Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma

Neuro-Oncology - Tập 16 Số 7 - Trang 960-970 - 2014
Shinji Kohsaka1,2,3, Kunihiko Hinohara1,2,3, Lei Wang1,2,3, Tatsunori Nishimura1,2,3, Masana Urushido1,2,3, Kazuhiro Yachi1,2,3, Masumi Tsuda1,2,3, Mishie Tanino1,2,3, Taichi Kimura1,2,3, Hiroshi Nishihara1,2,3, Noriko Gotoh1,2,3, Shinya Tanaka1,2,3
1Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan (S.K., M.U., K.Y., M.T., M.T., T.K., S.T.)
2Department of Translational Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan (L.W., H.N.)
3Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, Tokyo, Japan (K.H., T.N., N.G.)

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Louis, 2007, The 2007 WHO classification of tumours of the central nervous system, Acta Neuropathol, 114, 97, 10.1007/s00401-007-0243-4

Van Meir, 2010, Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma, CA Cancer J Clin, 60, 166, 10.3322/caac.20069

Mrugala, 2008, Mechanisms of disease: temozolomide and glioblastoma—look to the future, Nat Clin Pract Oncol, 5, 476, 10.1038/ncponc1155

Stupp, 2005, Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma, N Engl J Med, 352, 987, 10.1056/NEJMoa043330

Network TCGAR, 2008, Comprehensive genomic characterization defines human glioblastoma genes and core pathways, Nature, 455, 1061, 10.1038/nature07385

Phillips, 2006, Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis, Cancer Cell, 9, 157, 10.1016/j.ccr.2006.02.019

Wick, 2011, Pathway inhibition: emerging molecular targets for treating glioblastoma, Neuro Oncol, 13, 566, 10.1093/neuonc/nor039

Reya, 2001, Stem cells, cancer, and cancer stem cells, Nature, 414, 105, 10.1038/35102167

Liu, 2013, The multiple roles for Sox2 in stem cell maintenance and tumorigenesis, Cell Signal, 25, 1264, 10.1016/j.cellsig.2013.02.013

Lathia, 2010, Integrin alpha 6 regulates glioblastoma stem cells, Cell Stem Cell, 6, 421, 10.1016/j.stem.2010.02.018

Ogden, 2008, Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas, Neurosurgery, 62, 505, 10.1227/01.neu.0000316019.28421.95

Read, 2009, Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma, Cancer Cell, 15, 135, 10.1016/j.ccr.2008.12.016

Son, 2009, SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma, Cell Stem Cell, 4, 440, 10.1016/j.stem.2009.03.003

Bao, 2008, Targeting cancer stem cells through L1CAM suppresses glioma growth, Cancer Res, 68, 6043, 10.1158/0008-5472.CAN-08-1079

Galli, 2004, Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma, Cancer Res, 64, 7011, 10.1158/0008-5472.CAN-04-1364

Singh, 2004, Identification of human brain tumour initiating cells, Nature, 432, 396, 10.1038/nature03128

Tabu, 2010, Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks, Mol Cancer, 9, 39, 10.1186/1476-4598-9-39

Brescia, 2012, Current strategies for identification of glioma stem cells: adequate or unsatisfactory?, J Oncol, 2012, 376894, 10.1155/2012/376894

Verhaak, 2010, Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1, Cancer Cell, 17, 98, 10.1016/j.ccr.2009.12.020

Eltarhouny, 2008, Genes controlling spread of breast cancer to lung “gang of 4.”, Exp Oncol, 30, 91

Komurasaki, 1997, Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4, Oncogene, 15, 2841, 10.1038/sj.onc.1201458

Inatomi, 2006, Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts, Int J Mol Med, 18, 497

Gupta, 2007, Mediators of vascular remodelling co-opted for sequential steps in lung metastasis, Nature, 446, 765, 10.1038/nature05760

Lee, 2004, Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage, Mol Cell Biol, 24, 8907, 10.1128/MCB.24.20.8907-8916.2004

Yun, 2012, Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers, Lab Invest, 92, 1033, 10.1038/labinvest.2012.61

Jin, 2011, EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction, Cancer Res, 71, 7125, 10.1158/0008-5472.CAN-11-1330

Mazzoleni, 2010, Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis, Cancer Res, 70, 7500, 10.1158/0008-5472.CAN-10-2353

Bleau, 2009, PTEN/PI3 K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells, Cell Stem Cell, 4, 226, 10.1016/j.stem.2009.01.007

Hambardzumyan, 2008, PI3 K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo, Genes Dev, 22, 436, 10.1101/gad.1627008

Zhu, 2013, Moesin is a glioma progression marker that induces proliferation and Wnt/beta-catenin pathway activation via interaction with CD44, Cancer Res, 73, 1142, 10.1158/0008-5472.CAN-12-1040

De Bacco, 2012, The MET oncogene is a functional marker of a glioblastoma stem cell subtype, Cancer Res, 72, 4537, 10.1158/0008-5472.CAN-11-3490

Guryanova, 2011, Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3, Cancer Cell, 19, 498, 10.1016/j.ccr.2011.03.004

Sherry, 2009, STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells, Stem Cells, 27, 2383, 10.1002/stem.185

Ikushima, 2009, Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors, Cell Stem Cell, 5, 504, 10.1016/j.stem.2009.08.018

Fassl, 2012, Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1, Oncogene, 31, 4698, 10.1038/onc.2011.615

Fan, 2010, NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts, Stem Cells, 28, 5, 10.1002/stem.254

Hinohara, 2012, ErbB receptor tyrosine kinase/NF-kappaB signaling controls mammosphere formation in human breast cancer, Proc Natl Acad Sci U S A, 109, 6584, 10.1073/pnas.1113271109

de Groot, 2008, Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma, J Neurooncol, 90, 89, 10.1007/s11060-008-9637-y

Peereboom, 2010, Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme, J Neurooncol, 98, 93, 10.1007/s11060-009-0067-2

Prados, 2009, Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma, J Clin Oncol, 27, 579, 10.1200/JCO.2008.18.9639

Reardon, 2010, Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma, J Neurooncol, 96, 219, 10.1007/s11060-009-9950-0

van den Bent, 2009, Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC Brain Tumor Group study 26034, J Clin Oncol, 27, 1268, 10.1200/JCO.2008.17.5984

Thiessen, 2010, A phase I/II trial of GW572016 (lapatinib) in recurrent glioblastoma multiforme: clinical outcomes, pharmacokinetics and molecular correlation, Cancer Chemother Pharmacol, 65, 353, 10.1007/s00280-009-1041-6

He, 1995, A eukaryotic transcriptional repressor with carboxypeptidase activity, Nature, 378, 92, 10.1038/378092a0

Ro, 1991, The C/EBP-binding region and adjacent sites regulate expression of the adipose P2 gene in human preadipocytes, Mol Cell Biol, 11, 2303, 10.1128/MCB.11.4.2303

Ladha, 2012, Identification of genomic targets of transcription factor Aebp1 and its role in survival of glioma cells, Mol Cancer Res, 10, 1039, 10.1158/1541-7786.MCR-11-0488

Akagi, 2003, Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation, Proc Natl Acad Sci U S A, 100, 13567, 10.1073/pnas.1834876100

Kohsaka, 2011, A population of BJ fibroblasts escaped from Ras-induced senescence susceptible to transformation, Biochem Biophys Res Commun, 410, 878, 10.1016/j.bbrc.2011.06.082