Epidemiology of mobile colistin resistance (mcr) genes in aquatic environments

Marti, 2014, The role of aquatic ecosystems as reservoirs of antibiotic resistance, Trends Microbiol, 22, 36, 10.1016/j.tim.2013.11.001 Shlaes, 2018, Antibiotics—from there to where?, Pathog Immun, 3, 19, 10.20411/pai.v3i1.231 Berglund, 2015, Environmental dissemination of antibiotic resistance genes and correlation to anthropogenic contamination with antibiotics, Infect Ecol Epidemiol, 5, 28564 Allen, 2010, Call of the wild: antibiotic resistance genes in natural environments, Nat Rev Microbiol, 8, 251, 10.1038/nrmicro2312 Abat, 2018, Are we living in an antibiotic resistance nightmare?, Clin Microbiol Infect, 24, 568, 10.1016/j.cmi.2018.01.004 Nicolaou, 2018, A brief history of antibiotics and select advances in their synthesis, J Antibiot (Tokyo), 71, 153, 10.1038/ja.2017.62 Kuenzli, 2016, Antibiotic resistance and international travel: causes and consequences, Travel Med Infect Dis, 14, 595, 10.1016/j.tmaid.2016.11.010 Carvalho, 2016, Antibiotics in the aquatic environments: a review of the European scenario, Environ Int, 94, 736, 10.1016/j.envint.2016.06.025 Doi, 2017, The ecology of extended-spectrum β-lactamases (ESBLs) in the developed world, J Travel Med, 24, S44, 10.1093/jtm/taw102 Dhariwal, 2013, Colistin: re-emergence of the ‘forgotten’ antimicrobial agent, J Postgrad Med, 59, 208, 10.4103/0022-3859.118040 Biswas, 2012, Colistin: an update on the antibiotic of the 21st century, Expert Rev Anti Infect Ther, 10, 917, 10.1586/eri.12.78 Caniaux, 2017, MCR: modern colistin resistance, Eur J Clin Microbiol Infect Dis, 36, 415, 10.1007/s10096-016-2846-y Liu, 2016, Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study, Lancet Infect Dis, 16, 161, 10.1016/S1473-3099(15)00424-7 Baron, 2016, Molecular mechanisms of polymyxin resistance: knowns and unknowns, Int J Antimicrob Agents, 48, 583, 10.1016/j.ijantimicag.2016.06.023 Feng, 2018, Transferability of MCR-1/2 polymyxin resistance: complex dissemination and genetic mechanism, ACS Infect Dis, 4, 291, 10.1021/acsinfecdis.7b00201 Laxminarayan, 2016, Access to effective antimicrobials: a worldwide challenge, Lancet, 387, 168, 10.1016/S0140-6736(15)00474-2 Paschoal, 2017, Concentration and variety of carbapenemase producers in recreational coastal waters showing distinct levels of pollution, Antimicrob Agents Chemother, 61, 10.1128/AAC.01963-17 Toleman, 2015, Extensively drug-resistant New Delhi metallo-β-lactamase-encoding bacteria in the environment, Dhaka, Bangladesh, 2012, Emerg Infect Dis, 21, 1027, 10.3201/eid2106.141578 Jorgensen, 2017, First environmental sample containing plasmid-mediated colistin-resistant ESBL-producing Escherichia coli detected in Norway, APMIS, 125, 822, 10.1111/apm.12720 Sanderson, 2016, Antibiotic resistance genes as an emerging environmental contaminant, Environmental Reviews, 24, 205, 10.1139/er-2015-0069 Laurens, 2018, Transmission of IMI-2 carbapenemase-producing Enterobacteriaceae from river water to human, J Glob Antimicrob Resist, 15, 88, 10.1016/j.jgar.2018.06.022 Baquero, 2008, Antibiotics and antibiotic resistance in water environments, Curr Opin Biotechnol, 19, 260, 10.1016/j.copbio.2008.05.006 Hocquet, 2016, What happens in hospitals does not stay in hospitals: antibiotic-resistant bacteria in hospital wastewater systems, J Hosp Infect, 93, 395, 10.1016/j.jhin.2016.01.010 Pruden, 2013, Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment, Environ Health Perspect, 121, 878, 10.1289/ehp.1206446 Khedher, 2020, Massive analysis of 64,628 bacterial genomes to decipher water reservoir and origin of mobile colistin resistance genes: is there another role for these enzymes?, Sci Rep, 10, 5970, 10.1038/s41598-020-63167-5 Kieffer, 2017, Moraxella species as potential sources of MCR-like polymyxin resistance determinants, Antimicrob Agents Chemother, 61, 10.1128/AAC.00129-17 Snesrud, 2018, The birth and demise of the ISApl1–mcr-1–ISApl1 composite transposon: the vehicle for transferable colistin resistance, mBio, 9, 10.1128/mBio.02381-17 Zhang, 2019, Definition of a family of nonmobile colistin resistance (NMCR-1) determinants suggests aquatic reservoirs for MCR-4, Adv Sci (Weinh), 6 Zhang, 2019, Action and mechanism of the colistin resistance enzyme MCR-4, Commun Biol, 2, 36, 10.1038/s42003-018-0278-1 Manaia, 2016, Antibiotic resistance in urban aquatic environments: can it be controlled?, Appl Microbiol Biotechnol, 100, 1543, 10.1007/s00253-015-7202-0 Zhao, 2017, Remarkable diversity of Escherichia coli carrying mcr-1 from hospital sewage with the identification of two new mcr-1 variants, Front Microbiol, 8, 2094, 10.3389/fmicb.2017.02094 Haller, 2018, Occurrence and characteristics of extended-spectrum β-lactamase- and carbapenemase- producing bacteria from hospital effluents in Singapore, Sci Total Environ, 615, 1119, 10.1016/j.scitotenv.2017.09.217 Kümmerer, 2004, Resistance in the environment, J Antimicrob Chemother, 54, 311, 10.1093/jac/dkh325 Broom, 2017, The sub-inhibitory theory for antibiotic growth promoters, Poult Sci, 96, 3104, 10.3382/ps/pex114 Hong, 2013, Environmental and public health implications of water reuse: antibiotics, antibiotic resistant bacteria, and antibiotic resistance genes, Antibiotics (Basel), 2, 367, 10.3390/antibiotics2030367 Hoelzer, 2017, Antimicrobial drug use in food-producing animals and associated human health risks: what, and how strong, is the evidence?, BMC Vet Res, 13, 211, 10.1186/s12917-017-1131-3 Madec, 2017, Extended-spectrum β-lactamase/AmpC- and carbapenemase-producing Enterobacteriaceae in animals: a threat for humans?, Clin Microbiol Infect, 23, 826, 10.1016/j.cmi.2017.01.013 Olaitan, 2021, Banning colistin in feed additives: a small step in the right direction, Lancet Infect Dis, 21, 29, 10.1016/S1473-3099(20)30915-4 Shen, 2020, Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing-based molecular epidemiological study, Lancet Microbe, 1, e34, 10.1016/S2666-5247(20)30005-7 Usui, 2021, Decreased colistin resistance and mcr-1 prevalence in pig-derived Escherichia coli in Japan after banning colistin as a feed additive, J Glob Antimicrob Resist, 24, 383, 10.1016/j.jgar.2021.01.016 Wang, 2020, Changes in colistin resistance and mcr-1 abundance in Escherichia coli of animal and human origins following the ban of colistin-positive additives in China: an epidemiological comparative study, Lancet Infect Dis, 20, 1161, 10.1016/S1473-3099(20)30149-3 Kümmerer, 2009, Antibiotics in the aquatic environment—a review—part II, Chemosphere, 75, 435, 10.1016/j.chemosphere.2008.12.006 Rizzo, 2013, Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review, Sci Total Environ, 447, 345, 10.1016/j.scitotenv.2013.01.032 Michael-Kordatou, 2018, The role of operating parameters and oxidative damage mechanisms of advanced chemical oxidation processes in the combat against antibiotic-resistant bacteria and resistance genes present in urban wastewater, Water Res, 129, 208, 10.1016/j.watres.2017.10.007 Karkman, 2018, Antibiotic-resistance genes in waste water, Trends Microbiol, 26, 220, 10.1016/j.tim.2017.09.005 Vaz-Moreira, 2014, Bacterial diversity and antibiotic resistance in water habitats: searching the links with the human microbiome, FEMS Microbiol Rev, 38, 761, 10.1111/1574-6976.12062 Gao, 2018, Complex migration of antibiotic resistance in natural aquatic environments, Environ Pollut, 232, 1, 10.1016/j.envpol.2017.08.078 Manaia, 2018, Antibiotic resistance in wastewater treatment plants: tackling the black box, Environ Int, 115, 312, 10.1016/j.envint.2018.03.044 Barcelos, 2018, Emergence and dispersion of resistance genes by the aquatic environment: a review, Pollution, 4, 305 Santos, 2018, Antimicrobial resistance in aquaculture: current knowledge and alternatives to tackle the problem, Int J Antimicrob Agents, 52, 135, 10.1016/j.ijantimicag.2018.03.010 Cabello, 2017, Aquaculture and mcr colistin resistance determinants, mBio, 8, 10.1128/mBio.01229-17 Shen, 2020, Farm animals and aquaculture: significant reservoirs of mobile colistin resistance genes, Environ Microbiol, 22, 2469, 10.1111/1462-2920.14961 Zarfel, 2017, Troubled water under the bridge: screening of River Mur water reveals dominance of CTX-M harboring Escherichia coli and for the first time an environmental VIM-1 producer in Austria, Sci Total Environ, 593–594, 399, 10.1016/j.scitotenv.2017.03.138 Zurfluh, 2013, Characteristics of extended-spectrum β-lactamase- and carbapenemase-producing Enterobacteriaceae isolates from rivers and lakes in Switzerland, Appl Environ Microbiol, 79, 3021, 10.1128/AEM.00054-13 Diab, 2018, Extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing Enterobacteriaceae in water sources in Lebanon, Vet Microbiol, 217, 97, 10.1016/j.vetmic.2018.03.007 Drali, 2018, Emergence of mcr-1 plasmid-mediated colistin-resistant Escherichia coli isolates from seawater, Sci Total Environ, 642, 90, 10.1016/j.scitotenv.2018.05.387 Caltagirone, 2017, Occurrence of extended spectrum β-lactamases, KPC-type, and MCR-1.2-producing Enterobacteriaceae from wells, river water, and wastewater treatment plants in Oltrepo Pavese Area, Northern Italy, Front Microbiol, 8, 2232, 10.3389/fmicb.2017.02232 Zhang, 2009, Antibiotic resistance genes in water environment, Appl Microbiol Biotechnol, 82, 397, 10.1007/s00253-008-1829-z Rathinasabapathi, 2015, Molecular detection of New Delhi metallo-β-lactamase-1 (NDM-1) positive bacteria from environmental and drinking water samples by loop mediated isothermal amplification of blaNDM-1, Indian J Microbiol, 55, 400, 10.1007/s12088-015-0540-x Walsh, 2011, Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study, Lancet Infect Dis, 11, 355, 10.1016/S1473-3099(11)70059-7 Waglechner, 2017, Antibiotic resistance: it's bad, but why isn't it worse?, BMC Biol, 15, 84, 10.1186/s12915-017-0423-1 Fletcher, 2015, Understanding the contribution of environmental factors in the spread of antimicrobial resistance, Environ Health Prev Med, 20, 243, 10.1007/s12199-015-0468-0 Heuer, 2007, Horizontal gene transfer between bacteria, Environ Biosafety Res, 6, 3, 10.1051/ebr:2007034 Baur, 1996, Genetic transformation in freshwater: Escherichia coli is able to develop natural competence, Appl Environ Microbiol, 62, 3673, 10.1128/aem.62.10.3673-3678.1996 Arber, 2014, Horizontal gene transfer among bacteria and its role in biological evolution, Life (Basel), 4, 217 Kumar, 2013, An overview of mechanisms and emergence of antimicrobials drug resistance, Adv Anim Vet Sci, 1, 7 Subirats, 2016, Metagenomic analysis reveals that bacteriophages are reservoirs of antibiotic resistance genes, Int J Antimicrob Agents, 48, 163, 10.1016/j.ijantimicag.2016.04.028 Davies, 2010, Origins and evolution of antibiotic resistance, Microbiol Mol Biol Rev, 74, 417, 10.1128/MMBR.00016-10 Alanis, 2005, Resistance to antibiotics: are we in the post-antibiotic era?, Arch Med Res, 36, 697, 10.1016/j.arcmed.2005.06.009 Schwarz, 2016, Transferable resistance to colistin: a new but old threat, J Antimicrob Chemother, 71, 2066, 10.1093/jac/dkw274 Fernandes, 2017, Colistin-resistant mcr-1-positive Escherichia coli on public beaches, an infectious threat emerging in recreational waters, Antimicrob Agents Chemother, 61, 10.1128/AAC.00234-17 Sun, 2017, Occurrence of blaKPC-2, blaCTX-M, and mcr-1 in Enterobacteriaceae from well water in rural China, Antimicrob Agents Chemother, 61, 10.1128/AAC.02569-16 Lupo, 2012, Origin and evolution of antibiotic resistance: the common mechanisms of emergence and spread in water bodies, Front Microbiol, 3, 18, 10.3389/fmicb.2012.00018 Martínez, 2008, Antibiotics and antibiotic resistance genes in natural environments, Science, 321, 365, 10.1126/science.1159483 Yahav, 2012, Colistin: new lessons on an old antibiotic, Clin Microbiol Infect, 18, 18, 10.1111/j.1469-0691.2011.03734.x Li, 2005, Evaluation of colistin as an agent against multi-resistant Gram-negative bacteria, Int J Antimicrob Agents, 25, 11, 10.1016/j.ijantimicag.2004.10.001 El-Sayed Ahmed, 2020, Colistin and its role in the era of antibiotic resistance: an extended review (2000–2019), Emerg Microbes Infect, 9, 868, 10.1080/22221751.2020.1754133 Zhang, 2019, Genetic and biochemical mechanisms for bacterial lipid A modifiers associated with polymyxin resistance, Trends Biochem Sci, 44, 973, 10.1016/j.tibs.2019.06.002 Nordmann, 2016, Plasmid-mediated colistin resistance: an additional antibiotic resistance menace, Clin Microbiol Infect, 22, 398, 10.1016/j.cmi.2016.03.009 Zurfuh, 2016, Occurrence of the plasmid-borne mcr-1 colistin resistance gene in extended-spectrum-β-lactamase-producing Enterobacteriaceae in river water and imported vegetable samples in Switzerland, Antimicrob Agents Chemother, 60, 2594, 10.1128/AAC.00066-16 Yu, 2016, Emergence of mcr-1-mediated colistin resistance in Escherichia coli in Malaysia, Int J Antimicrob Agents, 47, 504, 10.1016/j.ijantimicag.2016.04.004 Yu, 2017, Complete genome sequencing revealed novel genetic contexts of the mcr-1 gene in Escherichia coli strains, J Antimicrob Chemother, 72, 1253 Zhao, 2016, Kluyvera ascorbata strain from hospital sewage carrying the mcr-1 colistin resistance gene, Antimicrob Agents Chemother, 60, 7498, 10.1128/AAC.01165-16 Runcharoen, 2017, Whole genome sequencing of ESBL-producing Escherichia coli isolated from patients, farm waste and canals in Thailand, Genome Med, 9, 81, 10.1186/s13073-017-0471-8 Islam, 2017, Colistin resistant Escherichia coli carrying mcr-1 in urban sludge samples: Dhaka, Bangladesh, Gut Pathog, 9, 77, 10.1186/s13099-017-0227-4 Ovejero, 2017, Spread of mcr-1-carrying Enterobacteriaceae in sewage water from Spain, J Antimicrob Chemother, 72, 1050 Chen, 2017, Widespread distribution of mcr-1-bearing bacteria in the ecosystem, 2015 to 2016, Euro Surveill, 22, 17, 10.2807/1560-7917.ES.2017.22.39.17-00206 Zhou, 2017, Occurrence of plasmid- and chromosome-carried mcr-1 in waterborne Enterobacteriaceae in China, Antimicrob Agents Chemother, 61, 10.1128/AAC.00017-17 Jin, 2018, Emergence of mcr-1 and carbapenemase genes in hospital sewage water in Beijing, China. J Antimicrob Chemother, 73, 84, 10.1093/jac/dkx355 Zhao, 2017, IncP plasmid carrying colistin resistance gene mcr-1 in Klebsiella pneumoniae from hospital sewage, Antimicrob Agents Chemother, 61, 10.1128/AAC.02229-16 Wu, 2018, Evidence for environmental dissemination of antibiotic resistance mediated by wild birds, Front Microbiol, 9, 745, 10.3389/fmicb.2018.00745 Tuo, 2018, The prevalence of colistin resistant strains and antibiotic resistance gene profiles in Funan River, China. Front Microbiol, 9, 3094, 10.3389/fmicb.2018.03094 Sacramento, 2018, Genomic analysis of MCR-1 and CTX-M-8 co-producing Escherichia coli ST58 isolated from a polluted mangrove ecosystem in Brazil, J Glob Antimicrob Resist, 15, 288, 10.1016/j.jgar.2018.10.024 Long, 2019, The co-transfer of plasmid-borne colistin-resistant genes mcr-1 and mcr-3.5, the carbapenemase gene blaNDM-5 and the 16S methylase gene rmtB from Escherichia coli, Sci Rep, 9, 696, 10.1038/s41598-018-37125-1 Schages, 2020, Winter is coming—impact of temperature on the variation of β-lactamase and mcr genes in a wastewater treatment plant, Sci Total Environ, 712, 10.1016/j.scitotenv.2020.136499 Falgenhauer, 2019, Multidrug-resistant and clinically relevant Gram-negative bacteria are present in German surface waters, Front Microbiol, 10, 2779, 10.3389/fmicb.2019.02779 Han, 2020, Co-existence of mcr-1 and blaNDM-5 in an Escherichia coli strain isolated from the pharmaceutical industry, WWTP. Infect Drug Resist, 13, 851, 10.2147/IDR.S245047 Hayashi, 2019, Acquisition of mcr-1 and cocarriage of virulence genes in avian pathogenic Escherichia coli isolates from municipal wastewater influents in Japan, Appl Environ Microbiol, 85, 10.1128/AEM.01661-19 Igwaran, 2018, Molecular characterization and antimicrobial resistance pattern of Escherichia coli recovered from wastewater treatment plants in Eastern Cape South Africa, Int J Environ Res Public Health, 15, 1237, 10.3390/ijerph15061237 Hassen, 2021, Genetic characterization of extended-spectrum β-lactamase-producing Enterobacteriaceae from a biological industrial wastewater treatment plant in Tunisia with detection of the colistin-resistance mcr-1 gene, FEMS Microbiol Ecol, 97, fiaa231, 10.1093/femsec/fiaa231 Wang, 2019, Genetic environment of colistin resistance genes mcr-1 and mcr-3 in Escherichia coli from one pig farm in China, Vet Microbiol, 230, 56, 10.1016/j.vetmic.2019.01.011 Ji, 2019, Dissemination of extended-spectrum β-lactamase-producing Escherichia coli carrying mcr-1 among multiple environmental sources in rural China and associated risk to human health, Environ Pollut, 251, 619, 10.1016/j.envpol.2019.05.002 Yang, 2019, Swine waste: a reservoir of high-risk blaNDM and mcr-1, Sci Total Environ, 683, 308, 10.1016/j.scitotenv.2019.05.251 Zhai, 2020, Contaminated in-house environment contributes to the persistence and transmission of NDM-producing bacteria in a Chinese poultry farm, Environ Int, 139, 10.1016/j.envint.2020.105715 Zhu, 2020, Comprehensive understanding of the plasmid-mediated colistin resistance gene mcr-1 in aquatic environments, Environ Sci Technol, 54, 1603, 10.1021/acs.est.9b05919 Gogry, 2019, Emergence of mcr-1 conferred colistin resistance among bacterial isolates from urban sewage water in India, Environ Sci Pollut Res Int, 26, 33715, 10.1007/s11356-019-06561-5 Johura, 2020, Colistin-resistant Escherichia coli carrying mcr-1 in food, water, hand rinse, and healthy human gut in Bangladesh, Gut Pathog, 12, 5, 10.1186/s13099-020-0345-2 Zhong, 2021, Characterization of extended-spectrum β-lactamase-producing Escherichia coli isolates from Jurong Lake, Singapore with whole-genome-sequencing, Int J Environ Res Public Health, 18, 937, 10.3390/ijerph18030937 Ahmed, 2019, Evidence of colistin resistance genes (mcr-1 and mcr-2) in wild birds and its public health implication in Egypt, Antimicrob Resist Infect Control, 8, 197, 10.1186/s13756-019-0657-5 Savin, 2020, ESKAPE bacteria and extended-spectrum-β-lactamase-producing Escherichia coli isolated from wastewater and process water from German poultry slaughterhouses, Appl Environ Microbiol, 86, 10.1128/AEM.02748-19 Savin, 2020, Antibiotic-resistant bacteria and antimicrobial residues in wastewater and process water from German pig slaughterhouses and their receiving municipal wastewater treatment plants, Science Total Environ, 727, 10.1016/j.scitotenv.2020.138788 Savin, 2020, Colistin-resistant Enterobacteriaceae isolated from process waters and wastewater from German poultry and pig slaughterhouses, Front Microbiol, 11, 10.3389/fmicb.2020.575391 Pérez-Etayo, 2020, Multidrug-resistant bacteria isolated from different aquatic environments in the north of Spain and south of France, Microorganisms, 8, 1425, 10.3390/microorganisms8091425 Shen, 2019, Integrated aquaculture contributes to the transfer of mcr-1 between animals and humans via the aquaculture supply chain, Environ Int, 130, 10.1016/j.envint.2019.03.056 Gomi, 2019, Molecular characterization of a multidrug-resistant IncF plasmid carrying mcr-3.1 in an Escherichia coli sequence type 393 strain of wastewater origin, Int J Antimicrob Agents, 54, 524, 10.1016/j.ijantimicag.2019.06.024 Xu, 2021, A novel host of MCR-5 belonging to Enterobacter spp. isolated from hospital sewage water, Environ Microbiol Rep, 13, 234, 10.1111/1758-2229.12937 Xu, 2021, Identification of mcr-10 carried by self-transmissible plasmids and chromosome in Enterobacter roggenkampii strains isolated from hospital sewage water, Environ Pollut, 268, 10.1016/j.envpol.2020.115706 Hmede, 2019, Emergence of plasmid-borne colistin resistance gene mcr-1 in multidrug-resistant Escherichia coli isolated from irrigation water in Lebanon, Int J Antimicrob Agents, 54, 102, 10.1016/j.ijantimicag.2019.05.005 Alhaj Sulaiman, 2020, First report of the plasmid-borne colistin resistance gene (mcr-1) in Proteus mirabilis isolated from domestic and sewer waters in Syrian refugee camps, Travel Med Infect Dis, 33, 10.1016/j.tmaid.2019.101482 Nasser, 2021, Draft genome sequences of multidrug-resistant and mcr-1.1-harboring Escherichia coli isolated from drinking and well waters used in Syrian refugee camps, Microbiol Resour Accounc, 10 Touati, 2020, Emergence of Escherichia coli harbouring mcr-1 and mcr-3 gene in North West Algerian farmlands, J Glob Antimicrob Resist, 21, 132, 10.1016/j.jgar.2019.10.001 Shen, 2018, Prevalence and genetic analysis of mcr-3-positive Aeromonas species from humans, retail meat, and environmental water samples, Antimicrob Agents Chemother, 62, 10.1128/AAC.00404-18 Li, 2019, Co-occurrence of colistin and meropenem resistance determinants in a Stenotrophomonas strain isolated from sewage water, Microb Drug Resist, 25, 317, 10.1089/mdr.2018.0418 Meng, 2020, Genetic diversity, antimicrobial resistance, and virulence genes of Aeromonas isolates from clinical patients, tap water systems, and food, Biomed Environ Sci, 33, 385 Hembach, 2017, Occurrence of the mcr-1 colistin resistance gene and other clinically relevant antibiotic resistance genes in microbial populations at different municipal wastewater treatment plants in Germany, Front Microbiol, 8, 1282, 10.3389/fmicb.2017.01282 Reichert, 2021, Determination of antibiotic resistance genes in a WWTP-impacted river in surface water, sediment, and biofilm: influence of seasonality and water quality, Sci Total Environ, 768, 10.1016/j.scitotenv.2020.144526 Lekunberri, 2017, Detection and quantification of the plasmid-mediated mcr-1 gene conferring colistin resistance in wastewater, Int J Antimicrob Agents, 50, 734, 10.1016/j.ijantimicag.2017.08.018 Wang, 2019, Occurrence of super antibiotic resistance genes in the downstream of the Yangtze River in China: prevalence and antibiotic resistance profiles, Sci Total Environ, 651, 1946, 10.1016/j.scitotenv.2018.10.111 Rodríguez, 2021, Metagenomic analysis of urban wastewater resistome and mobilome: a support for antimicrobial resistance surveillance in an endemic country, Environ Pollut, 276, 10.1016/j.envpol.2021.116736 Kneis, 2019, High prevalence of colistin resistance genes in German municipal wastewater, Sci Total Environ, 694, 10.1016/j.scitotenv.2019.07.260 Yang, 2017, The occurrence of the colistin resistance gene mcr-1 in the Haihe River (China), Int J Environ Res Public Health, 14, 576, 10.3390/ijerph14060576 Marathe, 2017, Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics, Water Res, 124, 388, 10.1016/j.watres.2017.07.060 Dias, 2020, Amaral Nascimento AM. Exploring the resistome, virulome and microbiome of drinking water in environmental and clinical settings, Water Res, 174, 10.1016/j.watres.2020.115630 Dos Santos, 2020, Co-occurrence of mcr-1, mcr-3, mcr-7 and clinically relevant antimicrobial resistance genes in environmental and fecal samples, Arch Microbiol, 202, 1795, 10.1007/s00203-020-01890-3 Furlan, 2020, Occurrence of clinically relevant antimicrobial resistance genes, including mcr-3 and mcr-7.1, in soil and water from a recreation club, Int J Environ Health Res, 10.1080/09603123.2020.1799953 Nguyen, 2021, Association of the colistin resistance gene mcr-1 with faecal pollution in water environments in Hanoi, Vietnam, Lett Appl Microbiol, 72, 275, 10.1111/lam.13421 Chen, 2021, Environmental risk characterization and ecological process determination of bacterial antibiotic resistome in lake sediments, Environ Int, 147, 10.1016/j.envint.2020.106345 Wang, 2018, Metagenomic insights into the contribution of phages to antibiotic resistance in water samples related to swine feedlot wastewater treatment, Front Microbiol, 9, 2474, 10.3389/fmicb.2018.02474 Xia, 2019, Association of colistin residues and manure treatment with the abundance of mcr-1 gene in swine feedlots, Environ Int, 127, 361, 10.1016/j.envint.2019.03.061 Fleres, 2019, Detection of a novel mcr-5.4 gene variant in hospital tap water by shotgun metagenomic sequencing, J Antimicrob Chemother, 74, 3626, 10.1093/jac/dkz363 Voigt, 2020, The investigation of antibiotic residues, antibiotic resistance genes and antibiotic-resistant organisms in a drinking water reservoir system in Germany, Int J Hyg Environ Health, 224, 10.1016/j.ijheh.2020.113449 Khan, 2020, Behavior of last resort antibiotic resistance genes (mcr-1 and blaNDM-1) in a drinking water supply system and their possible acquisition by the mouse gut flora, Environ Pollut, 259, 10.1016/j.envpol.2019.113818 Khan, 2021, DNA phosphorothioate modification facilitates the dissemination of mcr-1 and blaNDM-1 in drinking water supply systems, Environ Pollut, 268, 10.1016/j.envpol.2020.115799 Ribeiro-Gonçalves, 2016, PHYLOViZ Online: web-based tool for visualization, phylogenetic inference, analysis and sharing of minimum spanning trees, Nucleic Acids Res, 44, W246, 10.1093/nar/gkw359 Giamarellou, 2016, Epidemiology of infections caused by polymyxin-resistant pathogens, Int J Antimicrob Agents, 48, 614, 10.1016/j.ijantimicag.2016.09.025