Epstein-Barr virus—recent advances

The Lancet Infectious Diseases - Tập 3 - Trang 131-140 - 2003
Karen F Macsween1, Dorothy H Crawford2
1KFM is a clinical research fellow at the University of Edinburgh, Edinburgh, UK
2DHC is Professor of Medical Microbiology and Head of School of Biomedical and Clinical Laboratory Sciences at Edinburgh University Medical School, Edinburgh, UK

Tài liệu tham khảo

Epstein, 1964, Virus particles in cultured lymphoblasts from Burkitt's lymphoma, Lancet, 1, 702, 10.1016/S0140-6736(64)91524-7 Raab-Traub, 1991, Epstein-Barr virus infection in carcinoma of the salivary gland, J Virol, 65, 7032, 10.1128/JVI.65.12.7032-7036.1991 Bonnet, 1999, Detection of Epstein-Barr virus in invasive breast cancers, J Natl Cancer Inst, 91, 1376, 10.1093/jnci/91.16.1376 Sugarawa, 1999, Detection of Epstein-Barr virus (EBV) in hepatocellular carcinoma tissue: a novel EBV latency characterized by the absence of EBV-encoded small RNA expression, Virology, 256, 196, 10.1006/viro.1999.9619 Leywraz, 1985, Association of Epstein-Barr virus with thymic carcinoma, New Engl J Med, 213, 1296, 10.1056/NEJM198505163122006 Crawford, 2001, Biology and disease associations of Epstein-Barr virus, Phil Trans R Soc Lond B, 356, 461, 10.1098/rstb.2000.0783 Henle, 1969, Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups, J Nat Cancer Inst, 43, 1147 Babcock, 1998, EBV persistence in memory B cells in vivo, Immunity, 9, 395, 10.1016/S1074-7613(00)80622-6 Thorley-Lawson, 1996, Epstein-Barr virus and the B cell: that's all it takes, Trends Microbiol, 4, 204, 10.1016/S0966-842X(96)90020-7 Yao, 1985, A reexamination of the Epstein-Barr virus carrier state in healthy seropositive individuals, Int J Cancer, 35, 35, 10.1002/ijc.2910350107 Niederman, 1976, Infectious mononucleosis. Epstein-Barr-virus shedding in saliva and the oropharynx, N Engl J Med, 29, 1355, 10.1056/NEJM197606172942501 Fleisher, 1979, Primary infection with Epstein-Barr virus in infants in the United States: clinical and serologic observations, J Infect Dis, 139, 553, 10.1093/infdis/139.5.553 Fleisher, 1981, Pasqariello. Intrafamilial transmission of Epstein-Barr virus infections, J Pediatr, 98, 16, 10.1016/S0022-3476(81)80525-2 Gratama, 1990, EBNA size polymorphism can be used to trace Epstein-Barr virus spread within families, J Virol, 64, 4703, 10.1128/JVI.64.10.4703-4708.1990 Biggar, 1978, Primary Epstein-Barr virus infections in African infants. II. Clinical and serological observations during seroconversion, Int J Cancer, 22, 244, 10.1002/ijc.2910220305 Hallee, 1974, Infectious mononucleosis at the United States Military Academy. A prospective study of a single class over four years, Yale J Biol Med, 3, 182 1971, Infectious mononucleosis and its relationship to EB virus antibody. A joint investigation by university health physicians and PHLS laboratories, BMJ, 4, 643, 10.1136/bmj.4.5788.643 Niederman, 1970, Prevalence, incidence and persistence of EB virus antibody in young adults, N Engl J Med, 282, 361, 10.1056/NEJM197002122820704 Sawyer, 1971, Prospective studies of a group of Yale University freshmen. 1. Occurrence of infectious mononucleosis, J Infect Dis, 123, 263, 10.1093/infdis/123.3.263 Israele, 1991, Excretion of the Epstein-Barr virus from the genital tract of men, J Infect Dis, 163, 1341, 10.1093/infdis/163.6.1341 Sixbey, 1986, A second site for Epstein-Barr virus shedding: the uterine cervix, Lancet, 2, 1122, 10.1016/S0140-6736(86)90531-3 Crawford, 2002, Sexual history and Epstein-Barr virus infection, J Infect Dis, 186, 731, 10.1086/342596 Gerber, 1969, Association of EB-virus infection with the post-perfusion syndrome, Lancet, 1, 593, 10.1016/S0140-6736(69)91532-3 Alfieri, 1996, Epstein-Barr virus transmission from a blood donor to an organ transplant recipient with recovery of the same virus strain from the recipient's blood and oropharynx, Blood, 87, 812, 10.1182/blood.V87.2.812.bloodjournal872812 Cen, 1991, Epstein-Barr virus transmission via the donor organs in solid organ transplantation: polymerase chain reaction and restriction fragment length polymorphism analysis of IR2, IR3 and IR4, J Virol, 65, 976, 10.1128/JVI.65.2.976-980.1991 Haque, 1996, Transmission of donor Epstein-Barr virus (EBV) in transplant organs causes lymphoproliferative disease in EBV-seronegative recipients, J Gen Virol, 77, 1169, 10.1099/0022-1317-77-6-1169 Zimber, 1986, Geographical prevalence of two types of Epstein-Barr virus, Virology, 154, 56, 10.1016/0042-6822(86)90429-0 Anagnostopoulos, 1995, Morphology, immunophenotype, and distribution of latently and/or productively Epstein-Barr virus-infected cells in acute infectious mononucleosis: implications for the interindividual infection route of Epstein-Barr virus, Blood, 85, 744, 10.1182/blood.V85.3.744.bloodjournal853744 Farrell, 2002, Cell-switching and kissing, Nat Med, 8, 559, 10.1038/nm0602-559 Borza, 2002, Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus, Nat Med, 8, 594, 10.1038/nm0602-594 Faulkner, 2000, The ins and outs of EBV infection, Trends Microbiol, 8, 185, 10.1016/S0966-842X(00)01742-X Perry, 1988, Structure of the crypt epithelium in human palantine tonsils, Acta Otolaryngol, 454, 53, 10.3109/00016488809125005 Babcock, 2000, Tonsillar memory B cells, latently infected with Epstein-Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumors, Proc Natl Acad Sci USA, 97, 12250, 10.1073/pnas.200366597 Gires, 1997, Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule, EMBO J, 16, 6131, 10.1093/emboj/16.20.6131 Kilger, 1998, Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein1, which stimulates an activated CD40 receptor, EMBO J, 17, 1700, 10.1093/emboj/17.6.1700 Zimber-Strobl, 1996, Epstein-Barr virus latent membrane protein 1 (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival, EMBO J, 15, 7070, 10.1002/j.1460-2075.1996.tb01098.x Uchida, 1999, Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses, Science, 286, 300, 10.1126/science.286.5438.300 Caldwell, 1998, Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals, Immunity, 9, 405, 10.1016/S1074-7613(00)80623-8 Miyashita, 1995, A novel form of Epstein-Barr virus latency in normal B cells in vivo, Cell, 80, 593, 10.1016/0092-8674(95)90513-8 Wagner, 1992, Detection and quantification of latently infected B lymphocytes in Epstein-Barr virus-seropositive, healthy individuals by polymerase chain reaction, J Clin Microbiol, 30, 2826, 10.1128/JCM.30.11.2826-2829.1992 Qu, 1992, Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes, J Virol, 66, 3715, 10.1128/JVI.66.6.3715-3724.1992 Miyashita, 1997, Identification of the site of Epstein-Barr virus persistence in vivo as a resting cell, J Virol, 71, 4882, 10.1128/JVI.71.7.4882-4891.1997 Miller, 1995, Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases, Immunity, 2, 155, 10.1016/S1074-7613(95)80040-9 Miller, 1994, An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking, Proc Natl Acad Sci USA, 91, 772, 10.1073/pnas.91.2.772 Thorley-Lawson, 2001, Epstein-Barr virus: exploiting the immune system, Nat Rev Immunol, 1, 75, 10.1038/35095584 Crawford, 1986, EB virus induction is associated with B-cell maturation, Immunology, 59, 405 Yates, 1985, Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells, Nature, 313, 812, 10.1038/313812a0 Levitskaya, 1997, Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1, Proc Natl Acad Sci USA, 94, 12616, 10.1073/pnas.94.23.12616 Rickinson, 2001, Epstein-Barr virus, 2575 Moore, 2001, Interleukin-10 and the interleukin-10 receptor, Ann Rev Immunol, 19, 683, 10.1146/annurev.immunol.19.1.683 Cohen, 1999, Epstein-Barr virus BARF1 protein is dispensable for B-cell transformation and inhibits alpha interferon secretion from mononuclear cells, J Virol, 73, 7627, 10.1128/JVI.73.9.7627-7632.1999 Morrison, 2001, Inhibition of IFN-γ signaling by an Epstein-Barr virus immediate-early protein, Immunity, 15, 787, 10.1016/S1074-7613(01)00226-6 Henderson, 1993, Epstein-Barr virus-coded BHRF1 protein, a viral homolgue of Bcl-2, protects human B cells from programmed cell death, Proc Natl Acad Sci USA, 90, 8479, 10.1073/pnas.90.18.8479 Hoagland, 1964, The incubation period of infectious mononucleosis, Am J Public Health, 54, 1699, 10.2105/AJPH.54.10.1699 Schooley, 2000, Epstein-Barr virus (infectious mononucleosis), 1599 Dommerby, 1986, Hepatosplenomegaly in infectious mononucleosis, assessed by ultrasonic scanning, J Laryngol Otol, 100, 573, 10.1017/S0022215100099680 McCarthy, 1964, Cutaneous manifestations of infectious mononucleosis, JAMA, 187, 153, 10.1001/jama.1964.03060150077029 Pullen, 1967, Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis, Lancet, 2, 1176, 10.1016/S0140-6736(67)91893-4 Kerns, 1973, Ampicillin rash in children. Relationship to penicillin allergy and infectious mononucleosis, Am J Dis Child, 125, 187, 10.1001/archpedi.1973.04160020023004 Evans, 1978, Infectious mononucleosis and related syndromes, Am J Med Sci, 276, 325, 10.1097/00000441-197811000-00010 Fleisher, 1983, Limitations of available tests for diagnosis of infectious mononucleosis, J Clin Microbiol, 17, 619, 10.1128/JCM.17.4.619-624.1983 Sumaya, 1985, Epstein-Barr virus infectious mononucleosis in children. II. Heterophil antibody and viral-specific responses, Pediatrics, 75, 1011, 10.1542/peds.75.6.1011 Vidrih, 2001, Positive Epstein-Barr virus heterophile antibody tests in patients with primary human immunodeficiency virus infection, Am J Med, 111, 192, 10.1016/S0002-9343(01)00804-X Horowitz, 1979, Persistent falsely positive rapid tests for infectious mononucleosis, Am J Clin Pathol, 72, 807, 10.1093/ajcp/72.5.807 Wynne Jones, 1994, Human parvovirus B19, 308 Hendry, 1982, Systemic lupus erythematosus presenting as infectious monoucleosis with a false positive monospot test, Lancet, 1, 455, 10.1016/S0140-6736(82)91666-X Okano, 1988, Epstein-Barr virus and human diseases: recent advances in diagnosis, Clin Microbiol Rev, 1, 300, 10.1128/CMR.1.3.300 Henle, 1979, Rheumatoid factor as a cause of positive reactions in tests for Epstein-Barr virus specific IgM antibodies, Clin Exper Immunol, 36, 415 White, 1998, Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever, Br J Psychiatry, 173, 475, 10.1192/bjp.173.6.475 Whiting, 2001, Interventions for the treatment and management of chronic fatigue syndrome. A systematic review, JAMA, 286, 1360, 10.1001/jama.286.11.1360 Pagano, 1983, Acyclovir and Epstein-Barr virus infection, J Antimicrob Chemother, 12, 113, 10.1093/jac/12.suppl_B.113 Andersson, 1986, Effect of acyclovir on infectious mononucleosis: a double-blind, placebo-controlled study, J Infect Dis, 153, 283, 10.1093/infdis/153.2.283 Andersson, 1987, Acyclovir treatment in infectious mononucleosis: a clinical and virological study, Infection, 15, S14, 10.1007/BF01650106 Brandfonbrener, 1986, Corticosteroid therapy in Epstein-Barr virus infection. Effect on lymphocyte class, subset, and response to early antigen, Arch Intern Med, 146, 337, 10.1001/archinte.1986.00360140167024 Straus, 1993, Epstein-Barr virus infections: biology, pathogenesis, and management, Ann Intern Med, 118, 45, 10.7326/0003-4819-118-1-199301010-00009 McGowan, 1992, Guidelines for the use of systemic glucocorticosteroids in the management of selected infections, J Infect Dis, 165, 1, 10.1093/infdis/165.1.1 Sudderick, 1987, Steroids for airway problems in glandular fever, J Laryngol Otol, 101, 673, 10.1017/S0022215100102506 Foss, 1994, Patterns of cytokine gene expression in infectious mononucleosis, Blood, 83, 707, 10.1182/blood.V83.3.707.707 Linde, 1992, Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome, J Infect Dis, 165, 994, 10.1093/infdis/165.6.994 Callan, 1998, Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo, J Exp Med, 187, 1395, 10.1084/jem.187.9.1395 Kimura, 2001, Clinical and virologic characteristics of chronic active Epstein-Barr virus infection, Blood, 98, 280, 10.1182/blood.V98.2.280 Straus, 1988, The chronic mononucleosis syndrome, J Infect Dis, 157, 405, 10.1093/infdis/157.3.405 Okamura, 2000, Blood stem-cell transplantation for chronic active Epstein-Barr virus with lymphoproliferation, Lancet, 356, 223, 10.1016/S0140-6736(00)02488-0 Kuzushima, 1996, Establishment of anti-Epstein-Barr virus (EBV) cellular immunity by adoptive transfer of virus-specific cytotoxic T lymphocytes from an HLA-matched sibling to a patient with severe chronic active EBV infection, Clin Exp Immunol, 103, 192, 10.1046/j.1365-2249.1996.d01-619.x Bar, 1974, Fatal infectious mononucleosis in a family, N Engl J Med, 290, 363, 10.1056/NEJM197402142900704 Purtilo, 1975, X-linked recessive progressive combined variable immunodeficiency (Duncan's Disease), Lancet, 1, 935, 10.1016/S0140-6736(75)92004-8 Mroczek, 1987, Fatal infectious mononucleosis and virus-associated hemophagocytic syndrome, Arch Pathol Lab Med, 111, 530 Seemayer, 1995, X-linked lymphoproliferative disease: twenty-five years after the discovery, Pediatr Res, 38, 471, 10.1203/00006450-199510000-00001 Hamilton, 1980, Finkelstein GZ, landing B, Grunnet M, Purtilo DT. X-linked lymphoproliferative syndrome registry report, J Pediatr, 96, 669, 10.1016/S0022-3476(80)80735-9 Arkwright, 1998, X linked lymphoproliferative disease in a United Kingdom family, Arch Dis Child, 79, 52, 10.1136/adc.79.1.52 Migliorati, 1994, Treatment of EBV-induced lymphoproliferative disorder with epipodophyllotoxin VP16-213, Acta Pædiatr, 83, 1322, 10.1111/j.1651-2227.1994.tb13030.x Gross, 1996, Cure of X-linked lymphoproliferative disease (XLP) with allogeneic hematopoietic stem cell transplantation (HSCT): report from the XLP registry, Bone Marrow Transplant, 17, 741 Coffey, 1998, Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene, Nat Genet, 20, 129, 10.1038/2424 Sayos, 1998, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM, Nature, 395, 462, 10.1038/26683 Nichols, 1998, Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome, Proc Natl Acad Sci USA, 95, 13765, 10.1073/pnas.95.23.13765 Sumegi, 2000, Correlation of mutations of the SH2D1A gene and Epstein-Barr virus infection with clinical phenotype and outcome in X-linked lymphoproliferative disease, Blood, 96, 3118 Morra, 2001, Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome, Blood, 98, 1321, 10.1182/blood.V98.5.1321 Nistala, 2001, Gaspar, Jones AM. X-linked lymphoproliferative disease: three atypical cases, Clin Exp Immunol, 126, 126, 10.1046/j.1365-2249.2001.01599.x Dutz, 2001, Lymphocytic vasculitis in X-linked lymphoproliferative disease, Blood, 97, 95, 10.1182/blood.V97.1.95 Brandau, 1999, Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene, as are patients with X-linked lymphoproliferative disease (XLP), Hum Mol Genet, 8, 2407, 10.1093/hmg/8.13.2407 Cocks, 1995, A novel receptor involved in T-cell activation, Nature, 376, 260, 10.1038/376260a0 Tangye, 2000, Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome, J Immunol, 165, 2932, 10.4049/jimmunol.165.6.2932 Gaspar, 2002, X-linked lymphoproliferative disease: clinical, diagnostic and molecular perspective, Br J Haematol, 119, 585, 10.1046/j.1365-2141.2002.03851.x Savoie, 1994, Direct correlation between the load of Epstein-Barr virus-infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease, Blood, 83, 2715, 10.1182/blood.V83.9.2715.2715 Lucas, 1996, The development of cellular immunity to Epstein-Barr virus after allogeneic bone marrow transplantation, Blood, 87, 2594, 10.1182/blood.V87.6.2594.bloodjournal8762594 Nalesnik, 1998, Clinical and pathological features of post-transplant lymphoproliferative disorders (PTLD), Springer Semin Immunopathol, 20, 325, 10.1007/BF00838047 Ho, 1988, The frequency of Epstein-Barr virus infection and associated lymphoproliferative disease after transplantation and its manifestations in children, Transplantation, 45, 719, 10.1097/00007890-198804000-00011 Ho, 1985, Epstein-Barr virus infections and DNA hybidization studies in posttransplantation lymphoma and lymphoproliferative lesions: the role of primary infection, J Infect Dis, 152, 876, 10.1093/infdis/152.5.876 Stevens, 2001, Nucleic acid-based diagnostic approaches in EBV-associated disease, EBV Rep, 8, 31 Lucas, 1998, Semi-quantitative Epstein-Barr virus polymerase chain reaction analysis of peripheral blood from organ transplant patients and risk for the development of lymphoproliferative disease, Blood, 92, 3977, 10.1182/blood.V92.10.3977 Kimura, 1999, Quantitative analysis of Epstein-Barr virus load by using a realtime PCR assay, J Clin Microbiol, 37, 132, 10.1128/JCM.37.1.132-136.1999 Baldanti, 2000, High levels of Epstein-Barr virus DNA in blood of solid-organ transplant recipients and their value in predicting post-transplant lymphoproliferative disorders, J Clin Microbiol, 38, 613, 10.1128/JCM.38.2.613-619.2000 Hopwood, 2002, Persistent Epstein-Barr virus infection: unrestricted latent and lytic viral gene expression in healthy immunosuppressed transplant recipients, Transplantation, 74, 194, 10.1097/00007890-200207270-00009 Nalesnik, 1988, Clonal chacteristics of posttransplant lymphoproliferative disorders, Transplant Proc, 20, 280 Timms, 2003, Epstein-Barr virus (EBV)-positive post transplant lymphoproliferative disease frequently arises from B cells with randomly mutated or sterile immunoglobulin genes: a mechanistic link with EBV-positive Hodgkin's Disease, Lancet, 361, 217, 10.1016/S0140-6736(03)12271-4 Starzl, 1984, Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy, Lancet, 1, 583, 10.1016/S0140-6736(84)90994-2 Armitage, 1991, Posttransplant lymphoproliferative disease in thoracic organ transplant patients: ten years of cyclosporine-based immunosuppression, J Heart Lung Transplant, 10, 877 Cook, 1999, Treatment of post-transplant lymphoproliferative disease with rituximab monoclonal antibody after lung transplantation, Lancet, 354, 1698, 10.1016/S0140-6736(99)02058-9 Kuehnle, 2000, CD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantation., Blood, 95, 1502, 10.1182/blood.V95.4.1502.004k40_1502_1505 Verschuuren, 2002, Treatment of posttransplant lymphoproliferative disease with rituximab: the remission, the relapse and the complication, Transplantation, 73, 100, 10.1097/00007890-200201150-00019 1999, Rituximab (MabThera): serious infusion-related adverse reactions., Curr Probl Pharmacovigilance, 25, 2 Suzan, 2001, Fatal reactivation of cytomegalovirus infection after use of rituximab for a post-transplantation lymphoproliferative disorder., N Engl J Med, 13, 1000, 10.1056/NEJM200109273451315 Sharma, 2000, Pure red cell aplasia due to parvovirus B19 in a patient treated with rituximab., Blood, 96, 1184, 10.1182/blood.V96.3.1184 Rooney, 1998, Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients, Blood, 92, 1549, 10.1182/blood.V92.5.1549 Haque, 2002, Treatment of Epstein-Barr virus-positive post-transplantation lymphoproliferative disease with partly HLA-matched allogeneic cytotoxic T cells, Lancet, 360, 436, 10.1016/S0140-6736(02)09672-1 Herbst, 1996, Epstein-Barr virus in Hodgkin's disease., Sem Cancer Biol, 7, 183, 10.1006/scbi.1996.0025 Mueller, 1989, Hodgkin's disease and Epstein-Barr virus. Altered antibody pattern before diagnosis., N Engl J Med, 320, 689, 10.1056/NEJM198903163201103 Gutensohn, 1980, Epidemiology of Hodgkin's disease, Semin Oncol, 7, 92 Weiss, 1989, Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease, N Engl J Med, 320, 502, 10.1056/NEJM198902233200806 Jarrett, 2002, Viruses and Hodgkin's lymphoma, Ann Oncol, 13, 23, 10.1093/annonc/13.S1.23 Pallesen, 1991, Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease, Lancet, 337, 320, 10.1016/0140-6736(91)90943-J Young, 2000, The expression and function of Epstein-Barr virus encoded latent genes, J Clin Pathol: Molecular Pathology, 53, 238 Anagnostopoulos, 1989, Demonstration of monoclonal EBV genomes in Hodgkin's disease and KI-1 positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization, Blood, 74, 810, 10.1182/blood.V74.2.810.810 Marafioti, 2000, Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal centre B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription, Blood, 95, 1443, 10.1182/blood.V95.4.1443.004k55_1443_1450 Lukes, 1969, Reed-Sternberg-like cells in infectious mononucleosis, Lancet, 2, 1003, 10.1016/S0140-6736(69)90552-2 Chetty, 1997, Hum Pathol, 28, 493, 10.1016/S0046-8177(97)90040-X Rickinson, 1997, Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection, Ann Rev Immunol, 15, 405, 10.1146/annurev.immunol.15.1.405 Roskrow, 1998, Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the treatment of patients with EBV-positive relapsed Hodgkin's disease, Blood, 91, 2925, 10.1182/blood.V91.8.2925.2925_2925_2934 van Baarle, 2001, Dysfunctional Epstein-Barr virus (EBV)-specific CD8+ T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hogkin lymphoma, Blood, 98, 146, 10.1182/blood.V98.1.146 Beral, 1991, AIDS associated non-Hodgkin Lymphoma, Lancet, 337, 805, 10.1016/0140-6736(91)92513-2 MacMahon, 1991, Epstein-Barr virus in AIDS-related primary central nervous system lymphoma, Lancet, 338, 969, 10.1016/0140-6736(91)91837-K Cinque, 1993, Epstein-Barr virus DNA in cerebrospinal fluid from patients with AIDS-related lymphoma of the central nervous system, Lancet, 342, 398, 10.1016/0140-6736(93)92814-A Kirk, 2001, Non-Hodgkin lymphoma in HIV-infected patients in era of highly active antiretroviral therapy, Blood, 98, 3406, 10.1182/blood.V98.12.3406 Hoffman, 2001, Survival of AIDS patients with primary central nervous system lymphoma is dramatically improved by HAART-induced immune recovery, AIDS, 15, 2119, 10.1097/00002030-200111090-00007 Powles, 2000, HIV-associated Hodgkin's disease, Int J STD AIDS, 11, 492, 10.1258/0956462001916362 Grulich, 2002, Rates of non AIDS-defining cancers in people with HIV infection before and after AIDS diagnosis, AIDS, 16, 1155, 10.1097/00002030-200205240-00009 Greenspan, 1985, Replication of Epstein-Barr virus within the epithelial cells of oral hairy leukoplakia: virus replication in the absence of a detectable latent phase, N Engl J Med, 313, 1564, 10.1056/NEJM198512193132502 Itin, 1988, Oral hairy leuloplakia in a HIV-negative renal transplant patient: a marker for immunosuppression?, Dermatologica, 177, 126, 10.1159/000248529 Greenspan, 1989, Oral hairy leukoplakia in an HIV-negative renal transplant recipient, Oral Pathol, 18, 32, 10.1111/j.1600-0714.1989.tb00729.x Flückiger, 1994, Oral hairy leukoplakia in a patient with ulcerative colitis, Gastroenterology, 106, 506, 10.1016/0016-5085(94)90612-2 Niedobitek, 1991, Epstein-Barr virus infection in oral hairy leukoplakia: virus replication in the absence of a detectable latent phase, J Gen Virol, 72, 3035, 10.1099/0022-1317-72-12-3035 Thomas, 1991, Epstein-Barr virus gene expression and epithelial cell differentiation in oral hairy leukoplakia, Am J Path, 139, 1369 Resnick, 1988, Regression of oral hairy leukoplakia after orally administered acyclovir therapy, JAMA, 259, 384, 10.1001/jama.1988.03720030044031 Thorley-Lawson, 1982, Identification and isolation of the main component (gp350-gp220) of Epstein-Barr virus responsible for generating neutralising antibodies in vivo, J Virol, 43, 730, 10.1128/JVI.43.2.730-736.1982 Khanna, 1999, EBV structural antigens, gp350 and gp85, as targets for ex vivo virus-specific CTL during acute infectious mononucleosis: potential use of gp350/gp85 CTL epitopes for vaccine design, J Immunol, 162, 3063, 10.4049/jimmunol.162.5.3063 Airey, 2002 Silins, 2001, Asymptomatic primary Epstein-Barr virus infection occurs in the absence of blood T-cell repertoire perturbations despite high levels of systemic viral load, Blood, 98, 3739, 10.1182/blood.V98.13.3739 Wang, 2001, A new animal model for Epstein-Barr virus pathogenesis, Curr Top Microbiol Immunol, 258, 201