Epidemiological and molecular characterization of dengue viruses imported into Guangzhou during 2009–2013
Tóm tắt
Dengue virus causes one of the most significant infectious diseases in tropical and subtropical regions, notable number of which is imported into China every year. In this study, the molecular epidemiologic and phylogenetic analyses of dengue cases imported into Guangzhou in South China during 2009–2013 were conducted. During that period, 46 imported dengue cases were identified, including four serotypes. Most of the dengue patients were travelling from Southeast Asia, South Asia and Africa. The envelope (E) genes of 20 imported dengue viruses introduced from 13 countries and regions, were sequenced and used for phylogenetic analyses. The results indicated that the DENV-1 genotype I and DENV-2 Asian genotype I were the most predominant DENV strains, which were circulating in Southeast Asia and imported into South China. In addition, the new introduction of DENV-3 genotype III from West Asia was observed. This study provided an overview on the genetic diversity of DENV strains imported into South China, and also gave information about the geographic distribution, dynamic transmission and molecular evolution of epidemic DENV strains.
Tài liệu tham khảo
Arima Y, Edelstein ZR, Han HK, Matsui T (2013) Epidemiologic update on the dengue situation in the Western Pacific Region, 2011. Western Pac Surveill Response J 4:47–54
Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI (2013) The global distribution and burden of dengue. Nature 496:504–507
Calisher CH, Karabatsos N, Dalrymple JM, Shope RE, Porterfield JS, Westaway EG, Brandt WE (1989) Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera. J Gen Virol 70(Pt 1):37–43
Chew MH, Rahman MM, Hussin S (2015) Molecular epidemiology and phylogenetic analysis of dengue virus type-1 and 2 isolated in Malaysia. Pak J Med Sci 31:615–620
Dorji T, Yoon IK, Holmes EC, Wangchuk S, Tobgay T, Nisalak A, Chinnawirotpisan P, Sangkachantaranon K, Gibbons RV, Jarman RG (2009) Diversity and origin of dengue virus serotypes 1, 2, and 3, Bhutan. Emerg Infect Dis 15:1630–1632
Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, Hunsperger E, Kroeger A, Margolis HS, Martinez E, Nathan MB, Pelegrino JL, Simmons C, Yoksan S, Peeling RW (2010) Dengue: a continuing global threat. Nat Rev Microbiol 8:S7–16
Halstead SB (2007) Dengue. Lancet 370:1644–1652
Huang JH, Su CL, Yang CF, Liao TL, Hsu TC, Chang SF, Lin CC, Shu PY (2012) Molecular characterization and phylogenetic analysis of dengue viruses imported into Taiwan during 2008–2010. Am J Trop Med Hyg 87:349–358
Huang L, Luo X, Shao J, Yan H, Qiu Y, Ke P, Zheng W, Xu B, Li W, Sun D, Cao D, Chen C, Zhuo F, Lin X, Tang F, Bao B, Zhou Y, Zhang X, Li H, Li J, Wan D, Yang L, Chen Y, Zhong Q, Gu X, Liu J, Huang L, Xie R, Li X, Xu Y, Luo Z, Liao M, Wang H, Sun L, Li H, Lau GW, Duan C (2016) Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014. Eur J Clin Microbiol Infect Dis 35:269–277
Mackey TK, Liang BA (2012) Threats from emerging and re-emerging neglected tropical diseases (NTDs). Infect Ecol Epidemiol 2. doi:10.3402/iee.v2i0.18667
Martina BE, Koraka P, Osterhaus AD (2009) Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev 22:564–581
OhAinle M, Balmaseda A, Macalalad AR, Tellez Y, Zody MC, Saborio S, Nunez A, Lennon NJ, Birren BW, Gordon A, Henn MR, Harris E (2011) Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. Sci Transl Med 3:114ra128
Shepard DS, Undurraga EA, Halasa YA (2013) Economic and disease burden of dengue in Southeast Asia. PLoS Negl Trop Dis 7:e2055
Shu PY, Su CL, Liao TL, Yang CF, Chang SF, Lin CC, Chang MC, Hu HC, Huang JH (2009) Molecular characterization of dengue viruses imported into Taiwan during 2003–2007: geographic distribution and genotype shift. Am J Trop Med Hyg 80:1039–1046
Sun J, Lin J, Yan J, Fan W, Lu L, Lv H, Hou J, Ling F, Fu T, Chen Z, Cong L, Liu Q, Zhang Y, Chai C (2011) Dengue virus serotype 3 subtype III, Zhejiang Province, China. Emerg Infect Dis 17:321–323
Sun J, Wu D, Zhou H, Zhang H, Guan D, He X, Cai S, Ke C, Lin J (2016) The epidemiological characteristics and genetic diversity of dengue virus during the third largest historical outbreak of dengue in Guangdong, China, in 2014. J Infect 72:80–90
Teichmann D, Rogler G, Grobusch MP, Schuler-Maue W, Klein E (1999) Imported dengue virus type 2 infection acquired during an outbreak in India. Eur J Clin Microbiol Infect Dis 18:310–312
Vu TT, Holmes EC, Duong V, Nguyen TQ, Tran TH, Quail M, Churcher C, Parkhill J, Cardosa J, Farrar J, Wills B, Lennon NJ, Birren BW, Buchy P, Henn MR, Simmons CP (2010) Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia. PLoS Negl Trop Dis 4:e757
Wesolowski A, Qureshi T, Boni MF, Sundsoy PR, Johansson MA, Rasheed SB, Engo-Monsen K, Buckee CO (2015) Impact of human mobility on the emergence of dengue epidemics in Pakistan. Proc Natl Acad Sci USA 112:11887–11892
Zangmo S, Klungthong C, Chinnawirotpisan P, Tantimavanich S, Kosoltanapiwat N, Thaisomboonsuk B, Phuntsho K, Wangchuk S, Yoon IK, Fernandez S (2015) Epidemiological and molecular characterization of dengue virus circulating in Bhutan, 2013–2014. PLoS Negl Trop Dis 9:e0004010