Epigenetic regulation and fetal programming

Christine Gicquel1, Assam El‐Osta1, Yves Le Bouc2
1Epigenetics in Human Health and Disease, Baker Medical Research Institute, 75 Commercial Road, Melbourne, 3004 Victoria, Australia
2APHP-UPMC, Hôpital Armand Trousseau, Laboratoire d'Explorations Fonctionnelles Endocriniennes; INSERM U.515, Paris, France

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McMillen, 2005, Developmental origins of the metabolic syndrome: prediction, plasticity, and programming, Physiological Reviews, 85, 571, 10.1152/physrev.00053.2003

Gluckman, 2007, Early life events and their consequences for later disease: a life history and evolutionary perspective, American Journal of Human Biology, 19, 1, 10.1002/ajhb.20590

Neel, 1962, Diabetes mellitus: a ‘thrifty’ genotype rendered detrimental by ‘progress’?, American Journal of Human Genetics, 14, 353

Hales, 1992, Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis, Diabetologia, 35, 595, 10.1007/BF00400248

Barker, 1993, Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth, Diabetologia, 36, 62, 10.1007/BF00399095

Gluckman, 2004, Living with the past: evolution, development, and patterns of disease, Science, 305, 1733, 10.1126/science.1095292

Bateson, 2004, Developmental plasticity and human health, Nature, 430, 419, 10.1038/nature02725

Gluckman, 2005, Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studies, Proceedings. Biological Sciences, 272, 671, 10.1098/rspb.2004.3001

Gluckman, 2007, Developmental plasticity and human disease: research directions, Journal of Internal Medicine, 261, 461, 10.1111/j.1365-2796.2007.01802.x

Fowden, 2006, Intrauterine programming of physiological systems: causes and consequences, Physiology (Bethesda, Md.), 21, 29, 10.1152/physiol.00050.2005

Roseboom, 2006, The Dutch famine and its long-term consequences for adult health, Early Human Development, 82, 485, 10.1016/j.earlhumdev.2006.07.001

Fowden, 2005, Endocrine and metabolic programming during intrauterine development, Early Human Development, 81, 723, 10.1016/j.earlhumdev.2005.06.007

Karlberg, 1997, The timing of early postnatal catch-up growth in normal, full-term infants born short for gestational age, Hormone Research, 48, 17, 10.1159/000191279

Ong, 2000, Association between postnatal catch-up growth and obesity in childhood: prospective cohort study, BMJ (Clinical Research Ed.), 320, 967, 10.1136/bmj.320.7240.967

Jaquet, 2000, Insulin resistance early in adulthood in subjects born with intrauterine growth retardation, The Journal of Clinical Endocrinology and Metabolism, 85, 1401, 10.1210/jc.85.4.1401

Huxley, 2000, The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature, Journal of Hypertension, 18, 815, 10.1097/00004872-200018070-00002

Seckl, 2004, Prenatal glucocorticoids and long-term programming, European Journal of Endocrinology/European Federation of Endocrine Societies, 151, U49, 10.1530/eje.0.151U049

Matthews, 2002, Early programming of the hypothalamo-pituitary-adrenal axis, Trends in Endocrinology and Metabolism, 13, 373, 10.1016/S1043-2760(02)00690-2

Lesage, 2001, Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat, Endocrinology, 142, 1692, 10.1210/en.142.5.1692

Fowden, 2001, Intra-uterine programming of the endocrine pancreas, British Medical Bulletin, 60, 123, 10.1093/bmb/60.1.123

Petrik, 1998, Apoptosis in the pancreatic islet cells of the neonatal rat is associated with a reduced expression of insulin-like growth factor II that may act as a survival factor, Endocrinology, 139, 2994, 10.1210/en.139.6.2994

Boujendar, 2002, Taurine supplementation to a low protein diet during fetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets, Diabetologia, 45, 856, 10.1007/s00125-002-0833-6

Ozanne, 2002, Early programming of glucose-insulin metabolism, Trends in Endocrinology and Metabolism, 13, 368, 10.1016/S1043-2760(02)00666-5

Gicquel, 2006, Hormonal regulation of fetal growth, Hormone Research, 65, 28, 10.1159/000091503

Heude, 2007, Study of association between common variation in the IGF2 gene and indices of obesity and body size in middle-age men and women, The Journal of Clinical Endocrinology and Metabolism, 92, 2734, 10.1210/jc.2006-1948

Murrell, 2004, An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype, Human Molecular Genetics, 13, 247, 10.1093/hmg/ddh013

Petry, 2005, Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood height, Growth Hormone & IGF Research, 15, 363, 10.1016/j.ghir.2005.07.003

Gaunt, 2001, Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males, Human Molecular Genetics, 10, 1491, 10.1093/hmg/10.14.1491

Roth, 2002, IGF2 genotype and obesity in men and women across the adult age span, International Journal of Obesity and Related Metabolic Disorders, 26, 585, 10.1038/sj.ijo.0801927

Petry, 2005, Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans, BMC Genetics, 6, 22, 10.1186/1471-2156-6-22

Fowden, 2003, The insulin-like growth factors and feto-placental growth, Placenta, 24, 803, 10.1016/S0143-4004(03)00080-8

Arends, 2002, Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA), The Journal of Clinical Endocrinology and Metabolism, 87, 2720, 10.1210/jc.87.6.2720

Vaessen, 2002, Association between genetic variation in the gene for insulin-like growth factor-I and low birthweight, Lancet, 359, 1036, 10.1016/S0140-6736(02)08067-4

Johnston, 2003, Association between insulin-like growth factor I (IGF-I) polymorphisms, circulating IGF-I, and pre- and postnatal growth in two European small for gestational age populations, The Journal of Clinical Endocrinology and Metabolism, 88, 4805, 10.1210/jc.2003-030563

Frayling, 2002, A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations, Diabetes, 51, 2313, 10.2337/diabetes.51.7.2313

Hattersley, 1999, The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease, Lancet, 353, 1789, 10.1016/S0140-6736(98)07546-1

Frayling, 2001, The role of genetic susceptibility in the association of low birth weight with type 2 diabetes, British Medical Bulletin, 60, 89, 10.1093/bmb/60.1.89

Hattersley, 1998, Mutations in the glucokinase gene of the fetus result in reduced birth weight, Nature Genetics, 19, 268, 10.1038/953

Eriksson, 2002, The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth, Diabetes, 51, 2321, 10.2337/diabetes.51.7.2321

Dunger, 2006, Genetic variations and normal fetal growth, Hormone Research, 65, 34, 10.1159/000091504

Le Stunff, 2000, The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity, Nature Genetics, 26, 444, 10.1038/82579

Le Fur, 2006, Heterogeneity of class I INS VNTR allele association with insulin secretion in obese children, Physiological Genomics, 25, 480, 10.1152/physiolgenomics.00311.2005

Le Stunff, 2001, Paternal transmission of the very common class I INS VNTR alleles predisposes to childhood obesity, Nature Genetics, 29, 96, 10.1038/ng707

Waterland, 2004, Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases, Nutrition, 20, 63, 10.1016/j.nut.2003.09.011

Feil, 2006, Environmental and nutritional effects on the epigenetic regulation of genes, Mutation Research, 600, 46, 10.1016/j.mrfmmm.2006.05.029

Jaenisch, 2003, Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals, Nature Genetics, 33, 245, 10.1038/ng1089

Jirtle, 2007, Environmental epigenomics and disease susceptibility, Nature Reviews. Genetics, 8, 253, 10.1038/nrg2045

Godfrey, 2007, Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease, Pediatric Research, 61, 5R, 10.1203/pdr.0b013e318045bedb

Vickaryous, 2005, The role of early embryonic environment on epigenotype and phenotype, Reproduction, Fertility, and Development, 17, 335, 10.1071/RD04133

Egger, 2004, Epigenetics in human disease and prospects for epigenetic therapy, Nature, 429, 457, 10.1038/nature02625

Reik, 2001, Genomic imprinting: parental influence on the genome, Nature Reviews. Genetics, 2, 21, 10.1038/35047554

El-Osta, 2004, Understanding the consequences of epigenetic mechanisms and its effects on transcription in health and disease, Cancer Biology & Therapy, 3, 816, 10.4161/cbt.3.9.1100

Wassenegger, 2005, The role of the RNAi machinery in heterochromatin formation, Cell, 122, 13, 10.1016/j.cell.2005.06.034

Harikrishnan, 2005, Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing, Nature Genetics, 37, 254, 10.1038/ng1516

Delaval, 2004, Epigenetic regulation of mammalian genomic imprinting, Current Opinion in Genetics & Development, 14, 188, 10.1016/j.gde.2004.01.005

Constancia, 2002, Placental-specific IGF-II is a major modulator of placental and fetal growth, Nature, 417, 945, 10.1038/nature00819

Constancia, 2005, Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems, Proceedings of the National Academy of Sciences of the United States of America, 102, 19219, 10.1073/pnas.0504468103

Angiolini, 2006, Regulation of placental efficiency for nutrient transport by imprinted genes, Placenta, 27, S98, 10.1016/j.placenta.2005.12.008

Fowden, 2006, Programming placental nutrient transport capacity, The Journal of Physiology, 572, 5, 10.1113/jphysiol.2005.104141

Reik, 2001, Epigenetic reprogramming in mammalian development, Science, 293, 1089, 10.1126/science.1063443

Gicquel, 2005, Epimutation of the telomeric imprinting center region on chromosome 11p15 in Silver–Russell syndrome, Nature Genetics, 37, 1003, 10.1038/ng1629

Gaston, 2001, Analysis of the methylation status of the KCNQ1OT and H19 genes in leukocyte DNA for the diagnosis and prognosis of Beckwith–Wiedemann syndrome, European Journal of Human Genetics, 9, 409, 10.1038/sj.ejhg.5200649

Poulsen, 2007, The epigenetic basis of twin discordance in age-related diseases, Pediatric Research, 61, 38R, 10.1203/pdr.0b013e31803c7b98

Fraga, 2005, Epigenetic differences arise during the lifetime of monozygotic twins, Proceedings of the National Academy of Sciences of the United States of America, 102, 10604, 10.1073/pnas.0500398102

Wong, 2005, Phenotypic differences in genetically identical organisms: the epigenetic perspective, Human Molecular Genetics, 14 Spec No 1, R11, 10.1093/hmg/ddi116

Kant, 2005, Monozygous triplets discordant for transient neonatal diabetes mellitus and for imprinting of the TNDM differentially methylated region, Human Genetics, 117, 398, 10.1007/s00439-005-1304-1

Weksberg, 2002, Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith–Wiedemann syndrome, Human Molecular Genetics, 11, 1317, 10.1093/hmg/11.11.1317

Khosla, 2001, Culture of preimplantation embryos and its long-term effects on gene expression and phenotype, Human Reproduction Update, 7, 419, 10.1093/humupd/7.4.419

Doherty, 2000, Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo, Biology of Reproduction, 62, 1526, 10.1095/biolreprod62.6.1526

Khosla, 2001, Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes, Biology of Reproduction, 64, 918, 10.1095/biolreprod64.3.918

Mann, 2004, Selective loss of imprinting in the placenta following preimplantation development in culture, Development, 131, 3727, 10.1242/dev.01241

Young, 2001, Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture, Nature Genetics, 27, 153, 10.1038/84769

Gicquel, 2003, In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene, American Journal of Human Genetics, 72, 1338, 10.1086/374824

Arnaud, 2005, Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction, Birth Defects Research. Part C, Embryo Today, 75, 81, 10.1002/bdrc.20039

Rossignol, 2006, The epigenetic imprinting defect of Beckwith-Wiedemann patients born following assisted reproductive technology is not restricted to the 11p15 region, Journal of Medical Genetics, 43, 902, 10.1136/jmg.2006.042135

MacLennan, 2004, Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats, Physiological Genomics, 18, 43, 10.1152/physiolgenomics.00042.2004

Lillycrop, 2005, Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring, The Journal of Nutrition, 135, 1382, 10.1093/jn/135.6.1382

Lillycrop, 2007, Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications, The British Journal of Nutrition, 97, 1, 10.1017/S000711450769196X

Weaver, 2004, Epigenetic programming by maternal behavior, Nature Neuroscience, 7, 847, 10.1038/nn1276

Meaney, 2007, Epigenetic mechanisms of perinatal programming of hypothalamic–pituitary–adrenal function and health, Trends in Molecular Medicine, 13, 269, 10.1016/j.molmed.2007.05.003

Pham, 2003, Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 285, R962, 10.1152/ajpregu.00201.2003

Waterland, 2003, Transposable elements: targets for early nutritional effects on epigenetic gene regulation, Molecular and Cellular Biology, 23, 5293, 10.1128/MCB.23.15.5293-5300.2003

Dolinoy, 2006, Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome, Environmental Health Perspectives, 114, 567, 10.1289/ehp.8700

Waterland, 2006, Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus, Human Molecular Genetics, 15, 705, 10.1093/hmg/ddi484

Ingrosso, 2003, Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia, Lancet, 361, 1693, 10.1016/S0140-6736(03)13372-7

Drake, 2004, The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk, The Journal of Endocrinology, 180, 1, 10.1677/joe.0.1800001

Gluckman, 2007, Non-genomic transgenerational inheritance of disease risk, Bioessays, 29, 145, 10.1002/bies.20522

Stewart, 1975, Twelve generations of marginal protein deficiency, The British Journal of Nutrition, 33, 233, 10.1079/BJN19750027

Drake, 2005, Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 288, R34, 10.1152/ajpregu.00106.2004

Chong, 2004, Epigenetic germline inheritance, Current Opinion in Genetics & Development, 14, 692, 10.1016/j.gde.2004.09.001

Morgan, 1999, Epigenetic inheritance at the agouti locus in the mouse, Nature Genetics, 23, 314, 10.1038/15490

Lane, 2003, Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse, Genesis, 35, 88, 10.1002/gene.10168

Anway, 2005, Epigenetic transgenerational actions of endocrine disruptors and male fertility, Science, 308, 1466, 10.1126/science.1108190

Chong, 2007, Heritable germline epimutation is not the same as transgenerational epigenetic inheritance, Nature Genetics, 39, 574, 10.1038/ng0507-574

Vickers, 2005, Neonatal leptin treatment reverses developmental programming, Endocrinology, 146, 4211, 10.1210/en.2005-0581