Epidemiologic and Microbiologic Characteristics of Occult Bacteremia Among Febrile Children in Southern Israel, Before and After Initiation of the Routine Antipneumococcal Immunization (2005–2012)

Baraff, 1993, Practice guideline for the management of infants and children 0 to 36 months of age with fever without source. Agency for Health Care Policy and Research, Ann Emerg Med, 22, 1198, 10.1016/S0196-0644(05)80991-6 Baraff, 2000, Management of fever without source in infants and children, Ann Emerg Med, 36, 602, 10.1067/mem.2000.110820 Klein, 2002, Management of the febrile child without a focus of infection in the era of universal pneumococcal immunization, Pediatr Infect Dis J, 21, 584, 10.1097/00006454-200206000-00033 McCarthy, 2005, Fever without apparent source on clinical examination, Curr Opin Pediatr, 17, 93, 10.1097/00008480-200502000-00019 See, 2005, Bloodstream infection in children, Pediatr Crit Care Med, 6, S42, 10.1097/01.PCC.0000161945.98871.52 Marshall, 1979, Unsuspected bacteremia due to Haemophilus influenzae: outcome in children not initially admitted to hospital, J Pediatr, 95, 690, 10.1016/S0022-3476(79)80712-X Alario, 1989, Blood cultures in the management of febrile outpatients later found to have bacteremia, J Pediatr, 115, 195, 10.1016/S0022-3476(89)80064-2 Ladhani, 2010, Invasive Haemophilus influenzae disease, Europe, 1996–2006, Emerg Infect Dis, 16, 455, 10.3201/eid1603.090290 Black, 2000, Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group, Pediatr Infect Dis J, 19, 187, 10.1097/00006454-200003000-00003 Pelton, 2004, Seven valent pneumococcal conjugate vaccine immunization in two Boston communities. Changes in serotypes and antimicrobial susceptibility among Streptococcus pneumoniae isolates, Pediatr Infect Dis J, 23, 1015, 10.1097/01.inf.0000143645.58215.f0 Herz, 2006, Changing epidemiology of outpatient bacteremia in 3- to 36-month-old children after the introduction of the heptavalent-conjugated pneumococcal vaccine, Pediatr Infect Dis J, 25, 293, 10.1097/01.inf.0000207485.39112.bf Isaacman, 2010, Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines, Int J Infect Dis, 14, e197, 10.1016/j.ijid.2009.05.010 Tan, 2012, Pediatric invasive pneumococcal disease in the United States in the era of pneumococcal conjugate vaccines, Clin Microbiol Rev, 25, 409, 10.1128/CMR.00018-12 Ben-Shimol, 2012, Rapid reduction in invasive pneumococcal disease after introduction of PCV7 into the National Immunization Plan in Israel, Vaccine, 30, 6600, 10.1016/j.vaccine.2012.08.012 Baraff, 2008, Management of infants and young children with fever without source, Pediatr Ann, 37, 673, 10.3928/00904481-20081001-01 Stoll, 2004, Incidence of occult bacteremia among highly febrile young children in the era of the pneumococcal conjugate vaccine: a study from a Children's Hospital Emergency Department and Urgent Care Center, Arch Pediatr Adolesc Med, 158, 671, 10.1001/archpedi.158.7.671 Carstairs, 2007, Pneumococcal bacteremia in febrile infants presenting to the emergency department before and after the introduction of the heptavalent pneumococcal vaccine, Ann Emerg Med, 49, 772, 10.1016/j.annemergmed.2006.10.026 Wilkinson, 2009, Prevalence of occult bacteremia in children aged 3 to 36 months presenting to the emergency department with fever in the post pneumococcal conjugate vaccine era, Acad Emerg Med, 16, 220, 10.1111/j.1553-2712.2008.00328.x Waddle, 2009, Outcomes of febrile children without localising signs after pneumococcal conjugate vaccine, Arch Dis Child, 94, 144, 10.1136/adc.2007.130583 Benito-Fernández, 2010, Pneumococcal bacteremia in febrile infants presenting to the emergency department 8 years after the introduction of pneumococcal conjugate vaccine in the Basque Country of Spain, Pediatr Infect Dis J, 29, 1142, 10.1097/INF.0b013e3181eaf89a Bressan, 2012, Bacteremia in feverish children presenting to the emergency department: a retrospective study and literature review, Acta Paediatr, 101, 271, 10.1111/j.1651-2227.2011.02478.x Rosenthal, 1988, Differences in the epidemiology of childhood community-acquired bacterial meningitis between two ethnic populations cohabiting in one geographic area, Pediatr Infect Dis J, 7, 630, 10.1097/00006454-198809000-00006 Fraser, 2001, A decade (1989–1998) of pediatric invasive pneumococcal disease in 2 populations residing in 1 geographic location: implications for vaccine choice, Clin Infect Dis, 33, 421, 10.1086/321874 Novack, 2007, Differences between Bedouin and Jewish populations in incidence and characteristics of patients hospitalized with community-acquired pneumonia, Ethn Dis, 17, 441 Ben-Shimol, 2014, Early impact of sequential introduction of 7-valent and 13-valent pneumococcal conjugate vaccine on IPD in Israeli children < 5 years: an active prospective nationwide surveillance, Vaccine, 32, 3452, 10.1016/j.vaccine.2014.03.065 Kaplan, 2013, Early trends for invasive pneumococcal infections in children after the introduction of the 13-valent pneumococcal conjugate vaccine, Pediatr Infect Dis J, 32, 203, 10.1097/INF.0b013e318275614b Gur, 2006, Community-acquired bloodstream infections in children > one month old in southern Israel (1992–2001): Epidemiological, clinical and microbiological aspects, Scand J Infect Dis, 38, 604, 10.1080/00365540600606572 Jacobs, 1995, Viridans streptococci isolated from the bloodstream. Relevance of species identification, Diagn Microbiol Infect Dis, 22, 267, 10.1016/0732-8893(95)00137-Y Jacobs, 1995, Streptococcus anginosus, Streptococcus constellatus and Streptococcus intermedius. Clinical relevance, hemolytic and serologic characteristics, Am J Clin Pathol, 104, 547, 10.1093/ajcp/104.5.547 Weightman, 2004, Streptococcus milleri group bacteraemia in North Yorkshire, England (1989–2000), Indian J Med Res, 119, 164 Huang, 2007, Clinical features and complications of viridans streptococci bloodstream infection in pediatric hemato-oncology patients, J Microbiol Immunol Infect, 40, 349 Stelzmueller, 2007, Relevance of Group Milleri Streptococci in thoracic surgery: a clinical update, Am Surg, 73, 492, 10.1177/000313480707300515 Stelzmueller, 2009, Group Milleri Streptococci in paediatric infections, Eur J Pediatr Surg, 19, 21, 10.1055/s-2008-1039009 Shelburne, 2014, Streptococcus mitis strains causing severe clinical disease in cancer patients, Emerg Infect Dis, 20, 762, 10.3201/eid2005.130953 Siegman-Igra, 2012, Milleri group streptococcus-a stepchild in the viridans family, Eur J Clin Microbiol Infect Dis, 31, 2453, 10.1007/s10096-012-1589-7 Yagupsky, 1997, Kingella kingae: an emerging cause of invasive infections in young children, Clin Infect Dis, 24, 860, 10.1093/clinids/24.5.860 Yagupsky, 2009, Dissemination of Kingella kingae in the community and long-term persistence of invasive clones, Pediatr Infect Dis J, 28, 707, 10.1097/INF.0b013e31819f1f36 Amit, 2012, Epidemiology of invasive Kingella kingae infections in 2 distinct pediatric populations cohabiting in one geographic area, Pediatr Infect Dis J, 31, 415, 10.1097/INF.0b013e318240cf8a Gené, 2004, Enhanced culture detection of Kingella kingae, a pathogen of increasing clinical importance in pediatrics, Pediatr Infect Dis J, 23, 886, 10.1097/01.inf.0000137591.76624.82 Yagupsky, 2011, Kingella kingae: an emerging pathogen in young children, Pediatrics, 127, 557, 10.1542/peds.2010-1867