Epidermal self-powered sweat sensors for glucose and lactate monitoring
Tóm tắt
Sweat could be a carrier of informative biomarkers for health status identification; therefore, wearable sweat sensors have attracted significant attention for research. An external power source is an important component of wearable sensors, however, the current power supplies, i.e., batteries, limit further shrinking down the size of these devices and thus limit their application areas and scenarios. Herein, we report a stretchable self-powered biosensor with epidermal electronic format that enables the in situ detection of lactate and glucose concentration in sweat. Enzymatic biofuel cells serve as self-powered sensing modules allowing the sweat sensor to exhibit a determination coefficient (R2) of 0.98 with a sensitivity of 2.48 mV/mM for lactate detection, and R2 of 0.96 with a sensitivity of 0.11 mV/μM for glucose detection. The microfluidic channels developed in an ultra-thin soft flexible polydimethylsiloxane layer not only enable the effective collection of sweat, but also provide excellent mechanical properties with stable performance output even under 30% stretching. The presented soft sweat sensors can be integrated at nearly any location of the body for the continuous monitoring of lactate and glucose changes during normal daily activities such as exercise. Our results provide a promising approach to develop next-generation sweat sensors for real-time and in situ sweat analysis.
Tài liệu tham khảo
Crawford KE, Ma YJ, krishnan S, et al (2018) Advanced approaches for quantitative characterization of thermal transport properties in soft materials using thin, conformable resistive sensors. Extreme Mech Lett 22:27–35. https://doi.org/10.1016/j.eml.2018.04.002
Schwartz G, Tee CKB, Mei J et al (2013) Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring. Nat Commun 4:1859
Chung HU, Bong HK, Jong YL et al (2019) Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care. Science 363:6430. https://doi.org/10.1126/science.aau0780
Li D, Yao K, Gao Z et al (2021) Recent progress of skin-integrated electronics for intelligent sensing. Light Adv Manuf 2:1–20
Bandodkar AJ, Gutruf P, Choi J et al (2019) Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat. Sci Adv. https://doi.org/10.1126/sciadv.aav3294
Gao W, Emaminejad S, Nyein HYY et al (2016) Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature 529:509–514. https://doi.org/10.1038/nature16521
Koh A, Kang D, Xue Y et al (2016) A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat. Sci Transl Med. https://doi.org/10.1126/scitranslmed.aaf2593
He W, Wang C, Wang H et al (2019) Integrated textile sensor patch for real-time and multiplex sweat analysis. Sci Adv. https://doi.org/10.1126/sciadv.aax0649
Yu Y, Nassar J, Xu C et al (2020) Biofuel-powered soft electronic skin with multiplexed and wireless sensing for human–machine interfaces. Sci Robot 5:41. https://doi.org/10.1126/scirobotics.aaz7946
Huang X, Zhang L, Zhang Z et al (2019) Wearable biofuel cells based on the classification of enzyme for high power outputs and lifetimes. Biosens Bioelectron 124–125:40–52. https://doi.org/10.1016/j.bios.2018.09.086
Yu X, Xie Z, Rogers JA et al (2019) Skin-integrated wireless haptic interfaces for virtual and augmented reality. Nature 575:473–479. https://doi.org/10.1038/s41586-019-1687-0
Liu Y, Zheng H, Zhao L et al (2020) Electronic skin from high-throughput fabrication of intrinsically stretchable lead zirconate titanate elastomer. Research. https://doi.org/10.34133/2020/1085417
Liu Y, Wang L, Zhao L et al (2020) Recent progress on flexible nanogenerators toward self-powered systems. Information 2:318–340. https://doi.org/10.1002/inf2.12079
Wu M, Gao Z, Hou S et al (2021) Thin, soft, skin-integrated foam-based triboelectric nanogenerators for tactile sensing and energy harvesting. Mater Today Energy 20:100657. https://doi.org/10.1016/j.mtener.2021.100657
Yao K, Liu Y, Li D et al (2020) Mechanics designs-performance relationships in epidermal triboelectric nanogenerators. Nano Energy 76:105017. https://doi.org/10.1016/j.nanoen.2020.105017
He J, Xie Z, Yao K et al (2021) Trampoline inspired stretchable triboelectric nanogenerators as tactile sensors for epidermal electronics. Nano Energy 81:105590. https://doi.org/10.1016/j.nanoen.2020.105590
Wang ZL, Song J (2006) Piezoelectric nanogenerators based on zinc oxide nanowire arrays. Science 312:242–246. https://doi.org/10.1126/science.1124005
Gao PX, Song JL, Wang ZL et al (2007) Nanowire piezoelectric nanogenerators on plastic substrates as flexible power sources for nanodevices. Adv Mater 19(1):67–72. https://doi.org/10.1002/adma.200601162
Yang L, Zhao Q, Chen K et al (2020) PVDF-based composition-gradient multilayered nanocomposites for flexible high-performance piezoelectric nanogenerators. ACS Appl Mater Interfaces 12(9):11045–11054. https://doi.org/10.1021/acsami.9b23480
Huang X, Zhang J, Su H et al (2021) Exploring the shape and distribution of electrodes in membraneless enzymatic biofuel cells for high power output. Int J Hydrogen Energy 46(33):17414–17420. https://doi.org/10.1016/j.ijhydene.2021.02.150
Zhang J, Huang X, Zhang L et al (2020) Layer-by-layer assembly for immobilizing enzymes in enzymatic biofuel cells. Sustain Energy Fuels 4:68–79. https://doi.org/10.1039/c9se00643e
Wu M, Yao K, Li D et al (2021) Self-powered skin electronics for energy harvesting and healthcare monitoring. Mater Today Energy. https://doi.org/10.1016/j.mtener.2021.100786
Jia W, Bandodkar JB, Valdés-Ramírez G et al (2013) Electrochemical tattoo biosensors for real-time noninvasive lactate monitoring in human perspiration. Anal Chem 85:6553–6560. https://doi.org/10.1021/ac401573r
Yang HW, Hua MY, Chen SL et al (2013) Reusable sensor based on high magnetization carboxyl-modified graphene oxide with intrinsic hydrogen peroxide catalytic activity for hydrogen peroxide and glucose detection. Biosens Bioelectron 41:172–179. https://doi.org/10.1016/j.bios.2012.08.008
Newman JD, Turner AP (2005) Home blood glucose biosensors: a commercial perspective. Biosens Bioelectron 20:2435–2453. https://doi.org/10.1016/j.bios.2004.11.012
Jeerapan I, Sempionatto JR, Wang J (2020) On-body bioelectronics: wearable biofuel cells for bioenergy harvesting and self-powered biosensing. Adv Func Mater 30:1906243. https://doi.org/10.1002/adfm.201906243
Ming Z, Wang J (2012) Biofuel cells for self-powered electrochemical biosensing and logic biosensing: a review. Electroanalysis 24:197–209. https://doi.org/10.1002/elan.201100631
Mercier P, Wang J (2020) Powered by sweat: throw out the batteries: biofuels will change the future of wearable devices. IEEE Spectr 57:28–33. https://doi.org/10.1109/MSPEC.2020.9126108
Ghaffari R, Choi J, Raj MS et al (2020) Soft wearable systems for colorimetric and electrochemical analysis of biofluids. Adv Funct Mater 30:37. https://doi.org/10.1002/adfm.201907269
Martin A, Kim J, Kurniawan JF et al (2017) Epidermal microfluidic electrochemical detection system: enhanced sweat sampling and metabolite detection. ACS Sens 2:1860–1868. https://doi.org/10.1021/acssensors.7b00729
Abellan-Llobregat A, Jeerapan I, Bandodkaret A et al (2017) A stretchable and screen-printed electrochemical sensor for glucose determination in human perspiration. Biosens Bioelectron 91:885–891. https://doi.org/10.1016/j.bios.2017.01.058
Kudo H, Sawada T, Kazawa E et al (2006) A flexible and wearable glucose sensor based on functional polymers with soft-MEMS techniques. Biosens Bioelectron 22:558–562. https://doi.org/10.1016/j.bios.2006.05.006
Gong S, Du S, Kong J et al (2020) Skin-like stretchable fuel cell based on gold-nanowire-impregnated porous polymer scaffolds. Small 16:e2003269. https://doi.org/10.1002/smll.202003269
Jia W, Valdés-Ramírez G, Bandodkar AJ et al (2013) Epidermal biofuel cells: energy harvesting from human perspiration. Angew Chem Int Ed Engl 52:7233–7236. https://doi.org/10.1002/anie.201302922
Yin S, Jin Z, Miyake T (2019) Wearable high-powered biofuel cells using enzyme/carbon nanotube composite fibers on textile cloth. Biosens Bioelectron 141:111471. https://doi.org/10.1016/j.bios.2019.111471
Zhang J, Liu J, Su H et al (2021) A wearable self-powered biosensor system integrated with diaper for detecting the urine glucose of diabetic patients. Sens Actu B Chem 341:130046. https://doi.org/10.1016/j.snb.2021.130046
Li D, Wang S, He J et al (2021) Bioinspired ultrathin piecewise controllable soft robots. Adv Mater Technol 6(5): 2001095. https://doi.org/10.1002/admt.202001095
Liu Y, Wang L, Zhao L et al (2019) Thin, skin-integrated, stretchable triboelectric nanogenerators for tactile sensing. Adv Electron Mater 6:1901174. https://doi.org/10.1002/aelm.201901174
Arumugam V, Naresh MD, Sanjeevi R (1994) Effect of strain-rate on the fracture-behavior of skin. J Biosci 19:307–313. https://doi.org/10.1007/Bf02716820
Gray H, Goss C (1973) Anatomy of the human body, 29th American ed. Lea Febiger 42:488–499. https://doi.org/10.1136/pgmj.42.493.734-b
Sonner Z, Wilder E, Heikenfeld J et al (2015) The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications. Biomicrofluidics 9:031301. https://doi.org/10.1063/1.4921039