Epidemiology of Asthma in Children and Adults

Shyamali C. Dharmage1, Jennifer L. Perret1,2, Adnan Čustović3
1Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Australia
2Institute for Breathing and Sleep, Australia
3Department of Paediatrics, Imperial College, London, United Kingdom

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Network, 2018, The Global Asthma Report

To, 2012, Global asthma prevalence in adults: findings from the cross-sectional world health survey, BMC Public Health., 12, 5, 10.1186/1471-2458-12-204

Fuhlbrigge, 2002, Gender and asthma, Immunol Allergy Clin North Am., 22, 10, 10.1016/S0889-8561(02)00022-X

Eder, 2006, The asthma epidemic, N Engl J Med., 355, 2226, 10.1056/NEJMra054308

Pavord, 2018, After asthma: redefining airways diseases, Lancet., 391, 350, 10.1016/S0140-6736(17)30879-6

Ellwood, 2005, The international study of asthma and allergies in childhood (ISAAC): phase three rationale and methods, Int J Tubercul Lung Dis., 9, 10

Weiland, 2004, Phase II of the international study of asthma and allergies in childhood (ISAAC II): rationale and methods, Eur Respirat J., 24, 406, 10.1183/09031936.04.00090303

Asher, 1995, International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods, Eur Respirat J., 8, 483, 10.1183/09031936.95.08030483

1996, Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS), Eur Respir J., 9, 687, 10.1183/09031936.96.09040687

Asher, 2006, Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys, Lancet., 368, 733, 10.1016/S0140-6736(06)69283-0

Addo-Yobo, 2007, Exercise-induced bronchospasm and atopy in Ghana: two surveys ten years apart, PLoS Med., 4, e70, 10.1371/journal.pmed.0040070

Strachan, 1989, Hay fever, hygiene, and household size, BMJ., 299, 2, 10.1136/bmj.299.6710.1259

Rook, 2003, Innate immune responses to mycobacteria and the downregulation of atopic responses, Curr Opin Allergy Clin Immunol, 3, 5, 10.1097/00130832-200310000-00003

Mitchell, 1985, International trends in hospital admission rates for asthma, Arch Dis Childhood., 60, 376, 10.1136/adc.60.4.376

Ebmeier, 2017, Trends in international asthma mortality: analysis of data from the WHO Mortality Database from 46 countries (1993–2012), Lancet., 390, 935, 10.1016/S0140-6736(17)31448-4

Haldar, 2008, Cluster analysis and clinical asthma phenotypes, Am J Respir Crit Care Med., 178, 218, 10.1164/rccm.200711-1754OC

Van Wonderen, 2010, Different definitions in childhood asthma: how dependable is the dependent variable?, Eur Respir J., 36, 48, 10.1183/09031936.00154409

Jenkins, 1996, Validation of questionnaire and bronchial hyperresponsiveness against respiratory physician assessment in the diagnosis of asthma, Int J Epidemiol., 25, 609, 10.1093/ije/25.3.609

Peat, 2000, Epidemiology and the Changing Prevalence of Asthma, Understanding Asthma A Management Companion, 11

Burgess, 2006, Who remembers whether they had asthma as children?, J Asthma., 43, 727, 10.1080/02770900601028587

Anderson, 2008, Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease, Lancet., 372, 1107, 10.1016/S0140-6736(08)61452-X

Lotvall, 2011, Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome, J Allergy Clin Immunol., 127, 355, 10.1016/j.jaci.2010.11.037

Custovic, 2015, The Study Team for Early Life Asthma Research (STELAR) consortium 'Asthma e-lab': team science bringing data, methods and investigators together, Thorax., 70, 799, 10.1136/thoraxjnl-2015-206781

Belgrave, 2013, Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management, Exp Rev Clin Immunol., 9, 921, 10.1586/1744666X.2013.836450

Belgrave, 2017, Disaggregating asthma: big investigation versus big data, J Allergy Clin Immunol., 139, 400, 10.1016/j.jaci.2016.11.003

Makikyro, 2017, Subtypes of asthma based on asthma control and severity: a latent class analysis, Resp Res, 18, 24, 10.1186/s12931-017-0508-y

Weinmayr, 2013, Asthma phenotypes identified by latent class analysis in the ISAAC phase II Spain study, Clin Exp Allergy., 43, 223, 10.1111/cea.12035

Jeong, 2017, Heterogeneity of obesity-asthma association disentangled by latent class analysis, the SAPALDIA cohort, Respir Med., 125, 25, 10.1016/j.rmed.2017.02.014

Martinez, 1995, Asthma and wheezing in the first six years of life, N Engl J Med., 332, 133, 10.1056/NEJM199501193320301

Lodge, 2014, Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort, J Pediatr., 164, 289, 10.1016/j.jpeds.2013.09.056

Lodge, 2014, Childhood wheeze phenotypes show less than expected growth in FEV1 across adolescence, Am J Respir Crit Care Med., 189, 1351, 10.1164/rccm.201308-1487OC

Wi, 2018, Natural language processing for asthma ascertainment in different practice settings, J Allergy Clin Immunol Pract., 6, 126, 10.1016/j.jaip.2017.04.041

Wi, 2017, Application of a natural language processing algorithm to asthma ascertainment, Am J Respir Crit Care Med., 196, 430, 10.1164/rccm.201610-2006OC

Sohn, 2018, Clinical documentation variations and NLP system portability: a case study in asthma birth cohorts across institutions, J Am Med Inform Assoc., 25, 353, 10.1093/jamia/ocx138

Chung, 2014, International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma, Eur Resp J., 43, 343, 10.1183/09031936.00202013

Larsson, 2018, Prevalence and management of severe asthma in primary care: an observational cohort study in Sweden (PACEHR), Respir Res., 19, 12, 10.1186/s12931-018-0719-x

von Bulow, 2014, The prevalence of severe asthma and low asthma control among Danish adults, J Allergy Clin Immunol Pract., 2, 759, 10.1016/j.jaip.2014.05.005

BleeckerER The Epidemiology of Severe Asthma: The TENOR Study and SARP (NIH).

Mincheva, 2018, High prevalence of severe asthma in a large random population study, J Allergy Clin Immunol., 141, 2256, 10.1016/j.jaci.2017.07.047

Rusconi, 2018, European Lung Foundation severe asthma patient advisory g, Eur Resp J., 52, 1801665, 10.1183/13993003.01665-2018

Bousquet, 2010, Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma, J Allergy Clin Immunol., 126, 926, 10.1016/j.jaci.2010.07.019

Nordlund, 2014, Prevalence of severe childhood asthma according to the WHO, Respir Med., 108, 1234, 10.1016/j.rmed.2014.05.015

Lang, 2008, Severe asthma in childhood: assessed in 10 year olds in a birth cohort study, Allergy., 63, 1054, 10.1111/j.1398-9995.2008.01672.x

Belgrave, 2013, Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing, J Allergy Clin Immunol., 132, 575, 10.1016/j.jaci.2013.05.041

Belgrave, 2014, Trajectories of lung function during childhood, Am J Respir Crit Care Med., 189, 1101, 10.1164/rccm.201309-1700OC

Bush, 2017, Severe asthma: looking beyond the amount of medication, Lancet Respir Med., 5, 844, 10.1016/S2213-2600(17)30379-X

Fitzpatrick, 2016, Severe asthma in children: lessons learned and future directions, J Allergy Clin Immunol Pract., 4, 11, 10.1016/j.jaip.2015.10.008

Bush, 2010, Management of severe asthma in children, Lancet., 376, 814, 10.1016/S0140-6736(10)61054-9

Bush, 2008, Severe childhood asthma: a common international approach?, Lancet., 372, 1019, 10.1016/S0140-6736(08)61422-1

Jochmann, 2017, Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children, Eur Resp J., 50, 1700910, 10.1183/13993003.00910-2017

McDonald, 2017, Adherence in severe asthma: time to get it right, Eur Resp J., 50, 1702191, 10.1183/13993003.02191-2017

Murray, 2006, Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children, Thorax., 61, 376, 10.1136/thx.2005.042523

Tunnicliffe, 1999, Sensitivity and exposure to indoor allergens in adults with differing asthma severity, Eur Resp J., 13, 654, 10.1183/09031936.99.13365499

Lowe, 2004, Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens, Arch Pediatr Adolesc Med., 158, 996, 10.1001/archpedi.158.10.996

Puranik, 2017, Predicting severe asthma exacerbations in children, Am J Respir Crit Care Med., 195, 854, 10.1164/rccm.201606-1213PP

Gehring, 2013, Air pollution exposure and lung function in children: the ESCAPE project, Environ Health Perspect., 121, 1357, 10.1289/ehp.1306770

Molter, 2015, A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project, Eur Resp J., 45, 610, 10.1183/09031936.00083614

Taggart, 1996, Asthmatic bronchial hyperresponsiveness varies with ambient levels of summertime air pollution, Eur Resp J., 9, 1146, 10.1183/09031936.96.09061146

Osman, 2002, Psychological factors in asthma control and attack risk, Thorax., 57, 190, 10.1136/thorax.57.3.190

Calam, 2005, Behavior problems antecede the development of wheeze in childhood: a birth cohort study, Am J Respir Crit Care Med., 171, 323, 10.1164/rccm.200406-791OC

Calam, 2003, Childhood asthma, behavior problems, and family functioning, J Allergy Clin Immunol., 112, 499, 10.1016/S0091-6749(03)00008-3

Saglani, 2016, How to manage a child with difficult asthma?, Exp Rev Respir Med., 10, 873, 10.1080/17476348.2016.1191355

Yorke, 2007, A systematic review of psychological interventions for children with asthma, Pediatr Pulmonol., 42, 114, 10.1002/ppul.20464

Roberts, 2017, Asthma comorbidities and making progress with food allergy, Clin Exp Allergy., 47, 1230, 10.1111/cea.13028

Deliu, 2014, Impact of rhinitis on asthma severity in school-age children, Allergy., 69, 1515, 10.1111/all.12467

Wang, 2014, Differing associations of BMI and body fat with asthma and lung function in children, Pediatr Pulmonol., 49, 1049, 10.1002/ppul.22927

Porsbjerg, 2017, Co-morbidities in severe asthma: clinical impact and management, Respirology., 22, 651, 10.1111/resp.13026

Chan, 2015, The effect of an electronic monitoring device with audiovisual reminder function on adherence to inhaled corticosteroids and school attendance in children with asthma: a randomised controlled trial, Lancet Respir Med., 3, 210, 10.1016/S2213-2600(15)00008-9

Langley, 2003, Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma, J Allergy Clin Immunol., 112, 362, 10.1067/mai.2003.1654

Langley, 2005, Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects, Thorax., 60, 17, 10.1136/thx.2004.027839

Langley, 2003, Relationship among pulmonary function, bronchial reactivity, and exhaled nitric oxide in a large group of asthmatic patients, Ann Allergy Asthma Immunol., 91, 398, 10.1016/S1081-1206(10)61688-2

Bush, 2017, Severe asthma in children, Respirology., 22, 886, 10.1111/resp.13085

Pike, 2018, Managing problematic severe asthma: beyond the guidelines, Arch Dis Childhood., 103, 392, 10.1136/archdischild-2016-311368

von Bulow, 2018, Differentiation of adult severe asthma from difficult-to-treat asthma - Outcomes of a systematic assessment protocol, Respir Med., 145, 41, 10.1016/j.rmed.2018.10.020

Guilbert, 2014, Severe asthma in children, J Allergy Clin Immunol Pract., 2, 489, 10.1016/j.jaip.2014.06.022

Ramratnam, 2017, Severe asthma in children, J Allergy Clin Immunol Pract., 5, 889, 10.1016/j.jaip.2017.04.031

Jackson, 2010, The role of viruses in acute exacerbations of asthma, J Allergy Clin Immunol., 125, 1178, 10.1016/j.jaci.2010.04.021

Kim, 2018, Viral Infections and associated factors that promote acute exacerbations of asthma, Allergy Asthma Immunol Res., 10, 12, 10.4168/aair.2018.10.1.12

Edwards, 2013, Impaired innate interferon induction in severe therapy resistant atopic asthmatic children, Mucosal Immunol., 6, 797, 10.1038/mi.2012.118

Custovic, 2018, Cytokine Responses to rhinovirus and development of asthma, allergic sensitization and respiratory infections during childhood, Am J Respir Crit Care Med., 197, 1265, 10.1164/rccm.201708-1762OC

Green, 2002, Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study, BMJ., 324, 763, 10.1136/bmj.324.7340.763

Fitzpatrick, 2006, Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide, J Allergy Clin Immunol., 118, 1218, 10.1016/j.jaci.2006.08.019

Frith, 2011, The complexities of defining atopy in severe childhood asthma, Clin Exp Allergy., 41, 948, 10.1111/j.1365-2222.2011.03729.x

Just, 2012, Two novel, severe asthma phenotypes identified during childhood using a clustering approach, Eur Resp J., 40, 55, 10.1183/09031936.00123411

Holt, 2016, Distinguishing benign from pathologic TH2 immunity in atopic children, J Allergy Clin Immunol., 137, 379, 10.1016/j.jaci.2015.08.044

Konradsen, 2014, Severe childhood asthma and allergy to furry animals: refined assessment using molecular-based allergy diagnostics, Pediatr Allergy Immunol., 25, 187, 10.1111/pai.12198

Sylvestre, 2016, Component-based allergen-microarray: Der p 2 and Der f 2 Dust mite sensitization is more common in patients with severe asthma, J Investig Allergol Clin Immunol., 26, 141, 10.18176/jiaci.0035

Simpson, 2010, Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study, Am J Respir Crit Care Med., 181, 1200, 10.1164/rccm.200907-1101OC

Lazic, 2013, Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts, Allergy., 68, 764, 10.1111/all.12134

Simpson, 2015, Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years, J Allerg Clin Immunol., 136, 1224, 10.1016/j.jaci.2015.03.027

Custovic, 2015, Evolution pathways of IgE responses to grass and mite allergens throughout childhood, 136, 1645, 10.1016/j.jaci.2015.03.041

Howard, 2018, Evolution of IgE responses to multiple allergen components throughout childhood, J Allergy Clin Immunol., 142, 1322, 10.1016/j.jaci.2017.11.064

Fontanella, 2018, Machine learning to identify pairwise interactions between specific IgE antibodies and their association with asthma: a cross-sectional analysis within a population-based birth cohort, PLoS Med., 15, e1002691, 10.1371/journal.pmed.1002691

30283711Global Strategy for Asthma Management and Prevention 2018.

Celedon, 2007, Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood, J Allergy Clin Immunol., 120, 144, 10.1016/j.jaci.2007.03.037

Lodge, 2011, House dust mite sensitization in toddlers predicts current wheeze at age 12 years, J Allergy Clin Immunol., 128, 782, 10.1016/j.jaci.2011.06.038

Lodrup Carlsen, 2012, Does pet ownership in infancy lead to asthma or allergy at school age?, PLoS ONE., 7, e43214, 10.1371/journal.pone.0043214

Takkouche, 2008, Exposure to furry pets and the risk of asthma and allergic rhinitis: a meta-analysis, Allergy., 63, 857, 10.1111/j.1398-9995.2008.01732.x

Erbas, 2018, Outdoor pollen is a trigger of child and adolescent asthma emergency department presentations: a systematic review and meta-analysis, Allergy, 73, 1632, 10.1111/all.13407

Salo, 2006, Exposure to Alternaria alternata in US homes is associated with asthma symptoms, J Allergy Clin Immunol., 118, 892, 10.1016/j.jaci.2006.07.037

Burr, 2007, Effects on patients with asthma of eradicating visible indoor mould: a randomised controlled trial, Thorax., 62, 767, 10.1136/thx.2006.070847

Downs, 2001, Clinical importance of alternaria exposure in children, Am J Respir Crit Care Med., 164, 455, 10.1164/ajrccm.164.3.2008042

O'Hollaren, 1991, Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma, N Engl J Med., 324, 359, 10.1056/NEJM199102073240602

Tham, 2017, Associations between outdoor fungal spores and childhood and adolescent asthma hospitalizations, J Allergy Clin Immunol., 139, 1140, 10.1016/j.jaci.2016.06.046

Fairs, 2010, IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma, Am J Respir Crit Care Med., 182, 1362, 10.1164/rccm.201001-0087OC

Thien, 2018, The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors, Lancet Planet Health., 2, e255, 10.1016/S2542-5196(18)30120-7

Andrew, 2017, Stormy weather: a retrospective analysis of demand for emergency medical services during epidemic thunderstorm asthma, BMJ., 359, j5636, 10.1136/bmj.j5636

Liu, 2010, National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005–2006, J Allergy Clin Immunol., 126, 798, 10.1016/j.jaci.2010.07.026

Burks, 2012, ICON: food allergy, J Allergy Clin Immunol., 129, 906, 10.1016/j.jaci.2012.02.001

Bock, 2007, Further fatalities caused by anaphylactic reactions to food, 2001–2006, J Allergy Clin Immunol., 119, 1016, 10.1016/j.jaci.2006.12.622

Pumphrey, 2007, Further fatal allergic reactions to food in the United Kingdom, 1999–2006, J Allergy Clin Immunol., 119, 1018, 10.1016/j.jaci.2007.01.021

Crewe, 2016, A comprehensive list of asthmagens to inform health interventions in the Australian workplace, Aust N Z J Public Health., 40, 170, 10.1111/1753-6405.12479

Tarlo, 2014, Occupational asthma, N Engl J Med., 370, 640, 10.1056/NEJMra1301758

Malo, 2009, Agents causing occupational asthma, J Allergy Clin Immunol., 123, 545, 10.1016/j.jaci.2008.09.010

Baur, 2014, Allergens causing occupational asthma: an evidence-based evaluation of the literature, Int Arch Occup Environ Health., 87, 339, 10.1007/s00420-013-0866-9

Burke, 2012, Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis, Pediatrics., 129, 735, 10.1542/peds.2011-2196

Gilliland, 2006, Regular smoking and asthma incidence in adolescents, Am J Respir Crit Care Med., 174, 1094, 10.1164/rccm.200605-722OC

Genuneit, 2006, Smoking and the incidence of asthma during adolescence: results of a large cohort study in Germany, Thorax., 61, 572, 10.1136/thx.2005.051227

McLeish, 2010, Asthma and cigarette smoking: a review of the empirical literature, 47, 16, 10.3109/02770900903556413

Perret, 2016, Smoking cessation strategies for patients with asthma: improving patient outcomes, J Asthma Allergy., 9, 117, 10.2147/JAA.S85615

Anenberg, 2018, Estimates of the global burden of ambient [Formula: see text], Ozone, and [Formula: see text] on asthma incidence and emergency room visits, Environ Health Perspect., 126, 107004, 10.1289/EHP3766

Yang, 2018, Is smaller worse?, Environ Int., 120, 516, 10.1016/j.envint.2018.08.027

Gauderman, 2002, Association between air pollution and lung function growth in southern California children: results from a second cohort, Am J Respir Crit Care Med., 166, 76, 10.1164/rccm.2111021

Gauderman, 2000, Association between air pollution and lung function growth in southern California children, Am J Respir Crit Care Med., 162, 1383, 10.1164/ajrccm.162.4.9909096

Bowatte, 2017, Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age, Eur Respir J., 50, 1602357, 10.1183/13993003.02357-2016

McCreanor, 2007, Respiratory effects of exposure to diesel traffic in persons with asthma, N Engl J Med., 357, 2348, 10.1056/NEJMoa071535

Howden-Chapman, 2008, Effects of improved home heating on asthma in community dwelling children: randomised controlled trial, BMJ., 337, a1411, 10.1136/bmj.a1411

Accordini, 2018, A three-generation study on the association of tobacco smoking with asthma, Int J Epidemiol., 47, 1106, 10.1093/ije/dyy031

Zbikowski, 2002, Risk factors for smoking among adolescents with asthma, J Adolesc Health., 30, 279, 10.1016/S1054-139X(01)00394-9

Based on the Global Strategy for Asthma Management and Prevention and the Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease

Erbas, 2013, Persistent pollen exposure during infancy is associated with increased risk of subsequent childhood asthma and hayfever, Clin Exp Allergy, 43, 337, 10.1111/cea.12071

Guilbert, 2018, Relationships between aeroallergen levels and hospital admissions for asthma in the Brussels-Capital Region: a daily time series analysis, Environ Health., 17, 35, 10.1186/s12940-018-0378-x

Packe, 1985, Asthma outbreak during a thunderstorm, Lancet., 2, 199, 10.1016/S0140-6736(85)91510-7

Alderman, 1986, Asthma and thunderstorms, Arch Emerg Med., 3, 260, 10.1136/emj.3.4.260

Elliot, 2014, The impact of thunderstorm asthma on emergency department attendances across London during July 2013, Emerg Med J., 31, 675, 10.1136/emermed-2013-203122

Davidson, 1996, A major outbreak of asthma associated with a thunderstorm: experience of accident and emergency departments and patients' characteristics, BMJ., 312, 601, 10.1136/bmj.312.7031.601

Tan, 2012, Filaggrin loss-of-function mutations do not predict food allergy over and above the risk of food sensitization among infants, J Allergy Clin Immunol., 130, 1211, 10.1016/j.jaci.2012.07.022

Du Toit, 2015, Randomized trial of peanut consumption in infants at risk for peanut allergy, N Engl J Med., 372, 803, 10.1056/NEJMoa1414850

Gruchalla, 2015, Preventing peanut allergy through early consumption–ready for prime time?, N Engl J Med., 372, 875, 10.1056/NEJMe1500186

Vandenplas, 2017, Diagnosing occupational asthma, Clin Exp Allergy., 47, 6, 10.1111/cea.12858

Beach, 2007, A systematic review of the diagnosis of occupational asthma, Chest., 131, 569, 10.1378/chest.06-0492

Santos, 2007, Occupational asthma and work-exacerbated asthma: factors associated with time to diagnostic steps, Chest., 131, 1768, 10.1378/chest.06-2487

Tarlo, 1995, A workers' compensation claim population for occupational asthma, Chest., 107, 634, 10.1378/chest.107.3.634

Balmes, 2003, American thoracic society statement: occupational contribution to the burden of airway disease, Am J Respir Crit Care Med., 167, 787, 10.1164/rccm.167.5.787

Blanc, 1999, How much adult asthma can be attributed to occupational factors?, Am J Med., 107, 580, 10.1016/S0002-9343(99)00307-1

Toren, 2009, Asthma caused by occupational exposures is common - a systematic analysis of estimates of the population-attributable fraction, BMC Pulm Med., 9, 7, 10.1186/1471-2466-9-7

Henneberger, 2011, An official american thoracic society statement: work-exacerbated asthma, Am J Respir Crit Care Med., 184, 368, 10.1164/rccm.812011ST

Wood, 2017, Diet, Obesity, and Asthma, Anna Am Thor Soc., 14, S332, 10.1513/AnnalsATS.201702-124AW

Beuther, 2007, Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies, Am J Respir Crit Care Med., 175, 661, 10.1164/rccm.200611-1717OC

Matheson, 2007, Breast-feeding and atopic disease: a cohort study from childhood to middle age, J Allergy Clin Immunol., 120, 1051, 10.1016/j.jaci.2007.06.030

Lodge, 2015, Breastfeeding and asthma and allergies: a systematic review and meta-analysis, Acta Paediatr., 104, 38, 10.1111/apa.13132

Hallberg, 2015, Asthma phenotypes and lung function up to 16 years of age-the BAMSE cohort, Allergy., 70, 667, 10.1111/all.12598

Strunk, 2006, Mild to moderate asthma affects lung growth in children and adolescents, J Allergy Clin Immunol., 118, 1040, 10.1016/j.jaci.2006.07.053

Sears, 2003, A longitudinal, population-based, cohort study of childhood asthma followed to adulthood, N Engl J Med., 349, 1414, 10.1056/NEJMoa022363

Morgan, 2005, Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence, Am J Respir Crit Care Med., 172, 1253, 10.1164/rccm.200504-525OC

Lødrup Carlsen, 2014, Asthma and lower airway disease: lung function trajectories from birth through puberty reflect asthma phenotypes with allergic comorbidity, J Allergy Clin Immunol., 134, 917, 10.1016/j.jaci.2014.05.020

Phelan, 2002, The melbourne asthma study: 1964–1999, J Allergy Clin Immunol, 109, 189, 10.1067/mai.2002.120951

Tagiyeva, 2016, Outcomes of childhood asthma and wheezy bronchitis. A 50-year cohort study, Am J Respir Crit Care Med., 193, 23, 10.1164/rccm.201505-0870OC

Bui, 2018, Childhood respiratory risk factor profiles and middle-age lung function: a prospective cohort study from the first to sixth decade, Ann Am Thor Soc., 15, 1057, 10.1513/AnnalsATS.201806-374OC

Marossy, 2007, Childhood chest illness and the rate of decline of adult lung function between ages 35 and 45 years, Am J Respir Crit Care Med., 175, 355, 10.1164/rccm.200607-1023OC

Svanes, 2010, Early life origins of chronic obstructive pulmonary disease, Thorax., 65, 14, 10.1136/thx.2008.112136

Bui, 2018, Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life, Lancet Respir Med., 6, 535, 10.1016/S2213-2600(18)30100-0

McGeachie, 2016, Patterns of growth and decline in lung function in persistent childhood asthma, N Engl J Med., 374, 1842, 10.1056/NEJMoa1513737

Tan, 2015, Age-of-asthma onset as a determinant of different asthma phenotypes in adults: a systematic review and meta-analysis of the literature, Exp Rev Resp Med., 9, 109, 10.1586/17476348.2015.1000311

Perret, 2013, The interplay between the effects of lifetime asthma, smoking, and atopy on fixed airflow obstruction in middle age, Am J Respir Crit Care Med., 187, 42, 10.1164/rccm.201205-0788OC

Tan, 2016, Clinical and functional differences between early-onset and late-onset adult asthma: a population-based tasmanian longitudinal health study, Thorax., 71, 981, 10.1136/thoraxjnl-2015-208183

Aanerud, 2015, Interaction between asthma and smoking increases the risk of adult airway obstruction, Eur Respir J., 45, 635, 10.1183/09031936.00055514

Lange, 1998, A 15-year follow-up study of ventilatory function in adults with asthma, N Engl J Med., 339, 1194, 10.1056/NEJM199810223391703

James, 2005, Decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smoking, Am J Respir Crit Care Med., 171, 109, 10.1164/rccm.200402-230OC

Peat, 1987, Rate of decline of lung function in subjects with asthma, Eur J Resp Dis., 70, 171

Tai, 2014, Outcomes of childhood asthma to the age of 50 years, J Allergy Clin Immunol., 133, 1572, 10.1016/j.jaci.2013.12.1033

Porsbjerg, 2015, Lung function impairment increases with age of diagnosis in adult onset asthma, Respir Med., 109, 821, 10.1016/j.rmed.2015.04.012

Anto, 2010, Risk factors of new-onset asthma in adults: a population-based international cohort study, Allergy., 65, 1021, 10.1111/j.1398-9995.2009.02301.x

Zaidi, 2019, Why are people with asthma susceptible to pneumonia?, Respirology., 24, 423, 10.1111/resp.13528

Talbot, 2005, Asthma as a risk factor for invasive pneumococcal disease, N Engl J Med., 352, 2082, 10.1056/NEJMoa044113

Helby, 2017, Asthma, other atopic conditions and risk of infections in 105 519 general population never and ever smokers, J Int Med., 282, 254, 10.1111/joim.12635

Juhn, 2014, Risks for infection in patients with asthma (or other atopic conditions): is asthma more than a chronic airway disease?, J Allergy Clin Immunol., 134, 247, 10.1016/j.jaci.2014.04.024

Klemets, 2010, Risk of invasive pneumococcal infections among working age adults with asthma, Thorax., 65, 698, 10.1136/thx.2009.132670

Kankaanranta, 2016, Emerging comorbidities in adult asthma: risks, clinical associations, and mechanisms, Mediat Inflamm., 2016, 3690628, 10.1155/2016/3690628

Weatherburn, 2017, Comorbidities in adults with asthma: population-based cross-sectional analysis of 1, Clin Exp Allergy., 47, 1246, 10.1111/cea.12971

Gershon, 2012, Describing and quantifying asthma comorbidity [corrected]: a population study, PLoS ONE, 7, e34967, 10.1371/journal.pone.0034967

Szefler, 2018, Asthma across the lifespan: time for a paradigm shift, J Allergy Clin Immunol., 142, 773, 10.1016/j.jaci.2018.03.010