Epigenetic regulation of p14 and p16 expression in cutaneous and uveal melanoma

van den Bosch, 2010, Genetics of uveal melanoma and cutaneous melanoma: two of a kind?, Dermatol. Res. Pract., 2010, 360136, 10.1155/2010/360136

Caffo, 2013, Innovative therapeutic strategies in the treatment of brain metastases, Int. J. Mol. Sci., 14, 2135, 10.3390/ijms14012135

Bataille, 2013, Sun exposure, sunbeds and sunscreens and melanoma. What are the controversies?, Curr. Oncol. Rep., 15, 526, 10.1007/s11912-013-0342-4

Kessides, 2011, Cigarette smoking and malignant melanoma: a case–control study, J. Am. Acad. Dermatol., 64, 84, 10.1016/j.jaad.2010.01.041

Roszkowska, 2013, Contact lens wearing and chronic cigarette smoking positively correlate with TGF-β1 and VEGF tear levels and impaired corneal wound healing after photorefractive keratectomy, Curr. Eye Res., 38, 335, 10.3109/02713683.2012.745880

van den Hurk, 2012, Genetics and epigenetics of cutaneous malignant melanoma: a concert out of tune, Biochim. Biophys. Acta, 1826, 89

Merhavi, 2007, Promoter methylation status of multiple genes in uveal melanoma, Invest. Ophthalmol. Vis. Sci., 48, 4403, 10.1167/iovs.07-0272

Tannapfel, 2001, INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas, Oncogene, 20, 7104, 10.1038/sj.onc.1204902

Burri, 2001, Methylation silencing and mutations of the p14ARF and 16INK4a genes in colon cancer, Lab. Investig., 81, 217, 10.1038/labinvest.3780230

Shahnavaz, 2001, Patterns of CDKN2A gene loss in sequential oral epithelial dysplasias and carcinomas, Cancer Res., 61, 2371

Hashemi, 2002, A melanoma-predisposing germline CDKN2A mutation with functional significance for both p16 and p14ARF, Cancer Lett., 180, 211, 10.1016/S0304-3835(02)00027-7

Freedberg, 2008, Frequent p16-independent inactivation of p14ARF in human melanoma, J. Natl. Cancer Inst., 100, 784, 10.1093/jnci/djn157

Gonzalgo, 1997, Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors, Cancer Res., 57, 5336

Fujimoto, 1999, p16INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma, Oncogene, 18, 2527, 10.1038/sj.onc.1202803

Tellez, 2009, CpG island methylation profiling in human melanoma cell lines, Melanoma Res., 19, 146, 10.1097/CMR.0b013e32832b274e

Jonsson, 2010, High frequency of p16(INK4A) promoter methylation in NRAS-mutated cutaneous melanoma, J. Investig. Dermatol., 130, 2809, 10.1038/jid.2010.216

van der Velden, 2001, Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma, Cancer Res., 61, 5303

Edmunds, 2002, Mutational analysis of selected genes in the TGFbeta, Wnt, pRb, and p53 pathways in primary uveal melanoma, Invest. Ophthalmol. Vis. Sci., 43, 2845

Zeschnigk, 2003, Methylation analysis of several tumour suppressor genes shows a low frequency of methylation of CDKN2A and RARB in uveal melanomas, Comp. Funct. Genom., 4, 329, 10.1002/cfg.295

Moulin, 2008, Methylation of CpG island promoters in uveal melanoma, Br. J. Ophthalmol., 92, 281, 10.1136/bjo.2007.127035

Sigalotti, 2010, Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies, J. Transl. Med., 8, 56, 10.1186/1479-5876-8-56

Landreville, 2012, Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma, Clin. Cancer Res., 18, 408, 10.1158/1078-0432.CCR-11-0946

Venza, 2013, Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells, Pigment Cell Melanoma Res., 26, 193, 10.1111/pcmr.12049

Ou, 2007, The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1, EMBO J., 26, 3968, 10.1038/sj.emboj.7601825

Hara, 1996, Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence, Mol. Cell. Biol., 16, 859, 10.1128/MCB.16.3.859

Venza, 2011, Interleukin-8 overexpression in astrocytomas is induced by prostaglandin E2 and is associated with the transcription factors CCAAT/enhancer-binding protein-β and CCAAT/enhancer-binding homologous protein, Neurosurgery, 69, 713, 10.1227/NEU.0b013e31821954c6

Pérot, 2010, Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex genetics, Am. J. Pathol., 177, 2080, 10.2353/ajpath.2010.100104

Esteller, 2000, Hypermethylation-associated inactivation of p14ARF is independent of p16INK4a methylation and p53 mutational status, Cancer Res., 60, 129

Herman, 1996, Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands, Proc. Natl. Acad. Sci. U. S. A., 93, 9821, 10.1073/pnas.93.18.9821

Xu, 2006, Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of mu- and m-calpains, J. Biol. Chem., 281, 35567, 10.1074/jbc.M607702200

Riker, 2008, The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis, BMC Med Genom., 28

Sharpless, 1999, The INK4A/ARF locus and its two gene products, Curr. Opin. Genet. Dev., 9, 22, 10.1016/S0959-437X(99)80004-5

Chang, 2013, Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells, Clin. Cancer Res., 19, 549, 10.1158/1078-0432.CCR-12-0032

Merbs, 1999, Analysis of p16 (CDKN2/MTS-1/INK4A) alterations in primary sporadic uveal melanoma, Invest. Ophthalmol. Vis. Sci., 40, 779

Lamperska, 2002, Expression of p16 in sporadic primary uveal melanoma, Acta Biochim. Pol., 49, 377, 10.18388/abp.2002_3796

Stone, 1995, Complex structure and regulation of the P16 (MTS1) locus, Cancer Res., 55, 2988

Sharpless, 2003, The INK4a/ARF locus and melanoma, Oncogene, 22, 3092, 10.1038/sj.onc.1206461

Hearle, 2003, Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma, Invest. Ophthalmol. Vis. Sci., 44, 458, 10.1167/iovs.02-0026

Buecher, 2010, Contribution of CDKN2A/P16 (INK4A), P14 (ARF), CDK4 and BRCA1/2 germline mutations in individuals with suspected genetic predisposition to uveal melanoma, Familial Cancer, 9, 663, 10.1007/s10689-010-9379-9

Furuta, 2004, Promoter methylation profiling of 30 genes in human malignant melanoma, Cancer Sci., 23, 4014

Straume, 2002, Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase, Am. J. Pathol., 161, 229, 10.1016/S0002-9440(10)64174-0

Yuan, 2013, Long-term cadmium exposure leads to the enhancement of lymphocyte proliferation via down-regulating p16 by DNA hypermethylation, Mutat. Res., 757, 125, 10.1016/j.mrgentox.2013.07.007

Straume, 2000, Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma, Clin. Cancer Res., 6, 1845

Dreidax, 2013, Low p14ARF expression in neuroblastoma cells is associated with repressed histone mark status, and enforced expression induces growth arrest and apoptosis, Hum. Mol. Genet., 22, 1735, 10.1093/hmg/ddt020

Lu, 2012, Inhibition of breast tumor cell growth by ectopic expression of p16/INK4A via combined effects of cell cycle arrest, senescence and apoptotic induction, and angiogenesis inhibition, J. Cancer, 3, 333, 10.7150/jca.4046

Fung, 2013, p16(INK) (4a) deficiency promotes DNA hyper-replication and genetic instability in melanocytes, Pigment Cell Melanoma Res., 26, 236, 10.1111/pcmr.12062