kích thước hiệu ứng tổng thể không thay đổi khi loại trừ bất kỳ nghiên cứu đơn lẻ nào. Tỷ lệ OR chung cho các nghiên cứu đánh giá sự tiếp xúc với ED và nguy cơ trầm cảm là 2.92 (95% CI: 2.37–3.60; n = 5 công trình với 6 nghiên cứu). Không phát hiện sự khác biệt có ý nghĩa (P < .257, I2 = 23.5%) hoặc thiên lệch xuất bản (P = .260).

Từ khóa

#Rối loạn cương dương #Trầm cảm #Tổng quan hệ thống #Phân tích meta #Kết quả sức khỏe tâm thần.

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