Epigenetic Priming of Enhancers Predicts Developmental Competence of hESC-Derived Endodermal Lineage Intermediates

Cell Stem Cell - Tập 16 - Trang 386-399 - 2015
Allen Wang1,2, Feng Yue3, Yan Li4, Ruiyu Xie1,2, Thomas Harper1,2, Nisha A. Patel1,2, Kayla Muth1,2, Jeffrey Palmer1,2, Yunjiang Qiu4, Jinzhao Wang1,2, Dieter K. Lam1,2, Jeffrey C. Raum5, Doris A. Stoffers5, Bing Ren4,6,7,8, Maike Sander1,2,6,7,8
1Pediatric Diabetes Research Center, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093-0983, USA
2Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA
3Department of Biochemistry and Molecular Biology, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA
4Ludwig Institute for Cancer Research, La Jolla, CA 92093-0653, USA
5Division of Endocrinology, Diabetes, and Metabolism, Institute for Diabetes, Obesity and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
6Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA
7Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA 92093-0761, USA
8Moores Cancer Center, University of California San Diego, La Jolla, CA 92093-0653, USA

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