Epithelial Overexpression of SOCS-3 in Transgenic Mice Exacerbates Wound Inflammation in the Presence of Elevated TGF-β1

Journal of Investigative Dermatology - Tập 130 - Trang 866-875 - 2010
Andreas Linke1, Itamar Goren1, Michael R. Bösl2, Josef Pfeilschifter1, Stefan Frank1
1Pharmazentrum frankfurt/ZAFES, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany
2Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany

Tài liệu tham khảo

Abe, 1994, An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct, Anal Biochem, 216, 276, 10.1006/abio.1994.1042 Alexander, 2004, The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response, Annu Rev Immunol, 22, 503, 10.1146/annurev.immunol.22.091003.090312 Amendt, 2002, Resistance of keratinocytes to TGFbeta-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds, J Cell Sci, 115, 2189, 10.1242/jcs.115.10.2189 Bjarnsholt, 2008, Why chronic wounds will not heal: a novel hypothesis, Wound Repair Regen, 16, 2, 10.1111/j.1524-475X.2007.00283.x Chomczynski, 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal Biochem, 162, 156, 10.1016/0003-2697(87)90021-2 Darnell, 1997, STATs and gene regulation, Science, 264, 1415, 10.1126/science.8197455 Edwards, 2004, Bacteria and wound healing, Curr Opin Infect Dis, 17, 91, 10.1097/00001432-200404000-00004 Eming, 2007, Inflammation in wound repair: molecular and cellular mechanisms, J Invest Dermatol, 127, 514, 10.1038/sj.jid.5700701 Falanga, 2005, Wound healing and its impairment in the diabetic foot, Lancet, 366, 1736, 10.1016/S0140-6736(05)67700-8 Frank, 1996, Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing, J Biol Chem, 271, 10188, 10.1074/jbc.271.17.10188 Frank, 1999, Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair, FASEB J, 13, 2002, 10.1096/fasebj.13.14.2002 Gadina, 2001, Signaling by type I and II cytokine receptors: ten years after, Curr Opin Immunol, 13, 363, 10.1016/S0952-7915(00)00228-4 Gillitzer, 2001, Chemokines in cutaneous wound healing, J Leukoc Biol, 69, 513, 10.1189/jlb.69.4.513 Goren, 2003, Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators, Diabetes, 52, 2821, 10.2337/diabetes.52.11.2821 Goren, 2006, The suppressor of cytokine signaling-3 is upregulated in impaired skin repair: implications for keratinocyte proliferation, J Invest Dermatol, 126, 477, 10.1038/sj.jid.5700063 Goren, 2006, Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alpha, Am J Pathol, 168, 765, 10.2353/ajpath.2006.050293 Green, 1982, Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids, Anal Biochem, 126, 131, 10.1016/0003-2697(82)90118-X Hasan, 1997, Dermal fibroblasts from venous ulcers are unresponsive to the action of transforming growth factor-beta 1, J Dermatol Sci, 16, 59, 10.1016/S0923-1811(97)00622-1 Ihle, 1995, Jaks and Stats in signalling by the cytokine receptor superfamily, Trends Genet, 11, 69, 10.1016/S0168-9525(00)89000-9 Jeffcoate, 2003, Diabetic foot ulcers, Lancet, 361, 1545, 10.1016/S0140-6736(03)13169-8 Kämpfer, 2003, Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair, J Invest Dermatol, 120, 880, 10.1046/j.1523-1747.2003.12140.x Kämpfer, 2005, Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing, Diabetes, 54, 1543, 10.2337/diabetes.54.5.1543 Kane, 1991, Direct evidence for spatial and temporal regulation of transforming growth factor beta 1 expression during cutaneous wound healing, J Cell Physiol, 148, 157, 10.1002/jcp.1041480119 Kim, 2003, Fibroblasts from chronic wounds show altered TGF-beta-signaling and decreased TGF-beta Type II receptor expression, J Cell Physiol, 195, 331, 10.1002/jcp.10301 Kulkarni, 1993, Transforming growth factor β1 null mutation in mice causes excessive inflammatory responses and early death, Proc Natl Acad Sci USA, 90, 770, 10.1073/pnas.90.2.770 Lebre, 2007, Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9, J Invest Dermatol, 127, 331, 10.1038/sj.jid.5700530 Linke, 2009, The suppressor of cytokine signaling (SOCS)-3 determines keratinocyte proliferative and migratory potential during skin repair Loots, 2002, Fibroblasts derived from chronic diabetic ulcers differ in their response to stimulation with EGF, IGF-I, bFGF and PDGF-AB compared to controls, Eur J Cell Biol, 81, 153, 10.1078/0171-9335-00228 Loots, 1998, Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds, J Invest Dermatol, 111, 850, 10.1046/j.1523-1747.1998.00381.x Luster, 1998, Chemokines—chemotactic cytokines that mediate inflammation, N Engl J Med, 12, 436, 10.1056/NEJM199802123380706 Martin, 1997, Wound healing—aiming for perfect skin regeneration, Science, 276, 75, 10.1126/science.276.5309.75 Martin, 2005, Inflammatory cells during wound repair: the good, the bad and the ugly, Trends Cell Biol, 15, 599, 10.1016/j.tcb.2005.09.002 O'Neill, 2006, Targeting signal transduction as a strategy to treat inflammatory diseases, Nat Rev Drug Discov, 5, 549, 10.1038/nrd2070 O'Neill, 2006, How Toll-like receptors signal: what we know and what we don't know, Curr Opin Immunol, 18, 3, 10.1016/j.coi.2005.11.012 Pierce, 2001, Inflammation in nonhealing diabetic wounds. The space-time continuum does matter, Am J Pathol, 159, 399, 10.1016/S0002-9440(10)61709-9 Reiber, 1998, The burden of diabetic foot ulcers, Am J Surg, 176, 5, 10.1016/S0002-9610(98)00181-0 Rosner, 1995, Immunohistochemical characterization of the cutaneous cellular infiltrate in different areas of chronic leg ulcers, APMIS, 103, 293, 10.1111/j.1699-0463.1995.tb01109.x Sano, 2005, Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model, Nat Med, 11, 43, 10.1038/nm1162 Sano, 1999, Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis, EMBO J, 18, 4657, 10.1093/emboj/18.17.4657 Sellheyer, 1993, Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice, Proc Natl Acad Sci USA, 90, 5237, 10.1073/pnas.90.11.5237 Singer, 1999, Cutaneous wound healing, N Engl J Med, 341, 738, 10.1056/NEJM199909023411006 Stallmeyer, 1999, The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization, J Invest Dermatol, 113, 1090, 10.1046/j.1523-1747.1999.00784.x Stanley, 2005, Pressure-induced cellular senescence: a mechanism linking venous hypertension to venous ulcers, J Surg Res, 124, 112, 10.1016/j.jss.2004.09.013 Tokamura, 2005, SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration, Biochem Biophys Res Commun, 327, 100, 10.1016/j.bbrc.2004.11.145 Werner, 2003, Regulation of wound healing by growth factors and cytokines, Physiol Rev, 83, 835, 10.1152/physrev.2003.83.3.835 Wetzler, 2000, Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair, J Invest Dermatol, 115, 245, 10.1046/j.1523-1747.2000.00029.x Wormald, 2004, Inhibitors of cytokine signal transduction, J Biol Chem, 279, 821, 10.1074/jbc.R300030200 Xie, 1992, Cloning and characterization of inducible nitric oxide synthase from mouse macrophages, Science, 256, 225, 10.1126/science.1373522 Yamasaki, 2003, Suppressor of cytokine signaling 1/JAB and suppressor of cytokine signaling 3/cytokine-inducible SH2 containing protein 3 negatively regulate the signal transducers and activators of transcription signaling pathway in normal human epidermal keratinocytes, J Invest Dermatol, 120, 571, 10.1046/j.1523-1747.2003.12100.x Zhu, 2008, SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healing, J Invest Dermatol, 128, 1821, 10.1038/sj.jid.5701224